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Rare forms of renal hypertension (1981)

Lüscher, T. ; Vetter, H. ; Pouliadis, G. ; [et al.]

Springer

Journal of molecular medicine 59 (1981), S. 35-45

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ISSN: 1432-1440

Keywords: Renal artery aneurysm ; Renal cyst ; Hydronephrosis ; Coarctation of the aorta ; Radiation nephritis ; Hypertension ; Renin angiotensin system ; Nierenarterienaneurysma ; Nierencyste ; Hydronephrose ; Coarctatio aortae ; Strahlennephritis ; Hypertonie ; Renin-Angiotensin-System

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Description / Table of Contents: Zusammenfassung In der vorliegenden Studie wurden 19 Patienten mit seltenen Formen renaler Hypertonie untersucht: 6 Patienten mit Nierenarterienaneurysma, 6 Fälle mit unilateraler Hydronephrose, 4 Patienten mit unilateraler Nierencyste, 2 Fälle mit Coarctatio aortae und assozierter Nierenarterienstenose und ein Patient mit Strahlennephritis. Die Plasma-Renin-Aktivität (PRA) im Nierenvenenblut wurde bei 17 der 19 Fälle bestimmt. 7 dieser 17 (41%) Patienten zeigten einen signifikanten Seitenunterschied (PRA betroffene/PRA nicht betroffene Seite) ≧1,5. Der Prozentsatz positiver Tests war in verschiedenen Kollektiven vergleichbar hoch. Nur Patienten mit unilateraler Nierencyste zeigten in keinem Fall einen signifikanten PRA-Quotienten. Eine superselektive Nierenvenenrenin-Bestimmung bei 2 Patienten mit Nierenarterienaneurysma der oberen Segmentarterie zeigte in beiden Fällen eine erhöhte Plasma-Renin-Aktivität im Bereiche des Oberpols. 15 der 19 Patienten (79%) wurden operiert. Dabei kamen entweder plastisch rekonstruktive Verfahren oder eine Nephrektomie zur Anwendung. 4 Fälle mit Nierenarterienaneurysma wurden antihypertensiv behandelt. Patienten mit unilateraler Hydronephrose zeigten postoperativ die besten Ergebnisse (3 geheilt, 3 gebessert), während bei keinem der 4 Patienten mit unilateraler Nierencyste die Blutdruckwerte durch den operativen Eingriff normalisiert werden konnten (3 gebessert, 1 nicht gebessert). Die Patienten mit Coarctatio aortae und assozierter Nierenarterienstenose sowie die 2 operierten Fälle mit Nierenarterienaneurysma zeigten alle ein gutes Ansprechen auf den gefäßrekonstruktiven Eingriff (2 geheilt, 2 gebessert). Der Patient mit Strahlennephritis schließlich war 2 Jahre nach Nephrektomie gebessert. Im Gesamtkollektiv unserer operierten Patienten war die prognostische Aussagekraft der Nierenvenenreninbestimmung beschränkt. Allerdings erwies sich die selektive Nierenvenenreninbestimmung bei Patienten mit einem Aneurysma einer Nierensegmentarterie als nützlich zur Entdeckung lokaler Reninüberproduktion.

Notes: Summary In the present study 19 patients with rare forms of renal hypertension were investigated: 6 patients with renal artery aneurysm, 6 cases with unilateral hydronephrosis, 4 patients with unilateral simple renal cyst, 2 cases with coarctation of the abdominal aorta and associated renal artery stenosis and 1 patient with radiation nephritis. Renal venous renin activity (PRA) was determined in 17 of the 19 cases. Seven of these 17 (41%) patients showed significant PRA-ratios (PRA affected/PRA unaffected side ≧1.5). The percentage of positive tests was comparably high in the various subgroups except in patients with renal cyst, none of them showing lateralisation of renin secretion. Selective sampling in 2 patients with renal artery branch aneurysm revealed in both cases marked local renin oversecretion. Fifteen of the 19 patients (79%) were operated either by reconstruction surgery or nephrectomy. Four cases with a renal artery aneurysm were treated with antihypertensive drugs. Patients with unilateral hydronephrosis showed the best response to surgery in terms of cure rate (3 cured, 3 improved), whereas blood pressure normalisation could not be achieved in patients with simple renal cyst (2 improved, 1 unimproved). Patients with coarctation of the abdominal aorta and associated renal artery stenosis and the 2 operated cases with renal artery aneurysm showed a good effect of corrective surgery (2 cured, 2 improved). The patient with radiation nephritis finally was improved 2 years after nephrectomy. For the total group the prognostic validity of renal venous renin determination was limited. However, selective blood sampling from peripheral renal veins may be useful in cases with renal artery branch aneurysm to detect local oversecretion of renin.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01477328

