Note: e9780123819789v1.pdf -- Front Cover -- Vitamin D -- Copyright -- Contents -- Preface to the 3rd Edition -- Preface to the 2nd Edition -- Preface to the 1st Edition -- Contributors -- Introduction -- Abbreviations -- Relevant Lab Values in Adults and Children -- Criteria for Vitamin D Deficiency: 25(OH)D Serum Levels -- Approximate normal ranges for serum values in adultsaaNormal ranges differ in various laboratories and these values are pro ... -- Approximate normal ranges for serum values in childrena -- Useful equivalencies of different units -- Section I -Chemistry, Metabolism, Circulation -- Chapter 1 - Historical Overview of Vitamin D -- Discovery of the Vitamins -- Discovery that Vitamin D is not a Vitamin -- Isolation and Identification of Nutritional Forms of Vitamin D -- Discovery of the Physiological Functions of Vitamin D -- Discovery of the Hormonal Form of Vitamin D -- Acknowledgments -- References -- Chapter 2 - Photobiology of Vitamin D -- Introduction -- Historical Perspective -- Photobiology of Vitamin D -- Role of Sunlight and Dietary Vitamin D in Bone Health, Overall Health, and Well-Being -- Sunlight, Vitamin D, and Skin Cancer -- Conclusion -- Acknowledgment -- References -- Chapter 3 - The Activating Enzymes of Vitamin D Metabolism (25- and 1α-Hydroxylases) -- Introduction -- General Information Regarding Vitamin D Hydroxylases -- Vitamin D3-25-Hydroxylases -- 25-Hydroxyvitamin D-1α-Hydroxylase -- Additional Topics -- References -- Chapter 4 - CYP24A1: Structure, Function, and Physiological Role -- Overview -- CYP24A1-Catalyzed Pathways -- Structure-Function Relationships -- Putative CYP24A1 Involvement in Nonclassical Systems -- Perspectives -- References -- Chapter 5 - The Vitamin D Binding Protein DBP -- Introduction -- Vitamin D Binding Protein: Protein and Gene Structure -- Functions of DBP. , Conclusions and Perspectives -- References -- Chapter 6 - Industrial Aspects of Vitamin D -- History of Vitamin D Leading To Commercialization -- Manufacture of the Provitamins -- Irradiation of 7-Dehydrocholesterol and Ergosterol -- Metabolite Manufacture -- Analytical -- Dietary Requirements -- Economic Aspects -- Storage and Shipping -- References -- Section II -Mechanisms of Action -- Chapter 7 - The Vitamin D Receptor: Biochemical, Molecular, Biological, and Genomic Era Investigations -- Introduction -- Vitamin D Biology -- Discovery of the Vitamin D Receptor -- VDR Research: The Biochemical Era -- VDR Research: The Molecular Biological Era -- VDR Research: The Genomic Era -- VDR Chromosomal Gene: Structure and Molecular Regulation -- Concluding Comments -- Acknowledgment -- References -- Chapter 8 - Nuclear Vitamin D Receptor: Natural Ligands, Molecular Structure-Function, and Transcriptional Control of Vital ... -- Ligands, Gene Targets, and Biological Actions of Vdr -- VDR as a Member of the Nuclear Receptor Superfamily -- Molecular Structure-Function Of VDR -- Mechanisms of VDR-Mediated Control of Gene Expression -- VDR-Mediated Control of Vital Genes in Healthful Aging and Disease Prevention -- Conclusions and Perspectives -- Acknowledgment -- References -- Chapter 9 - Structural Basis for Ligand Activity in VDR -- Introduction -- Crystal Structure of hvdrΔ Bound to 1,25(Oh)2d3 -- Crystal Structure of zVDR Wild-Type LBD Bound to 1,25(OH)2D3 -- Structure