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  • 1
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] We used illegitimate transcription in lymphoblastoid cell lines6 to obtain laminin α2 chain mRNA from probands of consanguineous laminin α2 and non-consanguineous chain-deficient families for mutation analysis by RT-PCR. Twenty-four pairs of overlapping primers (see Methods) were ...
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] DNA-adenine methylation at certain GATC sites plays a pivotal role in bacterial and phage gene expression as well as bacterial virulence. We report here the crystal structures of the bacteriophage T4Dam DNA adenine methyltransferase (MTase) in a binary complex with the methyl-donor product ...
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  • 3
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    Nature Publishing Group
    In:  EPIC3Nature, Nature Publishing Group, 512(7514), pp. 290-294, ISSN: 0028-0836
    Publication Date: 2014-09-04
    Description: During glacial periods of the Late Pleistocene, an abundance of proxy data demonstrates the existence of large and repeated millennial-scale warming episodes, known as Dansgaard–Oeschger (DO) events1. This ubiquitous feature of rapid glacial climate change can be extended back as far as 800,000 years before present (BP) in the ice core record2, and has drawn broad attention within the science and policy-making communities alike3. Many studies have been dedicated to investigating the underlying causes of these changes, but no coherent mechanism has yet been identified3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15. Here we show, by using a comprehensive fully coupled model16, that gradual changes in the height of the Northern Hemisphere ice sheets (NHISs) can alter the coupled atmosphere–ocean system and cause rapid glacial climate shifts closely resembling DO events. The simulated global climate responses—including abrupt warming in the North Atlantic, a northward shift of the tropical rainbelts, and Southern Hemisphere cooling related to the bipolar seesaw—are generally consistent with empirical evidence1, 3, 17. As a result of the coexistence of two glacial ocean circulation states at intermediate heights of the ice sheets, minor changes in the height of the NHISs and the amount of atmospheric CO2 can trigger the rapid climate transitions via a local positive atmosphere–ocean–sea-ice feedback in the North Atlantic. Our results, although based on a single model, thus provide a coherent concept for understanding the recorded millennial-scale variability and abrupt climate changes in the coupled atmosphere–ocean system, as well as their linkages to the volume of the intermediate ice sheets during glacials.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 4
    Publication Date: 2020-04-14
    Description: The Asian monsoon (AM) played an important role in the dynastic history of China, yet it remains unknown whether AM-mediated shifts in Chinese societies affect earth surface processes to the point of exceeding natural variability. Here, we present a dust storm intensity record dating back to the first unified dynasty of China (the Qin Dynasty, 221–207 B.C.E.). Marked increases in dust storm activity coincided with unified dynasties with large populations during strong AM periods. By contrast, reduced dust storm activity corresponded to decreased population sizes and periods of civil unrest, which was co-eval with a weakened AM. The strengthened AM may have facilitated the development of Chinese civilizations, destabilizing the topsoil and thereby increasing the dust storm frequency. Beginning at least 2000 years ago, human activities might have started to overtake natural climatic variability as the dominant controls of dust storm activity in eastern China.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
    Format: application/pdf
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  • 5
    Publication Date: 2021-02-03
    Description: The dominant feature of large-scale mass transfer in the modern ocean is the Atlantic meridional overturning circulation (AMOC). The geometry and vigour of this circulation influences global climate on various timescales. Palaeoceanographic evidence suggests that during glacial periods of the past 1.5 million years the AMOC had markedly different features from today; in the Atlantic basin, deep waters of Southern Ocean origin increased in volume while above them the core of the North Atlantic Deep Water (NADW) shoaled. An absence of evidence on the origin of this phenomenon means that the sequence of events leading to global glacial conditions remains unclear. Here we present multi-proxy evidence showing that northward shifts in Antarctic iceberg melt in the Indian–Atlantic Southern Ocean (0–50°E) systematically preceded deep-water mass reorganizations by one to two thousand years during Pleistocene-era glaciations. With the aid of iceberg-trajectory model experiments, we demonstrate that such a shift in iceberg trajectories during glacial periods can result in a considerable redistribution of freshwater in the Southern Ocean. We suggest that this, in concert with increased sea-ice cover, enabled positive buoyancy anomalies to ‘escape’ into the upper limb of the AMOC, providing a teleconnection between surface Southern Ocean conditions and the formation of NADW. The magnitude and pacing of this mechanism evolved substantially across the mid-Pleistocene transition, and the coeval increase in magnitude of the ‘southern escape’ and deep circulation perturbations implicate this mechanism as a key feedback in the transition to the ‘100-kyr world’, in which glacial–interglacial cycles occur at roughly 100,000-year periods.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 6
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    Institute of Physics (IOP)
    Publication Date: 2014-07-24
    Description: We propose a hyperbolic function form of the Cardassian component in the Cardassian model. Using the repartition of this Cardassian component, we can obtain a non-zero gravitational interaction between the time derivative of Ricci scalar curvature and the baryon/lepton number current in the radiation-dominated universe. Furthermore, the other term that acts like a non-zero cosmological constant would give an accelerated expansion of current universe and the features of this model do not violate our desired requirements.
