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  • 1
    Online Resource
    Online Resource
    Milton :Jenny Stanford Publishing,
    Keywords: Electronic books.
    Description / Table of Contents: This book focuses on the current state of the art of polymer-based capsules. It discusses the fundamental knowledge of the formations and formulations and the properties and performances of typical polymers capsules, together with their applications.
    Type of Medium: Online Resource
    Pages: 1 online resource (419 pages)
    Edition: 1st ed.
    ISBN: 9780429767883
    Language: English
    Note: Cover -- Half Title -- Title Page -- Copyright Page -- Contents -- Preface -- 1. Redox-Responsive Nanocarriers: A Promising Drug Delivery Platform -- 1.1 Introduction -- 1.2 Redox-Responsive Polymeric Micelles -- 1.3 Redox-Responsive Liposomes -- 1.4 Redox-Responsive Polymersomes -- 1.5 Redox-Responsive Nanogels -- 1.6 Redox-Responsive Nanospheres -- 1.7 Redox-Responsive Nanocapsules -- 1.8 Conclusions -- 2. Smart Polymers-Functionalized Carbon Nanotubes Delivery Systems -- 2.1 Introduction -- 2.2 Polymers-Functionalized Carbon Nanotubes for Drugs Delivery -- 2.2.1 Paclitaxel -- 2.2.2 Doxorubicin -- 2.2.3 Platinum Metallodrugs -- 2.3 Polymers-Functionalized Carbon Nanotubes for Gene Delivery -- 2.4 Polymers-Functionalized Carbon Nanotubes for Protein Delivery -- 2.5 Summary and Future Perspectives -- 3. Smart Polymer Capsules -- 3.1 Introduction -- 3.2 Preparation -- 3.2.1 The Method of the Self-Assembly Approaches of Amphiphilic Block Copolymers -- 3.2.1.1 Film dispersion technique -- 3.2.1.2 Solvent-switching technique -- 3.2.1.3 Polymerization-induced self-assembly -- 3.2.2 Self-Assembly Approaches of Homopolymers -- 3.2.3 Self-Assembly Approaches of Hyperbranched Polymers -- 3.2.4 Self-Assembly Approaches of Graft Copolymers -- 3.2.5 Self-Assembly Approaches of Proteins -- 3.2.6 Dendrimers -- 3.2.7 Layer-by-Layer Assembly Approach -- 3.2.8 Surface/Interfacial Polymerization Approaches -- 3.2.8.1 NMRP techniques -- 3.2.8.2 ATRP techniques -- 3.2.8.3 RAFT techniques -- 3.2.8.4 Precipitation polymerization -- 3.2.8.5 Photopolymerization -- 3.2.9 Single-Step Adsorption Approaches -- 3.2.10 Polymerization and Self-Assembly Approaches in Nanodroplet -- 3.3 Application -- 3.3.1 Drug Delivery -- 3.3.1.1 Physical stimuli for drug delivery -- 3.3.1.2 Chemical stimuli for drug delivery -- 3.3.1.3 Biological stimuli for drug delivery. , 3.3.2 Gene Delivery -- 3.3.3 Biomimetic Microreactors -- 3.3.3.1 Enzyme catalysis -- 3.3.3.2 Polymerization -- 3.3.3.3 Nanoparticles synthesis -- 3.3.3.4 Artificial organelles -- 3.3.4 Sensing -- 3.4 Conclusion -- 4. On the Use of Complex Coacervates for Encapsulation -- 4.1 Introduction -- 4.2 Coacervation -- 4.2.1 Conditions for Complex Coacervation -- 4.2.1.1 Polyelectrolytes -- 4.2.1.2 Ions -- 4.2.1.3 Temperature -- 4.2.1.4 Foreign molecules -- 4.2.2 Properties of Complex Coacervate Phase -- 4.2.2.1 Response to changes in external conditions -- 4.2.2.2 Wetting -- 4.2.2.3 Rheological properties -- 4.3 Process of Encapsulation -- 4.3.1 Emulsification -- 4.3.2 Loading -- 4.3.3 Crosslinking -- 4.3.4 Separation and Further Processing -- 4.4 Application of Complex Coacervates for Encapsulation -- 4.5 Concluding