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  • 1
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    Regional climate downscaling over Europe: perspectives from the EURO-CORDEX community (2020)
    Springer Berlin Heidelberg
    Details
    Publikationsdatum: 2023-06-21
    Beschreibung: The European CORDEX (EURO-CORDEX) initiative is a large voluntary effort that seeks to advance regional climate and Earth system science in Europe. As part of the World Climate Research Programme (WCRP) - Coordinated Regional Downscaling Experiment (CORDEX), it shares the broader goals of providing a model evaluation and climate projection framework and improving communication with both the General Circulation Model (GCM) and climate data user communities. EURO-CORDEX oversees the design and coordination of ongoing ensembles of regional climate projections of unprecedented size and resolution (0.11° EUR-11 and 0.44° EUR-44 domains). Additionally, the inclusion of empirical-statistical downscaling allows investigation of much larger multi-model ensembles. These complementary approaches provide a foundation for scientific studies within the climate research community and others. The value of the EURO-CORDEX ensemble is shown via numerous peer-reviewed studies and its use in the development of climate services. Evaluations of the EUR-44 and EUR-11 ensembles also show the benefits of higher resolution. However, significant challenges remain. To further advance scientific understanding, two flagship pilot studies (FPS) were initiated. The first investigates local-regional phenomena at convection-permitting scales over central Europe and the Mediterranean in collaboration with the Med-CORDEX community. The second investigates the impacts of land cover changes on European climate across spatial and temporal scales. Over the coming years, the EURO-CORDEX community looks forward to closer collaboration with other communities, new advances, supporting international initiatives such as the IPCC reports, and continuing to provide the basis for research on regional climate impacts and adaptation in Europe.
    Schlagwort(e): ddc:551.6 ; EURO-CORDEX ; CORDEX ; Climate change ; Regional climate models ; Regional climate modelling
    Sprache: Englisch
    Materialart: doc-type:article
    Standort Signatur Einschränkungen Verfügbarkeit
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    CITATION GEO-LEO
  • 2
    Digitale Medien
    Digitale Medien
    Analysis of therapy-resistant venous leg ulcers (1993)
    Oxford, UK : Blackwell Science
    Wound repair and regeneration 1 (1993), S. 0 
    Details
    ISSN: 1524-475X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Chronic leg ulcers represent a major health-care problem with considerable socioeconomic impact. Patients with seemingly therapy-resistant leg ulcers are common to all clinics. The purpose of the present study was to (1) examine a group of patients with nonhealing venous leg ulcers treated with a double-layer bandage and (2) evaluate whether the addition of an interactive hydrocolloid wound dressing could initiate healing in these patients. Twenty-two patients with ulcers caused by venous insufficiency were included. The patients had a mean ulcer duration of 27.6 years. Duration of the present ulcer was at least 1 year (mean ≥ 4.1 years). Twenty of the 22 patients showed massive lipodermatosclerosis. Before inclusion, all patients had used double-layer bandage consisting of a zinc-impregnated bandage or stocking and a self-adhesive compression bandage for 1 year or longer without improvement. The new regimen was a triple-layer treatment with the hydrocolloid water applied over the ulcer and the traditional double-layer bandage unchanged. Three patients were dropped from the study. Nineteen patients were followed until healing or for 10 months. Nine of the 19 patients who completed the study healed. Ulcer area was reduced by 70% or greater in 7 patients and by 30% to 40% in two patients. One ulcer did not respond to the treatment and worsened slightly. The results of this study were encouraging and indicate that the triple-layer treatment with the hydrocolloid dressing applied to the ulcer should be evaluated in a randomized, controlled study in patients with less pessimistic prognoses.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1524-475X.1993.10204.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Nickel concentration of blood, urine and sweat after oral administration (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 5 (1979), S. 0 
    Details
    ISSN: 1600-0536
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Healthy volunteers without nickel hypersensitivity were given 5.6 mg nickel orally. The nickel concentration was assayed in urine, serum and saune-provocated sweat from hands and trunk before and after nickel ingestion. The nickel concentration in serum increased in all subjects, and in most cases in urine, but not decisively in sweat.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0536.1979.tb04885.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Effect on growth and nickel content of cabbage plants watered with nickel solutions (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 5 (1979), S. 0 
    Details
    ISSN: 1600-0536
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Chinese cabbage plants were watered with different concentrations of NiCl2 solutions and the effect on growth and uptake of nickel in the plants were studied. No toxic effect on plant growth was observed. A higher content of nickel was found in the plants exposed to more concentrated nickel solutions. Nickel contamination and its clinical consequences are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0536.1979.tb04858.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Treatment of chronic hand eczema with UV-B Handylux® in the clinic and at home (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 31 (1994), S. 0 
