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  • 1
    Online Resource
    Online Resource
    Milton :Jenny Stanford Publishing,
    Keywords: Electronic books.
    Description / Table of Contents: This book focuses on the current state of the art of polymer-based capsules. It discusses the fundamental knowledge of the formations and formulations and the properties and performances of typical polymers capsules, together with their applications.
    Type of Medium: Online Resource
    Pages: 1 online resource (419 pages)
    Edition: 1st ed.
    ISBN: 9780429767883
    Language: English
    Note: Cover -- Half Title -- Title Page -- Copyright Page -- Contents -- Preface -- 1. Redox-Responsive Nanocarriers: A Promising Drug Delivery Platform -- 1.1 Introduction -- 1.2 Redox-Responsive Polymeric Micelles -- 1.3 Redox-Responsive Liposomes -- 1.4 Redox-Responsive Polymersomes -- 1.5 Redox-Responsive Nanogels -- 1.6 Redox-Responsive Nanospheres -- 1.7 Redox-Responsive Nanocapsules -- 1.8 Conclusions -- 2. Smart Polymers-Functionalized Carbon Nanotubes Delivery Systems -- 2.1 Introduction -- 2.2 Polymers-Functionalized Carbon Nanotubes for Drugs Delivery -- 2.2.1 Paclitaxel -- 2.2.2 Doxorubicin -- 2.2.3 Platinum Metallodrugs -- 2.3 Polymers-Functionalized Carbon Nanotubes for Gene Delivery -- 2.4 Polymers-Functionalized Carbon Nanotubes for Protein Delivery -- 2.5 Summary and Future Perspectives -- 3. Smart Polymer Capsules -- 3.1 Introduction -- 3.2 Preparation -- 3.2.1 The Method of the Self-Assembly Approaches of Amphiphilic Block Copolymers -- 3.2.1.1 Film dispersion technique -- 3.2.1.2 Solvent-switching technique -- 3.2.1.3 Polymerization-induced self-assembly -- 3.2.2 Self-Assembly Approaches of Homopolymers -- 3.2.3 Self-Assembly Approaches of Hyperbranched Polymers -- 3.2.4 Self-Assembly Approaches of Graft Copolymers -- 3.2.5 Self-Assembly Approaches of Proteins -- 3.2.6 Dendrimers -- 3.2.7 Layer-by-Layer Assembly Approach -- 3.2.8 Surface/Interfacial Polymerization Approaches -- 3.2.8.1 NMRP techniques -- 3.2.8.2 ATRP techniques -- 3.2.8.3 RAFT techniques -- 3.2.8.4 Precipitation polymerization -- 3.2.8.5 Photopolymerization -- 3.2.9 Single-Step Adsorption Approaches -- 3.2.10 Polymerization and Self-Assembly Approaches in Nanodroplet -- 3.3 Application -- 3.3.1 Drug Delivery -- 3.3.1.1 Physical stimuli for drug delivery -- 3.3.1.2 Chemical stimuli for drug delivery -- 3.3.1.3 Biological stimuli for drug delivery. , 3.3.2 Gene Delivery -- 3.3.3 Biomimetic Microreactors -- 3.3.3.1 Enzyme catalysis -- 3.3.3.2 Polymerization -- 3.3.3.3 Nanoparticles synthesis -- 3.3.3.4 Artificial organelles -- 3.3.4 Sensing -- 3.4 Conclusion -- 4. On the Use of Complex Coacervates for Encapsulation -- 4.1 Introduction -- 4.2 Coacervation -- 4.2.1 Conditions for Complex Coacervation -- 4.2.1.1 Polyelectrolytes -- 4.2.1.2 Ions -- 4.2.1.3 Temperature -- 4.2.1.4 Foreign molecules -- 4.2.2 Properties of Complex Coacervate Phase -- 4.2.2.1 Response to changes in external conditions -- 4.2.2.2 Wetting -- 4.2.2.3 Rheological properties -- 4.3 Process of Encapsulation -- 4.3.1 Emulsification -- 4.3.2 Loading -- 4.3.3 Crosslinking -- 4.3.4 Separation and Further Processing -- 4.4 Application of Complex Coacervates for Encapsulation -- 4.5 Concluding Remarks -- 5. Improving Drug Biological Effects by Encapsulation into Polymeric Nanocapsules -- 5.1 Introduction -- 5.2 Nanostructures -- 5.2.1 Nanoemulsion -- 5.2.2 