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  • 1
    Electronic Resource
    Electronic Resource
    Influence of initial conditions on the flow patterns of a shock-accelerated thin fluid layer (1994)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 6 (1994), S. 3510-3512 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Previous observations of three flow patterns generated by shock acceleration of a thin perturbed, fluid layer are now correlated with asymmetries in the initial conditions. Using a different diagnostic (planar laser Rayleigh scattering) than the previous experiments, upstream mushrooms, downstream mushrooms, and sinuous patterns are still observed. For each experiment the initial perturbation amplitude on one side of the layer can either be larger, smaller, or the same as the amplitude on the other side, as observed with two images per experiment, and these differences lead to the formation of the different patterns.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.868447
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  • 2
    Electronic Resource
    Electronic Resource
    Shock loading a rippled interface between liquids of different densities (1987)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 30 (1987), S. 331-336 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Experimental results of the nonlinear growth of perturbations on a shocked interface between liquids having a density ratio of 10 are reported. After the shock passes from the higher-density liquid into the lower-density liquid, spikes of the higher-density liquid are observed to grow into the other liquid without producing severe turbulence. The measured growth is compared with analytical estimates. The time-resolved shadowgraphs provide excellent data for testing hydrodynamics models.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.866382
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  • 3
    Electronic Resource
    Electronic Resource
    Synthesis and biological activities of ftorafur metabolites. 3'- and 4'-Hydroxyftorafur (1979)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 22 (1979), S. 1096-1100 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00195a017
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  • 4
    Electronic Resource
    Electronic Resource
    CLINICAL AND PHARMACOLOGIC INVESTIGATION OF THE EFFECTS OF α-TOCOPHEROL ON ADRIAMYCIN CARDIOTOXICITY (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 393 (1982), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1982.tb31279.x
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  • 5
    Electronic Resource
    Electronic Resource
    Chemotherapy of malignant melanoma (1979)
    Springer
    World journal of surgery 3 (1979), S. 321-327 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Plusieurs drogues sont utilisées dans la chimiothérapie du mélanome au stade avancé. Le DTIC est le plus fréquemment employé; utilisé seul, il donne quelques 20% de réponses favorables. Les études sur les nitrosurées ont donné entre 6 et 41% de réponses positives, avec une moyenne de 24%. L'association de ces deux types de drogues, ou d'autres, n'a, jusqu'à présent, pas amélioré les résultats. Mais plusieurs travaux associant chimio- et immunothérapie ont obtenu quelques 28% de réponses favorables, soit un peu mieux que la chimiothérapie seule.
    Notes: Abstract A number of drugs are being used in chemotherapy treatment programs of advanced melanoma. Of these, DTIC is the most important drug currently in use, producing a response rate of about 20% when used as a single agent. Studies with nitrosoureas report response rates ranging from 6 to 41%, with an average of 24%. Combinations of these 2 agents and other drugs have not yet shown a significant improvement in response over either drug used alone. However, several studies of chemo-immunotherapy have reported overall response rates in the vicinity of 28%, somewhat higher than that obtained with chemotherapy alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01556584
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  • 6
    Electronic Resource
    Electronic Resource
    Human tissue distribution of platinum after cis-diamminedichloroplatinum (1982)
    Springer
    Cancer chemotherapy and pharmacology 10 (1982), S. 51-54 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using X-ray fluorescence spectrometry, platinum concentrations were determined in autopsy tissue samples from 12 patients who had received cis-diamminedichloroplatinum (DDP) 20–120 mg/m2 up to 6 months antemortem. Tissue platinum concentrations were highest in liver (0.5–3.7 μg/g wet weight), prostate (1.6–3.6 μg/g), and kidney (0.4–2.9 μg/g), somewhat lower in bladder, muscle, testicle, pancreas, and spleen, and lowest in bowel, adrenal, heart, lung, cerebrum, and cerebellum, Platinum concentrations in tumors were generally somewhat lower than the concentration in the organ in which the tumor was located, with the exception of intracerebral tumors. Different metastatic sites in the same patient had substantially different platinum concentrations and hepatic metasutases had the highest concentrations. Intra-arterial administration of drug may augment tissue concentrations of platinum. In a patient undergoing therapeutic abortion 4 days after treatment, the platinum concentration was 0.5 μg/g in the placenta and 0.3 μg/g in the fetus. The data suggest that for in vitro sensitivity testing, DDP concentrations of ≦7 μg/ml should be used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257239
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  • 7
    Electronic Resource
    Electronic Resource
    Energy-dispersive X-ray fluorescence determination of platinum in plasma, urine, and cerebrospinal fluid of patients administered cis-dichlorodiammineplatinum(II) (1983)
    Springer
