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  • 1
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    The Chemical Monitoring Station of the Future - International Symposium, April 13-15, 2021 (2021)
    German Federal Institute of Hydrology
    In:  [Proceedings]
    Details
    Publikationsdatum: 2022-02-07
    Materialart: Proceedings , NonPeerReviewed
    Format: text
    DOI: 10.5675/BfG_Veranst_2021.1
    Standort Signatur Einschränkungen Verfügbarkeit
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    OceanRep: Konferenzband
  • 2
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    Intellectual property rights and biological resources : an overview of key issues and current debates (2005)
    Wuppertal : Wuppertal Institute for Climate, Environment and Energy | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Details
    Publikationsdatum: 2022-02-18
    Beschreibung: This paper aims to provide a comprehensive background and overview of key issues, debates and positions related to the international regulation and application of intellectual property rights over biological resources, including biotechnology, and the use and protection of the traditional knowledge of indigenous and local communities. It explores the linkages among biological diversity, rural livelihoods, biotechnology developments and intellectual property with specific view on the relationship between access to biological and genetic resources, agriculture systems, food security, and increased poverty levels around the world. The paper starts by outlining the background and evolution of intellectual property rights. It then provides two case studies on how intellectual property rights affect biodiversity and traditional knowledge. In the main part, the paper indulges on the international governance of biodiversity and intellecutal property rights, especially focussing on the Convention of Biological Diversity (CBD), the World Intellecutal Property Organization (WIPO), and the World Trade Organization with its Agreement on Trade-Related Aspects of Intellecutal Property Rights (TRIPS). However it also sheds light on the increasing impacts of bilateral agreements that govern intellectual property rights in conjunction with the plurilateral International Union for the Protection of New Varieties of Plants (UPOV), and it analyses their relationship with the FAO International Treaty on Plant Genetic Resources for Food and Agriculture and the CBD. The paper finishes by sketching out ideas for a way forward.
    Schlagwort(e): ddc:300
    Repository-Name: Wuppertal Institut für Klima, Umwelt, Energie
    Sprache: Englisch
    Materialart: workingpaper , doc-type:workingPaper
    Format: application/pdf
    Standort Signatur Einschränkungen Verfügbarkeit
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    ARTIKEL (OA)
  • 3
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    Planning operations before market launch for balancing time-to-market and risks in pharmaceutical supply chains (2014)
    Elsevier
    Details
    Publikationsdatum: 2014-11-11
    Beschreibung: Publication date: Available online 4 November 2014 Source: International Journal of Production Economics Author(s): Klaus Reinholdt Nyhuus Hansen , Martin Grunow Shorter product life cycles and the resulting increase in new product introductions boost the importance of product launch operations. In the pharmaceutical sector, product launch operations are of particular importance, as companies seek to reduce time-to-market to better exploit patent protection. Large volumes of product need to be ready to fill the downstream supply chain immediately at market launch. Building up the required inventory is, however, connected to several risks. In addition to the risk associated with the lack of demand information for a new product, there are several risks unique to the pharmaceutical sector. After approval by central authorities such as the FDA or EMA, a new drug still needs to receive market authorization, which is in most cases granted by some local authorities - in Europe, for example, by more than 30 national and regional bodies. The duration of these different market authorization processes as well as their outcomes (e.g. price and reimbursement levels, requirements of label or leaflet changes) are highly uncertain. We develop a two-stage stochastic model to support market launch preparation decisions. It trades off the costs of accepting these risks, for example by risk packaging before authorization, against the lost revenue caused by risk-averse operations. The model is applied to a case based on an empirical study. Our approach results in significant savings compared to current practices. We hereby provide an example of how quantitative methodology can provide valuable decision support for product launch operations, even when complex regulatory affairs need to be considered.
    Print ISSN: 0925-5273
    Digitale ISSN: 1873-7579
    Thema: Technik allgemein , Wirtschaftswissenschaften
    Publiziert von Elsevier
    Standort Signatur Einschränkungen Verfügbarkeit
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    PAPER CURRENT
  • 4
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    Substantive implementation of article 29 of directive 2008/98/EC : scientific-technical foundation for a national waste prevention programme (2013)
    Dessau-Roßlau : Umweltbundesamt
    Details
    Publikationsdatum: 2022-02-18
    Beschreibung: Based on the European Waste Framework Directive and the German Recycling Management Act of 01.06.2012 the objectives for a national waste prevention programme were defined. As main objective, according to art. 1 WFD, the "prevention or reduction of the disadvantageous impacts of waste generation and management on the human health and the environment" is recommended. Indicators for a quantitative and qualitative monitoring are derived for both, the individual measures as well as for a waste prevention programme.
