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  • 1
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. The waveforms of vessels supplying the ovaries of women on an in-vitro fertilization (IVF) programme were studied using transvaginal B-mode and Doppler ultrasound. There were 125 scans recorded in 65 women at weekly intervals from 3 days after embryo transfer or 5 days after gamete intrafallopian transfer (GIFT) until confirmation of pregnancy or onset of menses. At each examination the signals obtained from vessels supplying the ovaries were recorded and quantified using a resistance index (RI). Fifteen patients became pregnant of whom one has subsequently miscarried. There was a highly significant difference in the RI values between patients who became pregnant and those who did not; no patient who became pregnant had a RI greater than 0.5. Oestrogen to progesterone ratios were calculated in the subgroup of non-pregnant patients and there was no correlation between these values and the RI values. This new technique enables prediction of IVF treatment failure earlier than has been reported previously and may reflect the inadequacy of the corpus luteum.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 220 (1968), S. 281-282 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Medawar3 has pointed out that the efficacy of natural selection decreases with increasing relative age until, near the end of life expectancy, selection against harmful but late acting genes is insufficient to remove them from the population. Harmful genetic effects are postponed by selection and ...
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé On a utilisé chez 10 patients un manchon gonflable contrôlé à travers la peau et inséré autour du greffon pour changer le diamètre d'un shunt portacave en H. Gonfler le manchon diminue le diamètre du shunt en augmentant la pression porte ce qui réduit le débit du shunt. L'utilisation du shunt a été cliniquement décisive chez 3 des 7 patients ayant survécu à long terme. La réduction du diamètre du shunt a amélioré l'état clinique de 2 patients ayant une encéphalopathie, et la réouverture du shunt fermé par ce moyen a diminué l'ascite chez un troisième. Des modifications du débit porte après gonflage du manchon étaient toujours visibles à 6 mois par échographie et Doppler. On conclut qu'il faut continuer à expérimenter ce type de shunt portocave à débit variable.
    Abstract: Resumen Hemos desarrollado un manguito y reservorio de implantación subcutánea, el cual, mediante control percutáneo, permite modificar el diámetro de los “shunts” portacava en H; ha sido utilizado en 10 pacientes. Al inflar el manguito se comprime el injerto en H, con lo cual se aumenta la presión portal y se reduce el flujo a través del “shunt.” El uso del manguito ha sido de beneficio clínico en 3 de 7 sobrevivientes a largo plazo. La comprensión del “shunt” mejoró el estado clínico de 2 pacientes con encefalopatía, y su reapertura mejoró la ascitis en el tercer paciente. Estudios con ultrasonido duplex y ultrasonido profundo han demostrado una alteración en el flujo portal después de inflar el manguito a los 6 meses. Nuestra conclusión es que se justifica continuar desarrollando esta prótesis que permite establecer un “shunt” portacava en H controlado.
    Notes: Abstract A percutaneously-controlled inflatable cuff which can change the diameter of a portacaval H-graft has been developed and used in 10 patients. When inflated, the cuff narrows the H-graft to increase portal pressure and reduce shunting. Use of the cuff has been of clinical significance in 3 of 7 long-term surviving patients. Narrowing the shunt improved the clinical state in 2 patients with encephalopathy, and reopening a closed shunt improved ascites in the third patient. Duplex ultrasound and deep Doppler have demonstrated an alteration of hepatic portal blood flow following inflation of the cuff after 6 months. It is concluded that further development of this controlled portacaval H-graft is warranted.
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