of VDR LBD Complexed to Superagonist Ligands -- Structures of VDR Complexed to 2α-Substituted Analogs -- Structures of VDR With Nonsteroidal Ligands -- Structures of VDR With Analogs that Induce Structural Rearrangements -- Structural Basis for Vitamin D Receptor Antagonism -- Structure-based Design of Novel Superagonist Analogs -- Conclusion -- References. , Chapter 10 - Coregulators of VDR-mediated Gene Expression -- Introduction -- Coactivators of VDR -- Corepressors -- Conclusion - Integrated Model of Coregulator Activity -- References -- Chapter 11 - Target Genes of Vitamin D: Spatio-temporal Interaction of Chromatin, VDR, and Response Elements -- Introduction -- Transcriptional Regulation by 1,25(OH)2D3 -- Genomic VDR-Binding sites -- VDR Target Genes -- VDR Target Gene Analysis -- Transcriptional Cycling -- Conclusion -- Acknowledgments -- References -- Chapter 12 - Epigenetic Modifications in Vitamin D Receptor-mediated Transrepression -- Introduction -- WINAC: A Novel VDR-Associating ATP-Dependent Chromatin Remodeling Complex -- E-Box Motif Negative VDRE Mediates 1,25(OH)2D3-Induced Transrepression -- Coregulator Switching at E-Box nVdres in Ligand-Dependent Transrepression by VDR -- WINAC Mediates Ligand-Induced Transrepression by VDR -- 1,25(OH)2D3-Dependent VDR Transrepression Involves CpG Site Methylation in the CYP27B1 Promoter -- Cell-Cycle-Independent DNA Demethylation During CYP27B1 Transcriptional Derepression -- MBD4 Mediates Active DNA Demethylation -- MBD4 is a Downstream Mediator in PTH Signaling-Induced Transcriptional Derepression -- Conclusion -- References -- Chapter 13 - Vitamin D and Wnt/β-Catenin Signaling -- Introduction -- WNT Signaling -- Antagonism of Wnt/β-Catenin Pathway by 1,25(OH)2D3 in Colon Cancer -- Wnt and 1,25(OH)2D3 in the Bone -- Wnt and 1,25(OH)2D3 in the Skin -- Conclusions -- References -- Chapter 14 - Vitamin D Response Element-binding Protein -- Introduction -- Current View of Steroid/Sterol Hormone Action -- New World Primates -- New World Primate-Like VItamin D Resistance in Man -- Heterogeneous Nuclear Ribonucleoproteins (hnRNPs) -- hnRNPs as Multi-Level, Multi-Site, cis-Binding Regulators of Gene Expression. , The Estrogen Response Element Binding Protein (ERE-BP) and the Intracellular Estrogen Binding Protein (IEBP) -- Compensation for the Dominant-Negative Acting, Response Element-Binding Proteins -- Conclusion -- References -- Chapter 15 - Vitamin D Sterol/VDR Conformational Dynamics and Nongenomic Actions -- 1α,25(OH)2-Vitamin D3 (1,25(OH)2D3) Regulation of Genomic Versus Nongenomic Signaling -- Vitamin D3 Sterol (VDS) Chemistry -- 1,25(OH)2D3 Mediated Rapid, Nongenomic Responses -- The Plasma Membrane Vitamin D Receptor -- The VDR Conformational Ensemble Model -- VDR Ligand Specificity: Does an Unliganded VDR Ever Exist in Vivo? -- References -- Section III -Mineral and Bone Homeostasis -- Chapter 16 - Genetic and Epigenetic Control of the Regulatory Machinery for Skeletal Development and Bone Formation: Contrib ... -- Programs of Bone Formation -- Nuclear Organization of the Regulatory Machinery for Bone Formation -- Epigenetic Mechanism for Lineage Commitment -- Gene Expression within the Three-Dimensional Context of Nuclear Architecture -- Chromatin Remodeling Facilitates Bone-Specific and Vitamin-D-Mediated Promoter