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  • 1
    Electronic Resource
    Electronic Resource
    The liver stage of Plasmodium berghei inhibits host cell apoptosis (2005)
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 58 (2005), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Plasmodium berghei is the causative agent of rodent malaria and is widely used as a model system to study the liver stage of Plasmodium parasites. The entry of P. berghei sporozoites into hepatocytes has extensively been studied, but little is known about parasite–host interaction during later developmental stages of the intracellular parasite. Growth of the parasite far beyond the normal size of the host cell is an important stress factor for the infected cell. Cell stress is known to trigger programmed cell death (apoptosis) and we examined several apoptotic markers in P. berghei-infected cells and compared their level of expression and their distribution to that of non-infected cells. As none of the apoptotic markers investigated were found altered in infected cells, we hypothesized that parasite infection might confer resistance to apoptosis of the host cell. Treatment with peroxide or serum deprivation induced apoptosis in non-infected HepG2 cells, whereas P. berghei-infected cells appeared protected, indicating that the parasite interferes indeed with the apoptotic machinery of the host cell. To prove the physiological relevance of these results, mice were infected with high numbers of P. berghei sporozoites and treated with tumour necrosis factor (TNF)-α/d-galactosamine to induce massive liver apoptosis. Liver sections of these mice, stained for degraded DNA, confirmed that infected cells containing viable parasites were protected from programmed cell death. However, in non-treated control mice as well as in TNF-α-treated mice a small proportion of dead intracellular parasites with degraded DNA were detected. Most hepatocytes containing dead parasites provoked an infiltration of immunocompetent cells, indicating that these cells are no longer protected from cell death.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.2005.04888.x
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  • 2
    Electronic Resource
    Electronic Resource
    The role of CD95 in the regulation of peripheral T-cell apoptosis (2003)
    Oxford, UK : Munksgaard International Publishers
    Immunological reviews 193 (2003), S. 0 
    Details
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary:  Apoptosis of activated peripheral T cells during the termination phase of an immune response is critical to maintain T-cell homeostasis. Activated T cells can be removed by two mechanisms: activation-induced cell death (AICD) and death by neglect. AICD is triggered by death receptors, whereas death by neglect is induced by cytokine withdrawal. CD95 (APO-1/Fas) belongs to the subfamily of death receptors and plays a major role in AICD. In this review, we focus on the molecular mechanisms of AICD, in particular those involving the CD95 system. Moreover, we discuss the relative contribution of AICD and death by neglect to terminate a T-cell immune response. In order to become fully activated, T cells require a second signal provided by antigen-presenting cells. We discuss how these costimulatory signals counteract pro-apoptotic signals and, finally, which signals might protect T cells from death to generate a pool of memory T cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-065X.2003.00047.x
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  • 3
    Electronic Resource
    Electronic Resource
    Suramin inhibits death receptor–induced apoptosis in vitro and fulminant apoptotic liver damage in mice (2004)
    [s.l.] : Nature Publishing Group
    Nature medicine 10 (2004), S. 602-609 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Suramin is a polysulfonated derivative of urea and has been widely used both to treat infections and as a chemotherapeutic drug. Suramin has been shown to inhibit growth factor signaling pathways; however, its effect on apoptosis is unknown. Here we show that suramin inhibits apoptosis induced ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm1049
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  • 4
    Electronic Resource
    Electronic Resource
    Correlations between melanin pigmentation and element concentration in feathers of White-tailed Eagles (Haliaeetus albicilla) (1999)
    Springer
    Journal of ornithology 140 (1999), S. 355-362 
    Details
    ISSN: 1439-0361
    Keywords: melanin ; heavy-metal-concentration ; pigmentation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Es wurden die Elementkonzentrationen in Mauserfedern von Seeadlern untersucht. Mit Hilfe der Hamburger 2-MeV-Protonenmikrosonde, die die Analyse von Probendetails im Mikrometerbereich ermöglicht, versuchen wir zwischen Elementen zu unterscheiden, die vom Adler mit der Nahrung inkorporiert, verstoffwechselt und während der Mauser in die Feder eingelagert wurden und solchen, die während der etwa einjährigen Verweilzeit der Feder im Gefieder extern aus der Atmosphäre aufgelagert wurden. Im Hinblick auf die eingelagerten Elemente untersuchen wir mögliche Zusammenhänge zwischen der Elementkonzentration und der Federpigmentierung. Von den nachgewiesenen Elementen (Schwefel, Kalium, Calcium, Titan, Mangan, Eisen, Kupfer, Zink, Quecksilber und Blei) zeigen Calcium, Mangan und Zink eine erhebliche Anreicherung in der pigmentierten Feder im Vergleich zu pigmentfreien Federausschnitten. Dagegen wurden keine signifikanten Unterschiede der Elementkonzentrationen von Schwefel, Titan, Eisen, Kupfer, Quecksilber und Blei festgestellt. Die gefundenen Ergebnisse bedeuten eine erhebliche Anreicherung von Calcium, Mangan und Zink im Melanin, das für die Federpigmentierung verantwortlich ist. Die mögliche Funktion dieser Elemente im Hinblick auf die Melaninbildung wird diskutiert.
