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  • 1
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] We used illegitimate transcription in lymphoblastoid cell lines6 to obtain laminin α2 chain mRNA from probands of consanguineous laminin α2 and non-consanguineous chain-deficient families for mutation analysis by RT-PCR. Twenty-four pairs of overlapping primers (see Methods) were ...
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] DNA-adenine methylation at certain GATC sites plays a pivotal role in bacterial and phage gene expression as well as bacterial virulence. We report here the crystal structures of the bacteriophage T4Dam DNA adenine methyltransferase (MTase) in a binary complex with the methyl-donor product ...
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  • 3
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    Nature Publishing Group
    In:  EPIC3Nature, Nature Publishing Group, 512(7514), pp. 290-294, ISSN: 0028-0836
    Publication Date: 2014-09-04
    Description: During glacial periods of the Late Pleistocene, an abundance of proxy data demonstrates the existence of large and repeated millennial-scale warming episodes, known as Dansgaard–Oeschger (DO) events1. This ubiquitous feature of rapid glacial climate change can be extended back as far as 800,000 years before present (BP) in the ice core record2, and has drawn broad attention within the science and policy-making communities alike3. Many studies have been dedicated to investigating the underlying causes of these changes, but no coherent mechanism has yet been identified3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15. Here we show, by using a comprehensive fully coupled model16, that gradual changes in the height of the Northern Hemisphere ice sheets (NHISs) can alter the coupled atmosphere–ocean system and cause rapid glacial climate shifts closely resembling DO events. The simulated global climate responses—including abrupt warming in the North Atlantic, a northward shift of the tropical rainbelts, and Southern Hemisphere cooling related to the bipolar seesaw—are generally consistent with empirical evidence1, 3, 17. As a result of the coexistence of two glacial ocean circulation states at intermediate heights of the ice sheets, minor changes in the height of the NHISs and the amount of atmospheric CO2 can trigger the rapid climate transitions via a local positive atmosphere–ocean–sea-ice feedback in the North Atlantic. Our results, although based on a single model, thus provide a coherent concept for understanding the recorded millennial-scale variability and abrupt climate changes in the coupled atmosphere–ocean system, as well as their linkages to the volume of the intermediate ice sheets during glacials.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 4
    Publication Date: 2020-04-14
    Description: The Asian monsoon (AM) played an important role in the dynastic history of China, yet it remains unknown whether AM-mediated shifts in Chinese societies affect earth surface processes to the point of exceeding natural variability. Here, we present a dust storm intensity record dating back to the first unified dynasty of China (the Qin Dynasty, 221–207 B.C.E.). Marked increases in dust storm activity coincided with unified dynasties with large populations during strong AM periods. By contrast, reduced dust storm activity corresponded to decreased population sizes and periods of civil unrest, which was co-eval with a weakened AM. The strengthened AM may have facilitated the development of Chinese civilizations, destabilizing the topsoil and thereby increasing the dust storm frequency. Beginning at least 2000 years ago, human activities might have started to overtake natural climatic variability as the dominant controls of dust storm activity in eastern China.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
    Format: application/pdf
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  • 5
    Publication Date: 2021-02-03