Accessibility and Integration of Regulatory ... -- Scaffolding of Regulatory Components for Combinatorial Control of Gene Expression -- Closing Remarks -- Acknowledgments -- References -- Chapter 17 - Vitamin D Regulation of Osteoblast Function -- Introduction -- Properties of Mature Osteoblasts and Osteocytes -- Major Regulatory Functions of Osteoblasts and Osteocytes and Control by the Vitamin D Endocrine System -- Effects of 1,25(OH)2D3 on Osteoblast Differentiation -- Regulation of Intracellular Signaling Pathways by 1,25(OH)2D3 -- Summary and Conclusions -- Acknowledgments -- References -- Chapter 18 - Osteoclasts -- Introduction -- References. , Chapter 19 - Molecular Mechanisms for Regulation of Intestinal Calcium and Phosphate Absorption by Vitamin D -- An Overview of Intestinal Calcium Absorption -- Critical Role of VDR in Control of Intestinal Ca Absorption -- Can High Vitamin D Status Increase Intestinal Calcium Absorption? -- An Overview of Intestinal Phosphate Absorption -- Acknowledgments -- References -- Chapter 20 - The Calbindins: Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6 -- Introduction and General Considerations, The Calbindins -- Localization and Proposed Functional Significance of the Calbindins -- Regulation of Calbindin Gene Expression -- Epithelial Calcium Channels -- Conclusion -- References -- Chapter 21 - Mineralization -- Introduction -- Conclusions -- References -- Chapter 22 - Vitamin D Regulation of Type I Collagen Expression in Bone -- Introduction -- Regulation of Bone Collagen Synthesis -- Molecular Mechanisms of Regulation -- Conclusions and Perspectives -- References -- Chapter 23 - Target Genes: Bone Proteins -- Vitamin D and Skeletal Homeostasis -- Exogenous and Endogenous Sources of 1,25(OH)2D3 -- Direct Actions of Vitamin D in Bone -- Concluding Remarks -- References -- Chapter 24 - Vitamin D and the Calcium-Sensing Receptor -- Introduction -- What is the CaSR? -- Overview of Roles of CaSR and VDR in Maintaining Ca2+O Homeostasis -- The CaSR and VDR in Tissues Participating in Ca2+O Homeostasis -- The CaSR and VDR in Tissues Uninvolved in Ca2+O Homeostasis -- Polymorphisms of the CaSR and VDR and Calcium and Bone Homeostasis -- Summary and Perspectives -- References -- Chapter 25 - Effects of 1,25-Dihydroxyvitamin D3 on Voltage-Sensitive Calcium Channels in Osteoblast Differentiation and Mor ... -- Systemic and Intracellular Ca2+ Homeostasis -- Voltage-Sensitive Calcium Channels. , 1,25-Dihydroxyvitamin D3 Actions on Voltage-Sensitive Ca2+ Channels.

Note: 9780122526879v1 -- Front Cover -- Vitamin D -- Copyright Page -- Contents -- List of Contributors -- Preface to the 2nd Edition -- Preface to the 1st Edition -- Abbreviations -- Introduction -- Chapter 1. Historical Perspective -- Section I: CHEMISTRY, METABOLISM, AND CIRCULATION -- Chapter 2. Vitamin D Metabolism -- Chapter 3. Photobiology of Vitamin D -- Chapter 4. The Vitamin D 25-Hydroxylase -- Chapter 5. The 25-Hydroxyvitamin D 1- -Hydroxylase -- Chapter 6. The 25-Hydroxyvitamin D 24-Hydroxylase -- Chapter 7. Mutant Mouse Models of Vitamin D Metabolic Enzymes -- Chapter 8. Vitamin D Binding Protein -- Chapter 9. New Aspects of DBP -- Chapter 10. Endocytic Pathways for 25-(OH) Vitamin D3 -- Section II: MECHANISM OF ACTION -- Chapter 11. The Vitamin D Receptor -- Chapter 