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  • 1
    Online-Ressource
    Online-Ressource
    Aarhus :Aarhus University Press,
    Schlagwort(e): Genetics -- History. ; Genetics -- Research. ; Electronic books.
    Beschreibung / Inhaltsverzeichnis: Modellen har siden haft en kolossal indvirkning på videnskaben og samfundet.Indlejret i molekylets yndefulde kurver lå nøglen til en helt ny videnskab, molekylærbiologien, der over de efterfølgende 50 år har givet os en forbløffende indsigt i vores arts biologi. Ligeså betydningsfuld har indvirkningen været på lægevidenskaben, fødevareproduktionen og retssystemet. DNA er ikke længere noget, der kun interesserer forskere i laboratorier; det vedkommer os alle.Mennesket. Den genetiske arv giver i et letlæseligt sprog og ved hjælp af pædagogiske illustrationer sin læser redskaberne til at forstå den basale genetiske teori om DNA og det humane genom. Med udgangspunkt i denne teori tager forfatteren læseren på en spændende rejse, der belyser spørgsmålene om menneskets oprindelse, udvikling og sygdom. Bogen slutter med et bud på den fremtidige evolution inden for biologi.Peter K.A. Jensen er ledende overlæge ved Klinisk Genetisk Afdeling på Aarhus Universitetshospital. Han har tidligere udgivet populære bøger om menneskets oprindelse.
    Materialart: Online-Ressource
    Seiten: 1 online resource (233 pages)
    Ausgabe: 1st ed.
    ISBN: 9788779349414
    Serie: Univers
    DDC: 575.109
    Sprache: Dänisch
    Anmerkung: Omslag -- Forside -- Titelside -- Kolofon -- Indhold -- Forord -- 1. DNA - livets hemmelighed -- Den moderne genetik grundlægges af Mendel -- Tiden før Mendel -- Kromosomerne er bærere af generne -- DNA er arvemassen -- Tiden efter Watson-Crick-modellen -- Rekombinant DNA-teknologi -- DNA-undersøgelse for arvelige sygdomme -- DNA-profilanalyse inden for retsmedicinen -- Molekylær antropologi og fossilt DNA -- 2. Menneskets arvemasse - Det humane genom -- Genomets kemi -- Et individs genom -- Proteiner -- Den genetiske kode -- Genomets struktur -- Genduplikation -- Transposition -- Genfunktion -- Celledelinger - mitose og meiose -- Genetiske markører -- Mitokondrie-DNA og Y-kromosomet -- 3. EvolutIon -- Genotypisk og fænotypisk variation -- Hvordan skabes den genetiske variation? -- 4. Menneskets oprindelse -- Menneskets plads i naturen -- Oprindelse af menneskelinjen -- Australopitheciner -- Menneskets første udvandring fra Afrika -- Oprindelsen af Homo sapiens -- Verden koloniseres -- Mongolske befolkninger og kolonisering af Central- og Østasien -- 5. Menneskehedens mangfoldighed -- Mønstre i fordeling af menneskets genetiske variation -- Racer og etniske grupper -- Hudfarve -- Eksempler på etniske grupper -- 6. Gener, evolution og sygdom -- Kost, livsstil og sygdom -- Evolutionshypotesen og livsstilssygdomme -- Founder-mutationer -- Infektionssygdomme og blodtyper -- CCR5-genet og AIDS -- Hæmoglobin og malaria -- Tay-Sachs sygdom og tuberkulose -- Evnen til at nedbryde mælkesukker -- Overfølsomhed for gluten -- 7. Hvor er vi nu - og i den nære fremtid? -- Udvikler mennesket sig fortsat? -- Manipulation af genomet -- Hvor er vi på vej hen? -- Ordliste -- Supplerende litteratur -- Indeks.
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  • 2
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 639 (1991), S. 0 
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 172 (1999), S. 0 
    ISSN: 1600-065X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary: Major histocompatibihty complex (MHC)-encoded glycoproteins bind peptide antigens through non-covalent interactions to generate complexes that are displayed on tbe surface of antigen-presenting cells (APC) for recognition by T ceils, Peptide-binding site occupancy is necessary for stable assembly of newly synthesized MHC proteins and export from the endoplasmic reticulum (ER), The MHC class II antigen-processing pathway provides a mechanism for presentation of peptides generated in the endosomal pathway of APC, The chaperone protein, invariant chain, includes a surrogate peptide that stahilizes newly synthesized class II molecules during transport to endosomal compartments. The invariant chain-derived peptide must be replaced through a peptide exchange reaction that is promoted by acidic pH and the MHC-encoded co-factor HLA-DM, Peptide exchange reactions are not required for presentation of antigens by MHC class I molecules because they bind antigens during initial assembly in the ER, However, exchange reactions may play an important role in editing the repertoire of peptides presented by both class II and class I molecules, thus influencing the specificity of immunity and tolerance.
    Materialart: Digitale Medien
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  • 4
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    Industrial & engineering chemistry research 31 (1992), S. 164-171 
    ISSN: 1520-5045
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
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  • 5
    Digitale Medien
    Digitale Medien
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 83 (1985), S. 6457-6466 
    ISSN: 1089-7690
    Quelle: AIP Digital Archive
    Thema: Physik , Chemie und Pharmazie
    Notizen: We present a general theory of equilibrium polymerization in a binary mixture by applying the n-vector model for magnetism in a weak field. Results are given for the temperature dependence of the order parameters, polymer length, and phase diagrams in the concentration–temperature plane. In addition to phase separations between two monomer phases and between a monomer and a polymer phase, the phase diagrams show the possibility of coexistence between two polymer phases with a critical point. It is shown that our theory becomes identical to the earlier theory for equilibrium copolymerization of Tobolsky and Owen when the molecular field approximation and some additional approximations are used.
