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  • American Meteorological Society  (2)
  • The American Society for Biochemistry and Molecular Biology (ASBMB)  (1)
  • 1
    Publikationsdatum: 2022-05-25
    Beschreibung: Author Posting. © American Meteorological Society, 2017. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Climate 30 (2017): 3829-3852, doi:10.1175/JCLI-D-16-0479.1.
    Beschreibung: This study provides an assessment of the uncertainty in ocean surface (OS) freshwater budgets and variability using evaporation E and precipitation P from 10 atmospheric reanalyses, two combined satellite-based E − P products, and two observation-based salinity products. Three issues are examined: the uncertainty level in the OS freshwater budget in atmospheric reanalyses, the uncertainty structure and association with the global ocean wet/dry zones, and the potential of salinity in ascribing the uncertainty in E − P. The products agree on the global mean pattern but differ considerably in magnitude. The OS freshwater budgets are 129 ± 10 (8%) cm yr−1 for E, 118 ± 11 (9%) cm yr−1 for P, and 11 ± 4 (36%) cm yr−1 for E − P, where the mean and error represent the ensemble mean and one standard deviation of the ensemble spread. The E − P uncertainty exceeds the uncertainty in E and P by a factor of 4 or more. The large uncertainty is attributed to P in the tropical wet zone. Most reanalyses tend to produce a wider tropical rainband when compared to satellite products, with the exception of two recent reanalyses that implement an observation-based correction for the model-generated P over land. The disparity in the width and the extent of seasonal migrations of the tropical wet zone causes a large spread in P, implying that the tropical moist physics and the realism of tropical rainfall remain a key challenge. Satellite salinity appears feasible to evaluate the fidelity of E − P variability in three tropical areas, where the uncertainty diagnosis has a global indication.
    Beschreibung: Primary support for the study is provided by the NOAAModeling, Analysis, Predictions, and Projections (MAPP) Program’s Climate Reanalysis Task Force (CRTF) through Grant NA13OAR4310106.
    Beschreibung: 2017-11-02
    Schlagwort(e): Hydrologic cycle ; Precipitation ; Evaporation ; Salinity ; Water budget ; Reanalysis data
    Repository-Name: Woods Hole Open Access Server
    Materialart: Article
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Publikationsdatum: 2022-05-25
    Beschreibung: Author Posting. © American Meteorological Society, 2015. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Bulletin of the American Meteorological Society 96 (2015): 921–938, doi:10.1175/BAMS-D-13-00117.1.
    Beschreibung: El Niño–Southern Oscillation (ENSO) is a naturally occurring mode of tropical Pacific variability, with global impacts on society and natural ecosystems. While it has long been known that El Niño events display a diverse range of amplitudes, triggers, spatial patterns, and life cycles, the realization that ENSO’s impacts can be highly sensitive to this event-to-event diversity is driving a renewed interest in the subject. This paper surveys our current state of knowledge of ENSO diversity, identifies key gaps in understanding, and outlines some promising future research directions.
    Beschreibung: AC acknowledges support from the National Science Foundation for this study.
    Beschreibung: 2015-12-01
    Repository-Name: Woods Hole Open Access Server
    Materialart: Article
    Format: application/pdf
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Publikationsdatum: 2018-10-27
    Beschreibung: The RE1-silencing transcription factor (REST) is the major scaffold protein for assembly of neuronal gene silencing complexes that suppress gene transcription through regulating the surrounding chromatin structure. REST represses neuronal gene expression in stem cells and non-neuronal cells, but it is minimally expressed in neuronal cells to ensure proper neuronal development. Dysregulation of REST function has been implicated in several cancers and neurological diseases. Modulating REST gene silencing is challenging because cellular and developmental differences can affect its activity. We therefore considered the possibility of modulating REST activity through its regulatory proteins. The human small C-terminal domain phosphatase 1 (SCP1) regulates the phosphorylation state of REST at sites that function as REST degradation checkpoints. Using kinetic analysis and direct visualization with X-ray crystallography, we show that SCP1 dephosphorylates two degron phosphosites of REST with a clear preference for phosphoserine 861 (pSer-861). Furthermore, we show that SCP1 stabilizes REST protein levels, which sustains REST's gene silencing function in HEK293 cells. In summary, our findings strongly suggest that REST is a bona fide substrate for SCP1 in vivo and that SCP1 phosphatase activity protects REST against degradation. These observations indicate that targeting REST via its regulatory protein SCP1 can modulate its activity and alter signaling in this essential developmental pathway.
    Print ISSN: 0021-9258
    Digitale ISSN: 1083-351X
    Thema: Biologie , Chemie und Pharmazie
    Standort Signatur Einschränkungen Verfügbarkeit
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