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  • 1
    Online Resource
    Online Resource
    Ascites, hyponatremia and hepatorenal syndrome : progress in treatment (2011)
    Basel : Karger
    Details Availability
    Keywords: Hyponatremia Treatment ; Ascites ; Hepatorenal syndrome Treatment ; Liver Cirrhosis ; Complications ; Treatment ; Gastroenterology ; Pharmaceutics ; Hepatology ; Nephrology ; Radiology ; Transplantation ; Aufsatzsammlung ; Hepatorenales Syndrom ; Ascites ; Therapie
    Description / Table of Contents: Ascites is the most frequent and hepatorenal syndrome the most lethal complication in liver cirrhosis. In recent years, major progress has been made regarding effective treatment of these complications, thus reducing mortality in patients.This publication highlights and critically appraises recent achievements and novel advances, and at the same time provides the background needed to grasp novel concepts. Topics treated include complications of paracentesis, the right choice of plasma expanders, and selection of patients who will experience survival benefit from transjugular intrahepatic portosystemic shunt. Hepatorenal syndrome, on the other hand, is responsible for a broad spectrum of manifestations caused by acute kidney injury, which until recently was considered a lethal condition. Drug treatments to improve renal function and prolong survival are therefore also discussed, including important issues for clinical outcome which are still under debate. Moreover, the role of combined kidney-liver transplantation versus conventional liver-only transplantation is addressed, as well as the use of vaptans in hyponatremia and their controversial role in the treatment of ascites.Renowned experts share their knowledge and expertise and provide an international perspective. Their contributions include up-to-date references and a bullet-point summary, making this publication most valuable for practitioners, clinicians and scientists in the field
    Type of Medium: Online Resource
    Pages: Online-Ressource (VIII, 212 S)
    Edition: Karger eBooks Collection
    ISBN: 9783805595926
    Series Statement: Frontiers of gastrointestinal research 28
    URL: https://karger.com/books/book/2718
    URL: http://dx.doi.org/10.1159/isbn.978-3-8055-9592-6
    DDC: 616.6106
    Language: English
    Note: Differential diagnosis of ascites , Current treatment strategies : diuretics , Paracentesis , Large volume paracentesis : which plasma expander? , Albumin : not just a plasma expander , Transjugular intrahepatic portosystemic shunt for ascites : which patients will benefit? , Spontaneous bacterial peritonitis prophylaxis and treatment , Clinical implications of hyponatremia in cirrhosis , Vaptans for ascites : chances and risks , Cardiorenal syndrome : a new entity? , Renal failure in cirrhosis , Novel definition of hepatorenal syndrome : clinical consequences , Role of infections in HRS , Tips for HRS , Vasoconstrictor therapy for hepatorenal syndrome , Terlipressin for hepatorenal syndrome : the US experience , Terlipressin for hepatorenal syndrome : predictors of response , Safety of terlipressin for hepatorenal syndrome , Terlipressin for HRS : novel strategies and future perspectives , Hepatorenal syndrome and liver transplantation
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  • 2
    Electronic Resource
    Electronic Resource
    Suramin inhibits death receptor–induced apoptosis in vitro and fulminant apoptotic liver damage in mice (2004)
    [s.l.] : Nature Publishing Group
    Nature medicine 10 (2004), S. 602-609 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Suramin is a polysulfonated derivative of urea and has been widely used both to treat infections and as a chemotherapeutic drug. Suramin has been shown to inhibit growth factor signaling pathways; however, its effect on apoptosis is unknown. Here we show that suramin inhibits apoptosis induced ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm1049
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Case Report: Multiple Liver Abscesses Caused by Yersinia enterocolitica in a Patient Receiving Long-Term Transfusion Therapy for Osteomyelosclerosis (1997)
    Springer
    Digestive diseases and sciences 42 (1997), S. 2501-2504 
    Details
    ISSN: 1573-2568
    Keywords: YERSINIA ; DIARRHEA ; LIVER ABSCESSES
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018808527632
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  • 4