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Long-term effect of captopril on kidney function in various forms of hypertension (1984)

Vetter, W. ; Wehling, M. ; Foerster, E. -Ch. ; [et al.]

Springer

Journal of molecular medicine 62 (1984), S. 731-737

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ISSN: 1432-1440

Keywords: Captopril ; Kidney function ; Essential hypertension ; Renovascular hypertension ; Renal parenchymatous hypertension

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary To study long-term effects of captopril on renal function in patients with various forms of severe hypertension, serum creatinine values were monitored in 76 patients under captopril therapy over a period of up to 3 years. Three different groups were formed: (1) patients with essential hypertension (n=37); (2) patients with renovascular hypertension (n=20); (3) patients with renal parenchymatous hypertension (n=19). In each of the three groups reduction in blood pressure was accompanied by increases in serum creatinine. However, both changes were more pronounced in patients with renovascular hypertension. In this group only the rise in creatinine was statistically significant and showed a slight progression with duration of captopril treatment. Group specific analysis revealed that the increase was smaller in patients with unilateral (n=16) renovascular disease than in those with bilateral (n=4) involvement, but in the former it was still significantly higher than in patients with essential or renal parenchymatous hypertension. Separation of patients according to the underlying disease of renovascular hypertension showed that renal function deteriorated less in patients with arteriosclerotic origin (n=10) than in those with fibromuscular dysplasia (n=8). Statistical evaluation of subjects with renovascular and essential hypertension still revealed significant differences in creatinine when the patients with initial plasma renin activity (PRA) below and above 6 ng/ml·3 h were compared separately. A significant correlation (r=0.73;P〈0.05) between blood pressure reduction and creatinine changes was obtained only for patients with renovascular hypertension. Finally, in all three groups of patients creatinine changes were statistically independent from daily dosages of captopril. From these data we conclude that sustained impairment of kidney function by captopril is mainly restricted to patients with renovascular hypertension and possibly results from the combined effects of low renal perfusion pressure and interference with intrarenal regulation of glomerular filtration rate by a postulated angiotensin-II-mediated mechanism.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01725707

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Obesity, hypertension and intracellular electrolytes (1983)

Baumgart, P. ; Zidek, W. ; Losse, H. ; [et al.]

Springer

Journal of molecular medicine 61 (1983), S. 803-805

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ISSN: 1432-1440

Keywords: Obesity ; Hypertension ; Intracellular sodium ; Intracellular calcium

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Intracellular activities of sodium and calcium were determined in red cells of patients with obesity. Compared to normal people mean intracellular sodium and calcium were higher in obese patients. However, increased intracellular sodium and calcium could only be observed in those patients with obesity suffering from hypertension or showing a familial disposition to hypertension. In contrast there was no difference in intracellular sodium and calcium between obese normotensives lacking a familial disposition to hypertension and normal people. Thus, our results suggest, that the observed variations in intracellular sodium and calcium in obesity are due to an enhanced blood pressure or a familial disposition to hypertension and not specific for obesity.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01496724

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Renovaskuläre Hypertonie (1979)

Vetter, W. ; Vetter, H. ; Tenschert, W. ; [et al.]

