Note: Cover -- Contents -- In Remembrance of Rudolf Virchow (1821-1902) -- Foreword -- General Aspects -- In Memoriam of Rudolf Virchow: A Historical Retrospective Including Aspects of Inflammation, Infection and Neoplasia -- Abstract -- Note of Comment on Rudolf Ludwig Carl Virchow -- Who Was Rudolf Ludwig Carl Virchow? -- Virchow and Tumor Pathology -- Virchow's Theories about the Impact of Infection and Inflammation on Oncogenesis -- Inflammation -- Syphilis and Tuberculosis -- Generalization and 'Infection ' -- The 'Krebsbacillus' -- Discussion -- Acknowledgements -- References -- Aneuploidy and Cancer: From Correlation to Causation -- Abstract -- Cancer Is Not Heritable -- Long Neoplastic Latencies -- Non-Mutagenic Carcinogens Cause Cancer -- Karyotype-Phenotype Variations at Rates that Are Orders Higher than Mutation -- Cancer-Specific Aneuploidies -- Cancers Have Complex Phenotypes -- Nonselective Phenotypes of Cancer Cells -- No Carcinogenic Genes in Cancer -- A New, Chromosomal Evolution Theory of Carcinogenesis -- Testing Specific Predictions of the Chromosomal Theory against Competing Claims by Genetic Theories of Cancer -- Carcinogens Function as Aneuploidogens -- Aneuploidy Is Inherently Variable and Thus Sufficient to Catalyze the Evolution of Cancer-Specific Chromosome Patterns -- Carcinogenesis Independent of Somatic Mutation -- Explanatory Value of the Chromosomal Theory of Cancer -- Cancer Is Not Heritable -- Long Neoplastic Latencies -- High Rates of Karyotype-Phenotype Variations and the Origin of Immortality -- Cancer-Specific Aneuploidies -- Complex Phenotypes -- Nonselective Phenotypes -- Conclusions -- Appendix -- The Achilles Heels of the Mutation-Cancer Theory -- Acknowledgments -- References. , Adult Stem Cell Theory of the Multi-Stage, Multi-Mechanism Theory of Carcinogenesis: Role of Inflammation on the Promotion of Initiated Stem Cells -- Abstract -- 'Initiation', 'Promotion' and 'Progression' Concept of Carcinogenesis -- What Is that 'Initiated' Cell? -- Initiation: Is It the Induction of 'Immortalization' of a Normal,'Mortal' Cell or the Inhibition of 'Mortalization' of a Normal 'Immortal' Adult Stem Cell? -- Characteristics of Adult Stem Cells: Clues to the Stem Cell Hypothesis of Carcinogenesis -- Are There Adult Stem Cell Markers? -- Role of Gap Junctional Intercellular Communication in Normal Growth Control and Its Dysfunction in Carcinogenesis -- Cancer Stem Cells: Something New or a Newly Discovered Old Prediction -- Stem Cells, Oncogenic Viruses, and Cancer -- Inflammation,Tumor Promotion and Carcinogenesis -- Implications of the Stem Cell Theory for Cancer Chemoprevention and Chemotherapy: Cancer as a 'Treatable Chronic Disease' -- Conclusion -- References -- Specific Pathogens -- Helicobacter pylori and Gastric Neoplasia -- Abstract -- Epidemiology of Gastric Carcinoma -- Epidemiology of H. pylori Infection -- Gastric Carcinogenesis Cascade -- Molecular Events during Gastric Carcinogenesis -- Bacterial Factors -- cagA -- vacA -- babA2 -- Host Factors -- Prevention of Gastric Adenocarcinoma by H. pylori Eradication -- MALT Lymphoma -- References -- Schistosomiasis and Neoplasia -- Abstract -- Life Cycle of Schistosoma -- Epidemiology of Schistosomiasis -- Diagnosis of Schistosomiasis -- Schistosomiasis and Bladder Cancer -- Epidemiological Evidence -- Experimental Evidence -- Histopathological Evidence -- Pathogenesis of Bladder Cancer in S. hematobium Chronic Inflammation -- Urinary Tract Infection -- Altered Carcinogen Metabolism -- Disturbed Carcinogen Activation in Schistosomiasis. , Disturbed Carcinogen Inactivation in Schistosomiasis -- Molecular Mechanisms -- Tumor Suppressor Genes -- The p53 Tumor Suppressor Gene -- Retinoblastoma Tumor Suppressor Gene -- Chromosome 9 -- Microsatellite Instability -- Oncogenes -- H-ras -- Bcl-2 Gene -- Schistosomiasis and Colorectal Cancer -- Schistosomiasis and Liver Cancer -- Schistosomiasis and Prostate Cancer -- Schistosomiasis and Cancer of Other Sites -- References -- Relevant Oncogenic Viruses in Veterinary Medicine: Original Pathogens and Animal Models for Human Disease -- Abstract -- Viral Pathogens of Veterinary Importance -- Retroviruses -- Poultry -- Sheep -- Cat -- Cattle -- Fish -- Herpesviruses -- Papillomaviruses -- Mechanisms