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  • 1
    Publikationsdatum: 2022-05-25
    Beschreibung: Author Posting. © American Meteorological Society, 2017. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Climate 30 (2017): 3829-3852, doi:10.1175/JCLI-D-16-0479.1.
    Beschreibung: This study provides an assessment of the uncertainty in ocean surface (OS) freshwater budgets and variability using evaporation E and precipitation P from 10 atmospheric reanalyses, two combined satellite-based E − P products, and two observation-based salinity products. Three issues are examined: the uncertainty level in the OS freshwater budget in atmospheric reanalyses, the uncertainty structure and association with the global ocean wet/dry zones, and the potential of salinity in ascribing the uncertainty in E − P. The products agree on the global mean pattern but differ considerably in magnitude. The OS freshwater budgets are 129 ± 10 (8%) cm yr−1 for E, 118 ± 11 (9%) cm yr−1 for P, and 11 ± 4 (36%) cm yr−1 for E − P, where the mean and error represent the ensemble mean and one standard deviation of the ensemble spread. The E − P uncertainty exceeds the uncertainty in E and P by a factor of 4 or more. The large uncertainty is attributed to P in the tropical wet zone. Most reanalyses tend to produce a wider tropical rainband when compared to satellite products, with the exception of two recent reanalyses that implement an observation-based correction for the model-generated P over land. The disparity in the width and the extent of seasonal migrations of the tropical wet zone causes a large spread in P, implying that the tropical moist physics and the realism of tropical rainfall remain a key challenge. Satellite salinity appears feasible to evaluate the fidelity of E − P variability in three tropical areas, where the uncertainty diagnosis has a global indication.
    Beschreibung: Primary support for the study is provided by the NOAAModeling, Analysis, Predictions, and Projections (MAPP) Program’s Climate Reanalysis Task Force (CRTF) through Grant NA13OAR4310106.
    Beschreibung: 2017-11-02
    Schlagwort(e): Hydrologic cycle ; Precipitation ; Evaporation ; Salinity ; Water budget ; Reanalysis data
    Repository-Name: Woods Hole Open Access Server
    Materialart: Article
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Publikationsdatum: 2022-05-25
    Beschreibung: Author Posting. © American Meteorological Society, 2015. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Bulletin of the American Meteorological Society 96 (2015): 921–938, doi:10.1175/BAMS-D-13-00117.1.
    Beschreibung: El Niño–Southern Oscillation (ENSO) is a naturally occurring mode of tropical Pacific variability, with global impacts on society and natural ecosystems. While it has long been known that El Niño events display a diverse range of amplitudes, triggers, spatial patterns, and life cycles, the realization that ENSO’s impacts can be highly sensitive to this event-to-event diversity is driving a renewed interest in the subject. This paper surveys our current state of knowledge of ENSO diversity, identifies key gaps in understanding, and outlines some promising future research directions.
    Beschreibung: AC acknowledges support from the National Science Foundation for this study.
    Beschreibung: 2015-12-01
    Repository-Name: Woods Hole Open Access Server
    Materialart: Article
    Format: application/pdf
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Publikationsdatum: 2014-02-07
    Beschreibung: Background: Pyocyanin (PCN), an extracellular product of Pseudomonas aeruginosa and a blue redox active secondary metabolite, plays an important role in invasive pulmonary infection. However, the detailed inflammatory response triggered by PCN infection in inflammatory cells (particularly macrophages), if present, remains to be clarified. To investigate the effects of PCN on macrophages, the ability of PCN to induce inflammation reaction and the signaling pathway for IL-8 release in PCN-induced differentiated U937 cells were examined. Results: It was found that PCN increased IL-8 release and mRNA expression in Phorbol 12-myristate 13-acetate (PMA) differentiated U937 cells in both a concentration- and time-dependent manner by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). P38 and ERK MAPKs were activated after 10 min of induction with PCN and their levels returned to baselines after 30 min by Western blotting. It was also found that within 10 min of PCN incubation, the level of p-I-kappaBalpha in the cytosol was increased, which returned to baseline level after 60 min. Meanwhile, the level of p-p65 was increased in the nuclear extract and cytosol, and maintained high in total cell lysates. The results were further confirmed by the observation that p38, ERK1/2 and NF-kappaB inhibitors inhibited PCN-induced NF-kappaB activation and attenuated PCN-induced IL-8 expression in U937 cells as a function of their concentrations. Moreover, it was shown that PCN induced oxidative stress in U937 cells and N-acetyl cysteine, an antioxidant, was able to inhibit PCN-induced IL-8 protein expression. Conclusions: It is concluded that PCN induces IL-8 secretion and mRNA expression in PMA-differentiated U937 cells in a concentration- and time- dependent manner. Furthermore, p38 and ERK MAPKs and NF-kappaBeta signaling pathways may be involved in the expression of IL-8 in PCN-incubated PMA-differentiated U937 cells.