    Description: The dominant feature of large-scale mass transfer in the modern ocean is the Atlantic meridional overturning circulation (AMOC). The geometry and vigour of this circulation influences global climate on various timescales. Palaeoceanographic evidence suggests that during glacial periods of the past 1.5 million years the AMOC had markedly different features from today; in the Atlantic basin, deep waters of Southern Ocean origin increased in volume while above them the core of the North Atlantic Deep Water (NADW) shoaled. An absence of evidence on the origin of this phenomenon means that the sequence of events leading to global glacial conditions remains unclear. Here we present multi-proxy evidence showing that northward shifts in Antarctic iceberg melt in the Indian–Atlantic Southern Ocean (0–50°E) systematically preceded deep-water mass reorganizations by one to two thousand years during Pleistocene-era glaciations. With the aid of iceberg-trajectory model experiments, we demonstrate that such a shift in iceberg trajectories during glacial periods can result in a considerable redistribution of freshwater in the Southern Ocean. We suggest that this, in concert with increased sea-ice cover, enabled positive buoyancy anomalies to ‘escape’ into the upper limb of the AMOC, providing a teleconnection between surface Southern Ocean conditions and the formation of NADW. The magnitude and pacing of this mechanism evolved substantially across the mid-Pleistocene transition, and the coeval increase in magnitude of the ‘southern escape’ and deep circulation perturbations implicate this mechanism as a key feedback in the transition to the ‘100-kyr world’, in which glacial–interglacial cycles occur at roughly 100,000-year periods.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 6
    Publication Date: 2013-05-23
    Description: This paper compares the greenhouse gas (GHG) emissions of natural gas (NG)- based fuels to the GHG emissions of electric vehicles (EVs) powered with NG-to-electricity in China. A life-cycle model is used to account for full fuel cycle and use-phase emissions, as well as vehicle cycle and battery manufacturing. The reduction of life-cycle GHG emissions of EVs charged by electricity generated from NG, without utilizing carbon dioxide capture and storage (CCS) technology can be 36%–47% when compared to gasoline vehicles. The large range change in emissions reduction potential is driven by the different generation technologies that could in the future be used to generate electricity in China. When CCS is employed in power plants, the GHG emission reductions increase to about 71%–73% compared to gasoline vehicles. It is found that compressed NG (CNG) and liquefied NG (LNG) fuels can save about 10% of carbon as compared to gasoline vehicles. However, gas-to-liquid (GTL) fuel made through the Fischer-Tropsch method will likely lead to a life-cycle GHG emissions increase, potentially 3%–15% higher than gasoline, but roughly equal to petroleum-based diesel. When CCS is utilized, the GTL fueled vehicles emit roughly equal GHG emissions to petroleum-based diesel fuel high-efficient hybrid electric vehicle from the life-cycle perspective.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
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  • 7
    Publication Date: 2015-03-26
    Description: Our previous studies have shown that CNP-NPR-B/pGC-cGMP is upregulated in the diabetic rats. The present study was designed to determine whether the upregulation of CNP-NPR-B/pGC-cGMP signal pathway affects cGMP-PDE3-cAMP signal pathway in diabetic gastric smooth muscle. The gastric smooth muscle motility was observed by using isometric measurement. PDEs expressions in diabetic gastric smooth muscle tissue were observed by using immunohistochemistry, Western blotting, and RT-PCR methods. The results demonstrated that the inhibitory effect of CNP on the spontaneous contraction of gastric antral circular smooth muscle was potentiated in STZ-induced diabetic rat. CNP-induced increase of cGMP and cAMP was much higher in diabetic gastric smooth muscle tissue than in controls. The expression of PDE3 is downregulated while the levels of gene expression of PDE1, PDE2, PDE4, and PDE5 were not altered in the diabetic gastric smooth muscle tissue. The results suggest that the sensitivity of gastric smooth muscle to CNP is potentiated via activation of CNP-pGC-cGMP-PDE3-cAMP signal pathway in STZ-induced diabetic rats, which may be associated with diabetes-induced gastric motility disorder.
