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  • 1
    Online Resource
    Online Resource
    Tumors of the Brain and Spine (2006)
    Norwell : Springer Science+Business Media, LLC
    Details Availability
    Keywords: Medicine ; Neurology ; Neurosurgery ; Oncology ; Cancer Surgery ; Pathology ; Medicine & Public Health ; Cancer Surgery ; Neurology ; Neurosurgery ; Oncology ; Pathology ; Medicine ; Brain Neoplasms ; Spinal Cord Neoplasms ; Brain Neoplasms therapy ; Spinal Cord Neoplasms therapy ; Aufsatzsammlung ; Hirntumor ; Wirbelsäule ; Tumor ; Hirntumor ; Rückenmarkstumor
    Description / Table of Contents: Focuses on the standard approaches to the treatment of benign, primary low-grade to high-grade, and metastatic tumors in the brain and spine used by surgeons and clinicians at the University of Texas M D Anderson Cancer Center
    Type of Medium: Online Resource
    Pages: Online-Ressource (XII, 364 p. 73 illus, digital)
    ISBN: 9780387292021
    Series Statement: M. D. Anderson Cancer Care Series
    URL: https://doi.org/10.1007/978-0-387-29202-1
    URL: http://dx.doi.org/10.1007/978-0-387-29202-1
    URL: https://swbplus.bsz-bw.de/bsz266999069kap.htm
    URL: https://swbplus.bsz-bw.de/bsz266999069vor.htm
    URL: https://swbplus.bsz-bw.de/bsz266999069cov.jpg
    URL: https://swbplus.bsz-bw.de/bsz266999069inh.htm
    DOI: 10.1007/978-0-387-29202-1
    RVK:
    XH 8550
    RVK:
    XH 8600
    Language: English
    Note: Description based upon print version of record , Front Matter; Epidemiology of Brain Tumors; Neuropathology and Molecular Biology of Intracranial Tumors; Radiology of Brain Tumors: Structure and Physiology; Surgically Curable Brain Tumors of Adults; Low-Grade Gliomas: Evidence-Based Treatment Options; Surgical Strategies for High-Grade Gliomas; Radiation Oncology for Tumors of the Central Nervous System: Improving the Therapeutic Index; Cytotoxic Chemotherapy for Diffuse Gliomas; Innovative Treatment Strategies for High-Grade Gliomas; Pituitary Tumors in Oncology , Management of Lung Cancer, Breast Cancer, and Melanoma Metastatic to the BrainNeoplastic Meningitis; Lymphoma Affecting the Central Nervous System; Tumors of the Extradural Spine; Tumors of the Spinal Cord and Intradural Space; Symptom Management for Patients with Brain Tumors: Improving Quality of Life; Back Matter;
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  • 2
    Electronic Resource
    Electronic Resource
    Virus-augmented delayed hypersensitivity skin tests in gynecological malignancies (1984)
    Springer
    Cancer immunology immunotherapy 17 (1984), S. 142-146 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cultured human tumor cells of various histologic origins were infected with PR8/A/34 influenza virus. Nonviable crude membrane extracts were derived from the infected and uninfected cells. The extracts were coded and tested for their ability to produce delayed hypersensitivity skin reactions (DHSR) in allogeneic patients with squamous uterine cervical carcinoma, epithelial ovarian carcinoma, and malignant melanoma. Augmented antigen sensitivity to the virus-modified extracts compared with virus alone or to the unmodified extracts was observed in all patient groups. There was insufficient specificity to delineate a response by individual tumor type and related tumor extract, but some of the observed responses suggested tumor or organ site associations. Cervical carcinoma patients reacted more frequently to the virus-modified cervix extract, which also produced a high frequency of response in patients with ovarian carcinoma and melanoma. Ovarian carcinoma patients demonstrated increased sensitivity to both virus-modified ovarian carcinoma extracts, although 14 of 21 patients also showed responsiveness to one of the unmodified ovarian extracts. Malignant melanoma patients showed increased sensitivity to all virus-modified extracts except one of two derived from the ovarian carcinoma, and demonstrated a significantly augmented response to the virus-modified melanoma extract when the response to this extract was compared with that in ovarian carcinoma patients. The augmented reactions appear to be due to an association of the PR8 virus and as yet undetermined cellular components rather than to the virus alone. The possible involvement of tumor-associated determinants and the clinical significance of this phenomenon require further investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00200051
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of virus-modified tumor cell extracts, autologous mononuclear cell infusions and interleukin-2 on oncolytic activity of effector cells of patients with advanced ovarian cancer (1989)
    Springer
    Cancer immunology immunotherapy 30 (1989), S. 126-132 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied the biological responses of six ovarian cancer patients after intraperitoneal (i.p.) injections of virus-modified tumor cell extracts (VMTE) and autologous peripheral blood mononuclear cells, collected by leukapheresis after two injections of VMTE. VMTE was prepared from allogeneic ovarian cell lines, OV2774 and CaOV3, modified by influenza virus, A/PR8/34. A dose of 9 mg VMTE was given i.p. in total of 2–4 injections, and (1−9) × 108 autologous mononuclear cells were infused i.p., 24 h after the second VMTE injection, and 24 h and 72 h after the third VMTE injection. Both peripheral blood (PB) and peritoneal cavity (PC) effector cell cytotoxicity was significantly enhanced against the K562 cell line in the majority of patients, 24–48 h after the second and third VMTE injections. This was accompanied by a dramatic influx of neutrophils into PC (57-550-fold), increase in absolute numbers of lymphocytes, (including large granular lymphocytes) and monocytes, and resulted also in a significant decrease in the number of ascitic tumor cells (98% reduction). The infusion of autologous mononuclear cells did not appear to influence either cytotoxicity or cell infiltration of the peritoneal cavity. We also investigated the in vitro effect of recombinant interleukin-2 (IL-2) on effector cells from PB and PC from patients before and after VMTE treatment. Cytotoxicity of both of these compartments was significantly potentiated after culture with IL-2. In three out of five VMTE-treated patients, PC cytotoxicity was significantly higher after activation with IL-2 than that of patients before VMTE treatment. These data suggest that VMTE induces regional cellular immunity, which could be further potentiated by culture of PC effector cells with IL-2. Thus, combination of VMTE and IL-2 after regional administration could represent the effective therapy for patients with advanced ovarian cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01665964
