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  • 1
    Electronic Resource
    Electronic Resource
    Synthesis of Uridine Phosphoramidite Analogs: Reagents for Site-Specific Incorporation of Photoreactive Sites into RNA Sequences (1994)
    s.l. : American Chemical Society
    Bioconjugate chemistry 5 (1994), S. 508-512 
    Details
    ISSN: 1520-4812
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bc00030a005
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Distribution and Nucleotide Biases of the Somatic Hypermutations in the Functional Kappa Light Chain Gene of a Human Follicular Lymphoma Line (1996)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 43 (1996), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The immunoglobulin kappa chain gene of human lymphoma cell line HF-1.3.4 was partially sequenced from the 3′ end of the leader exon 2.0 kb downstream. The sequenced stretch of DNA included 1.5 kb of the non-coding JK region 3′ to the JK2 element of the mature gene. Among the known VK germline genes the closest relative was KV328, which was 91% homologous to HF-1.3.4. In the 1.5 kb JK region homology with JK allele of Whitehurst et al. (allele 2) was 89%, with the allele of Hieter et al. (allele 1) 87%. The vast majority of the differences located in the leader intron, the VJ exon or 0.6 kb 3′ to the exon, a localization characteristic of somatic hypermutations of immunoglobulin genes. Another indication that most of the differences observed were due to somatic hypermutations is that the 153 bp stretch of the kappa constant gene (CK) sequenced from the mRNA was 100% homologous with the published CK sequence. The most differences between the JK region sequence and that of Whitehurst et al. probably represent somatic mutations: 43% were transversions, 55% transitions and 2% deletions. In the non-coding JK region transversions of C.G to G.C rather than to A.T were heavily over-represented. This is possibly a feature of B-cell hypermutations in humans and mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.1996.d01-27.x
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    Paper (German National Licenses)
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  • 3
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    Seawater carbonate chemistry and data of physiological response of a golden tide alga (Sargassum muticum) to the interaction of ocean acidification and phosphorus enrichment (2017)
    PANGAEA
    In:  Supplement to: Xu, Zhiguang; Gao, Guang; Xu, Juntian; Wu, Hongyan (2017): Physiological response of a golden tide alga (Sargassum muticum) to the interaction of ocean acidification and phosphorus enrichment. Biogeosciences, 14(3), 671-681, https://doi.org/10.5194/bg-14-671-2017
    Details
    Publication Date: 2024-03-15
    Description: The development of golden tides is potentially influenced by global change factors, such as ocean acidification and eutrophication, but related studies are very scarce. In this study, we cultured a golden tide alga, Sargasssum muticum, at two levels of pCO2 (400 and 1000 µatm) and phosphate (0.5 and 40?µM) to investigate the interactive effects of elevated pCO2 and phosphate on the physiological properties of the thalli. Higher pCO2 and phosphate (P) levels alone increased the relative growth rate by 41 and 48%, the net photosynthetic rate by 46 and 55 %, and the soluble carbohydrates by 33 and 62 %, respectively, while the combination of these two levels did not promote growth or soluble carbohydrates further. The higher levels of pCO2 and P alone also enhanced the nitrate uptake rate by 68 and 36 %, the nitrate reductase activity (NRA) by 89 and 39 %, and the soluble protein by 19 and 15 %, respectively. The nitrate uptake rate and soluble protein was further enhanced, although the nitrate reductase activity was reduced when the higher levels of pCO2 and P worked together. The higher pCO2 and higher P levels alone did not affect the dark respiration rate of the thalli, but together they increased it by 32 % compared to the condition of lower pCO2 and lower P. The neutral effect of the higher levels of pCO2 and higher P on growth and soluble carbohydrates, combined with the promoting effect on soluble protein and dark respiration, suggests that more energy was drawn from carbon assimilation to nitrogen assimilation under conditions of higher pCO2 and higher P; this is most likely to act against the higher pCO2 that caused acid-base perturbation via synthesizing H+ transport-related protein. Our results indicate that ocean acidification and eutrophication may not boost golden tide events synergistically, although each one has a promoting effect.
