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  • 2010-2014  (52)
  • 2000-2004  (5)
  • 1
    Keywords: Statistics. ; Electronic books.
    Description / Table of Contents: a.
    Type of Medium: Online Resource
    Pages: 1 online resource (148 pages)
    Edition: 1st ed.
    ISBN: 9783319066325
    Series Statement: SpringerBriefs in Mathematics Series
    Language: English
    Note: Intro -- Preface -- Acknowledgments -- Contents -- 1 Introduction -- 2 Preliminaries -- 3 Well-Posedness of the Vector-Valued BSEEs -- 4 Well-Posedness Result for the Operator-Valued BSEEs with Special Data -- 5 Sequential Banach-Alaoglu-Type Theorems in the Operator Version -- 6 Well-Posedness of the Operator-Valued BSEEs in the General Case -- 7 Some Properties of the Relaxed Transposition Solutions to the Operator-Valued BSEEs -- 8 Necessary Condition for Optimal Controls, the Case of Convex Control Domains -- 9 Necessary Condition for Optimal Controls, the Case of Non-convex Control Domains -- References.
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  • 2
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Peripheral tissue injury-induced central sensitization may result from the altered biochemical properties of spinal dorsal horn. However, peripheral nerve injury-induced modification of genes in the dorsal horn remains largely unknown. Here we identified strong changes of 14 channels, 25 receptors and 42 signal transduction related molecules in Sprague–Dawley rat dorsal spinal cord 14 days after peripheral axotomy by cDNA microarray. Twenty-nine genes were further confirmed by semiquantitative RT-PCR, Northern blotting, in situ hybridization and immunohistochemistry. These regulated genes included Ca2+ channel α1E and α2/δ1 subunits, α subunits for Na+ channel 1 and 6, Na+ channel β subunit, AMAP receptor GluR3 and 4, GABAA receptor α5 subunit, nicotinic acetylcholine receptor α5 and β2 subunits, PKC α, βI and δ isozymes, JNK1–3, ERK2–3, p38 MAPK and BatK and Lyn tyrosine-protein kinases, indicating that several signal transduction pathways were activated in dorsal spinal cord by peripheral nerve injury. These results demonstrate that peripheral nerve injury causes phenotypic changes in spinal dorsal horn. Increases in Ca2+ channel α2/δ1 subunit, GABAA receptor α5 subunit, Na+ channels and nicotinic acetylcholine receptors in both dorsal spinal cord and dorsal root ganglia indicate their potential roles in neuropathic pain control.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Peripheral axotomy-induced sprouting of thick myelinated afferents (A-fibers) from laminae III–IV into laminae I–II of the spinal cord is a well-established hypothesis for the structural basis of neuropathic pain. However, we show here that the cholera toxin B subunit (CTB), a neuronal tracer used to demonstrate the sprouting of A-fibers in several earlier studies, also labels unmyelinated afferents (C-fibers) in lamina II and thin myelinated afferents in lamina I, when applied after peripheral nerve transection. The lamina II afferents also contained vasoactive intestinal polypeptide and galanin, two neuropeptides mainly expressed in small dorsal root ganglion (DRG) neurons and C-fibers. In an attempt to label large DRG neurons and A-fibers selectively, CTB was applied four days before axotomy (pre-injury-labelling), and sprouting was monitored after axotomy. We found that only a small number of A-fibers sprouted into inner lamina II, a region normally innervated by C-fibers, but not into outer lamina II or lamina I. Such sprouts made synaptic contact with dendrites in inner lamina II. Neuropeptide Y (NPY) was found in these sprouts in inner lamina II, an area very rich in Y1 receptor-positive processes. These results suggest that axotomy-induced sprouting from deeper to superficial layers is much less pronounced than previously assumed, in fact it is only marginal. This limited reorganization involves large NPY immunoreactive DRG neurons sprouting into the Y1 receptor-rich inner lamina II. Even if quantitatively small, it cannot be excluded that this represents a functional circuitry involved in neuropathic pain.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] DNA-adenine methylation at certain GATC sites plays a pivotal role in bacterial and phage gene expression as well as bacterial virulence. We report here the crystal structures of the bacteriophage T4Dam DNA adenine methyltransferase (MTase) in a binary complex with the methyl-donor product ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Acta mathematica sinica 16 (2000), S. 601-612 
    ISSN: 1000-9574
    Keywords: Keywords Controllability, Singular perturbation, Heat equation, Wave equation ; 1991MR Subject Classification 93B05, 93B07, 93D15
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract In this note we analyze the exact controllability of singularly perturbed damped wave equations under more general geometric control condition than that of [1]. We show that the null controllability of the heat equation can be obtained as a singular limit of the exact controllability of such sorts of wave equations.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Communications in mathematical physics 213 (2000), S. 381-411 
    ISSN: 1432-0916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract: This paper presents an answer to an open problem in the dynamical systems of three letters: the generalized Milnor–Thurston conjecture on the existence of infinitely many plateaus of topological entropy in the two-dimensional parameter plane. The concept of equal topological entropy class is introduced by the dual star product which is a generalization of the Derrida–Gervois–Pomeau star product to the symbolic dynamics of three letters for the endomorphisms on the interval. The algebraic rules established by the dual star products for the doubly superstable kneading sequences are equivalent to the normal factorization of the Milnor–Thurston characteristic polynomials. Moreover, the classification theory of symbolic primitive and compound sequences based on the topological conjugacy in the meaning of equal entropy is completed in the topological space Σ3 of three letters.
