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  • 1
    Online Resource
    Online Resource
    Entwicklung eines HTSL-SQUID-Messmoduls zur kontaktlosen Strommessung in Solarzellen : Abschlussbericht zum Teilvorhaben im BMBF-Verbundprojekt: Photoscanning SQUID-Messverfahren (2002)
    Freiberg
    Details Availability
    Keywords: Forschungsbericht
    Type of Medium: Online Resource
    Pages: Online-Ressource (20 p. = 6,75 MB) , ill., graphs
    Edition: [Elektronische Ressource]
    URL: https://edocs.tib.eu/files/e01fb02/362272824.pdf
    URL: https://edocs.tib.eu/files/e01fb02/362272824l.pdf
    Language: German
    Note: Contract BMBF 13N7503 6. - Differences between the printed and electronic version of the document are possible. - nBibliography p. 20 , Also available as printed version , Systemvoraussetzungen: Acrobat Reader.
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  • 2
    Electronic Resource
    Electronic Resource
    Melanocytes in nevi and melanomas synthesize basement membrane and basement membrane-like material. An immunohistochemical and electron microscopic study including immunoelectron microscopy (2000)
    Copenhagen : Munksgaard International Publishers
    Journal of cutaneous pathology 27 (2000), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Light microscopic studies have shown that nevus cell nests and melanoma nests are surrounded by basement membrane (BM) material containing type IV collagen and laminin. This study confirms this by electron microscopy and relates it to proteins which interact with the basement membrane. Nevi except for dysplastic and Spitz nevi, malignant melanomas, and melanoma metastases were studied by immunohistopathology, routine electron microscopy (EM), and immunoelectron microscopy. The lesions were incubated with monoclonal antibody (moAb) against type IV collagen, laminin, and the integrin α6 and studied by light microscopy. In addition, melanomas were studied by immuno-EM after incubation with a moAb against matrix metalloproteinase-2 (MMP-2). Nevus cell nests and melanoma nests are surrounded by BM material containing type IV collagen and laminin by immuno-EM. The BM material various in thickness and is amorphous. Type IV collagen, laminin, and MMP-2 are synthesized by melanoma cells as well as adjacent fibroblasts. Destruction or loss of the BM is not mandatory for melanoma invasion or even metastasis. Possibly the BM material is a protective wall for melanoma cells. Interactions between melanocytes and the extracellular matrix of which the BM is a part, can be traced back to the migration of melanocytes from the neural crest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0560.2000.027002067.x
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  • 3
    Electronic Resource
    Electronic Resource
    FS02.8
Patch testing with gold trichloride can give false test results (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
    Contact dermatitis 50 (2004), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Hydrochloric acid is formed in water solutions of gold trichloride. Hydrochloric acid in contact with aluminium generates hydrogen gas which can reduce and transform trivalent gold to elemental gold.Objective:  To investigate whether patch testing with aqueous gold trichloride can cause false positive (irritant) reactions in patients without contact allergy to gold and false negative reactions in patients with gold allergy.Methods:  13 patients with and 13 patients without positive patch test reactions to gold sodium thiosulfate were tested with gold trichloride in 2 different vehicles, water and alkaline buffer, using 2 different test techniques, the Finn Chamber technique with aluminium chambers and van der Bend technique with polypropene chambers.Results:  Irritant patch test reactions were obtained with aqueous gold trichloride tested in van der Bend chambers in 10 patients without gold allergy. In gold-allergic patients no positive test reactions were obtained from aqueous gold trichloride in Finn chambers while 2 positive test reactions were obtained from gold trichloride in alkaline buffer tested in van der Bend chambers.Conclusion:  If gold trichloride is patch tested in wrong vehicle and with wrong test technique irritant test reactions may occur which can be misinterpreted as positive allergic reactions in patients without gold allergy as well as negative reactions in patients with gold allergy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2004.0309z.x
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  • 4
    Electronic Resource
    Electronic Resource