    Keywords: Alkalinity, total; Alkalinity, total, standard deviation; Aragonite saturation state; Benthos; Bicarbonate ion; Bicarbonate ion, standard deviation; Bottles or small containers/Aquaria (〈20 L); Calcite saturation state; Calculated using CO2SYS; Calculated using seacarb after Nisumaa et al. (2010); Carbohydrates, soluble; Carbohydrates, soluble, standard deviation; Carbon, inorganic, dissolved; Carbon, inorganic, dissolved, standard deviation; Carbonate ion; Carbonate ion, standard deviation; Carbonate system computation flag; Carbon dioxide; Carbon dioxide, standard deviation; Chlorophyll a; Chlorophyll a, standard deviation; Chromista; Coast and continental shelf; EXP; Experiment; Experiment duration; Fugacity of carbon dioxide (water) at sea surface temperature (wet air); Growth; Growth/Morphology; Growth rate, standard deviation; Laboratory experiment; Lidao; Macroalgae; Macro-nutrients; Net photosynthesis rate, oxygen; Net photosynthesis rate, standard deviation; Nitrate reductase activity; Nitrate reductase activity, standard deviation; Nitrate uptake rate; Nitrate uptake rate, standard deviation; North Pacific; OA-ICC; Ocean Acidification International Coordination Centre; Ochrophyta; Other metabolic rates; Partial pressure of carbon dioxide, standard deviation; Partial pressure of carbon dioxide (water) at sea surface temperature (wet air); pH; pH, standard deviation; Potentiometric; Potentiometric titration; Primary production/Photosynthesis; Proteins, soluble; Proteins, standard deviation; Registration number of species; Respiration; Respiration rate, oxygen; Respiration rate, oxygen, standard deviation; Salinity; Sargassum muticum; Single species; Species; Temperate; Temperature, water; Treatment; Type; Uniform resource locator/link to reference
    Type: Dataset
    Format: text/tab-separated-values, 1312 data points
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    DATA PANGAEA
  • 4
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    Seawater carbonate chemistry and copper toxicity in the green tide alga Ulva prolifera in laboratory experiment (2017)
    PANGAEA
    In:  Supplement to: Gao, Guang; Liu, Yameng; Li, Xinshu; Feng, Zhihua; Xu, Zhiguang; Wu, Hongyan; Xu, Juntian (2017): Expected CO2-induced ocean acidification modulates copper toxicity in the green tide alga Ulva prolifera. Environmental and Experimental Botany, 135, 63-72, https://doi.org/10.1016/j.envexpbot.2016.12.007
    Details
    Publication Date: 2024-03-15
    Description: Cu is considered to be toxic to macroalgae at higher levels. Ocean acidification can also alter the physiological performances of macroalgae. However, little is known regarding the interactive effects of Cu and ocean acidification on macroalgae. In this study, a green tide macroalga, Ulva prolifera, was cultured at the conditions of three levels of Cu (control, 0.5 µM, and 2 µM) and pCO2 (ambient, 1000 µatm, and 1400 µatm) to investigate the responses of U. prolifera to interaction of Cu exposure and ocean acidification. The relative growth rate of thalli decreased with the rise of Cu for all pCO2 conditions except the 1000 ?atm pCO2. Compared with the control, 2 µM Cu reduced the net photosynthetic rate for all pCO2 conditions while 0.5 µM Cu only reduced it at 1400 µatm pCO2. The inhibition rate of Cu on the relative growth rate and net photosynthetic rate was reduced at 1000 µatm pCO2 but was magnified at 1400 ?atm pCO2. Contrary to growth, the dark respiration rate was enhanced by 0.5 µM Cu at ambient pCO2 and by 2 µM Cu at ambient and 1000 µatm pCO2, although it was reduced by 2 µM Cu at 1400 µatm pCO2 compared to the control. The 0.5 µM Cu did not affect the relative electron transport rate (rETR) for any pCO2 condition but 2 µM Cu decreased it for all pCO2 conditions except 1000 µatm pCO2. The mute effect of 0.5 µM Cu on the net photosynthetic rate and rETR at ambient pCO2 may be due to more Chl a and Chl b being synthesized. In addition, 2 µM Cu and 1400 µatm pCO2 led to branched thalli, which may be a defense mechanism against the stress of high Cu and pCO2. Our data, for the first time, demonstrate that a modest increase of pCO2 can alleviate the toxicity of Cu to U. prolifera whilst a further increase exacerbates it. U. prolifera can respond to the stress of Cu pollution and ocean acidification via physiological and morphological alterations.
