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  • 1
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 2 (1990), S. 226-228 
    ISSN: 0899-0042
    Keywords: optical isomers ; enantiomers ; vascular smooth muscle ; 5-hydroxytryptamine ; noradrenaline ; potassium ; calcium ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The effect of the enantiomers of a novel 5-HT2 receptor antagonist, (±)-(1R,3S)-1-[2-[4-[3-(p-fluorophenyl)-1-indanyl]-piperazinyl]ethyl]-2-imidazolidinone, was studied on serotonin (5-HT), noradrenaline (NA), potassium (K+), and calcium (Ca2+)-induced contractions in isolated rat thoracic aorta. The enantiomers shifted the 5-HT, NA, K+, and Ca2+ concentration-response curves to the right in a concentration-dependent manner and depressed the maximal contractile responses. The (+)-enantiomer was a far more potent inhibitor of 5-HT-induced contractions than the (-)-enantiomer. The (+)-enantiomer and phentolamine, both at 10-6 M, had equal inhibitory effects on NA-evoked contractions. The (+)-enantiomer was again more potent in inhibiting NA-induced contractions than the (-)-enantiomer. Both enantiomers had an equieffective inhibitory effect on K+ and Ca2+-induced contractions. The results show that the 5-HT and α-adrenoceptor antagonism of the two enantiomers is stereoselective, the (+)-enantiomer being more potent than the (-)-enantiomer. In contrast the enantiomers had equal, nonstereoselective inhibitory effects on K+ and Ca2+-evoked contractions.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2016-01-21
    Description: The modern polar cryosphere reflects an extreme climate state with profound temperature gradients towards high-latitudes. It developed in association with stepwise Cenozoic cooling, beginning with ephemeral glaciations and the appearance of sea ice in the late middle Eocene. The polar ocean gateways played a pivotal role in changing the polar and global climate, along with declining greenhouse gas levels. The opening of the Drake Passage finalized the oceanographic isolation of Antarctica, some 40 Ma ago. The Arctic Ocean was an isolated basin until the early Miocene when rifting and subsequent sea-floor spreading started between Greenland and Svalbard, initiating the opening of the Fram Strait / Arctic-Atlantic Gateway (AAG). Although this gateway is known to be important in Earth’s past and modern climate, little is known about its Cenozoic development. However, the opening history and AAG’s consecutive widening and deepening must have had a strong impact on circulation and water mass exchange between the Arctic Ocean and the North Atlantic. To study the AAG’s complete history, ocean drilling at two primary sites and one alternate site located between 73°N and 78°N in the Boreas Basin and along the East Greenland continental margin are proposed. These sites will provide unprecedented sedimentary records that will unveil (1) the history of shallow-water exchange between the Arctic Ocean and the North Atlantic, and (2) the development of the AAG to a deep-water connection and its influence on the global climate system. The specific overarching goals of our proposal are to study: (1) the influence of distinct tectonic events in the development of the AAG and the formation of deep water passage on the North Atlantic and Arctic paleoceanography, and (2) the role of the AAG in the climate transition from the Paleogene greenhouse to the Neogene icehouse for the long-term (~50 Ma) climate history of the northern North Atlantic. Getting a continuous record of the Cenozoic sedimentary succession that recorded the evolution of the Arctic-North Atlantic horizontal and vertical motions, and land and water connections will also help better understanding the post-breakup evolution of the NE Atlantic conjugate margins and associated sedimentary basins.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
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  • 3
    Publication Date: 2014-08-03
    Description: The modern polar cryosphere reflects an extreme climate state with profound temperature gradients towards high-latitudes. It developed in association with stepwise Cenozoic cooling, beginning with ephemeral glaciations and the appearance of sea ice in the late middle Eocene. The polar ocean gateways played a pivotal role in changing the polar and global climate, along with declining greenhouse gas levels. The opening of the Drake Passage finalized the oceanographic isolation of Antarctica, some 40 Ma ago. The Arctic Ocean was an isolated basin until the early Miocene when rifting and subsequent sea-floor spreading started between Greenland and Svalbard, initiating the opening of the Fram Strait / Arctic-Atlantic Gateway (AAG). Although this gateway is known to be important in Earth’s past and modern climate, little is known about its Cenozoic development. However, the opening history and AAG’s consecutive widening and deepening must have had a strong impact on circulation and water mass exchange between the Arctic Ocean and the North Atlantic. To study the AAG’s