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  • 1
    Electronic Resource
    Electronic Resource
    In vitro activities of oxolonic acid, ciprofloxacin and norfloxacin against Aeromonas salmonicida (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 13 (1990), S. 0 
    Details
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Abstract. Oxolinic acid and two new fluoroquinolones, ciprofloxacin and norfloxacin, were evaluated for in vitro antibacterial activity against Aeromonas salmonicida. Although oxolinic acid was as active as ciprofloxacin in terms of minimum inhibitory concentration (MIC), fluoroquinolones were significantly more active in terms of their ability to kill both oxolinic acid sensitive and resistant strains of A. salmonicida. Furthermore, the fluorinated drugs were active against non-dividing A. salmonicida. It would appear worthwhile to carry out further investigations with fluoroquinolones as they may be more effective in treating A. salmonicida infections than the current regime of oxolinic acid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2761.1990.tb00796.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Alterations in outer membrane proteins identified in a clinical isolate of Aeromonas salmonicida subsp. salmonicida (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 15 (1992), S. 0 
    Details
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2761.1992.tb00665.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Fluoroquinolones display rapid bactericidal activity and low mutation frequencies against Aeromonas salmonicida (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 14 (1991), S. 0 
    Details
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Abstract. Oxolinic acid and five new fluoroquinolones, sarafloxacin, enrofloxacin, PD127, 391, PD117, 596 and C1934, were evaluated for in vitro activity against Aeromonas salmonicida. Sarafloxacin, enrofloxacin, PD127, 391 and PD117, 596 were significantly more active than cither oxolinic acid or C1934 in terms of their bactericidal activity against both oxolinic-acid-resistant and sensitive strains of A. salmonicida, killing 99% of the bacteria after 1h exposure. Resistant mutants developed at lower frequency to the fluoroquinolones than to oxolinic acid or oxytctracycline at 5, 10 and 20 times the MIC. However, mutants selected with one quinolone were cross-resistant to all the other quinolones tested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2761.1991.tb00624.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Conditions required for the antibacterial activity of zidovudine (1989)
    Springer
    European journal of clinical microbiology & infectious diseases 8 (1989), S. 737-741 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a study to determine the conditions required for its antibacterial activity, zidovudine was found to be bactericidal againstEscherichia coli andSalmonella typhimurium in nutrient broth over 6 h. Zidovudine was also found to be active against ten clinical isolates ofSalmonella andEscherichia coli at 1 mg/l, which is a clinically achievable concentration of the drug. Bacterial protein synthesis was required for the bactericidal activity of zidovudine against bothEscherichia coli andSalmonella typhimurium. Zidovudine was found to be inactive against non-dividing bacteria, as it was unable to kill bacteria of either species when they were suspended in PBS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01963765
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  • 5
    Electronic Resource
    Electronic Resource
    The mode of action of quinolones: The paradox in activity of low and high concentrations and activity in the anaerobic environment (1991)
    Springer
    European journal of clinical microbiology & infectious diseases 10 (1991), S. 240-248 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract All 4-quinolones that have been examined display rapid bactericidal activity which is biphasic. At concentrations above the MIC, the lethality of the drugs increases until a concentration known as the optimum bactericidal concentration (OBC) beyond which the bactericidal activity then declines. The biphasic response appears to be due to the inhibition of RNA synthesis at concentrations above the OBC, as RNA synthesis is required for the full bactericidal activity of the 4-quinolones. However, differences in the biphasic response are observed as some fluoroquinolones are still able to kill bacteria in the absence of bacterial protein or RNA synthesis, thus reducing the inhibition of bactericidal activity at concentrations above the OBC. It has been proposed that this ability to kill bacteria in the absence of protein or RNA synthesis is due to the possession of an additional bactericidal mechanism by these fluoroquinolones. Oxygen also appears to be essential for the lethality of the clinically available 4-quinolones although it is not required for the drugs to inhibit bacterial multiplication. Therefore these drugs are not bactericidal under anaerobic conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966996
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  • 6
    Electronic Resource
    Electronic Resource
    Bactericidal activity of enoxacin and Lomefloxacin againstEscherichia coli KL16 (1989)
    Springer
    European journal of clinical microbiology & infectious diseases 8 (1989), S. 731-733 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Enoxacin and lomefloxacin were found to display a biphasic response when their bactericidal activities were investigated againstEscherichia coli KL16 in nutrient broth. Although enoxacin required bacterial protein and RNA synthesis to exert bactericidal activity, it was able to kill non-dividing bacteria. On the other hand, the protein synthesis inhibitor chloramphenicol and the RNA synthesis inhibitor rifampicin did not abolish enoxacin's killing activity againstEscherichia coli KL16 in nutrient broth. Lomefloxacin was also shown to be active against non-dividingEscherichia coli KL16.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01963763
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    Paper (German National Licenses)
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