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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing AG,
    Keywords: Environmental management. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (182 pages)
    Edition: 1st ed.
    ISBN: 9783030762315
    DDC: 363.705
    Language: English
    Note: Intro -- Preface -- Contents -- Chapter 1: Introduction -- 1.1 Overview -- 1.2 Organization of This Book -- 1.2.1 Chapter 1: Introduction -- 1.2.2 Chapter 2: National and International Developments -- 1.2.3 Chapter 3: Climate Change and Built Environment -- 1.2.4 Chapter 4: Energy and Carbon Emission -- 1.2.5 Chapter 5: Materials and Water -- 1.2.6 Chapter 6: Sustainable Waste Management -- 1.2.7 Chapter 7: Sustainable Building Design -- 1.2.8 Chapter 8: Resilience and Adaptation in Buildings -- 1.3 Sustainability and Sustainable Development -- 1.3.1 Sustainability -- 1.3.2 Sustainable Development -- 1.3.3 Key Themes in Sustainable Development -- 1.3.4 Key Principles of Sustainable Development -- 1.3.5 Key Questions in Sustainable Development -- 1.4 Sustainable Construction -- 1.4.1 Overview -- 1.4.2 Life Cycle Approach in Sustainable Construction -- 1.4.3 Challenges of Sustainable Construction -- 1.5 Summary -- 1.6 Discussion Queries -- References -- Chapter 2: International and National Sustainable Developments -- 2.1 Introduction -- 2.2 International Developments -- 2.2.1 History of Sustainable Development -- 2.2.2 UN Policy on Sustainable Development -- 2.2.3 CIB Agenda 21 on Sustainable Construction -- 2.2.4 OECD Policies on Sustainable Development -- 2.2.5 ISO Policies on Sustainable Development -- 2.2.6 Melbourne Principles for Sustainable Cities -- 2.3 National Developments -- 2.3.1 Introduction -- 2.3.2 Australia's Commitment to International Sustainable Development -- 2.3.3 Council of Australian Government (COAG) Agreements -- 2.3.4 Federal Australian Government Actions -- 2.4 State and Territory Developments -- 2.5 Summary -- References -- Chapter 3: Climate Change and Built Environment -- 3.1 What Is Climate Change? -- 3.1.1 Climate System -- 3.1.2 Climate States -- 3.1.3 Greenhouse Effect -- 3.1.4 Sources of GHG -- 3.2 Climate Change. , 3.3 Global Warming -- 3.4 Carbon Cycle -- 3.5 Climate Projection -- 3.6 Global Climate Change-Observations -- 3.7 Climate Projection -- 3.8 Impact of Climate Change on Built Environment -- 3.9 Coping with Climate Change: Mitigation and Adaptation -- 3.9.1 Mitigation to Climate Change -- 3.9.2 Adaptation to Climate Change -- 3.10 Summary -- References -- Chapter 4: Energy and Carbon Emission -- 4.1 Introduction -- 4.2 Energy Sources, Production and Consumption -- 4.2.1 Primary and Secondary Energy Sources -- 4.2.2 The Energy Consumption -- 4.3 Energy per Capita and Human Development -- 4.4 Energy and CO2 Emission of Construction Sector -- 4.5 Embodied Energy -- 4.6 Operating Energy -- 4.6.1 Residential End Use -- 4.6.2 Commercial End Use -- 4.7 Energy Efficiency in Buildings -- 4.8 Carbon Accounting in Construction -- 4.8.1 Emissions from Fuel Combustion -- 4.8.2 Emissions from Electricity -- 4.9 Implications of Climate Change to Residential Building Energy -- 4.10 Summary -- References -- Chapter 5: Materials and Water -- 5.1 Introduction -- 5.2 Sustainable Resource Management -- 5.2.1 Global Material Consumption Trend -- 5.2.2 Sustainable Material Management -- 5.3 