    Schlagwort(e): ddc:320
    Repository-Name: Wuppertal Institut für Klima, Umwelt, Energie
    Sprache: Englisch
    Materialart: report , doc-type:report
    Format: application/pdf
    Standort Signatur Einschränkungen Verfügbarkeit
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    ARTIKEL (OA)
  • 5
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    Analysis of a short tail type in farmed Atlantic salmon (Salmo salar) (2005)
    In:  Fish Veterinary Journal, 8 . pp. 71-79.
    Details
    Publikationsdatum: 2017-01-06
    Beschreibung: The short tail phenotype represents one of the main causes for downgrading of farmed Atlantic salmon (Salmo salar) at slaughterhouses. Prevalence of short tail is variable and the aetiology is suspected to be multi-factorial. Risk factors have been identified but descriptions of the aetiology and the pathology of the condition are still rare. In the current study, a radiological and histological analysis of short tails has been performed, examining six normal and six downgraded individuals from a slaughterhouse in southern Norway. In the short tail phenotype, vertebral bodies were shifted and bent at the contact zone of adjacent vertebral bodies. Changes either affected the entire spine or were located at the medial caudal-spine. While the internal bone structure of the vertebrae was similar in deformed and non-deformed animals, a lack of intervertebral space apparently caused a shortening of the vertebral column and corresponded to an elevated condition factor in deformed individuals. Histological analysis revealed different degrees of proliferation of cartilaginous tissues, which replaced the intervertebral notochord tissue. The displacement of adjacent vertebral bodies and the development of cartilage in between vertebral bodies suggest mechanical forces as a possible cause for the observed deformations, since mechanically-induced overload and a subsequent direct contact of bones are factors that can stimulate heterotopic cartilage development and pseudoarthrosis
    Materialart: Article , NonPeerReviewed
    Format: text
    Standort Signatur Einschränkungen Verfügbarkeit
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    OceanRep: Artikel in einer Fachzeitschrift - nicht begutachtet
  • 6
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    Successful invaders are better defended: The example of Gracilaria vermiculophylla (2013)
    International Phycological Society
    In:  Phycologia, 52 (4, Supplement). p. 119.
    Details
    Publikationsdatum: 2019-09-23
    Beschreibung: To evaluate the importance of anti-herbivore resistance for algal invasion success we compared resistance traits among specimens of the red macroalga Gracilaria vermiculophylla from six native populations in Korea and China and eight invasive populations in Europe and Mexico that were maintained under identical conditions in the laboratory. Herbivorous snails both from the native range (Littorina brevicula) and from the invaded range (Littorina littorea) consumed significantly less of seaweed specimens originating from non-native populations. Metabolome profiling revealed that this preference was correlated with an increased woundactivated production of deterring prostaglandins and hydroxyeicosatetraenoic acids. Thus, invasive populations of G. vermiculophylla are more strongly defended against challenge by herbivores and other biological enemies that cause local tissue or cell disruption and activate oxylipin production. Anthropogenic distribution of genotypes adapted to resist elevated feeding pressure probably contributed to the invasion success of this species.
    Materialart: Article , PeerReviewed
    Format: text
    Standort Signatur Einschränkungen Verfügbarkeit
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    OceanRep: Artikel in einer Fachzeitschrift - begutachtet
  • 7
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    Molecular support for temporal dynamics of induced anti-herbivory defenses in the brown seaweed Fucus Vesiculosus (2013)
    International Phycological Society
    In:  Phycologia, 52 (4,Supplement). p. 31.
    Details
    Publikationsdatum: 2019-09-23
    Beschreibung: Grazing by the isopod Idotea baltica induces chemical defenses in the brown seaweed Fucus vesiculosus. A combination of a 33 day induction experiment, feeding choice assays and functional genomic analyses was used to investigate temporal defense patterns and to correlate changes in palatability to changes in gene expression. Despite permanent grazing, seaweed palatability varied over time. Controls were significantly more consumed than grazed pieces only after 18 and 27 days of grazing. Relative to controls, 562/402 genes were up-/down-regulated in seaweed pieces that were grazed for 18 days, i.e. when defense induction was detected. Reprogramming of the regulative expression orchestra (translation, transcription), up-regulation of genes involved in lipid and carbohydrate metabolism, intracellular trafficking, defense and stress response, as well as downregulation of photosynthesis was found in grazed seaweed. These findings indicate short-term temporal variation in defenses and that modified gene expression patterns arise at the same time when grazed seaweed pieces show reduced palatability. Several genes with putative defensive functions and cellular processes potentially involved in defence, such as reallocation of resources from primary to secondary metabolism, were revealed
    Materialart: Article , PeerReviewed
    Format: text
    Standort Signatur Einschränkungen Verfügbarkeit
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    OceanRep: Artikel in einer Fachzeitschrift - begutachtet
  • 8
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    Exploring energy sufficiency : new challenges and options in times of crisis (2022)
    Details
    Publikationsdatum: 2022-07-20
    Beschreibung: The war in Ukraine is changing the political landscape at breakneck speed. How should politics and society react to high energy prices and a precarious dependence on fossil fuels imports? Can modern societies get by with much less energy? Energy sufficiency can play an important role in answering these questions. The contributions in this Special topic explore sufficiency as an interdisciplinary research topic for energy modeling, scenarios, and policy.