Springer

Journal of molecular medicine 57 (1979), S. 863-873

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ISSN: 1432-1440

Keywords: Renovascular hypertension ; Renal venous renin activity ; Effect of surgery ; Renovaskuläre Hypertonie ; Nierenvenenreninaktivität ; Operationserfolg

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Description / Table of Contents: Zusammenfassung In der vorliegenden Untersuchung wurde das postoperative Blutdruckverhalten bei 35 Patienten mit renovaskulärer Hypertonie untersucht: 17 Patienten mit fibromuskulärer Dysplasie (FMD) und 18 mit arteriosklerotischen Gefäßwandveränderungen (ASS). Patienten mit FMD waren im Mittel jünger (31,8 Jahre), zeigten eine kürzere Hypertonieanamnese (1,8 Jahre) und waren prävalent weiblich (82%), während Patienten mit ASS deutlich älter waren (48,2 Jahre), eine längere Hypertoniedauer (2,6 Jahre) zeigten und bevorzugt männlich (78%) waren. In beiden Gruppen zeigte das intravenöse Pyelogramm einen vergleichbar hohen Anteil positiver Befunde (FMD=64%, ASS=61%). Postoperativ waren in der Gruppe mit FMD 47% (n=8) geheilt, 47% (n=8) gebessert und nur 6% (n=1) der Patienten geringgradig gebessert. Die vergleichbaren Werte für die Gruppe mit ASS betrugen 28, 55 und 17%. Für das Gesamtkollektiv war folglich ein guter Operationserfolg (geheilt und gebessert) in 88,5% der Fälle zu beobachten. Patienten mit ASS und postoperativ nur geringgradiger Besserung (n=3) zeigten eine auffallend lange Hypertonieanamnese (7,0±1,4 Jahre). Bei allen Patienten wurde präoperativ die seitengetrennte Bestimmung der Renin-Aktivität (PRA) im Nierenvenenblut durchgeführt und aus den Werten die PRA-Quotienten (PRA betroffene/nicht betroffene Seite) errechnet. Bei 27 Patienten wurde die Bestimmung 15 und 30 min nach intravenöser Stimulation mit 40 mg Furosemid wiederholt. PRA-Quotienten von ≧1,5 wurden als signifikant bezeichnet. Bei 31 Patienten mit einseitiger renovaskulärer Hypertonie wurde die Höhe des PRA-Quotienten zum postoperativen Blutdruckverhalten korreliert. Dabei zeigte sich zwischen der Gruppe der postoperativ Geheilten und der der postoperativ Gebesserten kein signifikanter Unterschied im mittleren PRA-Quotienten. Ferner ließen sich für das Gesamtkollektiv der 31 Patienten mit einseitiger renovaskulärer Hypertonie unter Ausgangs- und Stimulationsbedingungen keine signifikanten Korrelationen zwischen Höhe der PRA-Quotienten und postoperativem Blutdruckabfall ermitteln. Unsere Ergebnisse unterstützen nicht die weit verbreitete Ansicht, daß sich die seitengetrennte Bestimmung der PRA im Nierenvenenblut als Parameter für den zu erwartenden Operationserfolg bei Patienten mit einseitiger renovaskulärer Hypertonie eignet. Die Methode kann deshalb nach unserer Ansicht nicht mehr als obligater Bestandteile der präoperativen Diagnostik der renovaskulären Hypertonie empfohlen werden.