Nanospheres -- 5.2.3 Nanotubes -- 5.2.4 Nanogels -- 5.2.5 Dendrimers -- 5.2.6 Nanocapsules -- 5.3 Nanocapsule and Its Advantages over Other Nanostructures -- 5.3.1 Nanocapsules -- 5.3.1.1 Efficiency parameters of nanocapsules -- 5.3.1.2 Fabrication techniques -- 5.4 Benefits of Polymeric Nanocapsules -- 5.4.1 Increased Drug Stability Against Chemical- and Photodegradation -- 5.4.2 Increased Interaction with Cells and Tissues and Drug Targeting -- 5.4.2.1 High Specific Surface Area to Volume Ratio -- 5.4.2.2 Polymeric Shell -- 5.4.2.3 Surface Modifications -- 5.4.2.4 Representative Examples of Polymeric Nanocapsules with Enhanced Interaction with Cells and Tissues -- 5.5 Other Ways to Enhance Efficiency of Polymeric Nanocapsules -- 5.6 Evaluation Tests on Efficiency of Polymeric Nanocapsules -- 5.6.1 In Vitro Research Test of Polymeric Nanocapsules. , 5.6.1.1 Antioxidative Effects of Drugs -- 5.6.1.2 Anti-inflammatory Effects of Drugs -- 5.6.1.3 Anti-proliferative Effects of Drugs -- 5.6.1.4 Anti-microbial Effects -- 5.6.1.5 Photodynamic Therapy -- 5.6.2 In Vivo Research Test of Polymeric Nanocapsules -- 5.6.2.1 Anti-proliferative Effects of Drugs -- 5.6.2.2 Surface Active Targeting Effects of Drugs -- 5.6.2.3 Photodynamic Therapy -- 5.6.2.4 Medical Applications of Drug Delivery -- 5.6.2.5 Efficacy of Lipid-Core Nanocapsules -- 5.6.2.6 Polymeric Nanocapsules Efficiency -- 5.7 Safety Concerns Over Polymeric Nanocapsules -- 5.7.1 In Vitro Tests -- 5.7.2 In Vivo Tests -- 5.8 Conclusion -- 6. Drug and Protein Encapsulation by Emulsification: Technology Enhancement Using Foam Formulations -- 6.1 Introduction -- 6.1.1 Particle Parameters -- 6.2 Double Emulsification-Based Techniques -- 6.2.1 Water in Oil in Water Emulsification (W/O/W) -- 6.2.2 Water in Oil in Oil Emulsification (W/O/O) -- 6.2.3 Solid in Oil in Water (S/O/W) or Solid in Oil in Oil (S/O/O) Emulsification -- 6.3 Supercritical Carbon Dioxide-Based Techniques -- 6.3.1 Particles from Gas Saturated Solutions (PGSS) -- 6.3.2 Rapid Expansion from Saturated Solutions (RESS) -- 6.3.3 Supercritical Anti-solvent (SAS) -- 6.4 Conclusion -- 7. Drug Delivery Vehicles with Improved Encapsulation Efficiency: Taking Advantage of Specific Drug-Carrier Interactions -- 7.1 Introduction -- 7.1.1 Drug Delivery Mechanism -- 7.2 Commonly Used Anticancer Drug: Doxorubicin -- 7.3 Types of Carriers -- 7.3.1 Dendrimers -- 7.3.1.1 Properties of dendrimers -- 7.3.1.2 Dendrimer-drug interactions -- 7.3.2 Solid Lipid Nanoparticles -- 7.3.2.1 Factors affecting loading capacity (EE) of lipids -- 7.3.2.2 Specific SLN interaction with DOX -- 7.3.2.3 Doxorubicin-docosahexaenoic acid (DHA) interactions -- 7.3.2.4 Doxorubicin-alpha-tocopherol succinate (TS). , 7.3.3 Polymeric Micelles -- 7.3.3.1 Formation of micelle and encapsulation interactions -- 7.3.3.2 Enhancing EE via π-π stacking interactions -- 7.3.3.3 Hydrogen bonding interactions and crystallinity of PCL-DOX drug delivery systems -- 7.3.4 Liposomes -- 7.3.4.1 Effect of composition on EE of hydrophilic drugs -- 7.3.4.2 Effect of charge -- 7.4 Conclusion -- 8. Biodegradable Multilayer Capsules for Functional Foods Applications -- 8.1 Introduction -- 8.2 Polysaccharides-Based Polyelectrolyte Multilayers -- 8.3 Proteins or Poly(Amino Acid)s-Based Multilayers -- 8.4 Composite Multilayers -- 8.5 Conclusion -- 9. Essential Oils: From Extraction to Encapsulation -- 9.1 Introduction -- 9.1.1 Structure of Oil-Secreting