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  • Articles  (57)
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  • 1
    Electronic Resource
    Electronic Resource
    A Novel Method for Identification of Peptide Contents from Individual Neurohypophysial Terminals after Patch-Clamp Recordings (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 689 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb55591.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of Ethanol on Calcium Channels, Potassium Channels, and Vasopressin Release (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 625 (1991), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb33844.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Two new carnivores from an unusual late Tertiary forest biota in eastern North America (2004)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 431 (2004), S. 556-559 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Late Cenozoic terrestrial fossil records of North America are biased by a predominance of mid-latitude deposits, mostly in the western half of the continent. Consequently, the biological history of eastern North America, including the eastern deciduous forest, remains largely hidden. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature02819
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Phosphorylation of HMG-I by Protein Kinase C Attenuates Its Binding Affinity to the Promoter Regions of Protein Kinase C γ and Neurogranin/RC3 Genes (2000)
    Oxford UK : Blackwell Science Ltd
    Journal of neurochemistry 74 (2000), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: A 20-kDa DNA-binding protein that binds the AT-rich sequences within the promoters of the brain-specific protein kinase C (PKC) γ and neurogranin/RC3 genes has been characterized as chromosomal nonhistone high-mobility-group protein (HMG)-I. This protein is a substrate of PKC α, β, γ, and δ but is poorly phosphorylated by PKC ε and ζ. Two major (Ser44 and Ser64) and four minor phosphorylation sites have been identified. The extents of phosphorylation of Ser44 and Ser64 were 1:1, whereas those of the four minor sites all together were 〈30% of the major one. These PKC phosphorylation sites are distinct from those phosphorylated by cdc2 kinase, which phosphorylates Thr53 and Thr78. Phosphorylation of HMG-I by PKC resulted in a reduction of DNA-binding affinity by 28-fold as compared with 12-fold caused by the phosphorylation with cdc2 kinase. HMG-I could be additively phosphorylated by cdc2 kinase and PKC, and the resulting doubly phosphorylated protein exhibited a 〉 100-fold reduction in binding affinity. The two cdc2 kinase phosphorylation sites of HMG-I are adjacent to the N terminus of two of the three predicted DNA-binding domains. In comparison, one of the major PKC phosphorylation sites, Ser64, is adjacent to the C terminus of the second DNA-binding domain, whereas Ser44 is located within the spanning region between the first and second DNA-binding domains. The current results suggest that phosphorylation of the mammalian HMG-I by PKC alone or in combination with cdc2 kinase provides an effective mechanism for the regulation of HMG-I function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2000.0740392.x
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  • 5
    Electronic Resource
    Electronic Resource
    MET-ENKEPHALIN AND THE ENKEPHALIN ANALOGUE FK-33824 CENTRALLY INHIBIT ADRENOCORTICOTROPHIC HORMONE SECRETION IN SHEEP (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 15 (1988), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: b1. The effects of central administration of met-enkephalin, leu-enkephalin, the enkephalin analogue FK-33824 and the opiate antagonist naloxone on plasma concentration of adrenocorticotrophic hormone (ACTH) were examined in conscious sheep.2. Intracerebroventricular infusion of met-enkephalin and FK-33824 significantly decreased the basal plasma concentration of ACTH.3. Intracerebroventricular infusion of FK-33824 inhibited the haemorrhage-induced increase in plasma concentration of ACTH.4. Intracerebroventricular infusion of naloxone attenuated the central inhibition of plasma concentration of ACTH induced by FK-33824, but intravenous infusion of naloxone had no effect on the reduction in plasma concentration of ACTH induced by FK-33824.5. These studies suggest that in sheep met-enkephalin may play a central inhibitory role in the control of ACTH secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1988.tb01029.x
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of Toxins on Ca2+ Currents and Peptide Release from Nerve Terminals (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 710 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb26610.x
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  • 7
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    A numerical model of mixing and convection driven by surface buoyancy flux (2012)
    Massachusetts Institute of Technology and Woods Hole Oceanographic Institution
    Details
    Publication Date: 2022-05-25
    Description: Submitted in partial fulfillment of the requirements for the degree of Master of Science at the Massachusetts Institute of Technology and the Woods Hole Oceanographic Institution September 1989
    Description: This thesis studies mixing and convection in a rectangular basin driven by a specified heat flux at the surface. A numerical model is constructed for this purpose. The main focus of the study is on the density and circulation structure resulting from the thermal forcing. In chapter two, a simple vertical one-dimensional model is developed to examine the mixing processes under a given surface heat flux. In order to simulate strong vertical mixing in the region where stratification is unstable, turbulent processes are modeled by a convective overturning parameterization of eddy viscosity and diffusivity. The results show that the density structure is strongly affected by the convective overturning adjustment as surface cooling prevails, and the resulting density field is nearly depth independent. In chapter three, a more complicated two-dimensional model is constructed to simulate mixing and circulation in a vertical rectangular basin with rigid boundaries. The aspect ratio of the basin ranges from 1 to 0.001 and Rayleigh number from 104 to 2 x 1012. It is found that the circulation pattern is dominated by these two important numbers. The roles of density overturning and density-momentum overturning mixing are further investigated. The results show that the convective overturning not only homogenizes the density field in the unstably stratified region but also contributes to increase the circulation. A crude scale analysis of the system shows that the characteristics of the density and momentum fields from the analysis agree well with the numerical results.