    Details
    ISSN: 1600-0536
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The efficacy of UV-B irradiation, administered by a new unit, Handylux®, in patients with chronic hand eczema was investigated. 15 patients were treated in the clinic and 11 patients at home. Treatments were performed 4–5 × weekly for approximately 10 weeks. According to the strict criteria used for clearing, none of the patients cleared during the study, but 18 of the 26 patients were defined as much improved by the investigator, while 17 of the patients considered themselves as 〉 80% improved. The compliance in both groups was very good and side-effects limited and dose-related. According to our experience, the effect of high dose UV-B in chronic hand eczema is almost comparable to PUVA, and offers an opportunity for patients to treat themselves at home.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0536.1994.tb01895.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    UVB serum factor: suppression of allergic contact dermatitis in guinea pigs (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 16 (1987), S. 0 
    Details
    ISSN: 1600-0536
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Serum from guinea pigs exposed to a single high dose of UVB and from controls was injected into the spleen of normal animals 5 days prior to sensitization. When 1.0 ml was transferred 4.5 h after irradiation, immunosuppression was obtained. Transfer of 1.5 ml of serum 2.5 h after irradiation failed to induce immunosuppression. This experimental model in guinea pigs might be valuable in further studies investigating the effect of other modalities of ultraviolet exposure (e.g., PUVA or high-dose UVA) on the release of soluble serum factor(s) inducing immunosuppression in allergic contact dermatitis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0536.1987.tb01426.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Nickel allergy and hand eczema (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 1 (1975), S. 0 
    Details
    ISSN: 1600-0536
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: A clinical study was performed in 66 female patients with hand eczema and contact allergy to nickel. They were drawn from a basic material of 165 patients with nickel allergy in which hand eczema occurred in 86 cases (52 %). The hand eczema started at an average age of 32 years and ii had been preceded by a metal hypersensitivity for an average of 6 years. The eczema was found to the chronic with a mean duration up to the time of examination of 8 years. It was associated with secondary eruptions in half of the cases. The hand eczema showed a low degree of relevance with regard to dependance of occupation or vacation, as well as to exacerbation of the dermatitis after a direct contact with nickel-coated objects. The clinical examination disclosed in 77 % a pompholyx, i.e. a symmetric vesicular eruption mainly located on the palms and volar aspects of fingers, and sides of fingers. The eczema often showed a periodic activity, with about 15 annual eruptions in the pompholyx cases. It is concluded that simple external contact with the metal can hardly explain the most common clinical pattern of the hand eczema in nickel allergy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0536.1975.tb05353.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    External and internal exposure to the antigen in the hand eczema of nickel allergy (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 1 (1975), S. 0 
    Details
    ISSN: 1600-0536
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: A provocation study was performed in twelve female patients with contact allergy to nickel and hand eczema of the pompholyx type. Intense handling of nickel-contaminated metal objects did not induce any visible eczematous activity. Oral administration of nickel in a double-blind test provoked an aggravation of the hand eczema in nine of the twelve patients, and in seven of the patients this was accompanied by secondary eruptions including outbreaks of earlier, healed eczema. The nickel dose given is probably in the upper limit of the presently known daily intake of the metal, but should be considered to be within the physiologic range. It is concluded that ingestion of small amounts of nickel may be of greater importance in maintaining the hand eczema than external contacts with the metal.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0536.1975.tb05354.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Uptake of nickel in cabbage plants (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 6 (1980), S. 0 
    Details
    ISSN: 1600-0536
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0536.1980.tb03878.x
    Standort Signatur Einschränkungen Verfügbarkeit
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    Artikel (Nationallizenzen)
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  • 10
    Digitale Medien
    Digitale Medien
    Release of nickel from cooking utensils (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 4 (1978), S. 0 
    Details
    ISSN: 1600-0536
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The release of nickel to boiling water from new and used saucepans of different material was measured. No nickel was released from aluminium, teflon and enamel. Certain amounts of nickel were released from stainless steel, but only al acid pH.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0536.1978.tb03847.x
    Standort Signatur Einschränkungen Verfügbarkeit
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