Sustainable Water Management -- 5.3.1 Overview -- 5.3.2 Water Efficiency and Recycling -- 5.3.3 Water Quality and Treatment -- 5.3.4 Rainwater Tanks -- 5.3.5 Desalination, Recycling and Energy -- 5.4 Summary -- References -- Chapter 6: Sustainable Waste Management -- 6.1 Introduction -- 6.2 Solid Waste Management: A Global and National View -- 6.2.1 Types of Solid Wastes -- 6.2.2 Impacts of Solid Waste -- 6.2.3 Construction and Demolition (C& -- D) Waste -- 6.3 Waste Treatments -- 6.4 Waste to Resource Management: A Circular Economy Approach -- 6.5 Challenges with Reuse and Recycling in the Construction Sector -- 6.6 Summary -- References -- Chapter 7: Sustainable Building Design. , 7.1 Introduction -- 7.2 Sustainable Building Design Opportunities -- 7.3 Green Building Design -- 7.4 Low-Energy Building Design -- 7.4.1 Building Orientation and Aspect Ratio -- 7.4.2 Building Envelope Design -- Building Envelope Design: Wall System -- Building Envelope Design: Windows -- Building Envelope Design: Roof -- 7.4.3 Daylighting Strategies -- 7.4.4 Ventilation Strategies -- 7.4.5 Thermal Mass and Insulation -- 7.4.6 Internal Load Reduction -- 7.5 Zero-Energy/Zero-Carbon Design -- 7.6 Summary -- References -- Chapter 8: Resilience and Adaptation in Buildings -- 8.1 Introduction -- 8.2 Sustainability -- 8.3 Built Environment -- 8.4 Climate Change Implications to Buildings -- 8.5 Resilience for Thermal Comfort -- 8.5.1 Thermal Comfort -- 8.5.2 Climate Change and Thermal Comfort -- 8.6 Resilience to Heat Waves -- 8.7 Resilience for Durability -- 8.7.1 Building Durability -- 8.7.2 Deterioration of Concrete Structures Under Changing Climate -- 8.7.3 Prevention of Concrete Deterioration -- 8.7.4 Durability of Timber -- 8.7.5 Deterioration of Timber Under Changing Climate -- 8.8 Summary -- References -- Chapter 9: Summary and Conclusions -- Index.
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 625 (1991), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 710 (1994), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 689 (1993), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 15 (1988), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: b1. The effects of central administration of met-enkephalin, leu-enkephalin, the enkephalin analogue FK-33824 and the opiate antagonist naloxone on plasma concentration of adrenocorticotrophic hormone (ACTH) were examined in conscious sheep.2. Intracerebroventricular infusion of met-enkephalin and FK-33824 significantly decreased the basal plasma concentration of ACTH.3. Intracerebroventricular infusion of FK-33824 inhibited the haemorrhage-induced increase in plasma concentration of ACTH.4. Intracerebroventricular infusion of naloxone attenuated the central inhibition of plasma concentration of ACTH induced by FK-33824, but intravenous infusion of naloxone had no effect on the reduction in plasma concentration of ACTH induced by FK-33824.5. These studies suggest that in sheep met-enkephalin may play a central inhibitory role in the control of ACTH secretion.
    Type of Medium: Electronic Resource
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  • 6
    Publication Date: 2016-06-09
    Description: The purpose of this study was to compare the efficacy and tolerability of the Ahmed glaucoma valve (AGV) implant and the Baerveldt implant for the treatment of refractory glaucoma.