12. Vitamin D Receptor Promoter and Regulation of Receptor Expression -- Chapter 13. Nuclear Vitamin D Receptor: Structure-Function, Molecular Control of Gene Transcription, and Novel Bioactions -- Chapter 14. Vitamin D Receptor Cofactors: Function, Regulation, and Selectivity -- Chapter 15. VDR LBD Crystal Structures -- Chapter 16. Comodulators of VDR-Mediated Gene Expression -- Chapter 17. Promoter Targeting of VDR Through A Chromatin Remodeling Complex -- Chapter 18. Molecular Basis of the Diversity of Vitamin D Target Genes -- Chapter 19. Intranuclear Organization of the Regulatory Machinery for Vitamin D-Mediated Control of Skeletal Gene Expression -- Chapter 20. Mouse Models of Vitamin D Receptor Ablation -- Chapter 21. Intranuclear Vitamin D Response Element Binding Proteins -- Chapter 22. VDR and RXR Subcellular Trafficking -- Chapter 23. 1 ,25(OH)2-Vitamin D3 Mediated Rapid and Genomic Responses are Dependent upon Critical Structure-Function Relationships for Both the Ligand and Receptor(s) -- Section III: MINERAL HOMEOSTASIS. , Chapter 24. Vitamin D and the Intestinal Absorption of Calcium: A View and Overview -- Chapter 25. Intestinal Calcium Absorption: Lessons from Knockout Mice and Men -- Chapter 26. Phosphate Homeostasis -- Chapter 27. Mineralization -- Chapter 28. Modeling and Remodeling: How Bone Cells Work Together -- Chapter 29. Vitamin D and the Kidney -- Chapter 30. Vitamin D and the Parathyroids -- Chapter 31. Calcium-Sensing Receptor -- Section IV: TARGET ORGANS AND TISSUES -- Chapter 32. Bone -- Chapter 33. Cartilage and Vitamin D: Genomic and Nongenomic Regulation by 1,25(OH)2D3 and 24,25(OH)2D3 -- Chapter 34. Dento-alveolar Bone Complex and Vitamin D -- Chapter 35. Vitamin D: Role in Skin and Hair -- Chapter 36. Regulation of Immune Responses by Vitamin D Receptor Ligands -- Chapter 37. Vitamin D and Osteoblasts -- Chapter 38. Vitamin D and Osteoclastogenesis -- Chapter 39. Vitamin D Control of the Calcitonin Gene in Thyroid C Cells -- Chapter 40. Vitamin D Regulation of Type I Collagen Expression in Bone -- Chapter 41. Target Genes: Bone Proteins -- Chapter 42. The Calbindins: Calbindin-D9K and Calbindin-D28K -- Chapter 43. Target Genes: PTHrP -- Chapter 44. Effects of 1,25-Dihydroxyvitamin D3 on Voltage-Sensitive Calcium Channels in the Vitamin D Endocrine System -- Chapter 45. Vitamin D and the Cellular Response to Oxidative Stress -- Section V: HUMAN PHYSIOLOGY -- Chapter 46. Vitamin D: Role in the Calcium Economy -- Chapter 47. Effects of Race, Geography, Body Habitus, Diet, and Exercise on Vitamin D Metabolism -- Chapter 48. Perinatal Vitamin D Actions -- Chapter 49. Vitamin D Deficiency and Calcium Absorption During Infancy and Childhood -- Chapter 50. Vitamin D Metabolism and Aging -- Chapter 51. Vitamin D Metabolism in Pregnancy and Lactation -- Chapter 52. Vitamin D and Reproductive Organs. , Chapter 53. Vitamin D Receptor as a Sensor for Toxic Bile Acids -- Chapter 54. Vitamin D and the Renin-Angiotensin System -- Chapter 55. Vitamin D and Muscle -- Chapter 56. Vitamin D and Cardiovascular Medicine -- 9780122526879v2 -- Front Cover -- Vitamin D -- Copyright Page -- Contents -- List of Contributors -- Preface to the 2nd Edition -- Preface to the 1st Edition -- Abbreviations -- Section VI: DIAGNOSIS AND MANAGEMENT -- Chapter 57. Approach to the Patient