GLORIA

GEOMAR Library Ocean Research Information Access

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: A 20-kDa DNA-binding protein that binds the AT-rich sequences within the promoters of the brain-specific protein kinase C (PKC) γ and neurogranin/RC3 genes has been characterized as chromosomal nonhistone high-mobility-group protein (HMG)-I. This protein is a substrate of PKC α, β, γ, and δ but is poorly phosphorylated by PKC ε and ζ. Two major (Ser44 and Ser64) and four minor phosphorylation sites have been identified. The extents of phosphorylation of Ser44 and Ser64 were 1:1, whereas those of the four minor sites all together were 〈30% of the major one. These PKC phosphorylation sites are distinct from those phosphorylated by cdc2 kinase, which phosphorylates Thr53 and Thr78. Phosphorylation of HMG-I by PKC resulted in a reduction of DNA-binding affinity by 28-fold as compared with 12-fold caused by the phosphorylation with cdc2 kinase. HMG-I could be additively phosphorylated by cdc2 kinase and PKC, and the resulting doubly phosphorylated protein exhibited a 〉 100-fold reduction in binding affinity. The two cdc2 kinase phosphorylation sites of HMG-I are adjacent to the N terminus of two of the three predicted DNA-binding domains. In comparison, one of the major PKC phosphorylation sites, Ser64, is adjacent to the C terminus of the second DNA-binding domain, whereas Ser44 is located within the spanning region between the first and second DNA-binding domains. The current results suggest that phosphorylation of the mammalian HMG-I by PKC alone or in combination with cdc2 kinase provides an effective mechanism for the regulation of HMG-I function.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 625 (1991), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 710 (1994), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 689 (1993), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 15 (1988), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: b1. The effects of central administration of met-enkephalin, leu-enkephalin, the enkephalin analogue FK-33824 and the opiate antagonist naloxone on plasma concentration of adrenocorticotrophic hormone (ACTH) were examined in conscious sheep.2. Intracerebroventricular infusion of met-enkephalin and FK-33824 significantly decreased the basal plasma concentration of ACTH.3. Intracerebroventricular infusion of FK-33824 inhibited the haemorrhage-induced increase in plasma concentration of ACTH.4. Intracerebroventricular infusion of naloxone attenuated the central inhibition of plasma concentration of ACTH induced by FK-33824, but intravenous infusion of naloxone had no effect on the reduction in plasma concentration of ACTH induced by FK-33824.5. These studies suggest that in sheep met-enkephalin may play a central inhibitory role in the control of ACTH secretion.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 6
    Publication Date: 2013-08-31
    Description: [1]  One of the primary goals for the Visible Infrared Imaging Radiometer Suite (VIIRS) onboard the Suomi National Polar-orbiting Partnership (SNPP) is to provide the science and user communities with the data continuity of the Environmental Data Records (EDR) (or Level-2 products) over global oceanic waters for various research and applications, including assessment of climatic and environmental variations. The ocean color EDR is one of the most important products derived from VIIRS. Since ocean color EDR is processed from the upstream Sensor Data Records (SDR) (or Level-1B data), the objective of this study is to evaluate the impact of the SDR on the VIIRS ocean color EDR. The quality of the SDR relies on pre-launch sensor characterizations as well as on-orbit radiometric calibrations, which are used to develop the sensor F-factor lookup tables (F-LUTs). VIIRS F-LUTs derived from solar and lunar calibrations have been used in processing data from the VIIRS Raw Data Records (RDR) (or Level-0 data) to SDR. In this study, three sets of F-LUTs with different generation schemes have been used to reprocess the SDR and then the ocean color EDR for product evaluations. VIIRS ocean color products are compared with in situ data from the Marine Optical Buoy (MOBY) and products from the Moderate Resolution Imaging Spectroradiometer (MODIS) on the satellite Aqua. It is found that the data quality of VIIRS operational ocean color products before 6 February 2012 is poor due to the inappropriate use of the at-launch F-LUTs for the SDR calibration, and that the recently updated VIIRS F-LUTs have significantly improved the SDR and ocean color EDR. Using reprocessed SDR with updated F-LUTs and including vicarious calibration, VIIRS ocean color EDR products are consistent with those from MODIS-Aqua in global deep waters. Although there are still some significant issues with VIIRS ocean color EDR, e.g., poor data quality over coastal regions, our results demonstrate that VIIRS has great potential to provide the science and user communities with consistently high quality global ocean color data records that are established from heritage ocean color sensors such as MODIS-Aqua.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 7
    Publication Date: 2017-01-11