    Keywords: Alkalinity, total; Alkalinity, total, standard deviation; Aragonite saturation state; Benthos; Bicarbonate ion; Bicarbonate ion, standard deviation; Bottles or small containers/Aquaria (〈20 L); Calcite saturation state; Calculated using CO2SYS; Calculated using seacarb after Nisumaa et al. (2010); Carbon, inorganic, dissolved; Carbon, inorganic, dissolved, standard deviation; Carbonate ion; Carbonate ion, standard deviation; Carbonate system computation flag; Carbon dioxide; Carbon dioxide, standard deviation; Carotenoids; Carotenoids, standard deviation; Chlorophyll a; Chlorophyll a, standard deviation; Chlorophyll b; Chlorophyll b, standard deviation; Chlorophyta; Coast and continental shelf; Electron transport rate, relative; Electron transport rate, relative, standard deviation; Electron transport rate efficiency; Electron transport rate efficiency, standard deviation; EXP; Experiment; Experiment duration; Fugacity of carbon dioxide (water) at sea surface temperature (wet air); Growth; Growth/Morphology; Growth inhibition; Growth inhibition, standard deviation; Growth rate, standard deviation; Inhibition of net photosynthesis; Inhibition of net photosynthesis, standard deviation; Inorganic toxins; Irradiance; Laboratory experiment; Lianyungang_OA; Light saturation; Light saturation, standard deviation; Macroalgae; Maximal electron transport rate, relative; Maximal electron transport rate, relative, standard deviation; Net photosynthesis rate, oxygen; Net photosynthesis rate, standard deviation; Non photochemical quenching; Non photochemical quenching, standard deviation; North Pacific; OA-ICC; Ocean Acidification International Coordination Centre; Partial pressure of carbon dioxide, standard deviation; Partial pressure of carbon dioxide (water) at sea surface temperature (wet air); pH; pH, standard deviation; Plantae; Potentiometric; Potentiometric titration; Primary production/Photosynthesis; Registration number of species; Respiration; Respiration rate, oxygen; Respiration rate, oxygen, standard deviation; Salinity; Single species; Species; Temperate; Temperature, water; Treatment; Type; Ulva prolifera; Uniform resource locator/link to reference
    Type: Dataset
    Format: text/tab-separated-values, 3435 data points
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    DATA PANGAEA
  • 5
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    BioHackathon series in 2011 and 2012: penetration of ontology and linked data in life science domains (2014)
    In:  EPIC3Journal of Biomedical Semantics, 5(1), pp. 5, ISSN: 2041-1480
    Details
    Publication Date: 2017-01-30
    Description: The application of semantic technologies to the integration of biological data and the interoperability of bioinformatics analysis and visualization tools has been the common theme of a series of annual BioHackathons hosted in Japan for the past five years. Here we provide a review of the activities and outcomes from the BioHackathons held in 2011 in Kyoto and 2012 in Toyama. In order to efficiently implement semantic technologies in the life sciences, participants formed various sub-groups and worked on the following topics: Resource Description Framework (RDF) models for specific domains, text mining of the literature, ontology development, essential metadata for biological databases, platforms to enable efficient Semantic Web technology development and interoperability, and the development of applications for Semantic Web data. In this review, we briefly introduce the themes covered by these sub-groups. The observations made, conclusions drawn, and software development projects that emerged from these activities are discussed.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
    Format: application/pdf
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    PAPER (OA)
  • 6
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    Evaluation of reported prostate cancer risk-associated SNPs from genome-wide association studies of various racial populations in Chinese men (2013)
    Wiley-Blackwell
    In: Prostate
    Details
    Publication Date: 2013-09-10
    Description: BACKGROUND Several genome-wide association studies (GWAS) of prostate cancer (PCa) have identified many single nucleotide polymorphisms (SNPs) that are significantly associated with PCa risk in various racial groups. The objective of this study is to evaluate which of these SNPs are associated with PCa risk in Chinese men and estimate their strength of association. METHODS All SNPs that were reported to be associated with PCa risk in GWAS from populations of European, African American, Japanese, and Chinese descent were evaluated in 1,922 PCa cases and 2,175 controls selected from the Chinese Consortium for Prostate Cancer Genetics (ChinaPCa). A logistic regression analysis was used to estimate allelic odds ratios (ORs) of these SNPs for PCa. RESULTS Among the 53 SNPs, 50 were polymorphic in the Chinese population. Of which, 10 and 24 SNPs were significantly associated with PCa risk in Chinese men at P  〈 0.001 and 〈0.05, respectively. These 24 significant SNPs included 17, 5, and 2 SNPs that were originally discovered in European, Japanese, and Chinese descent, respectively. The estimated ORs ranged from 1.10 to 1.49 and the direction of association was consistent with previous studies. When ORs were estimated separately for PCa with Gleason score ≤7 and ≥8, a marginally significant difference in ORs was found only for two of the 24 SNPs ( P  = 0.02 and 0.04). CONCLUSION About half of PCa risk-associated SNPs identified in GWAS of various populations are associated with PCa risk in Chinese men. Information on PCa risk-associated SNPs and their ORs may facilitate risk assessment of PCa risk in Chinese men. Prostate © 2013 Wiley Periodicals, Inc.