    Keywords: Ocean circulation
    Repository Name: Woods Hole Open Access Server
    Type: Thesis
    Format: application/pdf
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  • 8
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    Interaction of an eddy with a continental slope (2012)
    Massachusetts Institute of Technology and Woods Hole Oceanographic Institution
    Details
    Publication Date: 2022-05-26
    Description: Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at the Massachusetts Institute of Technology and the Woods Hole Oceanographic Institution September 1992
    Description: This study concerns the barotropic interactions between a mesoscale eddy and a straight monotonic bottom topography. Through simple to relatively complicated modeling effort, some of the fundamental properties of the interaction are investigated. In chapter two, the fundamental aspects of the interaction are examined using a simple contour dynamics model. With the simplest model configuration of an ideal vortex and a step topography, the basic dynamical features of the observed oceanic eddy-topography interaction are qualitatively reproduced. The results consist of eddy-induced cross-topography exchange, formation of topographic eddies, eddy propagation and generation of topographic waves. In chapter three, a more complicated primitive equation model is used to investigate a mesoscale eddy interacting with an exponential continental shelf/slope topography on both f and β-planes. The f-plane model recasts the important features of chapter two. The roles of the eddy size and strength and the geometry of topography are studied. It is seen that the multiple anticyclonic eddy-slope interactions strongly affect the total cross-slope volume transport and the evolution of both the original anticyclone and the topographic eddy. Since a cyclone is trapped at the slope and eventually moves on to the slope, it is most effective in causing perturbation on the shelf and slope. The responses on the shelf and slope are mainly wavelike with dispersion relation obeying that of the free shelf-trapped wave modes. On the β-plane, the problem of an eddy colliding onto a continental shelf/slope from a distance with straight or oblique incident angles is investigated. It is found that the straight eddy incident is more effective in achieving large onslope eddy penetration distance than the oblique eddy incident. The formation of a dipole-like eddy pair consisting of the original anticyclone and the topographic cyclone acts to suppress the eddy decay due to long Rossby wave radiation. A weak along-slope current near the edge of the slope is found, which is part of a outer slope circulation cell originated from the Rossby wave wake trailing the propagating eddy. Model-observation comparisons in_chapter four show favorable qualitative agreement of the model results with some of the observed events in the eastern U.S. continental margins and in the Gulf of Mexico. The model results give dynamical interpretations to some observed features of the oceanic eddy-topography interactions and provide enlightening insight into the problem.
    Keywords: Eddies ; Ocean currents ; Fluid dynamics
    Repository Name: Woods Hole Open Access Server
    Type: Thesis
    Format: application/pdf
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  • 9
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    Choroidal thickness and high myopia: a cross-sectional study and meta-analysis (2015)
    BioMed Central
    Details
    Publication Date: 2015-07-04
    Description: Background: The purpose of this study was to examine the choroidal thickness of patients with high myopia using enhanced depth imaging optical coherence tomography (EDI-OCT) and compare them with healthy subjects. Methods: We first conducted a cross-sectional study and then performed a meta-analysis to address this issue further. Using enhanced depth imaging optical coherence tomography (EDI-OCT), the macular choroidal thickness of high myopic eyes and normal control eyes were measured and compared at each location. Univariate and multivariate linear regression analyses were performed to assess the association between choroidal thickness and clinical factors such as axial length (AL), spherical equivalent (SE), and central corneal thickness. In the high myopic eyes, subgroup analysis of macular choroidal thickness was performed in eyes with or without lacquer cracks and choroidal neovascularization (CNV). The meta-analyses were conducted using the Stata software package. Results: The high myopic eyes had a thinner choroid than the control eyes at all macular locations (all P 
    Electronic ISSN: 1471-2415
    Topics: Medicine
    Published by BioMed Central
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  • 10
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    Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-04-11
    Description: Article Psoriasis is a chronic inflammatory disease affecting up to 3% of the population. Here, Zuo et al. perform exome array analysis, identify single-nucleotide polymorphisms at 15 new loci, implicating several biological pathways in psoriasis risk and disease heritability. Nature Communications doi: 10.1038/ncomms7793 Authors: Xianbo Zuo, Liangdan Sun, Xianyong Yin, Jinping Gao, Yujun Sheng, Jinhua Xu, Jianzhong Zhang, Chundi He, Ying Qiu, Guangdong Wen, Hongqing Tian, Xiaodong Zheng, Shengxiu Liu, Wenjun Wang, Weiran Li, Yuyan Cheng, Longdan Liu, Yan Chang, Zaixing Wang, Zenggang Li, Longnian Li, Jianping Wu, Ling Fang, Changbing Shen, Fusheng Zhou, Bo Liang, Gang Chen, Hui Li, Yong Cui, Aie Xu, Xueqin Yang, Fei Hao, Limin Xu, Xing Fan, Yuzhen Li, Rina Wu, Xiuli Wang, Xiaoming Liu, Min Zheng, Shunpeng Song, Bihua Ji, Hong Fang, Jianbin Yu, Yongxin Sun, Yan Hui, Furen Zhang, Rongya Yang, Sen Yang, Xuejun Zhang
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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