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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 290 (1975), S. 35-47 
    ISSN: 1432-1912
    Keywords: Guinea Pig Atrial Muscle ; Ryanodine ; Ryanodine Steady-State Condition ; Post-Rest Potentiation ; Calcium Exchange
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of ryanodine and ryanodine steady-state condition (RSSC) on contractile-related calcium were examined in isolated guinea pig left atrial muscle. 1. RSSC is a specific irreversible condition occurring after a brief exposure to 1×10−7 M ryanodine, followed by washing. It is characterized by elimination of the contraction following a 10-sec rest interval (post-rest) and prolongation of the associated action potential duration (AP50%) from 78.9 to 160.8 msec with minimal alteration in steady-state tension development determined at 1 Hz. 2. Induction of RSSC with a ryanodine-bovine serum albumin conjugate produced similar alterations in post-rest contractile strength and action potential duration. 3. In the presence of 1×10−7 M ryanodine, guinea pig left atria exhibit a significant increase in total 45Ca efflux from two rapidly exchangeable compartments (compartment 1, t 1/2=1.58 min; compartment 2, t 1/2-8.20 min). 4. In atria loaded after the induction of RSSC, total 45Ca release was significantly reduced by 7.2% of the total exchange. 5. The 45Ca exchange space for RSSC atria was reduced from 23.22±0.81 to 19.85±1.22 ml per 100 g muscle without a significant reduction in the total exchange space. 6. From these results, it is concluded that the effects of low concentrations of ryanodine and RSSC are to alter the contractile calcium levels of the tissue, primarily from sarcolemmal membrane sites which regulate post-rest contractile strength and action potential duration.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of comparative physiology 169 (1991), S. 323-330 
    ISSN: 1432-1351
    Keywords: Habituation ; Contralateral sensitization ; Leaky integrator ; Rotation detectors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Fruitflies (Drosophila melanogaster) may respond with landing reactions in tethered flight to unilateral progressive motion of single vertical dark stripes. The response frequency to repeated unilateral stimulation has a characteristic time course, a fast increase followed by a slower decrease. This behaviour is explained by the habituation of the input channels to a leaky integrator. The half-life of the integrated signal is in the range of 1 s. ‘Contralateral sensitization’ (CoS) describes the sensitization of the landing response to unilateral stimuli by preceding contralateral stimulation. It acts by increasing the initial reactivity, which habituates. The effects of CoS are thus still obvious after 1 min of repetitive stimulation. CoS can effectively be mediated by movement stimuli as well as by flickering light. We also show that binocular rotation rather than unilateral back to front motion inhibits the landing response (in the monocular part of the visual field). The biological significance of the described temporal characteristics of the landing response system and their possible neuronal basis are discussed.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0948-5023
    Keywords: High-Temperature MD Simulations ; Confor-mational Analysis ; Porphyrin-Quinone Systems ; Photosynthesis Models
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Photoinduced electron transfer reactions play an important role in the primary step of the biological photosynthesis process. In an attempt to understand better the mechanism of the charge separation organic donor-acceptor molecules containing porphyrins and quinones were designed as photosynthesis models. In order to study the structure dependence of the photoinduced electron transfer twofold and fourfold bridged porphyrin-quinone systems with increasing donor-acceptor distance were synthesized (Figure 1) [1, 2, 3]. It was assumed that in these molecules the porphyrin and quinone should be linked in a rigid and well-defined orientation. To verify this assumption the conformational behavior of these systems was studied by high-temperature MD simulations in combination with conformational analysis of selected minimized structures [4, 5].