Plants -- 9.1.2 Chemical Composition and Structure of Essential Oils -- 9.1.2.1 Terpenes -- 9.1.2.2 Terpenoids -- 9.1.3 Properties and Applications of Essential Oils -- 9.2 Extraction Methods -- 9.2.1 Hydrodistillation -- 9.2.1.1 Turbo-distillation -- 9.2.2 Organic Solvent Extraction -- 9.2.3 Cold Pressing -- 9.2.4 Innovations in Essential Oils Extraction -- 9.2.4.1 Supercriticalfluidextraction (SCFE) -- 9.2.4.2 Subcritical extraction liquids -- 9.2.4.3 Extraction with subcritical carbon dioxide -- 9.2.4.4 Ultrasound-assisted extraction (UAE) -- 9.2.4.5 Microwave-assisted extraction (MAE) -- 9.2.4.6 Solvent-free microwave extraction (SFME) -- 9.2.4.7 Microwave hydrodiffusion and gravity (MHG) -- 9.2.4.8 Microwave steam distillation (MSD) and microwave steam diffusion (MSDf) -- 9.3 Methods of Encapsulation -- 9.3.1 Encapsulation in Polymeric Particles -- 9.3.1.1 Nanoprecipitation -- 9.3.1.2 Coacervation -- 9.3.1.3 Spray drying -- 9.3.1.4 Rapid expansion of supercritical solutions (RESS) -- 9.3.2 Encapsulation in Liposomes -- 9.3.2.1 Thin film hydration -- 9.3.2.2 Reverse phase evaporation -- 9.3.2.3 Supercritical fluid technology. , 9.4 Encapsulation in Solid Lipid Nanoparticles -- 9.5 Conclusion -- 10. Semipermeable Polymeric Envelopes for Living Cells: Biomedical Applications -- 10.1 Introduction -- 10.2 Properties of Semipermeable Envelopes -- 10.2.1 Permeation Selectivity -- 10.2.2 Biocompatibility and Biostability -- 10.2.3 Mechanical Stability -- 10.3 Types of Semipermeable Envelopes -- 10.3.1 Macro-isolation Systems -- 10.3.1.1 Intravascular devices -- 10.3.1.2 Extravascular devices -- 10.3.2 Micro-isolation Systems -- 10.4 Fabrication Methods -- 10.4.1 Conformal Coating -- 10.4.2 Layer-by-Layer Technique -- 10.4.3 EMC Formation -- 10.4.4 Thermoreversible Gelation -- 10.4.5 Interfacial Polymerization -- 10.4.6 In Situ Polymerization -- 10.4.7 Interfacial Precipitation -- 10.4.8 Coacervation -- 10.4.9 Suspension Crosslinking -- 10.4.10 Coloidosomes -- 10.4.11 Incorporation of Porins -- 10.5 Polymers for Cell Encapsulation -- 10.6 Applications -- 10.6.1 Mammal Cells -- 10.6.1.1 Cell therapy -- 10.6.1.2 Cell transplantation -- 10.6.1.3 In vivo gene therapy by viral vectors -- 10.6.1.4 Stem cell therapy -- 10.6.1.5 Assisted reproduction technologies -- 10.6.1.6 Biosensors -- 10.6.1.7 Advanced tissue engineering -- 10.6.1.8 Minimizing of cell injuries upon cryopreservation -- 10.6.1.9 Other bioapplications -- 10.6.2 Bacteria -- 10.6.2.1 Probiotics -- 10.6.2.2 Bioreactor for delivery of therapeutic products -- 10.7 Conclusion -- 11. Bacteriophage Encapsulation: Trends and Potential Applications -- 11.1 Introduction -- 11.2 Motivations and Potential Applications -- 11.2.1 Food Preservation Technology -- 11.2.2 Healthcare -- 11.3 Biomaterials Involved in Encapsulation -- 11.3.1 Encapsulation Techniques -- 11.3.2 Emulsification -- 11.3.3 Extrusion -- 11.3.4 Spraydrying -- 11.3.5 Electrospun Nanofibers -- 11.4 Conclusion -- Index.
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  • 2
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 447 (2007), S. 342-345 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Enzyme-catalysed oxidations are some of the most common transformations in primary and secondary metabolism. The vancomycin biosynthetic enzyme DpgC belongs to a small class of oxygenation enzymes that are not dependent on an accessory cofactor or metal ion. The detailed mechanism of ...