    Print ISSN: 1674-1137
    Topics: Physics
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  • 7
    Publication Date: 2018-01-31
    Description: Currently, hydraulic fracturing is an important way to develop low permeability reservoirs. The fractures produced during the fracturing process are the main influencing factors of changing in-situ stress. In this paper, the influence of fracture extension on in-situ stress is studied by establishing a mathematical model to describe the relationship between fracture length and in-situ stress. The results show that the growth rate gradually decreases after the fracture reaches a certain length with the increase of fracturing time; the continuous extension of the fracture is the main factor to change the in-situ stress. In order to reduce the impact on the subsequent fracture extension due to the changing of in-situ stress, controlling fracturing time and fracture length without affecting the stimulated reservoir effect is an important way. The results presented in this study can effectively reduce the impact of changing of in-situ stress on subsequent fracturing construction.
    Print ISSN: 1755-1307
    Electronic ISSN: 1755-1315
    Topics: Geography , Geosciences , Physics
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  • 8
    Publication Date: 2018-11-06
    Description: At present, the research of Static Var Generator (SVG) mainly focuses on the main circuit topology, the optimization of control strategy, the method of selection, and lack of research on the low frequency oscillation of the wind farm caused by SVG minimum reactive output dead zone in practical engineering applications. For this reason, this paper first studies the mechanism of the low frequency oscillation of the wind electric field induced by the SVG minimum output dead zone of the wind farm, and discusses the conditions of this type of oscillation. On this basis, the automatic voltage control system (AVC) optimization model of wind farm is established with the minimum reactive variation of SVG output near the zero point as the optimization goal, and an optimization control strategy of wind farm with SVG minimum output reactive dead zone is proposed. Finally, the correctness of the result is verified by simulation. The results show that, due to the existence of the minimum outp...
    Print ISSN: 1755-1307
    Electronic ISSN: 1755-1315
    Topics: Geography , Geosciences , Physics
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  • 9
    Publication Date: 2011-10-20
    Description: In this paper, proceeding from the relation between the Cardassian model and the accelerated expansion of the universe, adopting a parametric method which does not depend on a precise mechanism for gravitational baryo/leptogenesis and using the model parameter of CPT -violating interaction, we study the role of the modified Friedmann equation which plays a role in the matter asymmetry of the early epoch and the accelerated expansion of the present universe. Thus the appropriate Cardassian component in the radiation-dominated era or in the matter-dominated universe can be obtained. The results indicate that early CPT -violation is included in the Cardassian term. In the same way, the present Cardassian term that belongs to a quintessence-like model can drive the universe towards a flat, matter-dominated and accelerating expansion.
    Print ISSN: 1674-1137
    Topics: Physics
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  • 10
    Publication Date: 2018-11-06
    Description: In recent years, China’s clean energy has developed rapidly. The development level of clean energy does not match the local power consumption, resulting in a large number of abandoned winds and abandoned light. With the gradual completion of the UHV network, the transmission capacity between regions has been rapidly enhanced, providing a broad space for optimizing the allocation of resources across a wide range of areas and improving the level of clean energy consumption. In order to cope with the problem of difficult local consumption in clean energy delivery areas and current cross-regional power delivery methods, this paper considers the factors of the adjustment of the tie line plan and increases the consumption of new energy through more reasonable tie line planning based on the traditional unit commitment algorithm. A case study shows that the model proposed in this paper can promote cross-regional consumption of clean energy and improve the economics of the interconnected...
    Print ISSN: 1755-1307
    Electronic ISSN: 1755-1315
    Topics: Geography , Geosciences , Physics
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