Remarks -- 5. Improving Drug Biological Effects by Encapsulation into Polymeric Nanocapsules -- 5.1 Introduction -- 5.2 Nanostructures -- 5.2.1 Nanoemulsion -- 5.2.2 Nanospheres -- 5.2.3 Nanotubes -- 5.2.4 Nanogels -- 5.2.5 Dendrimers -- 5.2.6 Nanocapsules -- 5.3 Nanocapsule and Its Advantages over Other Nanostructures -- 5.3.1 Nanocapsules -- 5.3.1.1 Efficiency parameters of nanocapsules -- 5.3.1.2 Fabrication techniques -- 5.4 Benefits of Polymeric Nanocapsules -- 5.4.1 Increased Drug Stability Against Chemical- and Photodegradation -- 5.4.2 Increased Interaction with Cells and Tissues and Drug Targeting -- 5.4.2.1 High Specific Surface Area to Volume Ratio -- 5.4.2.2 Polymeric Shell -- 5.4.2.3 Surface Modifications -- 5.4.2.4 Representative Examples of Polymeric Nanocapsules with Enhanced Interaction with Cells and Tissues -- 5.5 Other Ways to Enhance Efficiency of Polymeric Nanocapsules -- 5.6 Evaluation Tests on Efficiency of Polymeric Nanocapsules -- 5.6.1 In Vitro Research Test of Polymeric Nanocapsules. , 5.6.1.1 Antioxidative Effects of Drugs -- 5.6.1.2 Anti-inflammatory Effects of Drugs -- 5.6.1.3 Anti-proliferative Effects of Drugs -- 5.6.1.4 Anti-microbial Effects -- 5.6.1.5 Photodynamic Therapy -- 5.6.2 In Vivo Research Test of Polymeric Nanocapsules -- 5.6.2.1 Anti-proliferative Effects of Drugs -- 5.6.2.2 Surface Active Targeting Effects of Drugs -- 5.6.2.3 Photodynamic Therapy -- 5.6.2.4 Medical Applications of Drug Delivery -- 5.6.2.5 Efficacy of Lipid-Core Nanocapsules -- 5.6.2.6 Polymeric Nanocapsules Efficiency -- 5.7 Safety Concerns Over Polymeric Nanocapsules -- 5.7.1 In Vitro Tests -- 5.7.2 In Vivo Tests -- 5.8 Conclusion -- 6. Drug and Protein Encapsulation by Emulsification: Technology Enhancement Using Foam Formulations -- 6.1 Introduction -- 6.1.1 Particle Parameters -- 6.2 Double Emulsification-Based Techniques -- 6.2.1 Water in Oil in Water Emulsification (W/O/W) -- 6.2.2 Water in Oil in Oil Emulsification (W/O/O) -- 6.2.3 Solid in Oil in Water (S/O/W) or Solid in Oil in Oil (S/O/O) Emulsification -- 6.3 Supercritical Carbon Dioxide-Based Techniques -- 6.3.1 Particles from Gas Saturated Solutions (PGSS) -- 6.3.2 Rapid Expansion from Saturated Solutions (RESS) -- 6.3.3 Supercritical Anti-solvent (SAS) -- 6.4 Conclusion -- 7. Drug Delivery Vehicles with Improved Encapsulation Efficiency: Taking Advantage of Specific Drug-Carrier Interactions -- 7.1 Introduction -- 7.1.1 Drug Delivery Mechanism -- 7.2 Commonly Used Anticancer Drug: Doxorubicin -- 7.3 Types of Carriers -- 7.3.1 Dendrimers -- 7.3.1.1 Properties of dendrimers -- 7.3.1.2 Dendrimer-drug interactions -- 7.3.2 Solid Lipid Nanoparticles -- 7.3.2.1 Factors affecting loading capacity (EE) of lipids -- 7.3.2.2 Specific SLN interaction with DOX -- 7.3.2.3 Doxorubicin-docosahexaenoic acid (DHA) interactions -- 7.3.2.4 Doxorubicin-alpha-tocopherol succinate (TS). , 7.3.3 Polymeric Micelles -- 7.3.3.1 Formation of micelle and encapsulation interactions -- 7.3.3.2 Enhancing EE via π-π stacking interactions -- 7.3.3.3 Hydrogen bonding interactions and crystallinity of PCL-DOX drug delivery systems -- 7.3.4 Liposomes -- 7.3.4.1 Effect of composition on EE of hydrophilic drugs -- 7.3.4.2 Effect of charge -- 7.4 Conclusion -- 8. Biodegradable Multilayer Capsules for