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of medicinal chemistry 36 (1993), S. 4221-4229 
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 341 (1990), S. 149-157 
    ISSN: 1432-1912
    Keywords: Cis-(+)-8-hydroxy-1-methyl-2-(di-n-propyl-amino)tetralin [(+)ALK-3] ; Stereoselective 8-OHDPAT analogue ; 5-HT1A receptor ; Rat brain in vivo 5-HT release ; Microdialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The somatodendritic 5-HT1A autoreceptor regulating 5-HT neuronal activity is currently poorly defined pharmacologically because there are no specific antagonists, but also because potent and stereoselective agonists are scarce. Moreover, there have been few, if any, attempts to specifically investigate structure-activity relationships for agonists acting at this site. Employing brain microdialysis techniques, we have examined the effects of the enantiomers of cis-8-hydroxy-1-methyl-2-(di-n-propylamino)tetralin (ALK-3; 0.01-0.3 mg/kg s.c.), its trans-1-methyl analogue (ALK-4; 0.3 mg/kg s.c.) and the pure enantiomers of the parent compound - 8-OH-DPAT (0.3 mg/kg s.c.) — in an attempt to address stereochemical agonist structure-activity requirements of 5-HT release-controlling 5-HT1A autoreceptors in brain. The cis-1-methylated 8-OH-DPAT analogue (+)ALK-3 was comparable to the parent compound in reducing the 5-HT output from rat ventral hippocampus. In comparison, both (−)ALK-3 and the racemic rans-diastereomer to ALK-3, ALK-4, were inactive, while the two stereoisomers of 8-OH-DPAT strongly reduced 5-HT release. Pretreatment with (−)pindolol (8 mg/kg s.c.), which has high affinity for 5-HT1A radioligand binding sites, blocked the reduction of hippocampal 5-HT release induced by a submaximally effective dose of (+)ALK-3. The direct intrahippocampal administration of (+)ALK3 (10 μM) via the perfusion medium did not affect 5-HT output. In summary, the data indicate that (+)ALK-3, like 8-OH-DPAT, is a very potent 5-HT receptor agonist which inhibits terminal 5-HT release in rat hippocampus, probably via activation of somatodendritic 5-HT1A autoreceptors. However, unlike 8-OH-DPAT, (+)ALK-3 is highly stereoselective and may therefore represent a useful probe in the further characterization of 5-HT1A receptor-mediated mechanisms and function. The present study defines some of the stereochemical requirements for 5-HT1A receptor interaction, emphasizing the importance of the receptor region complementary to the C1 and C2 carbons of the 8-OH-DPAT molecule. These findings contribute to the establishment of structure-activity relationships for the cell body 5-HT1A autoreceptors and might be of value in resolving structural features that determine agonist/antagonist activity at central 5-HT1A receptors. Finally, in conjunction with our recent finding that (+)ALK-3 is a partial agonist at postsynaptic 5HT1A receptors, the present study extends previous observations suggesting that pre- and postsynaptic 5-HT1A receptor populations differ in their characteristics.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International journal of theoretical physics 38 (1999), S. 869-876 
    ISSN: 1572-9575
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract By virtue of the two-parameter deformedmultimode bosonic oscillator, the Nodvik andHolstein-Primakoff realizations of the two-parameterdeformed multimode quantum group SU(1,1)q,sare derived. The deformed mappings between the multimode quantum groupSU(1,1)q,s and the two-parameter deformedmultimode bosonic oscillators are alsopresented.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    International journal of theoretical physics 36 (1997), S. 3079-3084 
    ISSN: 1572-9575
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The generators and irreducible representation coherent state of the multimodeSU(2) group are constructed by using the inverse operators of the multimode bosonic harmonic oscillator, and the inhomogeneous inverse differential realization of the multimodeSU(2) group are derived.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    International journal of theoretical physics 36 (1997), S. 1965-1971 
    ISSN: 1572-9575
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The charge and current quantum zero-point fluctuations in a squeezed vacuum state of a nondissipative mesoscopic capacitance coupling circuit with source are given. The quantum noise of this circuit at absolute zero temperature is derived. It is found that there is a squeezing effect in this coupling circuit.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-6903
    Keywords: Glucose transporters ; GLUT3 ; PC12 cells ; neuronal differentiation ; poly-l-lysine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The levels of glucose transporters (GLUTs), specifically GLUT3 and GLUT1, increased dramatically in PC12 cells that were cultured on suitable adhesion substrata (poly-l-lysine [PLL]) and induced to differentiate with nerve growth factor (NGF). Closer examination of this response revealed that: (1) cellular attachment to PLL was sufficient to stimulate the increase in GLUT immunoreactivity, and (2) NGF alone was not effective unless the cells were cultured on PLL-treated surfaces. The response to PLL was detected as early as 4 hr after plating the cells and peaked within 24–48 hr. Other adhesion substrata, such as collagen and poly-l-ornithine, evoked a similar response, although the latter polymer was far less effective. The increase in GLUTs appeared to result from an accumulation of existing transporters because this response was not blocked by inhibiting protein synthesis. Cellular adhesion to PLL was also accompanied by a rapid activation of glucose metabolism. Thus, specific recognition of the adhesion substratum not only provides a context for cell attachment, but also elicits important functional changes in GLUT activity.
    Type of Medium: Electronic Resource
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