complete history, ocean drilling at two primary sites and one alternate site located between 73°N and 78°N are proposed. These sites will provide unprecedented sedimentary records that will unveil (1) the history of shallow-water exchange between the Arctic Ocean and the North Atlantic, and (2) the development of the AAG to a deep-water connection and its influence on the global climate system. The specific overarching goals of our proposal are to study: • the influence of distinct tectonic events in the development of the AAG and the formation of deep water passage on the North Atlantic and Arctic paleoceanography, and • the role of the AAG in the climate transition from the Paleogene greenhouse to the Neogene icehouse for the long-term (~50 Ma) climate history of the northern North Atlantic.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
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  • 4
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    American Association of Petroleum Geologists (AAPG)
    In:  EPIC33P Arctic: Polar Petroleum Potential Conference & Exhibition, Stavanger, Norway, 2015-09-29-2015-10-02American Association of Petroleum Geologists (AAPG)
    Publication Date: 2016-01-21
    Description: The modern polar cryosphere reflects an extreme climate state with profound temperature gradients towards high-latitudes. It developed in association with stepwise Cenozoic cooling, beginning with ephemeral glaciations and the appearance of sea ice in the late middle Eocene. The polar ocean gateways played a pivotal role in changing the polar and global climate, along with declining greenhouse gas levels. The opening of the Drake Passage finalized the oceanographic isolation of Antarctica, some 40 Ma ago. The Arctic Ocean was an isolated basin until the early Miocene when rifting and subsequent sea-floor spreading started between Greenland and Svalbard, initiating the opening of the Fram Strait / Arctic-Atlantic Gateway (AAG). Although this gateway is known to be important in Earth’s past and modern climate, little is known about its Cenozoic development. However, the opening history and AAG’s consecutive widening and deepening must have had a strong impact on circulation and water mass exchange between the Arctic Ocean and the North Atlantic. To study the AAG’s complete history, ocean drilling at two primary sites and one alternate site located between 73°N and 78°N in the Boreas Basin and along the East Greenland continental margin are proposed. These sites will provide unprecedented sedimentary records that will unveil (1) the history of shallow-water exchange between the Arctic Ocean and the North Atlantic, and (2) the development of the AAG to a deep-water connection and its influence on the global climate system. The specific overarching goals of our proposal are to study: (1) the influence of distinct tectonic events in the development of the AAG and the formation of deep water passage on the North Atlantic and Arctic paleoceanography, and (2) the role of the AAG in the climate transition from the Paleogene greenhouse to the Neogene icehouse for the long-term (~50 Ma) climate history of the northern North Atlantic. Getting a continuous record of the Cenozoic sedimentary succession that recorded the evolution of the Arctic-North Atlantic horizontal and vertical motions, and land and water connections will also help better understanding the post-breakup evolution of the NE Atlantic conjugate margins and associated sedimentary basins.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
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  • 5
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    Unknown
    Springer
    In:  EPIC3World Atlas of Submarine Gas Hydrates in Continental Margins, World Atlas of Submarine Gas Hydrates in Continental Margins, Springer, 514 p., pp. 263-273
    Publication Date: 2022-09-04
    Description: The glaciated Greenland continental margins contain favorable conditions for hydrate formation if gas is present. No gas hydrates have been encountered in the drilling of offshore wells, however, and only a limited focus has been placed on academic-led hydrate research to date. Nevertheless, analyses of 2D and 3D seismic reflection data have revealed the occurrence of BSRs, DHIs, chimneys and pockmarks. These seismic features all suggest the presence of gas and gas hydrates within three different sections of the Greenland margin. Seismic amplitude observations in Melville Bay, offshore northwest Greenland, indicate the existence of a *220 m thick gas hydrate deposit over a 50 m high gas column. It is suggested that the paleo-topography of the area has forced the migration of fluid into the overlying stratigraphy. In the Disco area, offshore central West Greenland, seismic observations together with heatflow measurements and sediment core samples suggest that gas and gas hydrates exist in regions with sub-cropping Cretaceous to Paleocene strata and in areas covered by thick postglacial sediments. Finally, 2D seismic reflection data indicate gas and gas hydrate deposits of potentially abiotic origin within the northeast Greenland margin and Molloy Basin, adjacent to the ocean spreading systems in the Fram Strait.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Inbook , NonPeerReviewed