    Electronic ISSN: 1471-2415
    Topics: Medicine
    Published by BioMed Central
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  • 7
    Publication Date: 2015-07-04
    Description: Background: The purpose of this study was to examine the choroidal thickness of patients with high myopia using enhanced depth imaging optical coherence tomography (EDI-OCT) and compare them with healthy subjects. Methods: We first conducted a cross-sectional study and then performed a meta-analysis to address this issue further. Using enhanced depth imaging optical coherence tomography (EDI-OCT), the macular choroidal thickness of high myopic eyes and normal control eyes were measured and compared at each location. Univariate and multivariate linear regression analyses were performed to assess the association between choroidal thickness and clinical factors such as axial length (AL), spherical equivalent (SE), and central corneal thickness. In the high myopic eyes, subgroup analysis of macular choroidal thickness was performed in eyes with or without lacquer cracks and choroidal neovascularization (CNV). The meta-analyses were conducted using the Stata software package. Results: The high myopic eyes had a thinner choroid than the control eyes at all macular locations (all P 
    Electronic ISSN: 1471-2415
    Topics: Medicine
    Published by BioMed Central
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  • 8
    Publication Date: 2015-04-30
    Description: Background: Hepatocyte carcinoma (HCC) is one of the most common malignancies worldwide. Despite many achievements in diagnosis and treatment, HCC mortality remains high due to the malignant nature of the disease. Novel approaches, especially for targeted therapy, are being extensively explored. Gene therapy is ideal for such purpose for its specific expression of exogenous genes in HCC cells driven by tissue-specific promoter. However strategies based on correction of mutations or altered expressions of genes responsible for the development/progression of HCC have limitations because these aberrant molecules are not presented in all cancerous cells. In the current work, we adopted a novel strategy by targeting the DNA replication step which is essential for proliferation of every cancer cell. Methods: A recombinant adenovirus with alpha fetoprotein (AFP) promoter-controlled expressions of artificial microRNAs targeting DNA polymerases α, δ, ε and recombinant active Caspase 3, namely Ad/AFP-Casp-AFP-amiR, was constructed. Results: The artificial microRNAs could efficiently inhibit the expression of the target polymerases in AFP-positive HCC cells at both RNA and protein levels, and HCC cells treated with the recombinant virus Ad/AFP-Casp-AFP-amiR exhibited significant G0/1 phase arrest. The proliferation of HCC cells were significantly inhibited by Ad/AFP-Casp-AFP-amiR with increased apoptosis. On the contrary, the recombinant adenovirus Ad/AFP-Casp-AFP-amiR did not inhibit the expression of DNA polymerases α, δ or ε in AFP-negative human normal liver cell HL7702, and showed no effect on the cell cycle progression, proliferation or apoptosis. Conclusions: Inhibition of DNA polymerases α, δ and ε by AFP promoter-driven artificial microRNAs may lead to effective growth arrest of AFP-positive HCC cells, which may represent a novel strategy for gene therapy by targeting the genes that are essential for the growth/proliferation of cancer cells, avoiding the limitations set by any of the individually altered gene.
    Electronic ISSN: 1471-2407
    Topics: Medicine
    Published by BioMed Central
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  • 9
    Publication Date: 2015-03-25
    Description: Background: Necrosis of alveolar macrophages following Mycobacterium tuberculosis infection has been demonstrated to play a vital role in the pathogenesis of tuberculosis. Our previous study demonstrated that Wnt/β-catenin signaling was able to promote mycobacteria-infected cell apoptosis by a caspase-dependent pathway. However, the functionality of this signaling in the necrosis of macrophage following mycobacterial infection remains largely unknown. Methods: Murine macrophage RAW264.7 cells were infected with Bacillus Calmette-Guerin (BCG) in the presence of Wnt/β-catenin signaling. The necrotic cell death was determined by cytometric assay and electronic microscopy; the productions of reactive oxygen species (ROS) and reduced glutathione (GSH) were measured by a cytometric analysis and an enzyme-linked immunosorbent assay, respectively; and the activity of poly (ADP-ribose) polymerase 1 (PARP-1)/apoptosis inhibition factor (AIF) signaling was examined by an immunoblotting assay. Results: The BCG can induce RAW264.7 macrophage cells necrosis in a dose- and time-dependent manner along with an accumulation of reactive oxygen species (ROS). Intriguingly, an enhancement of Wnt/β-catenin signaling shows an ability to reduce the mycobacteria-induced macrophage necrosis. Mechanistically, the activation of Wnt/β-catenin signaling is capable of inhibiting the necrotic cell death in BCG-infected RAW264.7 cells through a mechanism by which the Wnt signaling scavenges intracellular ROS accumulation and increases cellular GSH concentration. In addition, immunoblotting analysis further reveals that Wnt/β-catenin signaling is capable of inhibiting the ROS-mediated cell necrosis in part through a PARP-1/AIF- dependent pathway. Conclusions: An activation of Wnt/β-catenin signaling can inhibit BCG-induced macrophage necrosis by increasing the production of GSH and scavenging ROS in part through a mechanism of repression of PARP-1/AIF signaling pathway. This finding may thus provide an insight into the underlying mechanism of alveolar macrophage cell death in response to mycobacterial infection.
    Electronic ISSN: 1471-2172
    Topics: Medicine
    Published by BioMed Central
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