    FS11.2
Contact allergy to herbal teas from Asteraceae plants (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
    Contact dermatitis 50 (2004), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective:  A possible contact allergy to herbal teas, in particular those derived from the Asteraceae plant family, was investigated in patients allergic to sesquiterpene lactones (SL).Method:  Twenty patients with a contact allergy to SL were recalled and patch-tested with aqueous, ethanol and acetone extracts of 8 different herbal teas based on Asteraceae plants as well as with parthenolide and other SL.Results:  In 18/20 patients with SL allergy there were positive test reactions to the Asteraceae teas, mainly to those based on German chamomile, dandelion and milfoil. Among the SL, parthenolide was the most frequent co-reactor.Conclusion:  Most patients with a contact allergy to SL are allergic to commercial teas derived from the Asteraceae plant family as well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2004.0309cv.x
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  • 5
    Electronic Resource
    Electronic Resource
    Intact nerve supply for eczema (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 144 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04251.x
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  • 6
    Electronic Resource
    Electronic Resource
    Possible association between loudness dependence of auditory evoked potentials and tryptophan hydroxylase-alleles in alcoholics (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Addiction biology 5 (2000), S. 0 
    Details
    ISSN: 1369-1600
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The serotonergic neurotransmission was suggested to play an important role in the aetiology of alcoholism. This study explores the association between tryptophan hydroxylase (TPH)-alleles and Loudness Dependence of Auditory Evoked N1/P2 Potentials (LDAEP). The TPH is the rate-limiting biosynthetic enzyme in serotonergic pathway. The LDAEP is one of the best validated non-invasive indicators for serotonergic neurotransmission. A sample of 54 alcoholics was recruited. N1/P2 potentials were evoked by five different sound intensities. A dipole source analysis using BESA (brain electric signal topography) was performed and intensity dependence was computed. The TPH intron 7 polymorphism was determined by using PCR in DNA samples. There was a weak but significant association between low LDAEP and the L-TPH allele. No influence from an individual's history of alcohol dependence or a positive family history of alcohol dependence on LDAEP was found. The weak but significant relationship found between L-TPH-allele and high serotonergic neurotransmission may contribute to a more detailed neurobiological characterization of alcohol dependents using functional and genetic parameters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1369-1600.2000.tb00194.x
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  • 7
    Electronic Resource
    Electronic Resource
    Aktuelle Bewertung neuer/atypischer Neuroleptika (2000)
    Springer
    Der Nervenarzt 71 (2000), S. 329-344 
    Details
    ISSN: 1433-0407
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Atypische/neue Neuroleptika unterscheiden sich definitionsgemäß im Vergleich zur traditionellen Neuroleptika durch ihr geringeres Risiko extrapyramidal-motorischer Nebenwirkungen und durch eine bessere Wirksamkeit bei Negativsymptomatik. Die zusammenfassende Bewertung der publizierten Ergebnisse vorhandener klinischer Studien kommt zu dem Ergebnis, dass sowohl die neueren wie auch die älteren atypischen Neuroleptika diesem Definitionsanspruch insgesamt gesehen gerecht werden, selbst wenn man hohe methodische Anforderungen an klinische Prüfkonditionen stellt. Hinsichtlich des Ausmaßes, in dem das atypische Profil erreicht wird, zeigen sich Unterschiede zwischen den verschiedenen Neuroleptika, so dass eine dimensionale Betrachtungsweise z. B. im Sinne von stark ausgeprägtem bzw. weniger stark ausgeprägtem atypischem Profil der Datenlage besser gerecht wird als eine kategoriale Unterscheidung zwischen atypischen und traditionellen Neuroleptika. Überhaupt sollten die atypischen Neuroleptika als heterogene Klasse verstanden werden, da auch hinsichtlich der pharmakologischen Charakteristika und des klinischen Nebenwirkungsprofils eine Reihe wichtiger Unterschiede bestehen, die bei der klinischen Anwendung der atypischen Neuroleptika zu berücksichtigen sind. Nachdem inzwischen auch eine Reihe von ein-Jahres-Studien sowie Anwendungsbeobachtungen vorliegen, können die atypischen Neuroleptika angesichts ihres günstigen klinischen Wirk- und Nebenwirkungsprofils zunehmend als Medikation erster Wahl bei der Behandlung der Schizophrenie angesehen werden. Es besteht die Erwartung, dass durch eine Behandlung mit atypischen Neuroleptika Compliance-Probleme verringert, die Lebensqualität erhöhat und der Gesamtverlauf schizophrener Erkrankungen günstiger beeinflusst werden können.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050567
