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  • 1990-1994  (6)
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  • 1
    Electronic Resource
    Electronic Resource
    In vitro activities of oxolonic acid, ciprofloxacin and norfloxacin against Aeromonas salmonicida (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 13 (1990), S. 0 
    Details
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Abstract. Oxolinic acid and two new fluoroquinolones, ciprofloxacin and norfloxacin, were evaluated for in vitro antibacterial activity against Aeromonas salmonicida. Although oxolinic acid was as active as ciprofloxacin in terms of minimum inhibitory concentration (MIC), fluoroquinolones were significantly more active in terms of their ability to kill both oxolinic acid sensitive and resistant strains of A. salmonicida. Furthermore, the fluorinated drugs were active against non-dividing A. salmonicida. It would appear worthwhile to carry out further investigations with fluoroquinolones as they may be more effective in treating A. salmonicida infections than the current regime of oxolinic acid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2761.1990.tb00796.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Amoxycillin resistance in Scottish isolates of Aeromonas salmonicida (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 17 (1994), S. 0 
    Details
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Abstract. Eighty isolates of Aeromonas salmonicida, recovered from separate outbreaks of furunculosis in farmed and wild salmon in Scotland during 1988 and 1989, were examined for susceptibility to the β-lactam antibiotic amoxycillin. Susceptibility was determined in terms of minimum inhibitory concentration (MIC). All of the A. salmonicida subsp. salmonicida isolates investigated were susceptible to amoxycillin, with MICs of 0.30–1.50mg1-1. All of the A. salmonicida subsp. achromogenes isolates tested were resistant to amoxycillin, with MICs in excess of 500mgl-1. The A. salmonicida subsp. achromogenes produced a β-lactamase enzyme with a pI of approximately 8.0. The enzyme was inducible and its production was unaffected by plasmid curing with ethidium bromide, suggesting that resistance was chromosomal rather than plasmid mediated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2761.1994.tb00231.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Utilization of haem compounds by Aeromonas salmonicida (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 17 (1994), S. 0 
    Details
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Abstract. The ability of A-layer-positi ve (A+) and A-layer-negative (A−) strains of Aeromonas salmonicida to utilize haem sources of iron under conditions of iron-restriction was evaluated. In a plate bioassay, only A+ strains of A. salmonicida were able to utilize haem from a variety of sources including haem, haemin, myoglobin, haemoglobin, haemoglobin- haptoglobin and haem-albumin complexes. Trypsin-digestion of whole cells abolished haem- binding, indicating that binding was cell-surface associated, involving a protein binding site or receptor. Competitive binding studies indicated that all haem compounds were bound by a common receptor, which was not iron-regulated and was associated with the presence of the 49-kDa A-layer protein. The ability of both typical A+ (siderophore-positive) and atypical A+ (siderophore-negative) strains to utilize haem indicated that the mechanism of haem utilization was not siderophore-mediated and that A. salmonicida possesses both siderophore-dependent and siderophore-independent mechanisms to overcome iron-restricted conditions encountered in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2761.1994.tb00232.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Alterations in outer membrane proteins identified in a clinical isolate of Aeromonas salmonicida subsp. salmonicida (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 15 (1992), S. 0 
    Details
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2761.1992.tb00665.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Fluoroquinolones display rapid bactericidal activity and low mutation frequencies against Aeromonas salmonicida (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 14 (1991), S. 0 
    Details
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Abstract. Oxolinic acid and five new fluoroquinolones, sarafloxacin, enrofloxacin, PD127, 391, PD117, 596 and C1934, were evaluated for in vitro activity against Aeromonas salmonicida. Sarafloxacin, enrofloxacin, PD127, 391 and PD117, 596 were significantly more active than cither oxolinic acid or C1934 in terms of their bactericidal activity against both oxolinic-acid-resistant and sensitive strains of A. salmonicida, killing 99% of the bacteria after 1h exposure. Resistant mutants developed at lower frequency to the fluoroquinolones than to oxolinic acid or oxytctracycline at 5, 10 and 20 times the MIC. However, mutants selected with one quinolone were cross-resistant to all the other quinolones tested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2761.1991.tb00624.x
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  • 6
    Electronic Resource
    Electronic Resource
    Cultural conditions forAeromonas hydrophila affect the production of haemolysins with differing host specificities (1991)
    Springer
    Antonie van Leeuwenhoek 60 (1991), S. 67-72 
    Details
    ISSN: 1572-9699
    Keywords: haemolysin ; Aeromonas hydrophila
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Five strains ofAeromonas hydrophila were studied for production of haemolysin specific for erythrocytes of various animal species using three cultural methods. All the strains produced haemolysin for all the erythrocyte species when the organisms were cultured on blood agar. Using cellophane overlay method, all the strains produced haemolysin for fish erythrocytes and variable activity to mammalian erythrocytes. Only one strain produced haemolytic activity for various though not all of the erythrocyte species when grown in brain heart infusion broth. Data suggest thatA. hydrophila produces multiple haemolysins with specificities for erythrocytes of different animals. This was confirmed for trout and horse erythrocyte targeted haemolysins, by using iso-electric focussing separation and by measuring the effect of addition of ammonium sulphate to the growth medium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00572694
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