    Cancer chemotherapy and pharmacology 11 (1983), S. 120-123 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A method involving the use of an energy-dispersive X-ray fluorescence spectrometer was developed for assaying total platinum concentrations in body fluids of patients treated with the antitumor drug cis-dichlorodiammineplatinum(II). Sample preparation by this procedure is simple, consisting in adding an internal standard (Zr) to 1 ml of biological fluid or tissue homogenate, pipetting 20 μl of the sample onto a Mylar sample holder, and drying. This produces a thin-film sample, which effectively eliminates absorption enhancement effects due to other elements in the specimen. Standard addition studies were found to be linear in the concentration range of interest (0.1–10.0 μg/ml), with correlation coefficients exceeding 0.99. Minimum detection limits range from 0.10 to 0.25 μg Pt per ml, depending on the body fluid, which is adequate for routine patient monitoring after normal chemotherapeutic doses of cis-dichlorodiammineplatinum(II). In preliminary studies with mammalian liver, standard addition experiments were found to be linear and the minimum detection limit was found to be 1.4 μg/g dry weight.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254260
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  • 8
    Electronic Resource
    Electronic Resource
    Human tissue distribution of 4′-(9-acridinylamino)-methanesulfon-m-anisidide (NSC 141549, AMSA) (1984)
    Springer
    Cancer chemotherapy and pharmacology 12 (1984), S. 116-119 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Concentrations of AMSA were determined by HPLC in autopsy tissue samples from five patients who had received the drug antemortem. Relative organ concentrations of AMSA varied from patient to patient; however, concentrations were generally highest in gallbladder, liver, and kidney, while low levels were generally but not invariably found in lung, testicle, muscle, fat, spleen, bladder, pancreas, colon, prostate, and brain. One patient with ventricular fibrillation and seizures had high tissue AMSA concentrations in myocardium, but low concentrations in brain. Another patient with seizures during treatment had high brain concentrations of AMSA. Relative organ concentrations were similar to those found in mice, except that mice have high AMSA concentration in their spleens whereas our patients did not, even when the spleen was infiltrated with leukemic cells. High tissue concentrations of AMSA were still present 2 weeks after treatment. AMSA concentration was lower in a renal oncocytoma (1.1 μg/g) than in surrounding kidney (2.4 μg/g).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254602
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  • 9
    Electronic Resource
    Electronic Resource
    Bleomycin clinical pharmacology by radioimmunoassay (1982)
    Springer
    Cancer chemotherapy and pharmacology 9 (1982), S. 22-25 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bleomycin pharmacokinetics were studied by radioimmunoassay in 11 patients who received 7–30 U intravenously (IV) and eight patients who received 4–30 U subcutaneously (SC). For patients who received IV bleomycin plasma disappearance was biphasic, with a mean initial half-life of 0.26 h and a terminal half-life of 2.3 h. Mean plasma drug clearance was 67.8 ml/min/m2 and the volume of distribution was 13.2 l/m2. Urinary excretion accounted for 63.9% of the drug in 24 h. After SC administration peak plasma levels occurred in 1.1 h, with a mean elimination half-life of 4.3 h. Mean plasma drug clearance was 60.5 ml/min/m2 and the volume of distribution was 19.2 l/m2. Bleomycin plasma clearance correlated well with serum creatinine (r2=0.72). Bleomycin has a rapid plasma elimination and urinary excretion. Bleomycin bioavailability after SC administration appears comparable to that seen after IV administration as determined by the areas under the plasma disappearance curves. Prolonged plasma levels are seen after SC injection, suggesting this route of administration can produce plasma concentrations comparable to those attained with continuous IV infusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296756
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  • 10
    Electronic Resource
    Electronic Resource
    Clinical pharmacology of the anticancer polypeptide neocarzinostatin (1983)
    Springer
    Cancer chemotherapy and pharmacology 10 (1983), S. 200-204 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clinical pharmacology of the anticancer polypeptide neocarzinostatin was studied in 16 patients with disseminated neoplasia using a radioimmunoassay technique. Patients who received 2,400–3,600 U of the drug per square meter BSA by rapid IV infusion had triphasic plasma decay curves. For eight patients with normal hepatic and renal function, neocarzinostatin mean plasma half-lives were 0.14, 0.50, and 7.7h. The mean plasma drug clearance was 32.4 ml/min/m2 and the apparent volume of distribution 19.3l/m2. Two patients with liver dysfunction had shorter terminal plasma half-lives and greater drug clearances, while two with renal disease exhibited prolonged plasma half-lives and reduced drug clearances. The mean cumulative urinary excretion of neocarzinostatin was 69.1% of the administered dose at 72 h in three patients with normal hepatic and renal function. One patient with liver disease excreted 90.4%, while a patient with renal disease excreted only 58.1% of the dose in 24 h. In one patient with marked liver disease, biliary excretion accounted for 0.1% of the administered dose in 72 h. Cerebrospinal fluid concentrations of neocarzinostatin studied in two patients showed a CSF penetration of about 16% the plasma concentration at 1–5 h; concentrations persisted for 19 h in one patient with an Omayha reservoir. Neocarzinostatin was rapidly cleared from the plasma and eliminated in the urine. Dosage reductions of 50% are recommended for patients with impaired renal function, while no reduction or escalated doses could be tolerated by patients with liver disease. The pharmacologic data suggest a continuous IV infusion may be a more toxic but perhaps more effective schedule of administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00255763
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