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  • 8
    Electronic Resource
    Electronic Resource
    Have some guidelines for the treatment of acute bipolar depression gone too far in the restriction of antidepressants? (2000)
    Springer
    European archives of psychiatry and clinical neuroscience 250 (2000), S. 57-68 
    Details
    ISSN: 1433-8491
    Keywords: Key words Bipolar depression ; Tricyclic antidepressants ; Selective serotonin re-uptake inhibitors ; Drug treatment of acute bipolar depression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This paper gives a critical review of recommendations concerning the drug treatment of acute bipolar depression. The suggestions of different guidelines and consensus papers, especially in US-American and Canadian psychiatry, have a strong tendency against antidepressants in bipolar depression; they prefer mono-therapy with mood stabilizers and, in the case of co-medication with mood stabilizers and antidepressants in severe depression, to withdraw the antidepressant as early as possible. The intention of this restrictive use is to avoid the risk of mania and the risk of rapid cycling induced by antidepressants. However, apparently the risk of suicidal acts, which is as prominent in bipolar depression as in unipolar depression, has been totally neglected. Furthermore, the fact that none of the mood stabilizers have proven their antidepressive efficacy leads not only to the risk of depression-related suicidal behavior but also to the risk of chronicity of depressive symptoms due to undertreatment. Altogether the view expressed in some guidelines and consensus papers appears not well balanced. Furthermore, the fact that apparently the selective serotonin re-uptake inhibitors and possibly some other modern antidepressants have only a low risk of inducing a switch to mania should stimulate a rewriting of the guidelines on drug treatment in acute bipolar depression in a less restrictive way concerning the use of antidepressants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004060070035
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  • 9
    Electronic Resource
    Electronic Resource
    Aktuelle Aspekte der Sehnenheilung (2000)
    Springer
    Der Orthopäde 29 (2000), S. 182-187 
    Details
    ISSN: 1433-0431
    Keywords: Schlüsselwörter Sehnenheilung • Kollagen • Wachstumsfaktoren • Gentherapie ; Key words Tendon healing • Collagen • Growth factors • Gene therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary This review describes structure, function and healing of tendinous tissue and discusses new biologically based treatment options to modulate tendon healing. The repair process after tendon rupture results in a morphologically different and biomechanically inferior structure compared to a normal tendon. The collagen fibril diameters are decreased months after the traumatic lesion and show also different phenotypes. We know that cytokines and growth factors are key components for normal tissue development and regulate wound healing processes. Some growth factors have been detected to influence tenocytes by promoting cell proliferation and matrix synthesis. Application of the adequate growth factors at certain periods during the repair process might improve the healing result after tendon rupture. However, most of these growth factors are proteins which are rapidly metabolized by the organism. Transfer of growth factor genes into tenocytes might eliminate this problem by a continuous local release of growth factors at the healing site.