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0948-5023
    Keywords: Keywords: Protein-Carbohydrate interactions ; MD simulations ; Flexibility ; Sialyllactose ; Influenza A virus hemagglutinin ; Murine polyoma virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The attachment of a virus to the host cell surface is influenced by enthalpic and entropic factors. A detailed evaluation of all possible energetic interactions including the effects of solvent molecules seems to be a promising way to gain deeper insights in the overall process of binding. Here we performed intensive molecular dynamics studies to compare the conformational space available for the unbound sialyllactose in aqueous solution and when complexed with influenza A hemagglutinin and the murine polyoma virus. In general the conformational freedom of sialyllactose is considerably reduced compared to the free state. Remarkably, two different conformations of the Siaα(2-3)Galβ glycosidic linkages are preferred (which are both populated in the free state) when complexed with either protein.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 271 (1952), S. 240-252 
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wird über eine neue Methode der Hernienplastik bei Inguinal- und Cruralhernien berichtet, wobei auf folgende 3 Momente besonders Wert gelegt wird: 1. Die sorgfältige Präparation des Bruchsackes und seine ordnungsgemäße Versorgung durch Verlagerung nach medial und oben nach vorheriger Torsion sind die wichtigen Voraussetzungen für die Dauerheilung der Leisten- und Schenkelhernien. 2. Die plastische Wiederherstellung der Bauchwand im Bereiche des Trig. ing. ist grundsätzlich nach den vonBassini aufgestellten Richtlinien vorzunehmen, das Vorgehen wird dabei beim Einzelfall durch die Verhältnisse im Leistenkanal bestimmt. Als ganz besonders wichtig wird bei medialer Leistenhernie und bei cruraler Hernie betrachtet, das Schambeinperiost in die Naht mitzufassen. 3. Der Bruchsack wird bei allen großen Hernien der besprochenen Bruchformen zur Vermehrung der Bauchwandschichten verwendet. Dieser erhöht die Verschlußfestigkeit der Bruchpforte und schützt die Muskulatur vor Quetschung durch das Nahtmaterial.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 274 (1953), S. 159-169 
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenjassung Es wird versucht, den Ursachen für das häufig beobachtete Versagen einer einseitigen Calciumbehandlung bei Demineralisation der Knochen, in erster Linie bei verzögerter Frakturenheilung, nachzugehen und die heutige Auffassung von dem normalen und gestörten Mineralstoffwechsel des Skeletsystems zu resümieren. Daraus wird die Erkenntnis abgeleitet, daß es nicht genüge, bei derartigen Zuständen nur einen einzigen Ossifikationsfaktor zu ersetzen, sondern im Sinne einer spezifisehen Organotherapie die Darreichung eines Knochenvollpräparates nottue. Als geeignetes Präparat wurde bei 14 KrankenOssopan angewendet und damit ein regelmäßiger Erfolg erzielt, der nicht nur die deduzierten Erwartungen voll erfüllt hat, sondern diese Darreichung auch in Zukunft und auf breiter Basis empfiehlt.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurocytology 10 (1981), S. 805-818 
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A quantitative light microscopic analysis of the ventral grey matter in the lumbar spinal cord of homozygous nude (nu/nu) and heterozygous (nu/+) mice was performed to determine the possible contribution of lymphocytes to normal C.N.S. tissue. If lymphocytes were present in the neuropil, they could be mistaken for neuroglial cells. Athymic nude mice offer a good model, since they lack T-lymphocytes and symptoms of neurological involvement. Mean cell counts from 1 μm sections were tested by analysis of variance. There were no strain differences for the area and number of neurons. The total neuroglial cell count was also similar, but the number of oligodendrocytes decreased 28%, astrocytes increased 51% and microglia were unchanged in the nude compared with the heterozygous mouse. There were no qualitative differences at the ultrastructural level among the neuroglia of either strain. Either the genetic defect retards and alters neuroglial cell development, or some of the small, round dark nuclei belong to lymphocytes, which have earlier migrated into the C.N.S. parenchyma. Lymphocytes could then participate in a cell-mediated immune response with brain macrophages, which are thought to be primarily derived from mononuclear leukocytes.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 16 (1978), S. 118-120 
    ISSN: 1741-0444
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 9
    Publication Date: 2021-02-08