Notes: Summary In the present study the effect of surgery on blood pressure was investigated in 35 patients with renovascular hypertension: 17 patients with fibromuscular hyperplasia (FMD) and 18 with atherosclerosis (ASS) of the renal artery. Patients with FMD were younger (31,8 years), showed a shorter duration of hypertension (1.8 years) and were prevalently female (82%), whereas patients with ASS were markedly older (48.2 years), showed a longer duration of hypertension (2.6 years) and were most often male (78%). In both groups of patients the intravenous urogram was positive in a comparable high percentage (FMD=64%, ASS=61%). Following surgical intervention 47% (n=8) of the 17 patients with FMD were cured, 47% (n=8) were improved and only 6% (n=1) showed insufficient reduction of blood pressure values. In ASS the respective values were 28, 55 and 17%. Consequently a good effect of surgery (cured and improved) was observed in 88.5% of all patients. Patients with ASS who failed to respond to surgery (n=3) showed a remarkable long duration of hypertension (7.0±1.4 years). Plasma renin activity (PRA) was determined preoperatively in both renal veins in all 35 patients. From these values the PRA-ratio (PRA affected/unaffected side) was calculated. In 27 patients PRA determinations were repeated following (15 and 30 min) intravenous injection of 40 mg furosemide. PRA-ratios of ≧1.5 were considered to be significant. In 31 patients with unilateral renovascular hypertension PRA-ratios were correlated to the postoperative blood pressure reduction. No significant differences in mean PRA-ratios were observed between cured and improved patients. Furthermore, for the total group of 31 patients no significant correlations were obtained between PRA-ratios and postoperative blood pressure reduction. Our results do not support the widespread opinion that PRA determinations in both renal veins are useful to predict the effect of surgery in patients with unilateral renovascular disease. Therefore, from our experience this method should not be recommended as obligatory in the diagnostic work-up of renovascular hypertension.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01477025

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Extrarenaler Gefäßbefall bei fibromuskulär bedingter renovaskulärer Hypertonie (1980)

Lüscher, T. ; Vetter, H. ; Studer, A. ; [et al.]

Springer

Journal of molecular medicine 58 (1980), S. 493-500

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ISSN: 1432-1440

Keywords: Renovascular hypertension ; Fibromuscular hyperplasia ; Coarctation of the aorta ; Renin angiotensin system ; Renovaskuläre Hypertonie ; Fibromuskuläre Dysplasie ; Coarctatio aortae ; Renin-Angiotensin-System

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Description / Table of Contents: Zusammenfassung In der vorliegenden Studie wurden 10 Fälle mit fibromuskulär bedingter renovaskulärer Hypertonie und gleichzeitigem Befall extrarenaler Arterien untersucht. Das Patientenkollektiv zeigte eine deutliche Prävalenz des weiblichen Geschlechts (90%), das mittlere Alter betrug 31,4±12,0 Jahre und die Hypertoniedauer 3,2±4,0 Jahre. 4 der 10 Patienten wiesen Stenosen einer und 6 Stenosen bzw. Verschlüsse beider Nierenarterien auf. 2 (20%) Patientinnen zeigten neben fibromuskulären Umbauprozessen der Nierenarterien eine abdonale Coarctatio aortae. Andere Körperarterien waren mit abnehmender Häufigkeit wie folgt befallen: Arteria mesenterica superior (50%), Arteria subclavia und/oder Truncus brachiocephalicus (40%), Arteriae carotides und/oder deren Äste (30%), Truncus coeliacus (30%), Arterien der Beckenstrombahn (30%), Arteriae vertebrales (10%) und Arteria mesenterica inferior (10%). Im Vordergrund der klinischen Symptomatik stand bei 8 der 10 Patienten die Hypertonie. Beschwerden von seiten extrarenaler Gefäßveränderungen waren in diesen Fällen bei Diagnosestellung gering. In 2 Fällen mit Befall von 2 bzw. aller 3 Intestinalgefäße bestand eine Angina abdominalis. 2 Patientinnen mit Stenosen der Beckengefäße zeigten eine Claudicatio intermittens, während Stenosen bzw. Verschlüsse im Subclaviabereich nur bei starker Belastung zu Claudicationsbeschwerden führten und deshalb über einen längeren Zeitpunkt unerkannt blieben. Eine Patientin mit Verschlüssen der Arteriae carotides internae hatte zweimal einen cerebralen Insult durchgemacht. Eine seitengetrennte Bestimmung der Plasma-Renin-Aktivität im Nierenvenenblut wurde bei 7 der 10 Patienten durchgeführt. Dabei zeigten 4 dieser 7 Fälle entweder unter Ausgangsbedingungen oder 15 bzw. 30 min nach intravenöser Stimulation mit 40 mg Furosemid einen signifikanten Seitenunterschied (≧ 1,5). Bei 5 der 10 Patienten wurde eine rekonstruktive Gefäßoperation an den Nierenarterien und bei einem Patienten ein solcher nur an den Intestinalarterien vorgenommen; dabei zeigte nur einer der 5 an den Nierenarterien operierten Fälle eine Heilung. Bei 3 der 5 medikamentös behandelten Patienten ließ sich eine Blutdrucknormalisierung durch Antihypertensiva erzielen. Unsere Ergebnisse zeigen, daß bei Patienten mit fibromuskulär bedingter Nierenarterienstenose verschiedenste Körperarterien mitbeteiligt sein können, am häufigsten jedoch die Arteria mesenterica superior. Bei 2 der 10 Patienten fand sich neben der renovaskulären Hypertonie eine Coarctatio aortae. Wegen des schlechten Operationserfolges sollte zunächst der Versuch einer medikamentösen Blutdruckeinstellung unternommen werden. Wegen des hohen Anteils doppelseitiger Nierenarterienstenosen hat die seitengetrennte Bestimmung der Plasma-Renin-Aktivität im Nierenvenenblut nur eine beschränkte Aussagekraft.