    Print ISSN: 1687-6121
    Electronic ISSN: 1687-630X
    Topics: Medicine
    Published by Hindawi
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  • 8
    Publication Date: 2015-11-06
    Description: Determining the dominant optically active substances in water bodies via classification can improve the accuracy of bio-optical and water quality parameters estimated by remote sensing. This study provides four robust centroid sets from in situ remote sensing reflectance (Rrs (λ)) data presenting typical optical types obtained by plugging different similarity measures into fuzzy c-means (FCM) clustering. Four typical types of waters were studied: (1) highly mixed eutrophic waters, with the proportion of absorption of colored dissolved organic matter (CDOM), phytoplankton, and non-living particulate matter at approximately 20%, 20%, and 60% respectively; (2) CDOM-dominated relatively clear waters, with approximately 45% by proportion of CDOM absorption; (3) nonliving solids-dominated waters, with approximately 88% by proportion of absorption of nonliving particulate matter; and (4) cyanobacteria-composed scum. We also simulated spectra from seven ocean color satellite sensors to assess their classification ability. POLarization and Directionality of the Earth's Reflectances (POLDER), Sentinel-2A, and MEdium Resolution Imaging Spectrometer (MERIS) were found to perform better than the rest. Further, a classification tree for MERIS, in which the characteristics of Rrs (709)/Rrs (681), Rrs (560)/Rrs (709), Rrs (560)/Rrs (620), and Rrs (709)/Rrs (761) are integrated, is also proposed in this paper. The overall accuracy and Kappa coefficient of the proposed classification tree are 76.2% and 0.632, respectively.
    Electronic ISSN: 2072-4292
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Published by MDPI Publishing
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  • 9
    Publication Date: 2017-12-12
    Description: IJERPH, Vol. 14, Pages 1556: Investigating Lushan Earthquake Victims’ Individual Behavior Response and Rescue Organization International Journal of Environmental Research and Public Health doi: 10.3390/ijerph14121556 Authors: Peng Kang Yipeng Lv Qiangyu Deng Yuan Liu Yi Zhang Xu Liu Lulu Zhang Research concerning the impact of earthquake victims’ individual behavior and its association with earthquake-related injuries is lacking. This study examined this relationship along with effectiveness of earthquake rescue measures. The six most severely destroyed townships during the Lushan earthquake were examined; 28 villages and three earthquake victims’ settlement camp areas were selected as research areas. Inclusion criteria comprised living in Lushan county for a longtime, living in Lushan county during the 2013 Lushan earthquake, and having one’s home destroyed. Earthquake victims with an intellectual disability or communication problems were excluded. The earthquake victims (N (number) = 5165, male = 2396) completed a questionnaire (response rate: 94.7%). Among them, 209 were injured (5.61%). Teachers (p < 0.0001, OR (odds ratios) = 3.33) and medical staff (p = 0.001, OR = 4.35) were more vulnerable to the earthquake than were farmers. Individual behavior was directly related to injuries, such as the first reaction after earthquake and fear. There is an obvious connection between earthquake-related injury and individual behavior characteristics. It is strongly suggested that victims receive mental health support from medical practitioners and the government to minimize negative effects. The initial reaction after an earthquake also played a vital role in victims’ trauma; therefore, earthquake-related experience and education may prevent injuries. Self-aid and mutual help played key roles in emergency, medical rescue efforts.
    Print ISSN: 1661-7827
    Electronic ISSN: 1660-4601
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Published by MDPI Publishing
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  • 10
    Publication Date: 2018-09-13
    Description: Sensors, Vol. 18, Pages 3058: A KPI-Based Probabilistic Soft Sensor Development Approach that Maximizes the Coefficient of Determination Sensors doi: 10.3390/s18093058 Authors: Yue Zhang Xu Yang Yuri A. W. Shardt Jiarui Cui Chaonan Tong Advanced technology for process monitoring and fault diagnosis is widely used in complex industrial processes. An important issue that needs to be considered is the ability to monitor key performance indicators (KPIs), which often cannot be measured sufficiently quickly or accurately. This paper proposes a data-driven approach based on maximizing the coefficient of determination for probabilistic soft sensor development when data are missing. Firstly, the problem of missing data in the training sample set is solved using the expectation maximization (EM) algorithm. Then, by maximizing the coefficient of determination, a probability model between secondary variables and the KPIs is developed. Finally, a Gaussian mixture model (GMM) is used to estimate the joint probability distribution in the probabilistic soft sensor model, whose parameters are estimated using the EM algorithm. An experimental case study on the alumina concentration in the aluminum electrolysis industry is investigated to demonstrate the advantages and the performance of the proposed approach.
    Electronic ISSN: 1424-8220
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Published by MDPI Publishing
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