with Metabolic Bone Disease -- Chapter 58. Detection of Vitamin D and Its Major Metabolites -- Chapter 59. Bone Histomorphometry -- Chapter 60. Radiology of Rickets and Osteomalacia -- Chapter 61. The Pharmacology of Vitamin D, Including Fortification Strategies -- Section VII: DISORDERS OF THE VITAMIN D ENDOCRINE SYSTEM -- Chapter 62. How to Define Normal Values for Serum Concentrations of 25-Hydroxyvitamin D? An Overview -- Chapter 63. Vitamin D and the Pathogenesis of Rickets and Osteomalacia -- Chapter 64. The Hypocalcemic Disorders: Differential Diagnosis and Therapeutic Use of Vitamin D -- Chapter 65. Vitamin D Deficiency and Nutritional Rickets in Children -- Chapter 66. Vitamin D Insufficiency in Adults and the Elderly -- Chapter 67. Vitamin D and Osteoporosis -- Chapter 68. Genetic Vitamin D Receptor Polymorphisms and Risk of Disease -- Chapter 69. Clinical Disorders of Phosphate Homeostasis -- Chapter 70. Disorders of Phosphate Metabolism: Autosomal Dominant Hypophosphatemic Rickets, Tumor Induced Osteomalacia, Fibrous Dysplasia, and the Pathophysiological Relevance of FGF23 -- Chapter 71. Vitamin D Pseudodeficiency -- Chapter 72. Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets -- Chapter 73. Glucocorticoids and Vitamin D -- Chapter 74. Drug and Hormone Effects on Vitamin D Metabolism -- Chapter 75. Bone Disorders Associated with Gastrointestinal &. , Hepatobiliary Disease -- Chapter 76. Vitamin D and Renal Failure -- Chapter 77. Idiopathic Hypercalciuria and Nephrolithiasis -- Chapter 78. Hypercalcemia Due to Vitamin D Toxicity -- Chapter 79. Extra-renal 1 -hydroxylase Activity and Human Disease -- Section VIII: NEW VITAMIN D ANALOGS -- Overview -- Chapter 80. Overview: Rational Design of 1 ,25-Dihydroxyvitamin D3 Analogs (Deltanoids) -- Chapter 81. Analog Metabolism -- Chapter 82. Mechanisms for the Selective Actions of Vitamin D Analogs -- Chapter 83. Molecular Basis for Differential Action of Vitamin D Analogs -- Chapter 84. Development of New Vitamin D Analogs -- Chapter 85. Gemini: The 1,25-dihydroxy Vitamin D Analogs with Two Side-Chains -- Chapter 86. Development of OCT and ED-71 -- Chapter 87. 2-Carbon-Modified Analogs of 19-Nor-1 , 25-Dihydroxyvitamin D3 -- Chapter 88. Non-steroidal Analogs -- Section IX: VITAMIN D AND CANCER -- Chapter 89. Vitamin D: Cancer and Differentiation -- Chapter 90. Vitamin D, Sunlight, and the Natural History of Prostate Cancer -- Chapter 91. Epidemiology of Cancer Risk: Vitamin D and Calcium -- Chapter 92. Differentiation and the Cell Cycle -- Chapter 93. Vitamin D and Breast Cancer -- Chapter 94. Vitamin D and Prostate Cancer -- Chapter 95. Vitamin D and Colon Cancer -- Chapter 96. Vitamin D and Hematological Malignancy -- Chapter 97. Clinical Development of Calcitriol and Calcitriol Analogs in Oncology: Progress and Considerations for Future Development -- Section X: EMERGING USES -- Chapter 98. Vitamin D3: Autoimmunity and Immunosuppression -- Chapter 99. Vitamin D and Diabetes -- Chapter 100. Vitamin D, A Neuroactive Hormone: From Brain Development to Neurodegenerative Disorders -- Chapter 101. Psoriasis and Other Skin Diseases -- Chapter 102. Muscles and Falls -- Chapter 103. Renal Failure and Secondary Hyperparathyroidism. , Chapter 104. Inhibition of Benign Prostatic Hyperplasia by Vitamin D Receptor Ligands -- Index.