    Format: application/pdf
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  • 6
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    Unknown
    EGU
    In:  EPIC3EGU General Assembly 2013, 2013-04-07-2013-04-12Geophysical Research Abstracts, EGU
    Publication Date: 2022-09-29
    Description: Multi-proxy analyses of six sediment cores and analyses of swath bathymetry and chirp data were integrated to elucidate the Holocene sedimentary processes and palaeoenvironments in Smeerenburgfjorden, northwest Spits- bergen. Three basins separated by two sills define the present-day large-scale bathymetry. A transverse ridge in the innermost part of the fjord represents the Little Ice Age (LIA) maximum position of Smeerenburgbreen. Slide scars along the fjord sides and mass transport deposits in the basins indicate repeated mass wasting. Recessional moraines deposited during the last deglaciation suggest a mean annual retreat rate of 140 m/year. Another set of recessional moraines deposited between the maximum LIA position of Smeerenburgbreen and its present day ter- minus indicate a mean retreat rate of the ice front of ∼87 m/year. Strong out-fjord decreasing trends in magnetic susceptibility and Fe-content indicate that these properties are related to material originating from the Horneman- toppen granite in the catchment of Smeerenburgbreen and are, thus, useful proxies for the reconstruction of the activity of the glacier. Relatively little ice rafting, most likely related to warmer surface water conditions, occurred between 8650 and 7350 cal. years BP. Ice rafting from both sea-ice and icebergs increased around 6200 cal. years BP and peaked at ∼5200 cal. years BP, associated with a regional cooling. Smeerenburgbreen became more active around 2000 cal. years BP. It probably retreated during the Roman Warm Period (50 BC – AD 400) and advanced during the Dark Ages Cold Period (AD 400 – 800). From AD 1300 – 1500 (late Medieval Warm Period), ice rafting, sedimentation rates and productivity increased in the inner fjord. The Little Ice Age was characterised by reduced ice rafting, possibly linked to an increased sea-ice cover suppressing iceberg drift. An increase in Ice Rafted Debris (IRD) commencing around AD 1880 is suggested to represent the beginning of Smeerenburgbreen’s retreat from its LIA maximum towards its present position.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
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  • 7
    Publication Date: 2020-02-06
    Description: Highlights • Glacial sediment-landform assemblages are documented from Disko Bay, West Greenland. • Jakobshavn Isbræ extended through the bay onto the continental shelf during the LGM. • Retreat was topographically controlled and changed from rapid to slow. • The depositional sedimentary environment was similar to East Greenland. • Glacimarine sedimentary processes depend on local controls rather than climate. Fast-flowing outlet glaciers currently drain the Greenland Ice Sheet (GIS), delivering ice, meltwater and debris to the fjords around Greenland. Although such glaciers strongly affect the ice sheet's mass balance, their glacimarine processes and associated products are still poorly understood. This study provides a detailed analysis of lithological and geophysical data from Disko Bay and the Vaigat Strait in central West Greenland. Disko Bay is strongly influenced by Jakobshavn Isbræ, Greenland's fastest-flowing glacier, which currently drains ∼7% of the ice sheet. Streamlined glacial landforms record the former flow of an expanded Jakobshavn Isbræ and adjacent GIS outlets through Disko Bay and the Vaigat Strait towards the continental shelf. Thirteen vibrocores contain a complex set of lithofacies including diamict, stratified mud, interbedded mud and sand, and bioturbated mud deposited by (1) suspension settling from meltwater plumes and the water column, (2) sediment gravity flows, and (3) iceberg rafting and ploughing. The importance of meltwater-related processes to glacimarine sedimentation in West Greenland fjords and bays is emphasised by the abundance of mud preserved in the cores. Radiocarbon dates constrain the position of the ice margin during deglaciation, and suggest that Jakobshavn Isbræ had retreated into central Disko Bay before 10.6 cal ka BP and to beyond Isfjeldsbanken by 7.6–7.1 cal ka BP. Sediment accumulation rates were up to 1.7 cm a−1 for ice-proximal glacimarine mud, and ∼0.007–0.05 cm a−1 for overlying distal sediments. In addition to elucidating the deglacial retreat history of Jakobshavn Isbræ, our findings show that the glacimarine sedimentary processes in West Greenland are similar to those in East Greenland, and that variability in such processes is more a function of time and glacier proximity than of geographic location and associated climatic regime.