    Description: The GEOTRACES Intermediate Data Product 2017 (IDP2017) is the second publicly available data product of the international GEOTRACES programme, and contains data measured and quality controlled before the end of 2016. The IDP2017 includes data from the Atlantic, Pacific, Arctic, Southern and Indian oceans, with about twice the data volume of the previous IDP2014. For the first time, the IDP2017 contains data for a large suite of biogeochemical parameters as well as aerosol and rain data characterising atmospheric trace element and isotope (TEI) sources. The TEI data in the IDP2017 are quality controlled by careful assessment of intercalibration results and multi-laboratory data comparisons at crossover stations. The IDP2017 consists of two parts: (1) a compilation of digital data for more than 450 TEIs as well as standard hydrographic parameters, and (2) the eGEOTRACES Electronic Atlas providing an on-line atlas that includes more than 590 section plots and 130 animated 3D scenes. The digital data are provided in several formats, including ASCII, Excel spreadsheet, netCDF, and Ocean Data View collection. Users can download the full data packages or make their own custom selections with a new on-line data extraction service. In addition to the actual data values, the IDP2017 also contains data quality flags and 1-σ data error values where available. Quality flags and error values are useful for data filtering and for statistical analysis. Metadata about data originators, analytical methods and original publications related to the data are linked in an easily accessible way. The eGEOTRACES Electronic Atlas is the visual representation of the IDP2017 as section plots and rotating 3D scenes. The basin-wide 3D scenes combine data from many cruises and provide quick overviews of large-scale tracer distributions. These 3D scenes provide geographical and bathymetric context that is crucial for the interpretation and assessment of tracer plumes near ocean margins or along ridges. The IDP2017 is the result of a truly international effort involving 326 researchers from 22 countries. This publication provides the critical reference for unpublished data, as well as for studies that make use of a large cross-section of data from the IDP2017.
    Type: Article , PeerReviewed
    Format: text
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  • 10
    Publication Date: 2021-02-08
    Description: The cause of rapid hydrological changes in the tropical West Pacific during the last deglaciation remains controversial. In order to test whether these changes were triggered by abrupt climate change events in the North Atlantic Ocean, variations in precipitation during the last deglaciation (18–10 ka) were extracted from proxy records of chemical weathering and terrigenous input in the western Philippine Sea (WPS). The evolution of chemical weathering and terrigenous input since 27 ka was reconstructed using the chemical index of alteration (CIA), elemental ratios (K/Al, TOC/TN and Ti/Ca), δ13Corg, terrigenous fraction abundance and flux data from International Marine Global Change Study Program (IMAGES) core MD06-3054 collected on the upper continental slope of eastern Luzon (northern Philippines). Sediment deposited during the Last Glacial Maximum (LGM) shows weathering equal to or slightly greater than Holocene sediment in the WPS. This unusual state of chemical weathering, which is inconsistent with lower air temperatures and decreased precipitation in Luzon during the LGM, may be due to reworking of poorly consolidated sediments on the eastern Luzon continental shelf during the LGM sea-level lowstand. Rapid changes in chemical weathering, characterized by higher intensity during the Heinrich event 1 (H1) and Younger Dryas (YD) and lower intensity during the Bølling-Allerød (B/A), were linked to rapid variations in precipitation in the WPS during the last deglaciation. The higher terrigenous inputs during the LGM relative to those of the Holocene were controlled by sea-level changes rather than precipitation. The terrigenous inputs show a long-term decline during the last deglaciation, punctuated by brief spikes during the H1 and YD related to sea-level rises and rapid precipitation changes in the WPS, respectively. The proxy records of chemical weathering and terrigenous input from eastern Luzon suggest high rainfall during the H1 and YD events, consistent with inferred rainfall patterns based on Fe/Ca records from offshore Mindanao. Rapid precipitation changes in the WPS did not coincide with migrations of the Intertropical Convergence Zone (ITCZ) but, rather, were related to state shifts of the El Niño-Southern Oscillation (ENSO) during the last deglaciation. Based on proxy records and modeling results, we argue that the Atlantic meridional overturning circulation (AMOC) controlled rapid precipitation changes in the tropical West Pacific through zonal shifts of ENSO or meridional migration of the ITCZ during the last deglaciation. Our findings highlight the dominant role of the North Atlantic Ocean in the tropical hydrologic cycle during the last deglaciation.
    Type: Article , PeerReviewed
    Format: text
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