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  • 2015-2019  (183)
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  • 1
    Online Resource
    Online Resource
    Freiburg : Universitätsklinikum Freiburg, Department für Pathologie
    Keywords: Forschungsbericht ; Brustkrebs ; Genexpression ; miRNS
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (26 Seiten, 515 KB)
    Language: German
    Note: Förderkennzeichen BMBF 031A094A. - Verbund-Nummer 01126545 , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
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  • 2
    Keywords: Forschungsbericht ; Eurasien Nord ; Ladogasee ; Holozän ; Paläoklima
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (73 Seiten, 89,98 MB) , Illustrationen, Diagramme
    Language: German
    Note: Förderkennzeichen BMBF 03G0859A-C. - Verbund-Nummer 01161585 , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
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  • 3
    Publication Date: 2020-02-06
    Description: Changes in heat transport associated with fluctuations in the strength of the Atlantic meridional overturning circulation (AMOC) are widely considered to affect the position of the Intertropical Convergence Zone (ITCZ), but the temporal immediacy of this teleconnection has to date not been resolved. Based on a high‐resolution marine sediment sequence over the last deglaciation, we provide evidence for a synchronous and near‐linear link between changes in the Atlantic interhemispheric sea surface temperature difference and continental precipitation over northeast Brazil. The tight coupling between AMOC strength, sea surface temperature difference, and precipitation changes over northeast Brazil unambiguously points to a rapid and proportional adjustment of the ITCZ location to past changes in the Atlantic meridional heat transport.
    Type: Article , PeerReviewed
    Format: text
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  • 4
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    AGU (American Geophysical Union) | Wiley
    In:  Journal of Advances in Modeling Earth Systems, 9 (5). pp. 2027-2045.
    Publication Date: 2018-12-17
    Description: Understanding the dynamics of warm climate states has gained increasing importance in the face of anthropogenic climate change, and while it is possible to simulate warm interglacial climates, these simulated results cannot be evaluated without the aid of geochemical proxies. One such proxy is δ18O, which allows for inference about both a climate state's hydrology and temperature. We utilize a stable water isotope equipped climate model to simulate three stages during the Last Interglacial (LIG), corresponding to 130, 125, and 120 kyr before present, using forcings for orbital configuration as well as greenhouse gases. We discover heterogeneous responses in the mean δ18O signal to the climate forcing, with large areas of depletion in the LIG δ18O signal over the tropical Atlantic, the Sahel, and the Indian subcontinent, and with enrichment over the Pacific and Arctic Oceans. While we find that the climatology mean relationship between δ18O and temperature remains stable during the LIG, we also discover that this relationship is not spatially consistent. Our results suggest that great care must be taken when comparing δ18O records of different paleoclimate archives with the results of climate models as both the qualitative and quantitative interpretation of δ18O variations as a proxy for past temperature changes may be problematic due to the complexity of the signals.
    Type: Article , PeerReviewed
    Format: text
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  • 5
    Publication Date: 2021-02-08
    Description: Stable water isotope records from Antarctica are key for our understanding of Quaternary climate variations. However, the exact quantitative interpretation of these important climate proxy records in terms of surface temperature, ice sheet height and other climatic changes is still a matter of debate. Here we report results obtained with an atmospheric general circulation model equipped with water isotopes, run at a high-spatial horizontal resolution of one-by-one degree. Comparing different glacial maximum ice sheet reconstructions, a best model data match is achieved for the PMIP3 reconstruction. Reduced West Antarctic elevation changes between 400 and 800 m lead to further improved agreement with ice core data. Our modern and glacial climate simulations support the validity of the isotopic paleothermometer approach based on the use of present-day observations and reveal that a glacial ocean state as displayed in the GLAMAP reconstruction is suitable for capturing the observed glacial isotope changes in Antarctic ice cores.
