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  • 1980-1984  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    Feedback inhibition of NaCl entry inNecturus gallbladder epithelial cells (1984)
    Springer
    The journal of membrane biology 82 (1984), S. 95-104 
    Details
    ISSN: 1432-1424
    Keywords: NaCl cotransport ; Na/Ca exchange ; cell volume ; intracellular Na activity ; ouabain ; KCl transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary WhenNecturus gallbladder epithelium is treated with ouabain the cells swell rapidly for 20–30 minutes then stabilize at a cell volume 30% greater than control. The cells then begin to shrink slowly to below control size. During the initial rapid swelling phase cell Na activity, measured with microelectrodes, rises rapidly. Calculations of the quantity of intracellular Na suggest that the volume increase is due to NaCl entry. Once the peak cell volume is achieved, the quantity of Na in the cell does not increase, suggesting that NaCl entry has been inhibited. We tested for inhibition of apical NaCl entry during ouabain treatment either by suddenly reducing the NaCl concentration in the mucosal bath or by adding bumetanide to the perfusate. Both maneuvers caused rapid cell shrinkage during the initial phase of the ouabain experiment, but had no effect on cell volume if performed during the slow shrinkage period. The lack of sensitivity to the composition of the mucosal bath during the shrinkage period occurred because of apparent feedback inhibition of NaCl entry. Another maneuver, reduction of the Na in the serosal bath to 10mm, also resulted in inhibition of apical NaCl uptake. The slow shrinkage which occurred after one or more hours of ouabain treatment was sensitive to the transmembrane gradients for K and Cl across the basolateral membrane and could be inhibited by bumetanide. Thus during pump inhibition inNecturus gallbladder epithelium cell Na and volume first increase due to continuing NaCl entry and then cell volume slowly decreases due to inhibition of the apical NaCl entry and activation of basolateral KCl exit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01870736
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    PCV and modified hill procedure as surgical treatment of reflux esophagitis: Results in 108 patients (1982)
    Springer
    World journal of surgery 6 (1982), S. 412-417 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Cent huit malades atteints d'oesophagite par reflux ont subi une opération de Hill, associée à une vagotomie hypersélective. L'adjonction de ce type de vagotomie à l'opération anti-reflux a pour mérites de donner un meilleur accès au cardia et d'éviter les inconvénients de la vagotomie classique. Elle entraîne ainsi une réduction bénéfique du débit acide basal. Alors que le débit acide était inchangé chez les malades qui présentait des symptômes fonctionnels post opératoires, il était abaissé de façon significative chez les malades indemnes de tout trouble. Par ailleurs, la pression au niveau du sphincter inférieur de l'oesophage était toujours augmentée après l'intervention. Les complications ont été rares. 92% des malades ne présentaient aucun symptôme après 2 mois, 88% après un an et 71% après 2 ans. Une réduction remarquable des troubles pulmonaires a été remarquée, ce fait témoignant de la relation étroite qui existe entre les maladies respiratoires chroniques et le reflux gastro-oesophachez certains malades.
    Notes: Abstract Parietal cell vagotomy (PCV) and the Hill antireflux procedure were used in 108 patients with reflux esophagitis. The addition of PCV provides better access to the cardia and ensures that more extensive vagotomy than intended does not occur. Furthermore, a reduction in the basal acid output (BAO) is preferable. In patients still symptomatic after surgery, the BAO was unchanged, while in those without postoperative symptoms a significant decrease in BAO was found (p 〈 0.01). Gastroesophageal sphincter pressure was significantly higher postoperatively in all patients. Complications were few; 92% were asymptomatic at 2 months, 88% at 1 year, and 71% at 2 years. A remarkable reduction in pulmonary symptoms after operation indicates a close relationship between chronic pulmonary disease and gastroesophageal reflux in some patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01657669
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  • 3
    Electronic Resource
    Electronic Resource
    Barriers to working with impaired trainees: A resident's viewpoint (1983)
    Springer
    Psychiatric quarterly 55 (1983), S. 268-271 
    Details
    ISSN: 1573-6709
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Psychiatric trainees and educators alike know that significant impairment may occur during training. Although psychiatry programs can do much to identify, treat, and prevent traineee impairment, barriers that may hinder programs from adequately addressing the problems of the impaired trainee continue to exist. These barriers include stigmatization and rejection of the impaired trainee, lack of focus on primary prevention, problematic supervisor-resident relationships, and trainee resistance to intervention. An atmosphere of candor and support, impairment-related seminars, and informed and alert supervisors can be helpful in easing the stress of training and reducing trainee impairment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01074553
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    Paper (German National Licenses)
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