    Electronic Resource
    Electronic Resource
    Transjugular Intrahepatic Portosystemic Shunt (TIPS) for Variceal Bleeding in Portal Hypertension (Comparison of Emergency and Elective Interventions) (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 2463-2469 
    Details
    ISSN: 1573-2568
    Keywords: TRANSJUGULAR INTRAHEPATIC PORTOSYSTEMIC SHUNT ; SCLEROTHERAPY ; CIRRHOSIS ; PORTAL HYPERTENSION ; VARICEAL BLEEDING
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nonsurgical reduction of portal hypertension bytransjugular intrahepatic portosystemic shunt (TIPS) iswidely used for prevention of variceal rebleeding(elective TIPS). Information is limited about the value of emergency TIPS for acute varicealbleeding unresponsive to endoscopic and drug therapy.The aim of the present study was therefore to determinewhether the effects and complications differ between emergency and elective TIPS in patients withcirrhosis of the liver. TIPS was performed in 11patients with acute variceal bleeding unresponsive toendoscopic treatment and 22 patients in stable condition after an episode of variceal bleeding. Clinicalexamination, blood sampling, Doppler sonography of TIPSflow, and upper gastrointestinal endoscopy wereperformed at days 1, 7, and 30 and at three-month intervals after TIPS. Mean follow-up was 549(1-987) days. Bleeding was controlled by emergency TIPSin 10/11 patients. Probability of survival was notdifferent after emergency and elective TIPS (0.73 vs 0.84 at one year). Early rebleeding (≤2weeks) occurred more often after emergency TIPS (3/11 vs0/22 patients; P = 0.03), but there was no significantdifference in late rebleeding. Occlusion of TIPS was more frequent after emergency TIPS.Occurrence of TIPS stenoses was identical in both groups(4/11 vs 8/22). De novo or deterioration of preexistinghepatic encephalopathy was similar (18% vs 24%; NS). Itis concluded that TIPS is effective for control of acutevariceal bleeding unresponsive to endoscopic and drugtreatment. Early rebleeding and stent occlusion occurredmore often after emergency TIPS. Late rebleeding, complications, andlong-term survival did not differ from electiveTIPS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026686232756
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  • 5
    Electronic Resource
    Electronic Resource
    A role for chronic hepatitis C virus infection in a patient with cutaneous vasculitis, cryoglobulinemia, and chronic liver disease (1995)
    Springer
    Digestive diseases and sciences 40 (1995), S. 1221-1225 
    Details
    ISSN: 1573-2568
    Keywords: hepatitis C ; vasculitis ; cryoglobulinemia ; interferon-α
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A six-year history of repeated attacks of fatigue, fever, arthralgias, skin changes, Raynaud's phenomenon, and neuropathy is reported in a patient with chronic liver disease. The following diagnoses were made: (1) leukocytoclastic vasculitis; (2) acute urticaria; (3) cryoglobulinemia type II with Raynaud's phenomenon and low serum level of C4; (4) peripheral polyneuropathy; (5) sicca syndrome; and (6) chronic hepatitis C virus infection. Despite therapy with corticosteroids symptoms increased gradually over years. In the first PCR of the nested PCR analysis, HCV-RNA was exclusively detected in the cryoglobulin fraction but not in the serum supernatant, suggesting that antibodies bind HCV particles, forming circulating immune complexes. As diagnoses 1-5 are well-known organ manifestations of cryoglobulinemia, we speculated whether treatment of hepatitis C with IFN-μ (3 million IU IFN-μ2b three times a week) would inhibit HCV replication, decrease the cryocrit level and thereby ameliorate organ manifestations such as neuropathy and vasculities. During treatment with IFN-μ only a very weak or no signal could be detected for HCV-RNA in the cryoglobulin fraction as well as in the serum supernatant. This held true also for the serum supernatant in the second PCR. In parallel, cryoglobulin level, immunoglobulins, and liver enzymes decreased substantially to normal or near normal levels. Clinical symptoms—leukocytoclastic vasculitis and neuropathy—disappeared. We conclude that chronic HCV infection is involved in the pathogenesis of cryoglobulinemia and that IFN-μ might be an effective treatment in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02065527
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