    Materialart: Digitale Medien
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  • 6
    ISSN: 1600-0625
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Epidermolysis bullosa simplex (EBS) is a group of autosomal dominantly inherited skin disorders characterized by the development of intra-epidermal skin blisters on mild mechanical trauma. The three major clinical subtypes (Weber-Cockayne, Koebner and Dowling-Meara) are all caused by mutations in either the keratin 5 (KRT5) or keratin 14 (KRT14) gene.Previously, we identified three novel KRT14 missense mutations in Danish EBS patients associated with the three different forms of EBS (1). The identified KRT14 mutations represent the full spectrum of the classical EBS subtypes. In the present study we investigated these mutations in a cellular expression system in order to analyse their effects on the keratin cytoskeleton. KRT14 expression vectors were constructed by fusing the nucleotide sequence encoding the FLAG reporter peptide to the 3′ end of the KRT14 cDNA sequences. The expression vectors were transiently transfected into normal human primary keratinocytes (NHK), HaCaT or HeLa cells in order to analyze the ability of the mutant K14 proteins to integrate into the existing endogenous keratin filament network (KFN).No effect on the keratin cytoskeleton was observed upon transfection of NHK with the various K14 constructs neither with nor without a subsequently induced heat-stress. In contrast, all constructs, including wild-type K14, caused collapse of the endogenous KFN in a small fraction of the transfected HeLa and HaCaT cells. However, overexpression of the mutation associated with the most severe form of the disease, EBS Dowling-Meara, resulted in a higher number of transfected HaCaT cells with KFN collapse (P 〈 0.001). Thus, although a background KFN perturbance was observed upon transfection with the wild-type K14 construct, the mutant protein associated with the most severe form of EBS worsened the KFN perturbation significantly compared with the mutant proteins associated with the milder forms of the disease and the normal K14 protein. This shows that the clinical severity of disease-associated mutations identified in patients can be tested using this expression system, although it can not at present be used to discriminate between the milder forms.Assessment of the endogenous K14 protein expression in NHK and HaCaT cells indicated that the higher level of endogenous keratin expression in NHK might make these cells more resistant to perturbation of the keratin cytoskeleton by overexpressed K14 protein than HaCaT cells.
    Materialart: Digitale Medien
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  • 7
    ISSN: 1365-2958
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie , Medizin
    Notizen: ATP/ADP ratios were varied in different ways and the degree of negative supercoiling was determined in Escherichia coli. Independent of whether the ATP/ADP ratio was reduced by a shift to anaerobic conditions, by addition of a protonophore (dinitrophenol) or by potassium cyanide addition, DNA supercoiling decreased similarly with the ATP/ADP ratio. The experiments were performed under well-defined conditions, where oxidative phosphorylation was the dominant route for ATP synthesis, i.e. using a minimal salts medium with succinate as the sole free-energy and carbon source, and in the presence or absence of ammonia as the nitrogen source. The results of the different experiments were consistent with a single linear relationship between the log(ATP/ADP) and the change in linking number. The dependence of DNA supercoiling on the ATP/ADP ratio was not influenced by inhibitors of transcription or translation. Because the ATP/ADP ratio was modulated in different ways, the unique relationship suggests coupling between the phosphorylation potential and DNA supercoiling. This was most probably mediated by the DNA gyrase, independent of topoisomerase I or transcription.
    Materialart: Digitale Medien
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  • 8
    ISSN: 1546-1718
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Medizin
    Notizen: [Auszug] The c-kit-encoded transmembrane tyrosine kinase receptor for stem cell factor (Kit/SCF-R) is required for normal haematopoiesis, melanogenesis and gametogenesis. However, the roles of individual Kit/SCF-R-induced signalling pathways in the control of developmental processes in the intact animal are ...
    Materialart: Digitale Medien
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  • 9
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature 411 (2001), S. 355-365 
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Protein-tyrosine kinases (PTKs) are important regulators of intracellular signal-transduction pathways mediating development and multicellular communication in metazoans. Their activity is normally tightly controlled and regulated. Perturbation of PTK signalling by mutations and other genetic ...
    Materialart: Digitale Medien
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  • 10
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology reviews 29 (2005), S. 0 
    ISSN: 1574-6976
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie
    Notizen: Most metabolic reactions are connected through either their utilization of nucleotides or their utilization of nucleotides or their regulation by these metabolites. In this review the biosynthetic pathways for pyrimidine and purine metabolism in lactic acid bacteria are described including the interconversion pathways, the formation of deoxyribonucleotides and the salvage pathways for use of exogenous precursors. The data for the enzymatic and the genetic regulation of these pathways are reviewed, as well as the gene organizations in different lactic acid bacteria. Mutant phenotypes and methods for manipulation of nucleotide pools are also discussed. Our aim is to provide an overview of the physiology and genetics of nucleotide metabolism and its regulation that will facilitate the interpretation of data arising from genetics, metabolomics, proteomics, and transcriptomics in lactic acid bacteria.
    Materialart: Digitale Medien
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