Beschreibung: The foraminifera and geochemical element records from the Core CS2 in the center of the Okinawa Trough (OT) revealed a history of current circulation and bottom redox conditions over the last 19 Ka. During the last glaciation, the few Kuroshio Current (KC) and tropical/subtropical species components, the shoaled depth of thermocline (DOT) and high infaunal foraminifera, together suggest the hypoxia in the isolated and semiclosed OT might be related to an absence/shift of the KC. Furthermore, the hypoxia variations in three episodes coincided with changes in the North Pacific Intermediate Water (NPIW), as stronger hypoxia and enhanced NPIW occurred in the Heinrich Stadia 1 and Younger Dryas periods, and rapidly decreasing hypoxia corresponded with weaker NPIW ventilation in the Bølling/Allerød period. Previously recorded hypoxia in the OT occurred broadly at a water depth of between ~1,300 and 1,800 m. Meanwhile, the lowest productivity precluded the possibility of hypoxia caused by organic matter consumption. We thereby infer the enhanced glacial NPIW might be another reason for the hypoxia. After the postglaciation, the OT transitioned into a fully oceanic environment and was reoccupied by main pathway of the KC. This reoccupation greatly alleviated the hypoxia via weakening stratification and increasing vertical mixing. Evolution research of current circulation and bottom redox conditions can help in understanding the changes in the storage/release of carbon as the paleoclimate changed. Moreover, the variations in bottom redox conditions in the OT offer a possible informative window for understanding the influence of glacial NPIW in the mid-latitude zone.

Beschreibung: The monthly air temperature in 1153 stations and precipitation in 1202 stations in China and neighboring countries were collected to construct a monthly climate dataset in China on 0.025 ° resolution (approximately 2.5 km) named LZU0025 dataset designed by Lanzhou University (LZU), using a partial thin plate smoothing method embedded in the ANUSPLIN software. The accuracy of the LZU0025 was evaluated from analyzing three aspects: 1) Diagnostic statistics from surface fitting model in the period of 1951-2011, and results show low mean square root of generalized cross validation (RTGCV) for monthly air temperature surface (1.1 °C) and monthly precipitation surface (2 mm1/2) which interpolated the square root of itself. This indicate exact surface fitting models. 2) Error statistics based on 265 withheld stations data in the period of 1951-2011, and results show that predicted values closely tracked true values with mean absolute error (MAE) of 0.6 °C and 4 mm and standard deviation of mean error (STD) of 1.3 °C and 5 mm, and monthly STDs presented consistent change with RTGCV varying. 3) Comparisons to other datasets through two ways, one was to compare three indices namely the standard deviation, mean and time trend derived from all datasets to referenced dataset released by the China Meteorological Administration (CMA) in the Taylor diagrams, the other was to compare LZU0025 to the Camp Tibet dataset on mountainous remote area. Taylor diagrams displayed the standard deviation derived from LZU had higher correlation with that induced from CMA (Pearson correlation R=0.76 for air temperature case and R=0.96 for precipitation case). The standard deviation for this index derived from LZU was more close to that induced from CMA, and the centered normalized root-mean-square difference for this index derived from LZU and CMA was lower. The same superior performance of LZU were found in comparing indices of the mean and time trend derived from LZU and those induced from other datasets. LZU0025 had high correlation with the Camp dataset for air temperature despite of insignificant correlation for precipitation in few stations. Based on above comprehensive analyses, LZU0025 was concluded as the reliable dataset.

Beschreibung: DMSO is used to treat many diseases/symptoms. The molecular basis of the pharmacological actions of DMSO has been unclear. We hypothesized that DMSO exerts some of these actions by enhancing TGF-β activity. Here we show that DMSO enhances TGF-β activity by ∼3-4-fold in Mv1Lu and NMuMG cells expressing Smad-dependent luciferase reporters. In Mv1Lu cells, DMSO enhances TGF-β-stimulated expression of P-Smad2 and PAI-1. It increases cell-surface expression of TGF-β receptors (TβR-I and/or TβR-II) by ∼3-4-fold without altering their cellular levels as determined by 125 I-labeled TGF-β-cross-linking/Western blot analysis, suggesting the presence of large intracellular pools in these cells. Sucrose density gradient ultracentrifugation/Western blot analysis reveals that DMSO induces recruitment of TβR-II (but not TβR-I) from its intracellular pool to plasma-membrane microdomains. It induces more recruitment of TβR-II to non-lipid raft microdomains than to lipid rafts/caveolae. Mv1Lu cells transiently transfected with TβR-II-HA plasmid were treated with DMSO and analyzed by indirect immunofluoresence staining using anti-HA antibody. In these cells, TβR-II-HA is present as a vesicle-like network in the cytoplasm as well as in the plasma membrane. DMSO causes depletion of TβR-II-HA-containing vesicles from the cytoplasm and co-localization of TβR-II-HA and cveolin-1 at the plasma membrane. These results suggest that DMSO, a fusogenic substance, enhances TGF-β activity presumably by inducing fusion of cytoplasmic vesicles (containing TβR-II) and the plasma membrane, resulting in increased localization of TβR-II to non-lipid raft microdomains where canonical signaling occurs. Fusogenic activity of DMSO may play a pivotal role in its pharmacological actions involving membrane proteins with large cytoplasmic pools. This article is protected by copyright. All rights reserved

Beschreibung: Multidentate N-heterocyclic compounds form a variety of metal complexes with many intriguing structures and interesting properties. The title coordination polymer, catena -poly[zinc(II)-bis{μ-2-[(1 H -imidazol-1-yl)methyl]-1 H -benzimidazole}-κ 2 N 3 : N 3′ ; N 3′ : N 3 -zinc(II)-bis(μ-benzene-1,2-dicarboxylato)-κ 2 O 1 : O 2 ;κ 3 O 1 , O 1′ : O 2 ], [Zn 2 (C 8 H 4 O 4 ) 2 (C 11 H 10 N 4 ) 2 ] n , has been synthesized by the reaction of Zn(NO 3 ) 2 with 2-[(1 H -imidazol-1-yl)methyl]-1 H -benzimidazole (imb) and benzene-1,2-dicarboxylic acid (H 2 bdic) under hydrothermal conditions. There are two crystallographically distinct imb ligands [imb( A ) and imb( B )] in the structure which adopt very similar coordination geometries. The imb( A ) ligand bridges two symmetry-related Zn1 ions, yielding a binuclear [(Zn1) 2 {imb( A )} 2 ] unit, and the imb( B ) ligand bridges two symmetry-related Zn2 ions resulting in a binuclear [(Zn2) 2 {imb( B )} 2 ] unit. The above-mentioned binuclear units are further connected alternately by pairs of bridging bdic 2− ligands, forming an infinite one-dimensional chain. These one-dimensional chains are further connected through N—H...O hydrogen bonds, leading to a two-dimensional layered structure. In addition, the title polymer exhibits good fluorescence properties in the solid state at room temperature.

Beschreibung: A new subergane-type sesquiterpene, named epoxysubergorgic acid ( 1 ), along with seven known sesquiterpenes, were isolated from the gorgonian coral Subergorgia suberosa. The structure of the new compound was determined by extensive spectroscopic analyses. The previously uncertain absolute configuration of the known analogues 2 – 6 was determined on the basis of CD, Mosher 's method, and through chemical conversions. All compounds were evaluated for antibacterial activities.