Notes: Summary In the present study 10 patients with renovascular hypertension due to fibromuscular hyperplasia and fibromuscular lesions of extrarenal arteries were investigated. The 10 patients were predominantly female (90%), showed a mean age of 31.4±12.0 years and a mean duration of hypertension of 3.2±4.0 years. Four of the 10 patients (40%) showed unilateral and six (60%) bilateral stenosis or occlusions of the renal arteries. In two (20%) cases a combination of renal artery stenosis and coarctation of the abdominal aorta was observed. Other extrarenal arteries were affected as follows: mesenteric superior artery (50%), subclavian artery and/or arteria anonyma (40%), carotid arteries and/ or their branches (30%), vertebral arteries (10%), and mesenteric inferior artery (10%). In eight of the 10 patients the most prominent clinical symptom was hypertension. Clinical symptoms from extrarenal artery stenoses or occlusions were mild. Two patients with fibromuscular lesions of two and three intestinal arteries, respectively, suffered from angina abdominalis. In two cases with stenoses of the iliacal arteries intermittent claudicatio was observed, whereas involvement of the subclavian artery was associated with only mild symptoms. One patient with occlusions of both internal carotid arteries had two episodes of cerebrovascular ischemia. Plasma renin activity was determined in both renal veins in seven of the 10 patients (70%). Four of the seven patients (57%) showed a PRA-ratio of ≧1.5 either under basal conditions or 15 and/or 30 min after i.v. stimulation with 40 mg furosemide. Only one of the five patients with revascularization operations was cured postoperatively. In one patient only the intestinal arteries were operated. Three of five cases treated with various antihypertensive drugs were normotensive. Our results show that in patients with renovascular hypertension due to fibromuscular hyperplasia extrarenal arteries may be frequently affected. The most frequent site of extrarenal lesions was the mesenteric superior artery. In two of the 10 patients renovascular hypertension was combined with a coarctation of the abdominal aorta. In this study the effect of reconstructive renovascular surgery was insufficient. Thus, these cases should first be treated with antihypertensive drugs. The diagnostic validity of renal venous renin activity was limited because of the high percentage of bilateral renovascular lesions.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01477066

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The effect of saralasin (1-Sar-8-Ala-Angiotensin II) on blood pressure in patients with cushing's syndrome (1976)

Vetter, W. ; Vetter, H. ; Beckerhoff, R. ; [et al.]

Springer

Journal of molecular medicine 54 (1976), S. 661-663

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ISSN: 1432-1440

Keywords: Cushing-Syndrom ; Hypertonie ; Renin-Aktivität ; Aldosteronismus ; Cushing's syndrome ; Hypertension ; Renin activity ; Aldosteronism

