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  • 2010-2014  (47)
  • 2000-2004  (41)
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  • 1
    Online-Ressource
    Online-Ressource
    Aschheim-Dornach : Inst.f. Produktionstechnik
    Schlagwort(e): Forschungsbericht ; Produktionsplanung ; Logistikplanung ; Simulation
    Materialart: Online-Ressource
    Seiten: Online Ressource, 26 p. = 1,53 Mb., text and images , ill
    Ausgabe: [Elektronische Ressource]
    Sprache: Deutsch
    Anmerkung: Differences between the printed and electronic version of the document are possible. - Contract BMBF 02 PV 3102 6 , nIndex p. 20 , Also available as printed version , Systemvoraussetzungen: Acrobat Reader.
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  • 2
    Schlagwort(e): Hochschulschrift
    Materialart: Buch
    Seiten: VI, 88 S , graph. Darst., Kt
    Serie: Examensarbeit / Max-Planck-Institut für Meteorologhie 69
    Sprache: Englisch
    Anmerkung: Text engl , Zugl.: Hamburg, Univ., FB Geowiss., Diss., 2000
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  • 3
    Materialart: Buch
    Seiten: 87 S. , Abb , 30 cm
    ISSN: 0938-5177
    Serie: Max-Planck-Institut für Meteorologie Examensarbeit Nr. 69
    Sprache: Unbestimmte Sprache
    Anmerkung: Univ. Hamburg FB Geowiss. Diss. 2000
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  • 4
    ISSN: 1524-4741
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: The recently developed method of ultrarapid immunohistochemistry (IHC) was applied to the intraoperative examination of sentinel lymph nodes (SLNs) in breast cancer patients. In a prospective study of 50 patients with invasive breast carcinomas, a total of 60 SLNs were studied. Among them, 33 SLNs from 30 patients were studied intraoperatively using a direct immunoperoxidase method with anticytokeratin antibody clone MNF116. This technique has a turnaround time of less than 20 minutes Ultrarapid IHC revealed 15 positive SLNs compared to 14 positive SLNs using hematoxylin and eosin (H&E) frozen sections. The one SLN missed in H&E frozen sections presented with cytokeratin-positive isolated tumor cells in the lymph node sinus. After paraffin embedding, H&E-stained serial step sections of the SLN specimens detected another two patients with isolated tumor cells. We also examined the remaining axillary lymph nodes (ALNs) by H&E-stained serial step paraffin sections. From 17 of the 30 patients with positive SLNs, 6 patients also had metastatic involvement of the ALNs of level I or II. Thus ultrarapid IHC was a very sensitive and rapid technique for the intraoperative detection of metastatic involvement of SLNs in breast cancer patients. This technique may be a useful complementary tool for the intraoperative study of SLNs, particularly in tumors that are a diagnostic challenge, such as lobular carcinoma. 
    Materialart: Digitale Medien
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  • 5
    ISSN: 1432-2307
    Schlagwort(e): Key words Accreditation ; Diagnostic molecular pathology ; Quality assessment ; Technical standard
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  In order to assess the current technical standard of diagnostic molecular pathology, we have conducted a multicenter trial with 34 participating pathology laboratories in Germany, Austria and Switzerland. Formalin-fixed, paraffin-embedded tissue blocks were selected from 15 cases, comprising 4 B-cell non-Hodgkin’s lymphomas, 4 T-cell non-Hodgkin lymphomas, 4 cases with lymphadenitis, 2 cases with confirmed tuberculosis and 1 case of sarcoidosis. All participating laboratories received one 10-µm section from each of the 15 cases to detect clonality using immunoglobulin heavy chain (IgH) gene or T-cell receptor (TCR)-γ gene rearrangement analysis in 12 and mycobacterial DNA in 3 cases. In addition, participants had to answer technical questions about the application of internal quality controls and performance of fragment length or sequence analysis. Correct results were reported in 80% and 90% for IgH and TCR-γ gene rearrangement analysis, respectively, and in 83% for mycobacterial DNA analysis. No significant differences in the quality of results were obvious when the individual techniques used for molecular analysis were compared. However, when two independent techniques were used by the same laboratory, a higher rate of correct results was obtained for IgH and TCR rearrangement analysis. In conclusion, this study demonstrates a high technical standard of molecular diagnostic adjuncts among the participating laboratories. Regular multicenter trials with a greater number of participating laboratories working in this field will be indispensable to ensure a continuing or increasing standard in diagnostic molecular pathology.