of Papillomavirus-Induced Oncogenesis -- Cattle -- Horse -- Dog -- Tumor Viruses of Animals as Models of Human Oncogenesis -- Conceptual Work and Pioneering Studies in Oncology -- Tumor Induction by Viral and Cell-Derived Oncogenes and Additional Oncogenic Strategies of Retroviruses -- Importance of Cofactors in Virus-Induced Oncogenesis -- Abortive,Nonlytic Infections Can Promote Cancer Development -- Animal Models for Human Malignancies -- Zoonosis and Host-Species Exchange-Associated Oncogenesis -- Acknowledgements -- References -- Infection, Inflammation and Neoplasia -- The Inflammatory Tumor Microenvironment and Its Impact on Cancer Development -- Abstract -- Tumor Micro-Environment -- The Inflammatory Tumor Micro-Environment -- Acute versus Chronic Inflammation -- Clinical Association between Chronic Inflammation and Cancer -- Experimental Studies Linking Inflammation and Cancer -- Inflammatory Cell-Mediated Modulation of Neoplastic Progression -- Direct Effect on Neoplastic Cells -- Indirect Effect on Neoplastic Cells -- Concluding Remarks and Perspectives -- Acknowledgements -- References. , Co-Opting Macrophage Traits in Cancer Progression: A Consequence of Tumor Cell Fusion? -- Abstract -- Introduction -- Cell Fusion in Normal and Cancerous Tissues -- Putative BMT Tumor Cell Hybrids in Humans -- Gene Expression in Artificial Fusion Hybrids -- Beta1,6-Branched Oligosaccharides and Coarse Vesicles in Human BMT Tumor Hybrids -- Beta1,6-Branched Oligosaccharides and Coarse Vesicles Are Common in Human Cancers -- Conclusions -- Acknowledgements -- References -- Carcinogenesis Driven by Bone Marrow-Derived Stem Cells -- Abstract -- Instruction of Stem Cell Trans-Differentiation -- What Happens if BMDC Trans-Differentiation Is Directed by a Faulty Blueprint -- What Happens if Tumor Tissue Is the Blueprint for BMDC Trans-Differentiation? -- Conclusion -- Acknowledgments -- References -- Chemokine-Directed Metastasis -- Chemokine-Directed Metastasis -- Abstract -- Angiogenesis -- ELR Positive CXC Chemokines Promote Angiogenesis -- The Role of ELR-Positive CXC Chemokines in Tumorigenesis -- In General, Non-ELR Positive CXC Chemokines Are Inhibitors of Angiogenesis -- CXCR3 Appears to Be the Major Receptor for Non-ELR-Positive CXC Chemokine-Mediated Inhibition of Angiogenesis -- Non-ELR Positive CXC Chemokines Attenuate Angiogenesis and Reduce Tumorigenesis -- Evidence that Chemokines Are Involved in Tumor Cell Invasion -- Evidence that Chemokines Regulate the Pattern of Organ-Specific Metastasis of Cancer -- Conclusion -- Acknowledgements -- References -- Involvement of Chemokine Receptors in Organ-Specific Metastasis -- Abstract -- Chemokines -- Chemokines and Metastasis -- Mechanism of Action of CXCR4 in Cancer -- CXCR4 in Breast Cancer -- Conclusion and Future Directions -- References -- Visualization of Tumor Cell Extravasation -- Abstract -- Tumor Cell Extravasation -- Tumor Cell-Endothelial Cell Interactions during Extravasation. , Acknowledgements -- References -- Options for Visualizing Metastatic Disease in the Living Body -- Abstract -- Applications of Whole-Body in vivo Imaging Techniques -- Computed Tomography -- Magnetic Resonance Imaging -- Nuclear Medicine Modalities (PET/SPECT) -- Optical Imaging -- Clinical Imaging of Metastases -- In vivo Imaging of Metastases in Animal Models -- Models of Metastasis Utilizing Implanted Tumor Cells -- Choice of Imaging Techniques for Visualization of Metastasizing Tumor Cells in Animal Models -- Future Outlook -- References -- Outlook and Perspectives -- Infection, Inflammation and Neoplasia: An Interdisciplinary Challenge -- Abstract -- Inflammation, Wound Healing, and Carcinogenesis -- Multifunctionality of Cytokines and Chemokines -- 'Wounds that Never Heal' and Carcinogenesis -- Chemokine-Mediated Cell Function Inhibition - Where, Which and How? -- Cancer and Inflammation: From Epidemiological Perspectives to Molecular Mechanisms -- Infection and Cancer -- Interdisciplinary Challenge -- References -- Author Index -- Subject Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- R -- S -- T -- U -- V -- W.

Note: Abweichender Titel: Meteor-Berichte, Cruise 147, Las Palmas - Belém, April 09 - May 21 2018 , Förderkennzeichen: 458/2017/CB/Te Leitstelle CEN, Uni-Hamburg