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Description / Table of Contents: Summary To investigate the role of the renin angiotensin system in the pathogenesis of hypertension in Cushing's syndrome two patients with hypercorticism were infused with 20 mg saralasin (1-sar-8-alaangiotensin II) over a period of 30 minutes under constant blood pressure control. In addition, one patient with primary aldosteronism, an established form of mineralocorticoid hypertension, served as control. Neither in the two patients with Cushing's syndrome nor in the patient with primary aldosteronism could a blood pressure lowering effect of saralasin be observed. In the two patients with hypercorticism both renin activity and plasma aldosterone increased during saralasin infusion. The patient with primary aldosteronism only showed a weak increase in plasma aldosterone concentration. These results seem to exclude an important role of the renin angiotensin system in the pathogenesis of hypertension in Cushing's syndrome. The unresponsiveness of elevated blood pressure to saralasin in the two patients with hypercorticism and in the patient with primary aldosteronism indirectly supports the assumption that in patients with Cushing's syndrome increased mineralocorticoid activity may be the main factor in the pathogenesis of hypertension.

Notes: Zusammenfassung Um die Bedeutung des Renin-Angiotensin Systems in der Pathogenese der Hypertonie bei Cushing-Syndrom zu untersuchen, wurden bei 2 Patienten mit Hyperkortizismus 20 mg Saralasin (1-Sar-8-Ala-Angiotensin II) über einen Zeitraum von 30 min unter ständiger Blutdruckkontrolle infundiert. Zusätzlich diente ein Patient mit primärem Aldosteronismus, einer etablierten Form von Mineralokortikoidhochdruck, als Kontrolle. Weder bei den 2 Patienten mit Cushing-Syndrom noch bei dem Patienten mit primärem Aldosteronismus ließ sich ein blutdrucksenkender Effekt des Saralasins nachweisen. Die beiden Patienten mit Hyperkortizismus zeigten unter Saralasin sowohl einen Anstieg der Renin-Aktivität als auch des Plasmaaldosterons. Bei dem Patienten mit primärem Aldosteronismus ließ sich nur ein geringgradiger Anstieg der Plasmaaldosteronkonzentration nachweisen. Diese Ergebnisse sprechen gegen eine wichtige Rolle des Renin-Angiotensin Systems in der Pathogenese der Hypertonie bei Cushing-Syndrom. Die Unbeeinflußbarkeit des Hochdrucks durch Saralasin bei den beiden Patienten mit Hyperkortizismus und dem Patienten mit primärem Aldosteronismus stützen indirekt die Annahme, daß bei Patienten mit Cushing-Syndrom eine erhöhte Mineralokortikoidaktivität der Hauptfaktor in der Pathogenese der Hypertonie ist.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01469145

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Weight reduction and salt restriction in hypertension: Effects on blood pressure and intracellular electrolytes (1986)

Zidek, W. ; Karoff, Ch. ; Losse, H. ; [et al.]

Springer

Journal of molecular medicine 64 (1986), S. 1183-1185

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ISSN: 1432-1440

Keywords: Salt restriction ; Weight reduction ; Hypertension ; Intracellular electrolytes

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary In 16 essential hypertensives on a program of energy restriction (800 kcal/day) with and without simultaneous salt restriction, the effects on blood pressure and intracellular Na+ and Ca2+ in red blood cells were studied. A decrease in blood pressure and intracellular free Na+ and Ca2+ was only observed in the cases of simultaneous energy and salt restriction. The beneficial effect of weight reduction in hypertension thus depends on a diminished salt intake and is probably mediated by changes in intracellular free Ca2+.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01728458

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Platelet Na+/H+ antiport activity in patients with insulin-dependent diabetes mellitus with and without diabetic nephropathy (1993)

Düsing, R. ; Sorger, M. ; Mattes, L. ; [et al.]

Springer

Journal of molecular medicine 71 (1993), S. 119-125

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ISSN: 1432-1440

Keywords: Na+/H+ antiport ; Hypertension ; Diabetic nephropathy ; Hereditary factors