    Materialart: Digitale Medien
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  • 6
    facet.materialart.
    Unbekannt
    COPERNICUS GESELLSCHAFT MBH
    In:  EPIC3Atmospheric Chemistry and Physics, COPERNICUS GESELLSCHAFT MBH, 14(11), pp. 5853-5869, ISSN: 1680-7316
    Publikationsdatum: 2014-06-23
    Beschreibung: Global warming is associated with large increases in surface air temperature in Siberia. Here, we apply the isotope-enabled atmospheric general circulation model ECHAM5-wiso to explore the potential of water isotope measurements at a recently opened monitoring station in Kourovka (57.04° N, 59.55° E) in order to successfully trace climate change in western Siberia. Our model is constrained to atmospheric reanalysis fields for the period 1957–2013 to facilitate the comparison with observations of δD in total column water vapour from the GOSAT satellite, and with precipitation δ18O measurements from 15 Russian stations of the Global Network of Isotopes in Precipitation. The model captures the observed Russian climate within reasonable error margins, and displays the observed isotopic gradients associated with increasing continentality and decreasing meridional temperatures. The model also reproduces the observed seasonal cycle of δ18O, which parallels the seasonal cycle of temperature and ranges from −25 ‰ in winter to −5 ‰ in summer. Investigating West Siberian climate and precipitation δ18O variability during the last 50 years, we find long-term increasing trends in temperature and δ18O, while precipitation trends are uncertain. During the last 50 years, winter temperatures have increased by 1.7 °C. The simulated long-term increase of precipitation δ18O is at the detection limit (〈1 ‰ per 50 years) but significant. West Siberian climate is characterized by strong interannual variability, which in winter is strongly related to the North Atlantic Oscillation. In winter, regional temperature is the predominant factor controlling δ18O variations on interannual to decadal timescales with a slope of about 0.5 ‰ / °C. In summer, the interannual variability of δ18O can be attributed to short-term, regional-scale processes such as evaporation and convective precipitation. This finding suggests that precipitation δ18O has the potential to reveal hydrometeorological regime shifts in western Siberia which are otherwise difficult to identify. Focusing on Kourovka, the simulated evolution of temperature, δ18O and, to a smaller extent, precipitation during the last 50 years is synchronous with model results averaged over all of western Siberia, suggesting that this site will be representative to monitor future isotopic changes in the entire region.
    Repository-Name: EPIC Alfred Wegener Institut
    Materialart: Article , isiRev
    Format: application/pdf
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  • 7
    facet.materialart.
    Unbekannt
    In:  EPIC3European Geosciences Union General Assembly, Vienna, 2014-04-27-2014-05-02
    Publikationsdatum: 2014-07-08
    Beschreibung: During the past two decades, several atmospheric and oceanic general circulation models (GCMs) have been enhanced by the capability to explicitly simulate the hydrological cycle of the two stable water isotopes H218O and HDO. They have provided a wealth of understanding regarding changes of the water isotope signals in various archives under different past climate conditions. However, so far the number of fully coupled atmosphere-ocean GCMs with explicit water isotope diagnostics is very limited. Such coupled models are required for a more comprehensive simulation of both past climates as well as related isotope changes in the Earth’s hydrological cycle. Here, we report first results of a newly developed isotope diagnostics within the Earth system model ECHAM5-JSBACH/MPIMOM. Both H218O and HDO and their relevant fractionation processes are included in all compartments and branches of the water cycle within this model. First equilibrium simulations have been performed for both pre-industrial (PI) and Last Glacial Maximum (LGM) boundary conditions. Evaluation of the PI simulation reveals a good overall model performance in accordance with available modern isotope data from vapour measurements, precipitation samples as well as marine records. The LGM experiment results in spatially varying isotope depletion in precipitation between -20‰ and 0‰ in agreement with data from various isotope records. The simulated isotopic compoisiton of ccean surface waters shows a strong glacial enrichment in the Arctic. In further model analyses we investigate how the relation between water isotopes and key climate variables, e.g. land and surface temperatures, precipitation amounts, oceanic salinity, might has changed for different regions on a glacial-interglacial time scale. Moreover, the influence of glacial climates changes on second-order isotope signals, e.g. the Deuterium excess, is examined.