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  • 4
    Electronic Resource
    Electronic Resource
    Induction of interleukin-2 receptor by tumor necrosis factor α on cultured ovarian tumor-associated lymphocytes (1992)
    Springer
    Cancer immunology immunotherapy 35 (1992), S. 83-91 
    Details
    ISSN: 1432-0851
    Keywords: TNFα ; CD8+ CTL ; IL-2R ; TIL/TAL
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have recently reported that autologous tumor-specific cytotoxic T lymphocyte (CTL) lines and clones can be developed from lymphocytes infiltrating ovarian malignant ascites (TAL). In this study, we investigated the biological effects of tumor necrosis factor α (TNFα) in the induction, expansion, long-term proliferation and lytic function of CD8+ TAL. TNFα up-regulated the IL-2 receptor (IL-2R) α chain (Tac antigen) on the surface of CD3+ CD8+ CD4− TAL, enhanced the proliferation of autologous tumor-specific CTL, and potentiated their lytic function in long-term cultures. Furthermore, in the induction and expansion phase of CD8+ TAL, the presence of TNFα was associated with a selective increase in CD8+ IL-2R+ (Tac+) cells, and subsequent decrease in CD4+ IL-2R+ (Tac+) cells. These results suggest that the observed facilitation of the outgrowth of CD8+ cells in TAL cultures may be due, at least in part, to the up-regulation of IL-2R, and indicate the usefulness of TNFα in the analysis of signalling in autologous tumor-reactive CTL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01741854
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  • 5
    Electronic Resource
    Electronic Resource
    Comparison of recombinant-interleukin-2-activated peripheral blood and tumor-infiltrating lymphocytes of patients with epithelial ovarian carcinoma: Cytotoxicity, growth kinetics and phenotype (1990)
    Springer
    Cancer immunology immunotherapy 31 (1990), S. 169-175 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have compared the growth and tumordirected cytotoxic efficacy of recombinant-interleukin-2-(rIL-2)-activated peripheral blood (PBL) and tumor-infiltrating lymphocytes (TIL) from patients with epithelial ovarian carcinoma. These studies demonstrated that TIL and PBL displayed similar levels of cytotoxicity and a broad range of target cell killing, as exemplified by their reactivity against autologous and allogeneic ovarian tumors as well as against tumor cell lines. No specificity of autologous tumor cell killing was manifested by TIL. Even though TIL of some patients showed higher proliferative activity (especially at the later times in rIL-2 culture) this was not a general phenomenon. In fact, in one case TIL did not proliferate at all, and in the other case the PBL proliferated more actively. While the cultures were composed primarily of CD3+ lymphocytes, the major cytotoxic cells displayed the CD56+ and CD16+ phenotype. Addition of OKT3 mAb to rIL-2 cultures resulted in an increased proliferative index, but showed only a minor effect on the cytotoxic potential of cultured lymphocytes. The therapeutic potential of rIL-2-activated TIL and PBL is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01744732
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  • 6
    Electronic Resource
    Electronic Resource
    Multidimensional flow-cytometric analysis of dendritic cells in peripheral blood of normal donors and cancer patients (1997)
    Springer
    Cancer immunology immunotherapy 45 (1997), S. 234-240 
    Details
    ISSN: 1432-0851
    Keywords: Key words Dendritic cells ; Flow cytometry ; Stem cell transplantation ; Breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We studied the potential of multidimensional flow cytometry to evaluate the frequency and maturation/activation status of dendritic cells in minimally manipulated peripheral blood mononuclear cell preparations (i.e., only separated on Ficoll-Hypaque) of normal donors and cancer patients. A rare subset of HLA-DR+ leukocytes (less than 1% mononuclear cells) was detected in blood of normal donors that displayed all the features of dendritic cells: these cells had high forward-light-scatter characteristics and coexpressed CD4, CD86 and CD54 surface antigens, but lacked the lineage-associated surface markers of T cells, B cells, monocytes, granulocytes or NK i.e. they were CD3–, CD19–, CD20–, CD14–, CD11b–, CD16–, CD56–). These physical and phenotypic properties were virtually identical to those of immunomagnetically sorted leukocytes characterized as dendritic-cells on the basis of morphology, phenotype and high stimulatory activity in allogeneic mixed-lymphocyte cultures. Using this flow-cytometric approach we observed that the frequency of dendritic cell-like cells in peripheral blood mononuclear cell specimens of cancer patients receiving chemotherapy alone or those recovering from stem cell transplantation was significantly lower than that of normal individuals (mean ± SE: 0.36 ± 0.05%, 0.14 ± 0.06%, and 0.75 ± 0.04% respectively). Multidimensional flow-cytometric analysis of dendritic cells might represent an important new tool for assessing immunocompetence, and for monitoring the effects of therapeutic regimens on the immune system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050438
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