    Type of Medium: Electronic Resource
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  • 7
  • 8
    Publication Date: 2014-07-08
    Description: During the past two decades, several atmospheric and oceanic general circulation models (GCMs) have been enhanced by the capability to explicitly simulate the hydrological cycle of the two stable water isotopes H218O and HDO. They have provided a wealth of understanding regarding changes of the water isotope signals in various archives under different past climate conditions. However, so far the number of fully coupled atmosphere-ocean GCMs with explicit water isotope diagnostics is very limited. Such coupled models are required for a more comprehensive simulation of both past climates as well as related isotope changes in the Earth’s hydrological cycle. Here, we report first results of a newly developed isotope diagnostics within the Earth system model ECHAM5-JSBACH/MPIMOM. Both H218O and HDO and their relevant fractionation processes are included in all compartments and branches of the water cycle within this model. First equilibrium simulations have been performed for both pre-industrial (PI) and Last Glacial Maximum (LGM) boundary conditions. Evaluation of the PI simulation reveals a good overall model performance in accordance with available modern isotope data from vapour measurements, precipitation samples as well as marine records. The LGM experiment results in spatially varying isotope depletion in precipitation between -20‰ and 0‰ in agreement with data from various isotope records. The simulated isotopic compoisiton of ccean surface waters shows a strong glacial enrichment in the Arctic. In further model analyses we investigate how the relation between water isotopes and key climate variables, e.g. land and surface temperatures, precipitation amounts, oceanic salinity, might has changed for different regions on a glacial-interglacial time scale. Moreover, the influence of glacial climates changes on second-order isotope signals, e.g. the Deuterium excess, is examined.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
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  • 9
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    Nature Publishing Group
    In:  EPIC3Nature, Nature Publishing Group, 512(7514), pp. 290-294, ISSN: 0028-0836
    Publication Date: 2014-09-04
    Description: During glacial periods of the Late Pleistocene, an abundance of proxy data demonstrates the existence of large and repeated millennial-scale warming episodes, known as Dansgaard–Oeschger (DO) events1. This ubiquitous feature of rapid glacial climate change can be extended back as far as 800,000 years before present (BP) in the ice core record2, and has drawn broad attention within the science and policy-making communities alike3. Many studies have been dedicated to investigating the underlying causes of these changes, but no coherent mechanism has yet been identified3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15. Here we show, by using a comprehensive fully coupled model16, that gradual changes in the height of the Northern Hemisphere ice sheets (NHISs) can alter the coupled atmosphere–ocean system and cause rapid glacial climate shifts closely resembling DO events. The simulated global climate responses—including abrupt warming in the North Atlantic, a northward shift of the tropical rainbelts, and Southern Hemisphere cooling related to the bipolar seesaw—are generally consistent with empirical evidence1, 3, 17. As a result of the coexistence of two glacial ocean circulation states at intermediate heights of the ice sheets, minor changes in the height of the NHISs and the amount of atmospheric CO2 can trigger the rapid climate transitions via a local positive atmosphere–ocean–sea-ice feedback in the North Atlantic. Our results, although based on a single model, thus provide a coherent concept for understanding the recorded millennial-scale variability and abrupt climate changes in the coupled atmosphere–ocean system, as well as their linkages to the volume of the intermediate ice sheets during glacials.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 10
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    National Academy of Sciences
    In:  EPIC3PNAS, National Academy of Sciences, 111(34), pp. E3501-E3505, ISSN: 0027-8424
    Publication Date: 2016-12-09
    Description: A recent temperature reconstruction of global annual temperature shows Early Holocene warmth followed by a cooling trend through the Middle to Late Holocene [Marcott SA, et al., 2013, Science 339(6124):1198–1201]. This global cooling is puzzling because it is opposite from the expected and simulated global warming trend due to the retreating ice sheets and rising atmospheric greenhouse gases. Our critical reexamination of this contradiction between the reconstructed cooling and the simulated warming points to potentially significant biases in both the seasonality of the proxy reconstruction and the climate sensitivity of current climate models.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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