Functional Foods Applications -- 8.1 Introduction -- 8.2 Polysaccharides-Based Polyelectrolyte Multilayers -- 8.3 Proteins or Poly(Amino Acid)s-Based Multilayers -- 8.4 Composite Multilayers -- 8.5 Conclusion -- 9. Essential Oils: From Extraction to Encapsulation -- 9.1 Introduction -- 9.1.1 Structure of Oil-Secreting Plants -- 9.1.2 Chemical Composition and Structure of Essential Oils -- 9.1.2.1 Terpenes -- 9.1.2.2 Terpenoids -- 9.1.3 Properties and Applications of Essential Oils -- 9.2 Extraction Methods -- 9.2.1 Hydrodistillation -- 9.2.1.1 Turbo-distillation -- 9.2.2 Organic Solvent Extraction -- 9.2.3 Cold Pressing -- 9.2.4 Innovations in Essential Oils Extraction -- 9.2.4.1 Supercriticalfluidextraction (SCFE) -- 9.2.4.2 Subcritical extraction liquids -- 9.2.4.3 Extraction with subcritical carbon dioxide -- 9.2.4.4 Ultrasound-assisted extraction (UAE) -- 9.2.4.5 Microwave-assisted extraction (MAE) -- 9.2.4.6 Solvent-free microwave extraction (SFME) -- 9.2.4.7 Microwave hydrodiffusion and gravity (MHG) -- 9.2.4.8 Microwave steam distillation (MSD) and microwave steam diffusion (MSDf) -- 9.3 Methods of Encapsulation -- 9.3.1 Encapsulation in Polymeric Particles -- 9.3.1.1 Nanoprecipitation -- 9.3.1.2 Coacervation -- 9.3.1.3 Spray drying -- 9.3.1.4 Rapid expansion of supercritical solutions (RESS) -- 9.3.2 Encapsulation in Liposomes -- 9.3.2.1 Thin film hydration -- 9.3.2.2 Reverse phase evaporation -- 9.3.2.3 Supercritical fluid technology. , 9.4 Encapsulation in Solid Lipid Nanoparticles -- 9.5 Conclusion -- 10. Semipermeable Polymeric Envelopes for Living Cells: Biomedical Applications -- 10.1 Introduction -- 10.2 Properties of Semipermeable Envelopes -- 10.2.1 Permeation Selectivity -- 10.2.2 Biocompatibility and Biostability -- 10.2.3 Mechanical Stability -- 10.3 Types of Semipermeable Envelopes -- 10.3.1 Macro-isolation Systems -- 10.3.1.1 Intravascular devices -- 10.3.1.2 Extravascular devices -- 10.3.2 Micro-isolation Systems -- 10.4 Fabrication Methods -- 10.4.1 Conformal Coating -- 10.4.2 Layer-by-Layer Technique -- 10.4.3 EMC Formation -- 10.4.4 Thermoreversible Gelation -- 10.4.5 Interfacial Polymerization -- 10.4.6 In Situ Polymerization -- 10.4.7 Interfacial Precipitation -- 10.4.8 Coacervation -- 10.4.9 Suspension Crosslinking -- 10.4.10 Coloidosomes -- 10.4.11 Incorporation of Porins -- 10.5 Polymers for Cell Encapsulation -- 10.6 Applications -- 10.6.1 Mammal Cells -- 10.6.1.1 Cell therapy -- 10.6.1.2 Cell transplantation -- 10.6.1.3 In vivo gene therapy by viral vectors -- 10.6.1.4 Stem cell therapy -- 10.6.1.5 Assisted reproduction technologies -- 10.6.1.6 Biosensors -- 10.6.1.7 Advanced tissue engineering -- 10.6.1.8 Minimizing of cell injuries upon cryopreservation -- 10.6.1.9 Other bioapplications -- 10.6.2 Bacteria -- 10.6.2.1 Probiotics -- 10.6.2.2 Bioreactor for delivery of therapeutic products -- 10.7 Conclusion -- 11. Bacteriophage Encapsulation: Trends and Potential Applications -- 11.1 Introduction -- 11.2 Motivations and Potential Applications -- 11.2.1 Food Preservation Technology -- 11.2.2 Healthcare -- 11.3 Biomaterials Involved in Encapsulation -- 11.3.1 Encapsulation Techniques -- 11.3.2 Emulsification -- 11.3.3 Extrusion -- 11.3.4 Spraydrying -- 11.3.5 Electrospun Nanofibers -- 11.4 Conclusion -- Index.