    Repository-Name: EPIC Alfred Wegener Institut
    Materialart: Conference , notRev
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  • 8
    Publikationsdatum: 2018-03-06
    Beschreibung: Water stable isotopologues provide integrated tracers of the atmospheric water cycle, affected by changes in air mass origin, non-convective and convective processes and continental recycling. Novel remote sensing and in situ measuring techniques have recently offered opportunities for monitoring atmospheric water vapour isotopic composition. Recently developed infrared laser spectrometers allow for continuous in situ measurements of surface water vapour δDv and δ18Ov. So far, very few intercomparisons of measurements conducted using different techniques have been achieved at a given location, due to difficulties intrinsic to the comparison of integrated with local measurements. Nudged simulations conducted with high-resolution isotopically enabled general circulation models (GCMs) provide a consistent framework for comparison with the different types of observations. Here, we compare simulations conducted with the ECHAM5-wiso model with two types of water vapour isotopic data obtained during summer 2012 at the forest site of Kourovka, western Siberia: hourly ground-based FTIR total atmospheric columnar δDv amounts, and in situ hourly Picarro δDv measurements. There is an excellent correlation between observed and predicted δDv at surface while the comparison between water column values derived from the model compares well with FTIR estimates.
    Repository-Name: EPIC Alfred Wegener Institut
    Materialart: Article , isiRev
    Format: application/pdf
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  • 9
    facet.materialart.
    Unbekannt
    In:  EPIC3Geoscientific Model Development, 6, pp. 1463-1480
    Publikationsdatum: 2019-07-17
    Beschreibung: In this study we present first results of a new model development, ECHAM5-JSBACH-wiso, where we have incorporated the stable water isotopes H218O and HDO as tracers in the hydrological cycle of the coupled atmosphere–land surface model ECHAM5-JSBACH. The ECHAM5-JSBACH-wiso model was run under present-day climate conditions at two different resolutions (T31L19, T63L31). A comparison between ECHAM5-JSBACH-wiso and ECHAM5-wiso shows that the coupling has a strong impact on the simulated temperature and soil wetness. Caused by these changes of temperature and the hydrological cycle, the δ18O in precipitation also shows variations from −4‰ up to 4‰. One of the strongest anomalies is shown over northeast Asia where, due to an increase of temperature, the δ18O in precipitation increases as well. In order to analyze the sensitivity of the fractionation processes over land, we compare a set of simulations with various implementations of these processes over the land surface. The simulations allow us to distinguish between no fractionation, fractionation included in the evaporation flux (from bare soil) and also fractionation included in both evaporation and transpiration (from water transport through plants) fluxes. While the isotopic composition of the soil water may change for δ18O by up to +8‰:, the simulated δ18O in precipitation shows only slight differences on the order of ±1‰. The simulated isotopic composition of precipitation fits well with the available observations from the GNIP (Global Network of Isotopes in Precipitation) database.
    Repository-Name: EPIC Alfred Wegener Institut
    Materialart: Article , isiRev
    Format: application/pdf
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  • 10
    Publikationsdatum: 2019-07-17
    Repository-Name: EPIC Alfred Wegener Institut
    Materialart: Article , isiRev
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