    Type: Article , PeerReviewed
    Format: text
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  • 8
    Publication Date: 2023-02-08
    Description: Highlights • There is direct and indirect evidence for hydrate occurrence in several areas around Europe. • Hydrate is particularly widespread offshore Norway and Svalbard and in the Black Sea. • Hydrate occurrence often coincides with conventional thermogenic hydrocarbon provinces. • The regional abundance of hydrate in Europe is poorly known. Abstract Large national programs in the United States and several Asian countries have defined and characterised their marine methane hydrate occurrences in some detail, but European hydrate occurrence has received less attention. The European Union-funded project “Marine gas hydrate – an indigenous resource of natural gas for Europe” (MIGRATE) aimed to determine the European potential inventory of exploitable gas hydrate, to assess current technologies for their production, and to evaluate the associated risks. We present a synthesis of results from a MIGRATE working group that focused on the definition and assessment of hydrate in Europe. Our review includes the western and eastern margins of Greenland, the Barents Sea and onshore and offshore Svalbard, the Atlantic margin of Europe, extending south to the northwestern margin of Morocco, the Mediterranean Sea, the Sea of Marmara, and the western and southern margins of the Black Sea. We have not attempted to cover the high Arctic, the Russian, Ukrainian and Georgian sectors of the Black Sea, or overseas territories of European nations. Following a formalised process, we defined a range of indicators of hydrate presence based on geophysical, geochemical and geological data. Our study was framed by the constraint of the hydrate stability field in European seas. Direct hydrate indicators included sampling of hydrate; the presence of bottom simulating reflectors in seismic reflection profiles; gas seepage into the ocean; and chlorinity anomalies in sediment cores. Indirect indicators included geophysical survey evidence for seismic velocity and/or resistivity anomalies, seismic reflectivity anomalies or subsurface gas escape structures; various seabed features associated with gas escape, and the presence of an underlying conventional petroleum system. We used these indicators to develop a database of hydrate occurrence across Europe. We identified a series of regions where there is substantial evidence for hydrate occurrence (some areas offshore Greenland, offshore west Svalbard, the Barents Sea, the mid-Norwegian margin, the Gulf of Cadiz, parts of the eastern Mediterranean, the Sea of Marmara and the Black Sea) and regions where the evidence is more tenuous (other areas offshore Greenland and of the eastern Mediterranean, onshore Svalbard, offshore Ireland and offshore northwest Iberia). We provide an overview of the evidence for hydrate occurrence in each of these regions. We conclude that around Europe, areas with strong evidence for the presence of hydrate commonly coincide with conventional thermogenic hydrocarbon provinces.
    Type: Article , PeerReviewed , info:eu-repo/semantics/article
    Format: text
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  • 9
    Publication Date: 2011-10-30
    Print ISSN: 0022-1430
    Electronic ISSN: 1727-5652
    Topics: Geography , Geosciences
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