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The incidence of diabetic nephropathy in patients with insulin-dependent diabetes mellitus (IDDM) may depend on factors other than the quality of diabetes control. Hypertension is an additional factor associated with a high degree of renal involvement in IDDM. One abnormality consistantly observed in various tissues of patients with essential hypertension is enhanced activity of the Na+/H+ antiport. In the present study we have therefore studied platelet antiport activity in 41 healthy subjects (control), in 22 patients with untreated essential hypertension (EH), and in 35 normotensive IDDM patients (type 1). Of these patients 17 exhibited signs of diabetic nephropathy (group 1) while 18 had no evidence for renal involvement of IDDM in spite of a duration of IDDM of at least 10 years (group 2). The two IDDM patient groups were undistinguishable with respect to age, body mass index, and arterial blood pressure (group 1, 117.9±2.4/78.4±1.5 mmHg; group 2, 113.9±3.6/76.1±1.8 mmHg). Antiporter activity was determined from the rate of cell volume changes induced by propionic acid. Platelet Na+/H+ exchange activity averaged 23.43±0.43 10−3·s−1 in control subjects and was markedly elevated in EH (28.38±0.62 10−3·s−1 P〈0.01). Antiport activity in group 2 patients without nephropathy averaged 24.54±0.57 10−3·s−1 and was undistinguishable from the control group. However, platelet Na+/H+ antiport activity was significantly stimulated in group 1 patients with nephropathy as compared to group 2(26.95±0.73 10−3. s−1 ; P〈0.025). Our results show that renal involvement in IDDM is associated with enhanced activity of the platelet Na+/H+ antiport.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00179992

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Characterization of angiotensin receptors on human skin fibroblasts (1997)

Nickenig, Georg ; Geisen, Gabriele ; Vetter, Hans ; [et al.]

Springer

Journal of molecular medicine 75 (1997), S. 217-222

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ISSN: 1432-1440

Keywords: Key words Angiotensin II ; Human skin fibroblasts ; Hypertension ; Arteriosclerosis

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Angiotensin II is involved in blood pressure regulation, cell growth and angioneogenesis. The angiotensin receptors which mediate the intracellular effects of angiotensin II are expressed in numerous tissues and cell types. We studied the expression of angiotensin II receptors in cultured human skin fibroblasts derived from a skin biopsy. Angiotensin II binding characteristics were analyzed by radioligand binding assays. The DNA synthesis was assessed by [H]thymidine incorporation assays. Intracellular calcium concentrations were measured by fura-2 spectrofluorometry, and mRNA expression levels were analyzed by northern blot technology. Two distinct angiotensin receptors were detectable on human skin fibroblasts: the AT1 receptor with K d=1.0± 0.7 nmol/l and B max=17.9±0.9 fmol/mg protein, and an angiotensin(1–7) binding site with K d=26±6.6 nmol/l and B max=80.4±3.5 fmol/mg protein, as shown by competition binding assays using selective angiotensin II receptor antagonists and the heptapeptide angiotensin(1–7). The angiotensin AT1 receptor mRNA was substantially expressed in human skin fibroblasts and was subjected to homologous downregulation. In human skin fibroblasts angiotensin II caused a profound increase in intracellular calcium which was blocked by angiotensin AT1 receptor antagonists such as Exp-3174. Furthermore, both angiotensin II and angiotensin(1–7) led to increased DNA synthesis in human skin fibroblasts. In conclusion, cultured human skin fibroblasts express angiotensin AT1 receptors and a putatively new angiotensin receptor activated by angiotensin(1–7), both coupled to signaling pathways involved in DNA synthesis.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s001090050106

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Cellular calcium metabolism in primary hypertension (1987)

Zidek, W. ; Vetter, H.

Springer

Journal of molecular medicine 65 (1987), S. 155-160

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ISSN: 1432-1440

Keywords: Hypertension ; Ca2+

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Several disturbances of cellular Ca2+ metabolism have been described in essential hypertension and in the spontaneously hypertensive rat. Possibly the elevation of intracellular free Ca2+ concentration in arterial smooth muscle cells is one important step in the pathogenesis of primary hypertension. In most studies a decreased energy-dependent Ca2+ transport has been proposed as a mechanism. However, disturbances in cellular Ca2+ metabolism, which can be exclusively ascribed to essential hypertension, have not yet been found. The cause of altered cellular Ca2+ transport in primary hypertension may either be a genetically determined defect of membrane transport or a still-unidentified humoral factor.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01728224

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