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  • 2
    Electronic Resource
    Electronic Resource
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 35 (1997), S. 3403-3408 
    ISSN: 0887-624X
    Keywords: star-shaped ; poly(THF) ; ion-coupling ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The prepoly(tetrahydrofuran) [poly(THF)] capped with hydroxyl and tetrahydrothiophenium groups was prepared using tetrahydrothiophene to terminate the living cationic polymerization of THF initiated by BF3·OEt2 and epichlorohydrin (ECH) at low conversion. Well-defined star-shaped poly(THF) polyols were synthesized by an ion-coupling reaction of the prepoly(THF) with tri- or tetrafunctional benzenecarboxylates, respectively, and this process proceeded by precipitation when the solution of the prepolymer in THF was added to an aqueous solution containing an excess of the corresponding coupling reagent. GPC studies showed that all of the carboxylate groups of every coupling reagent molecule took part in the ion-coupling reaction simultanously. This was confirmed by IR spectra. Almost all of the prepolymers were coupled to form star polymers after repeating the precipitation four times. 1H-NMR illustrated that both the star-shaped polymers and the prepolymers contained primary and secondary hydroxyl end groups. © 1997 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 35: 3403-3408, 1997
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 36 (1998), S. 2899-2903 
    ISSN: 0887-624X
    Keywords: cationic ring-opening polymerization ; poly(1,3-dioxepane) triol ; 2,2-bis(hydroxymethyl)butanol ; transacetalization ; activated monomer mechanism ; activated chain mechanism ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Cationic polymerization of 1,3-dioxepane (DOP) initiated by triflic acid was carried out in the presence of 2,2-bis(hydroxymethyl)butanol (BHMB). The structure and molecular weight of the products were characterized by GPC and NMR spectra. The results showed that molecular weight of the polyacetal obtained could be controlled by the initial mole ratio of DOP/BHMB. GPC showed that as the mole ratio of BHMB/DOP increased, the content of cyclic oligomers also increased. Proton, 13C and 2D HMQC-fg NMR demonstrated that no hydroxymethyl group of BHMB appeared as an end group. It was also illustrated by proton NMR that some BHMB units existed in cyclic oligomers. The mechanism of formation of cyclic oligomers was discussed. © 1998 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 36: 2899-2903, 1998
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 58 (1995), S. 485-489 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Photosensitive polyimide BTDA-3MPDA was modified by UV irradiation. The structure of UV-irradiated polyimides was investigated by FTIR and gel fraction measurements. The results showed that longer UV exposure time resulted in a higher extent of crosslinking. The gas permeabilities of hydrogen, oxygen and nitrogen through UV-irradiated polyimides were characterized in a temperature range from 30°C to 90°C. Photocrosslinking resulted in a sharp decline in gas permeability for hydrogen, oxygen, and nitrogen through polyimide in the initial stage of photocrosslinking. Then, as the crosslinked benzophenone percentage amounted to 28-38% for hydrogen, 17-31% for oxygen and 3-28% for nitrogen, the gas permeabilities showed another sharp decline. Gas permselectivity increased significantly with the progress of photocrosslinking, and it can be adjusted in a wide range by controlling the extent of crosslinking. Arrhenius plots of gas permeability for hydrogen and oxygen through UV-irradiated polyimides are straight lines; for nitrogen, however, change in the slope of the straight line is observed and activation energies for hydrogen and oxygen permeation show abrupt increases when crosslinked benzophenone percentage amounts to about 30%. UV-irradiated polyimides with simultaneous high gas permeability and permselectivity make them ideal candidate materials for gas separation. © 1995 John Wiley & Sons, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Macromolecular Chemistry and Physics 198 (1997), S. 2613-2622 
    ISSN: 1022-1352
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The cationic polymerization of 1,3-dioxepane (DOP) initiated with trifluoromethanesulfonic acid (I) in the presence of ethylene glycol (EG) was investigated. At sufficiently low concentration of the initiator ([I] 〉 0.01 mol/L vs. [EG] 〈 0.20 mol/L), the molecular weights of the obtained polyacetal oligodiols are controlled by the mole ratio of consumed DOP to initial EG. Gel-permeation chromatography studies revealed that the concentration of cyclic oligomers in the products are negligible. The mechanism of the polymerization was investigated by means of kinetic studies. The results showed that the polymerization proceeds according to the active chain end mechanism (ACF) in combination with the activated monomer mechanism (AM); thus the cyclic oligomer in the obtained polymer is reduced, and intermolecular chain transfer to EG in ACE is dominant. It was also demonstrated that as [DOP]2[I]/[EG] decreases the contribution of ACE to the polymerization decreases and that of AM increases. In addition, 1H and 13C NMR data illustrated that each macromolecule of polyDOP oligodiols contained one EG unit on average and that no EG end groups exist.
    Additional Material: 5 Ill.
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