    Description: Unusual cold filaments are uncovered during the spring intermonsoon season in the South China Sea (SCS) using a suite of satellite observations. They have a width of about 100 km on average and extend several hundreds of kilometers offshore on the sea surface, providing significant cross-shelf transport of heat and nutrients. The eastward current associated with mesoscale eddies in spring in the western SCS is found to play an important role in the filament formation by advecting coastal cold waters far offshore. The meridional location of the cold filament displays considerable interannual variability ranging between 9 o N and 18 o N, which can be attributed to the interannual south-north shift of the eastward current associated with eddies. It is also found that in the spring, cold filaments have profound effects on the chlorophyll a concentration in the upper ocean and the overlying atmosphere. These findings provide new insights into the role of eddies in cross-shelf exchange and mesoscale air-sea interaction in the marginal seas.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 8
    Publication Date: 2014-08-13
    Description: P-n junction BiOBr/ZnO composites were prepared by a facile solvothermal process with double Br sources of CTAB and KBr. The samples were characterized by XRD, XPS, SEM, TEM, HRTEM, DRS, BET and PL. The BiOBr/ZnO composites exhibited much higher photocatalytic activity than single BiOBr and ZnO for the degradation of phenol under simulated sunlight irradiation. The enhanced photocatalytic activity of BiOBr/ZnO composites could be mainly ascribed to the high-efficiency separation of photogenerated electron-hole pairs through BiOBr/ZnO p-n junction. The reaction mechanism for the removal of phenol was also discussed. Hole and ·OH were the main reactive species. Moreover, the influence of disparate ratios of double Br sources to BiOBr/ZnO composites was also investigated. The results indicated that the BiOBr/ZnO composites prepared by double Br sources showed better photocatalytic activities than the sample prepared by single Br source. P-n junction BiOBr/ZnO composites were prepared by a facile solvothermal process with double Br sources and the composites exhibited higher photocatalytic activity than BiOBr and ZnO for the degradation of phenol, which could be ascribed to two reasons. One reason may be the high efficient separation of photogenerated electron-hole pairs through BiOBr/ZnO p-n junction. Another one would be the high surface area achieved by adjusting the content of CTAB.
    Print ISSN: 0232-1300
    Electronic ISSN: 1521-4079
    Topics: Geosciences , Physics
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 9
    Publication Date: 2013-03-26
    Description: AmyP is a raw-starch-degrading α-amylase newly identified from a marine metagenome library. It shares low sequence similarity with characterized glycoside hydrolases and was classified into a new subfamily of GH13. In particular, it showed preferential degradation to raw rice starch. Full-length AmyP was cloned and overexpressed in Escherichia coli , then purified and crystallized in the presence of its substrate analogue β-cyclodextrin. X-ray diffraction data were collected to a resolution of 2.1 Å. The crystal belonged to space group P 2 1 2 1 2, with unit-cell parameters a = 129.824, b = 215.534, c = 79.699 Å, α = β = γ = 90°, and was estimated to contain two molecules in one asymmetric unit.
    Electronic ISSN: 1744-3091
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Physics
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 10
    Publication Date: 2014-05-04
    Description: Purpose To investigate the diffusion abnormalities in the brain of children with idiopathic generalized epilepsy (IGE) with generalized tonic-clonic seizure (GTCS) by using diffusion kurtosis imaging (DKI). Materials and Methods Twenty-one IGE children with GTCS and 16 controls were recruited. DKI was performed and maps of radial diffusivity (λ ⊥ ), axial diffusivity (λ // ), mean diffusivity (MD), fractional anisotropy (FA), radial kurtosis (K ⊥ ), axial kurtosis (K // ) and mean kurtosis (MK) were calculated. Voxel-based analyses were employed to compare diffusion metrics in epilepsy versus the controls. Results In the case group, MD was found significantly higher in the right temporal lobe, the right occipital lobe, hippocampus, and some subcortical regions, while FA increased in bilateral supplementary motor area and the left superior frontal lobe (false discovery rate corrected P  〈 0.05). Analysis of λ ⊥ and λ // showed that the increased MD was mainly due to the elevated λ // . Significantly decreased MK was also detected in bilateral temporo-occipital regions, the right hippocampus, the left insula, the left post-central area, and some subcortical regions (false discovery rate corrected P  〈 0.05). In most regions the changed MK were due to the decreased K // . Conclusion The kurtosis parameters (K ⊥ , K // , and MK) reflect different microstructural information in the IGE children with GTCS, and this support the value of DKI in studying children GTCS. J. Magn. Reson. Imaging 2014 . © 2014 Wiley Periodicals, Inc .
    Print ISSN: 1053-1807
    Electronic ISSN: 1522-2586
    Topics: Medicine
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...