    Notes: Summary The element concentration of moult feathers of White-tailed Eagles was investigated. Using the 2- MeV Hamburg proton microprobe we tried to differentiate between elements incorporated into the feather via the food chain and those which are deposited externally onto the feather vane. Regarding incorporated elements, special attention has been given to a possible correlation between element concentration and feather pigmentation. Concerning the elements detected in this work (S, K, Ca, Ti, Mn, Fe, Cu, Zn, Hg, Pb), calcium, manganese and zinc show a considerable enhancement within the pigmented feather as compared with pigment-free feather sections. On the other hand, no differences were found in concentrations for sulfur, titanium, iron, copper, mercury and lead. Our findings therefore imply a special enrichment of Ca, Mn and Zn within melanin, the source of the feather's pigmentation. The possible role of these elements with regard to melanin formation is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01651032
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  • 5
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    Efficacy and safety of keratinocyte growth factor (palifermin) for prevention of oral mucositis in TBI-based allogeneic hematopoietic stem cell transplantation (2018)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2018-03-16
    Description: Efficacy and safety of keratinocyte growth factor (palifermin) for prevention of oral mucositis in TBI-based allogeneic hematopoietic stem cell transplantation Efficacy and safety of keratinocyte growth factor (palifermin) for prevention of oral mucositis in TBI-based allogeneic hematopoietic stem cell transplantation, Published online: 15 March 2018; doi:10.1038/s41409-018-0135-3 Efficacy and safety of keratinocyte growth factor (palifermin) for prevention of oral mucositis in TBI-based allogeneic hematopoietic stem cell transplantation
    Print ISSN: 0268-3369
    Electronic ISSN: 1476-5365
    Topics: Medicine
    Published by Nature Publishing Group (NPG)
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  • 6
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    Sensors, Vol. 15, Pages 31999-32019: One Small Step for a Man: Estimation of Gender, Age and Height from Recordings of One Step by a Single Inertial Sensor (2015)
    MDPI Publishing
    In: Sensors
    Details
    Publication Date: 2015-12-20
    Description: A number of previous works have shown that information about a subject is encoded in sparse kinematic information, such as the one revealed by so-called point light walkers. With the work at hand, we extend these results to classifications of soft biometrics from inertial sensor recordings at a single body location from a single step. We recorded accelerations and angular velocities of 26 subjects using integrated measurement units (IMUs) attached at four locations (chest, lower back, right wrist and left ankle) when performing standardized gait tasks. The collected data were segmented into individual walking steps. We trained random forest classifiers in order to estimate soft biometrics (gender, age and height). We applied two different validation methods to the process, 10-fold cross-validation and subject-wise cross-validation. For all three classification tasks, we achieve high accuracy values for all four sensor locations. From these results, we can conclude that the data of a single walking step (6D: accelerations and angular velocities) allow for a robust estimation of the gender, height and age of a person.
    Electronic ISSN: 1424-8220
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Published by MDPI Publishing
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  • 7
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    Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time (2016)
    Hindawi
    Details
    Publication Date: 2016-05-01
    Description: Acute physical exercise and repeated exercise stimuli affect whole-body metabolic and immunologic homeostasis. The aim of this study was to determine plasma protein profiles of trained (EET, ) and untrained (SED, ) individuals at rest and in response to an acute bout of endurance exercise. Participants completed a bicycle exercise test at an intensity corresponding to 80% of their . Plasma samples were taken before, directly after, and three hours after exercise and analyzed using multiplex immunoassays. Seventy-eight plasma variables were included in the final analysis. Twenty-nine variables displayed significant acute exercise effects in both groups. Seven proteins differed between groups, without being affected by acute exercise. Among these A2Macro and IL-5 were higher in EET individuals while leptin showed elevated levels in SED individuals. Fifteen variables revealed group and time differences with elevated levels for IL-3, IL-7, IL-10, and TNFR2 in EET individuals. An interaction effect could be observed for nine variables including IL-6, MMP-2, MMP-3, and muscle damage markers. The proteins that differ between groups indicate a long-term exercise effect on plasma protein concentrations. These findings might be of importance in the development of exercise-based strategies in the prevention and therapy of chronic metabolic and inflammatory diseases and for training monitoring.
    Print ISSN: 0962-9351
    Electronic ISSN: 1466-1861
    Topics: Medicine
    Published by Hindawi
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