    Digitale ISSN: 1471-2180
    Thema: Biologie
    Publiziert von BioMed Central
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Publikationsdatum: 2013-10-29
    Beschreibung: Background: Complementary and alternative medicine (CAM) is commonly used in China for the management of coronary artery disease (CAD). However, few studies have been conducted to investigate the prevalence, perceived effectiveness, types, and reasons of CAM use in patients diagnosed with CAD. Methods: A cross-sectional study design was adopted. Questionnaires were distributed at the outpatient cardiac clinics of four tertiary-level teaching general hospitals in Beijing. Quantitative data were analyzed using Student's t-test. Categorical data were analyzed using chi-square test. Logistic regression was employed to explore factors associated with the use of CAM as well as CAM use features in Chinese medicine (CM) hospitals when significant differences were found upon comparisons. Results: From May to July, 2009, a total of 600 questionnaires were distributed, and 546 patients with a diagnosis of CAD responded with valid values and were included in the present study. CAM was used by 69.1% of the patients with CAD; the majority (75.9%) of these CAM users believes that CAM is effective. "Few side effects" (49.6%) was the main reason of CAM use; whereas "doubt of effect" (61.5%) was the main reason for non-use. Patent herbal medicine (90.7%) was the most commonly used CAM type. Compared with non-CAM users, CAM users tended to be older (p 〈 0.01), have a longer disease duration (p = 0.02) and better current health status. In addition, CAM users had significant lower odds for emergency admission and hospitalization within the past one year. Patients with CAD from CM and WM hospitals differ in CAM use frequency, types, perceived effectiveness, as well as reasons for CAM use or non-CAM use. Conclusion: The present study suggested a group of significant factors which could influence the use of CAM in patients with CAD. CAM use patterns differ in patients from CM and WM hospitals.
    Digitale ISSN: 1472-6882
    Thema: Medizin
    Publiziert von BioMed Central
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Publikationsdatum: 2014-04-28
    Beschreibung: Background: Amino acid neurotransmitters and nitric oxide (NO) are involved in the pathogenesis of major depressive disorder (MDD). Here we want to establish whether changes in their plasma levels may serve as biomarker for the melancholic subtype of this disorder. Methods: Plasma levels of glutamic acid (Glu), aspartic acid (Asp), glycine (Gly), gamma-aminobutyric acid (GABA), and NO were determined in 27 medicine-naive melancholic MDD patients and 30 matched controls. Seven of the MDD patients participated also in a follow-up study after 2 months' antidepressant treatment. The relationship between plasma and cerebral-spinal fluid (CSF) levels of these compounds was analyzed in an additional group of 10 non-depressed subjects. Results: The plasma levels of Asp, Gly and GABA were significantly lower whereas the NO levels were significantly higher in melancholic MDD patients, also after 2 months of fluoxetine treatment. In the additional 10 non-depressed subjects, no significant correlation was observed between plasma and CSF levels of these compounds. Conclusion: These data give the first indication that decreased plasma levels of Asp, Gly and GABA and increased NO levels may serve as a clinical trait-marker for melancholic MDD. The specificity and selectivity of this putative trait-marker has to be investigated in follow-up studies.
    Digitale ISSN: 1471-244X
    Thema: Medizin
    Publiziert von BioMed Central
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Publikationsdatum: 2014-12-21
    Beschreibung: Background: The formation and development of bulblets are crucial to the Lilium genus since these processes are closely related to carbohydrate metabolism, especially to starch and sucrose metabolism. However, little is known about the transcriptional regulation of both processes. To gain insight into carbohydrate-related genes involved in bulblet formation and development, we conducted comparative transcriptome profiling of Lilium davidii var. unicolor bulblets at 0 d, 15 d (bulblets emerged) and 35 d (bulblets formed a basic shape with three or four scales) after scale propagation. Results: Analysis of the transcriptome revealed that a total of 52,901 unigenes with an average sequence size of 630?bp were generated. Based on Clusters of Orthologous Groups (COG) analysis, 8% of the sequences were attributed to carbohydrate transport and metabolism. The results of KEGG pathway enrichment analysis showed that starch and sucrose metabolism constituted the predominant pathway among the three library pairs. The starch content in mother scales and bulblets decreased and increased, respectively, with almost the same trend as sucrose content. Gene expression analysis of the key enzymes in starch and sucrose metabolism suggested that sucrose synthase (SuSy) and invertase (INV), mainly hydrolyzing sucrose, presented higher gene expression in mother scales and bulblets at stages of bulblet appearance and enlargement, while sucrose phosphate synthase (SPS) showed higher expression in bulblets at morphogenesis. The enzymes involved in the starch synthetic direction such as ADPG pyrophosphorylase (AGPase), soluble starch synthase (SSS), starch branching enzyme (SBE) and granule-bound starch synthase (GBSS) showed a decreasing trend in mother scales and higher gene expression in bulblets at bulblet appearance and enlargement stages while the enzyme in the cleavage direction, starch de-branching enzyme (SDBE), showed higher gene expression in mother scales than in bulblets. Conclusions: An extensive transcriptome analysis of three bulblet development stages contributes considerable novel information to our understanding of carbohydrate metabolism-related genes in Lilium at the transcriptional level, and demonstrates the fundamentality of carbohydrate metabolism in bulblet emergence and development at the molecular level. This could facilitate further investigation into the molecular mechanisms underlying these processes in lily and other related species.
    Digitale ISSN: 1471-2229
    Thema: Biologie
    Publiziert von BioMed Central
    Standort Signatur Einschränkungen Verfügbarkeit
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