Summary
In 16 essential hypertensives on a program of energy restriction (800 kcal/day) with and without simultaneous salt restriction, the effects on blood pressure and intracellular Na+ and Ca2+ in red blood cells were studied. A decrease in blood pressure and intracellular free Na+ and Ca2+ was only observed in the cases of simultaneous energy and salt restriction. The beneficial effect of weight reduction in hypertension thus depends on a diminished salt intake and is probably mediated by changes in intracellular free Ca2+.
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Zidek, W., Karoff, C., Losse, H. et al. Weight reduction and salt restriction in hypertension: Effects on blood pressure and intracellular electrolytes. Klin Wochenschr 64, 1183–1185 (1986). https://doi.org/10.1007/BF01728458
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DOI: https://doi.org/10.1007/BF01728458