    Print ISSN: 0270-4137
    Electronic ISSN: 1097-0045
    Topics: Medicine
    Published by Wiley-Blackwell
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  • 7
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    Higher temperature variability reduces temperature sensitivity of vegetation growth in Northern Hemisphere (2017)
    Wiley-Blackwell
    Details
    Publication Date: 2017-06-11
    Description: Interannual air temperature variability has changed over some regions in Northern Hemisphere (NH), accompanying with climate warming. However, whether and to what extent it regulates the interannual sensitivity of vegetation growth to temperature variability (i.e., interannual temperature sensitivity) −one central issue in understanding and predicting the responses of vegetation growth to changing climate−still remains poorly quantified and understood. Here, we quantify the relationships between the interannual temperature sensitivity of mean growing-season (April–October) Normalized Difference Vegetation Index (NDVI) and ecosystem model simulations of gross primary productivity (GPP), and variability in mean growing-season temperature for forest, shrub and grass over NH. We find higher interannual variability in mean growing-season temperature leads to consistent decrease in interannual temperature sensitivity of mean growing-season NDVI among all vegetation types, but not in model simulations of GPP. Drier condition associates with ~130 ± 150% further decrease in interannual temperature sensitivity of mean growing-season NDVI by temperature variability in forest and shrub. These results illustrate that varying temperature variability can significantly regulate the interannual temperature sensitivity of vegetation growth over NH, interacted with drought variability and nonlinear responses of photosynthesis to temperature. Our findings call for an improved characterization of the nonlinear effects of temperature variability on vegetation growth within global ecosystem models.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley-Blackwell on behalf of American Geophysical Union (AGU).
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  • 8
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    The Roles of Testicular C-kit Positive Cells in De novo Morphogenesis of Testis (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-08-05
    Description: C-kit positive (c-kit+) cells are usual tissue-specific stem cells. However, in postnatal testis, undifferentiated spermatogonial stem cells (SSCs) are c-kit negative (c-kit−) and activation of c-kit represents the start of SSC differentiation, leaving an intriguing question whether other c-kit+ cells exist and participate in the postnatal development of testis. To this end, a feasible system for testicular reconstitution, in which a specific type of cells can be manipulated, is needed. Here, we first establish de novo morphogenesis of testis by subcutaneous injection of testicular cells from neonatal testes into the backs of nude mice. We observe testicular tissue formation and spermatogenesis from all injected sites. Importantly, functional spermatids can be isolated from these testicular tissues. Using this system, we systemically analyze the roles of c-kit+ cells in testicular reconstitution and identify a small population of cells (c-kit+:CD140a+:F4/80+), which express typical markers of macrophages, are critical for de novo morphogenesis of testis. Interestingly, we demonstrate that these cells are gradually replaced by peripheral blood cells of recipient mice during the morphogenesis of testis. Thus, we develop a system, which may mimic the complete developmental process of postnatal testis, for investigating the testicular development and spermatogenesis. Scientific Reports 4 doi: 10.1038/srep05936
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 9
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    Ratiometric Fluorescence Sensor Based on a Pyrene Derivative and Quantification Detection of Heparin in Aqueous Solution and Serum (2011)
    American Chemical Society (ACS)
    Details
    Publication Date: 2011-08-16
    Description: Analytical Chemistry DOI: 10.1021/ac2008724
    Print ISSN: 0003-2700
    Electronic ISSN: 1520-6882
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 10
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    Differentiating drought legacy effects on vegetation growth over the temperate Northern Hemisphere (2017)
    Wiley-Blackwell
    Details
    Publication Date: 2017-10-04
    Description: In view of future changes in climate, it is important to better understand how different plant functional groups (PFGs) respond to warmer and drier conditions, particularly in temperate regions where an increase in both the frequency and severity of drought is expected. The patterns and mechanisms of immediate and delayed impacts of extreme drought on vegetation growth remain poorly quantified. Using satellite measurements of vegetation greenness, in-situ tree-ring records, eddy-covariance CO 2 and water flux measurements, and meta-analyses of source water of plant use among PFGs, we show that drought legacy effects on vegetation growth differ markedly between forests, shrubs and grass across diverse bioclimatic conditions over the temperate Northern Hemisphere (NH). Deep−rooted forests exhibit a drought legacy response with reduced growth during up to 4 years after an extreme drought, whereas shrubs and grass have drought legacy effects of approximately 2 years and 1 year, respectively. Statistical analyses partly attribute the differences in drought legacy effects among PFGs to plant eco-hydrological properties (related to traits), including plant water use and hydraulic responses. These results can be used to improve the representation of drought response of different PFGs in land surface models, and assess their biogeochemical and biophysical feedbacks in response to a warmer and drier climate. This article is protected by copyright. All rights reserved.
    Print ISSN: 1354-1013
    Electronic ISSN: 1365-2486
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering , Geography
    Published by Wiley-Blackwell
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