    Schlagwort(e): ddc:300
    Repository-Name: Wuppertal Institut für Klima, Umwelt, Energie
    Sprache: Englisch
    Materialart: article , doc-type:article
    Format: application/pdf
    Standort Signatur Einschränkungen Verfügbarkeit
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    ARTIKEL (OA)
  • 9
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    INTERACT Management planning for arctic and northern alpine research stations – Examples of good practices (2014)
    DCE – Danish Centre for Environment and Energy, Aarhus Univ.
    Details
    Publikationsdatum: 2020-02-12
    Beschreibung: This book is about management of arctic and northern alpine research stations. It has been produced by a group of station managers participating in the EU 7th Framework Programme Infrastructure project called INTERACT. With this book we want to share the knowledge and experiences we have gained from managing very different research stations in very different environmental and climatic settings. The target audience for the book is mainly managers of research stations in arctic and alpine areas, but we hope that it will also be useful for others involved in science coordination and logistics, e.g. research institutions, chief scientists and expedition planners. The book has been produced mainly based on input from practising station managers being part of ‘INTERACT Station Managers’ Forum (SMF), a forum established to provide a platform for exchange of information between station managers and other participants within INTERACT, and to collect and disseminate knowledge embedded within the network. The scope of this book is to identify and describe best practices and key considerations of relevance to station management under arctic and alpine conditions. As research stations operate under very different legal regimes, financial conditions, environmental and climatic conditions, as well as remoteness, it is not possible to identify specific best practices that fit all stations. Instead, we have described key issues that should be considered and addressed by station management, and supplemented this with examples of good practices from stations operating under different conditions (e.g. different climate, remoteness or size).
    Sprache: Englisch
    Materialart: info:eu-repo/semantics/book
    Format: application/pdf
    Standort Signatur Einschränkungen Verfügbarkeit
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    GFZ OAI
  • 10
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    The Mediterranean Sea we want (2021)
    Scielo
    Details
    Publikationsdatum: 2021-12-09
    Beschreibung: This paper presents major gaps and challenges for implementing the UN Decade of Ocean Science for Sustainable Development (2021-2030) in the Mediterranean region. The authors make recommendations on the scientific knowledge needs and co-design actions identified during two consultations, part of the Decade preparatory-phase, framing them in the Mediterranean Sea’s unique environmental and socio-economic perspectives. According to the ‘Mediterranean State of the Environment and Development Report 2020’ by the United Nations Environment Programme Mediterranean Action Plan and despite notable progress, the Mediterranean region is not on track to achieve and fully implement the Sustainable Development Goals of Agenda 2030. Key factors are the cumulative effect of multiple human-induced pressures that threaten the ecosystem resources and services in the global change scenario. The basin, identified as a climate change vulnerability hotspot, is exposed to pollution and rising impacts of climate change. This affects mainly the coastal zones, at increasing risk of extreme events and their negative effects of unsustainable management of key economic assets. Transitioning to a sustainable blue economy is the key for the marine environment’s health and the nourishment of future generations. This challenging context, offering the opportunity of enhancing the knowledge to define science-based measures as well as narrowing the gaps between the Northen and Southern shores, calls for a joint (re)action. The paper reviews the state of the art of Mediterranean Sea science knowledge, sets of trends, capacity development needs, specific challenges, and recommendations for each Decade’s societal outcome. In the conclusions, the proposal for a Mediterranean regional programme in the framework of the Ocean Decade is addressed. The core objective relies on integrating and improving the existing ocean-knowledge, Ocean Literacy, and ocean observing capacities building on international cooperation to reach the “Mediterranean Sea that we want”.
    Beschreibung: Published
    Beschreibung: e21031
    Beschreibung: 4A. Oceanografia e clima
    Beschreibung: JCR Journal
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Einschränkungen Verfügbarkeit
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    ARTIKEL (OA)
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