    Type: Article , PeerReviewed
    Format: text
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  • 6
    Publication Date: 2021-01-08
    Description: We present here the first results, for the preindustrial and mid-Holocene climatological periods, of the newly developed isotope-enhanced version of the fully coupled Earth system model MPI-ESM, called hereafter MPI-ESM-wiso. The water stable isotopes H162O, H182O and HDO have been implemented into all components of the coupled model setup. The mid-Holocene provides the opportunity to evaluate the model response to changes in the seasonal and latitudinal distribution of insolation induced by different orbital forcing conditions. The results of our equilibrium simulations allow us to evaluate the performance of the isotopic model in simulating the spatial and temporal variations of water isotopes in the different compartments of the hydrological system for warm climates. For the preindustrial climate, MPI-ESM-wiso reproduces very well the observed spatial distribution of the isotopic content in precipitation linked to the spatial variations in temperature and precipitation rate. We also find a good model–data agreement with the observed distribution of isotopic composition in surface seawater but a bias with the presence of surface seawater that is too 18O-depleted in the Arctic Ocean. All these results are improved compared to the previous model version ECHAM5/MPIOM. The spatial relationships of water isotopic composition with temperature, precipitation rate and salinity are consistent with observational data. For the preindustrial climate, the interannual relationships of water isotopes with temperature and salinity are globally lower than the spatial ones, consistent with previous studies. Simulated results under mid-Holocene conditions are in fair agreement with the isotopic measurements from ice cores and continental speleothems. MPI-ESM-wiso simulates a decrease in the isotopic composition of precipitation from North Africa to the Tibetan Plateau via India due to the enhanced monsoons during the mid-Holocene. Over Greenland, our simulation indicates a higher isotopic composition of precipitation linked to higher summer temperature and a reduction in sea ice, shown by positive isotope–temperature gradient. For the Antarctic continent, the model simulates lower isotopic values over the East Antarctic plateau, linked to the lower temperatures during the mid-Holocene period, while similar or higher isotopic values are modeled over the rest of the continent. While variations of isotopic contents in precipitation over West Antarctica between mid-Holocene and preindustrial periods are partly controlled by changes in temperature, the transport of relatively 18O-rich water vapor near the coast to the western ice core sites could play a role in the final isotopic composition. So, more caution has to be taken about the reconstruction of past temperature variations during warm periods over this area. The coupling of such a model with an ice sheet model or the use of a zoomed grid centered on this region could help to better describe the role of the water vapor transport and sea ice around West Antarctica. The reconstruction of past salinity through isotopic content in sea surface waters can be complicated for regions with strong ocean dynamics, variations in sea ice regimes or significant changes in freshwater budget, giving an extremely variable relationship between the isotopic content and salinity of ocean surface waters over small spatial scales. These complicating factors demonstrate the complexity of interpreting water isotopes as past climate signals of warm periods like the mid-Holocene. A systematic isotope model intercomparison study for further insights on the model dependency of these results would be beneficial.
    Type: Article , PeerReviewed
    Format: text
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  • 7
    Publication Date: 2022-03-09
    Description: All types of applications of stable water isotopes, for example, for the reconstruction of paleotemperatures or for climate model validation, rely on a proper understanding of the mechanisms determining the isotopic composition of water vapor and precipitation. In this study, we use the isotope‐enabled limited‐area model COSMOiso to characterize the impacts of continental evapotranspiration, rainout, and subcloud processes on δD of European water vapor and precipitation. To this end, we first confirm a reliable implementation of the most important isotope fractionation processes in COSMOiso by comparing 5 years of modeled δD values with multiplatform δD observations from Europe (remote sensing observations of the δD of water vapor around 2.6 km above ground level, in situ δD measurements in near‐surface water vapor, and δD precipitation data from the Global Network of Isotopes in Precipitation). Based on six 15 year sensitivity simulations, we then quantify the climatological impacts of the different fractionation processes on the δD values. We find δD of European water vapor and precipitation to be most strongly controlled by rainout. Superimposed to this are the effect of subcloud processes, which especially affects δD in precipitation under warm conditions, and the effect of continental evapotranspiration, which exerts an important control over the δD of near‐surface water vapor. In future studies, the validated COSMOiso model can be employed in a similar way for a comprehensive interpretation of European isotope records from climatologically different time periods.
    Type: Article , PeerReviewed
    Format: text
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  • 8
    Publication Date: 2017-08-24
    Description: Author(s): Selene Mor, Marc Herzog, Denis Golež, Philipp Werner, Martin Eckstein, Naoyuki Katayama, Minoru Nohara, Hide Takagi, Takashi Mizokawa, Claude Monney, and Julia Stähler We report on the nonequilibrium dynamics of the electronic structure of the layered semiconductor Ta 2 NiSe 5 investigated by time- and angle-resolved photoelectron spectroscopy. We show that below the critical excitation density of F C = 0.2     mJ   cm − 2 , the band gap narrows transiently, while it is enhance... [Phys. Rev. Lett. 119, 086401] Published Wed Aug 23, 2017
    Keywords: Condensed Matter: Electronic Properties, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 9
    Publication Date: 2015-03-12
    Description: Background: Retroperitoneal lipomas are an extremely rare condition with only 17 cases described in the literature since 1980. They can reach enormous size and cause significant abdominal symptoms. The most important differential diagnosis is the well-differentiated liposarcoma, which preoperatively often may not definitely be ruled out.Case presentationWe present the case of a 73 year-old Caucasian patient with a giant retroperitoneal lipoma of 9 kg measuring 55 cm in diameter. The patient presented with abdominal pain and swelling that had been slowly progressive for the last 15 years. On computerized tomography an immense retroperitoneal tumor was revealed. Intraoperatively, the tumor did not show any signs of infiltrative growth, therefore sole tumor extirpation was performed. Conclusion: Retroperitoneal lipomas are not clearly distinguishable from well-differentiated liposarcomas on imaging and even biopsies may be misleading. Moreover, abdominal symptoms, i.e. pain, obstipation and dysphagia may occur due to mechanical displacement. Therefore, surgical exploration with complete oncological resection is the therapy of choice if malignity cannot be ruled out.
    Electronic ISSN: 1756-0500
    Topics: Biology , Medicine
    Published by BioMed Central
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  • 10
    Publication Date: 2017-08-14
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
    Format: application/pdf
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