    Notes: Zusammenfassung Der Artikel beschreibt überblicksartig Struktur und Funktion von Sehnengewebe sowie die Abläufe im Rahmen der Sehnendefektheilung und mögliche therapeutische Einflussnahme. Im Vergleich zum unverletzten Sehnengewebe heilen Sehnenläsionen mit einem morphologisch unterschiedlichen und biomechanisch inferioren Regenerat. Vor allem die für die Funktion der Sehne entscheidenden kollagenen Fasern weisen langfristig veränderte Phänotypen und reduzierte Fibrillendurchmesser auf. Eine Einflußnahme auf die Prozesse im Rahmen der Sehnenheilung sind mittels zellulärer Wachstumsfaktoren denkbar. Zelluläre Wachstumsfaktoren nehmen während der embryonalen Gewebedifferenzierung und im Rahmen von Wundheilungsprozessen eine entscheidende Schlüsselfunktion ein. Von Wachstumsfaktoren ist bekannt, dass sie die Zellproliferation und Chemotaxis stimulieren, die Angiogenese vermitteln und die Zelldifferenzierung beeinflussen. Darüber hinaus regulieren sie zelluläre Synthese- und Sekretionsaktivität von Matrixbestandteilen. Der therapeutische Einsatz von heilungsstimulierenden Wachstumsfaktoren, bzw. der Transfer entsprechender Gene, könnte hierbei ein erfolgsversprechender Ansatz hinsichtlich einer Verbesserung der Sehnenheilung sein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00003718
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  • 10
    Electronic Resource
    Electronic Resource
    TGFβ-1-Gentransfer in Gelenkknorpelzellen (2000)
    Springer
    Der Orthopäde 29 (2000), S. 75-79 
    Details
    ISSN: 1433-0431
    Keywords: Schlüsselwörter Gentransfer • Gelenkknorpel • Wachstumsfaktoren • Kollagen • Matrixsynthese ; Key words ; Gene transfer • Hyaline cartilage • Growth factors • Collagen • Proteoglycan synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary TGFβ-1 has been shown to upregulate matrix synthesis in articular chondrocytes. TGFβ-gene transfer to chondrocytes has the potential to increase the local production of this key component within regenerating cartilage after trauma and could support the repair process in articular cartilage laesions. Primary rabbit articular chondrocytes were cultured and retrovirally transfected with the experimental TGFβ-1 and the lacZ marker gene for control purposes. After radioactive labeling of new synthesized matrix protiens results were compared with normal primary chondrocytes. After TGFβ-1 gene transfer the endogenous growth factor concentration was doubled compared to normal chondrocytes and decreased in the lacZ control group. The proteoglycan synthesis in TGFβ-1 transfected chondrocytes showed a 96 % increase compared to the basal production of normal chondrocytes. The LacZ transfected group revealed the opposite effect by a 44 % decrease. The collagen synthesis of TGFβ-1 transfected chondrocytes was 304 % compared to normal chondrocytes, predominantly type II collagen. The lacZ group collagen production was reduced by 35 %. We conclude that TGFβ-1 gene transfer overcomes the decreasing effect observed by transfection with the LacZ marker gene and increases matrix synthesis in articular chondrocytes. Genetically altered chondrocytes might improve the repair of cartilage lesions by stimulating matrix synthesis and supporting the expression of the hyaline phenotype.
    Notes: Zusammenfassung TGFβ-1 ist ein essentieller Wachstumsfaktor in der Gewebedifferenzierung und stimuliert auch die Syntheseaktivität in Knorpelzellen. Der Effekt einer Wachstumsfaktorsubstitution innerhalb eines biologischen Systems ist jedoch zeitlich stark limitiert, so dass der Transfer von Wachstumsfaktorgenen hier eine kontinuierliche lokale Bereitstellung des Zytokins ermöglichen würde und so zu verbesserten Resultaten in der Knorpelregeneration führen könnte. Gelenkknorpelzellen des Kaninchens wurden kultiviert und retroviral mit dem TGFβ-1 und dem LacZ-Gen transfiziert. Nach radioaktiver Markierung der Proteoglykan- und Kollagenneosynthese wurden die Ergebnisse der genveränderten Zellen mit unbehandelten Chondrozytenkulturen verglichen. Die TGFβ-1-Konzentration nach entsprechendem Gentransfer war im Vergleich zur unbehandelten Kontrollgruppe verdoppelt, nach LacZ-Gentransfer zeigte sich eine Reduktion der basalen TGFβ-1-Konzentration. Die Proteoglykansynthese in der TGFβ-1-Gruppe zeigte einen 96 %igen Anstieg verglichen zur normalen Knorpelzellproduktion. Bei der LacZ-Gruppe zeigte sich der gegenteilige Effekt in Form einer Reduktion der basalen Proteoglykansynthese um 44 %. Die Kollagenneosynthese in der TGFβ-1-transfizierten Gruppe betrug 304 % verglichen zur normalen Knorpelzellkultur und war um 35 % reduziert in der LacZ-Gruppe. Die Ergebnisse der TGFβ-1-transfizierten Gruppe unterschieden sich signifikant von den beiden Kontrollgruppen. Viraler Gentransfer in Chondrozyten ist möglich, jedoch werden die zellulären Syntheseleistungen beeinträchtigt. Der Transfer eines spezifischen Wachstumsfaktorgens hingegen überkompensiert diesen Effekt und bewirkt eine deutliche Steigerung in der Matrixneosynthese kultivierter Chondrozyten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00003713
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