Skip to main content
Log in

Obesity, hypertension and intracellular electrolytes

  • Originalien
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

Intracellular activities of sodium and calcium were determined in red cells of patients with obesity. Compared to normal people mean intracellular sodium and calcium were higher in obese patients. However, increased intracellular sodium and calcium could only be observed in those patients with obesity suffering from hypertension or showing a familial disposition to hypertension. In contrast there was no difference in intracellular sodium and calcium between obese normotensives lacking a familial disposition to hypertension and normal people. Thus, our results suggest, that the observed variations in intracellular sodium and calcium in obesity are due to an enhanced blood pressure or a familial disposition to hypertension and not specific for obesity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Belfiore F, Ianello S, Rabuazzo AM, Borzi V (1981) The activity of sodium and potassium-activated adenosine-triphosphatase (NaK-ATPase) in the adipose tissue of obese patients. In: Enzi G, Crepaldi G, Pozza G, Renold AE (eds) Obesity: Pathogenesis and Treatment. Academic press, London New York Toronto Sydney San Francisco, pp 129–134

    Google Scholar 

  2. Berchtold P, Jörgens V, Kemmer FW, Berger M (1982) Obesity and hypertension: Cardiovascular response to weight reduction. Hypertension 4 [Supp 3]: 3:50–55

    Google Scholar 

  3. Chian BN, Perlman LV, Epstein FH (1969) Overweight and hypertension. Circulation 39:403–421

    PubMed  Google Scholar 

  4. De Luise M, Blackburn GL, Flier JS (1980) Reduced activity of the red cell sodium-potassium pump in human obesity. N Engl J Med 303:1017–1022

    PubMed  Google Scholar 

  5. Dorst K, Zidek W, Losse H, Zumkley H, Wollnik S, Vetter H (1981) Intrazelluläres Natrium and Calcium als genetische Marker der essentiellen Hypertonie. Schweiz Med Wochenschr 111:1964–1966

    PubMed  Google Scholar 

  6. Kannel WB, Brand N, Skinner JN, Dawber TR, McNamara PM (1967) The relation of adiposity to blood pressure and development of hypertension: The Framingham study. Ann Intern Med 67:48–59

    PubMed  Google Scholar 

  7. Lin MH, Romsos DR, Akers T, Leveille GA (1978) Na+, K+-ATPase enzyme units in sceletal muscle from lean and obese mice. Biochem Biophys Res Comm 80:398–404

    PubMed  Google Scholar 

  8. Norbiato GT, Vago T, Bevilacqua Bosisio E (1981) Red-Cell sodium-potassium pump in obesity. N Engl J Med 304:540 (Letter)

    Google Scholar 

  9. Robinson RA, Stokes RH (1959) Electrolyte solutions. Butterworth, London

    Google Scholar 

  10. York DA, Bray GA, Yukimura Y (1978) An enzymatic defect in the obese (ob/ob) mouse: Loss of thyroidinduced sodium- and potassium-dependent adenosine-triphosphatase. Proc Natl Acad Sci USA 75:477–481

    PubMed  Google Scholar 

  11. Zidek W, Losse H, Dorst KG, Zumkley H, Vetter H (1982) Intracellular sodium and calcium in essential hypertension. Klin Wochenschr 60:859–682

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Baumgart, P., Zidek, W., Losse, H. et al. Obesity, hypertension and intracellular electrolytes. Klin Wochenschr 61, 803–805 (1983). https://doi.org/10.1007/BF01496724

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01496724

Key words

Navigation