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  • 1
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    BioHackathon series in 2011 and 2012: penetration of ontology and linked data in life science domains (2014)
    In:  EPIC3Journal of Biomedical Semantics, 5(1), pp. 5, ISSN: 2041-1480
    Details
    Publication Date: 2017-01-30
    Description: The application of semantic technologies to the integration of biological data and the interoperability of bioinformatics analysis and visualization tools has been the common theme of a series of annual BioHackathons hosted in Japan for the past five years. Here we provide a review of the activities and outcomes from the BioHackathons held in 2011 in Kyoto and 2012 in Toyama. In order to efficiently implement semantic technologies in the life sciences, participants formed various sub-groups and worked on the following topics: Resource Description Framework (RDF) models for specific domains, text mining of the literature, ontology development, essential metadata for biological databases, platforms to enable efficient Semantic Web technology development and interoperability, and the development of applications for Semantic Web data. In this review, we briefly introduce the themes covered by these sub-groups. The observations made, conclusions drawn, and software development projects that emerged from these activities are discussed.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
    Format: application/pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Structural analyses of new tri- and tetrasaccharides produced from disaccharides by transglycosylation of purified Trichoderma viride β-glucosidase (1999)
    Springer
    Glycoconjugate journal 16 (1999), S. 415-423 
    Details
    ISSN: 1573-4986
    Keywords: Trichoderma viride ; β-glucosidase ; transglycosylation ; two-dimensional NMR spectroscopy ; oligosaccharide synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A new β-glucosidase was partially purified from Trichoderma viride cellulase. This β-glucosidase catalyzed a transglycosylation reaction of cellobiose to give β-D-Glc-(1→6)-β-D-Glc-(1→4)-D-Glc (1, yield: 18.8%) and β-D-Glc-(1→6)-β-D-Glc-(1→6)-β-D-Glc-(1→4)-D-Glc (2, 3.7%), regioselectively. Furthermore, the enzyme regioselectively converted laminaribiose and gentiobiose into β-D-Glc-(1→6)-β-D-Glc-(1→3)-D-Glc (3, 15.3%) and β-D-Glc-(1→6)-β-D-Glc-(1→6)-D-Glc (4, 20.2%), respectively. The structures (1–4) of the products were determined by 1H and 13C NMR spectroscopies. This high regio- and stereoselectively of the β-glucosidase could be applied for oligosaccharide synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007034728857
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Evaluation of three hepatitis C virus-related antibodies C100, KCL-163, JCC (1992)
    Springer
    Digestive diseases and sciences 37 (1992), S. 1489-1494 
    Details
    ISSN: 1573-2568
    Keywords: blood donors ; hepatitis C virus ; antibodies to HCV ; anti-KCL-163 ; anti-JCC ; HCV RNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the most effective method for detecting hepatitis C virus (HCV) carriers in a large population of blood donors, HCV-related antibodies were measured in 919 donor serum samples using three different enzyme-linked immunosorbent assays. The antibodies were C100 and KCL-163, nonstructural proteins of HCV, as well as JCC, a translation product of the presumptive HCV core gene. Fourteen (1.5%), 12 (1.3%), and 13 (1.4%) specimens were positive for anti-C100, anti-KCL-163, and anti-JCC, respectively. HCV RNA was detected by the polymerase chain reaction in seven (25.0%) of the 28 specimens that were anti-HCV-positive by at least one of the three assays. Four of the seven specimens were detected by anti-C100 screening, while the remaining three were not. All seven specimens were positive for KCL-163 and/or JCC antibodies. These findings suggest that screening for both KCL-163 and JCC antibodies may be of particular use in accurately identifying HCV-positive blood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296491
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of choroidal congestion in retinal pigment epithelium function and the electroretinogram (1988)
    Springer
    Documenta ophthalmologica 69 (1988), S. 221-225 
    Details
    ISSN: 1573-2622
    Keywords: choroidal ischemia ; c-wave ; electroretinogram ; retinal pigment epithelium ; vortex vein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Increased choroidal pressure and choroidal stasis were induced in Dutch rabbit eyes by tying off vortex veins. Ligating one to three vortex veins caused a progressive diminution in the b- and c-waves of the electroretinogram so that the amplitudes were approximately half of control values when three vortices had been ligated. After ligation of four vortex veins, the responses rapidly disappeared. Release of the occlusion twenty minutes later caused the b-wave to return to normal over a few hours' time, but the c-wave showed variable recovery and was replaced by a large slow pIII response in half of the experiments. These observations may reflect a combination of hypoxia and alterations in fluid movement that affect the status of the subretinal space.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00154402
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  • 5
    Electronic Resource
    Electronic Resource
    Clinical study of IgA antibody against hepatitis C virus core antigen in patients with type C chronic liver disease (1995)
    Springer
    Digestive diseases and sciences 40 (1995), S. 457-464 
    Details
    ISSN: 1573-2568
    Keywords: IgA class antibody ; type C chronic liver disease ; HCV core ; histological activity ; IFN therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Immunoglobulin A class antibody to hepatitis C virus core antigen (IgA anti-HCc) was measured in the serum of 128 patients with type C chronic liver disease. Fifty-eight patients (45.3%) were seropositive. IgA anti-HCc was detected in only one of 20 patients with chronic persistent hepatitis; however, 52.3% (46/88) of patients with chronic active hepatitis and 55% (11/20) of patients with liver cirrhosis were seropositive. Histological examination revealed that 22 (71.0%) of 31 patients with severe disease activity were seropositive compared to 35 (44.9%) of 78 patients with moderate (P〈0.05) and one (5.3%) of 19 patients with mild (P〈0.01) histological changes. IgA anti-HCc was measured sequentially in 65 patients who underwent interferon therapy. There was a significant difference between responders and other patients in the mean ratio of IgA anti-HCc titers one month after therapy. Three months after therapy, IgA anti-HCc was detectable in only two of 15 responders who were IgA anti-HCc seropositive at the start of therapy. In contrast, IgA anti-HCc reappeared three months after therapy despite a temporary decrease to undetectable levels in all nonresponders. We conclude that IgA anti-HCc is a useful marker to identify the presence of active type C liver disease and that the disappearance of IgA anti-HCc three months after interferon therapy predicts a good response in treated patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02065435
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  • 6
    Electronic Resource
    Electronic Resource
    IgM and IgA antibodies generated against hepatitis C virus core antigen in patients with acute and chronic HCV infection (1994)
    Springer
    Digestive diseases and sciences 39 (1994), S. 2022-2031 
    Details
    ISSN: 1573-2568
    Keywords: hepatitis C virus ; IgA ; IgM ; IgG ; HCV RNA ; high performance liquid chromatography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Antibody subclasses directed against the core protein (HCc) of hepatitis C virus (HCV) were measured in 27 patients with acute non-A, non-B (NANB) hepatitis, and 99 patients with chronic HCV-associated liver disease. IgM, IgA, and IgG anti-HCc responses were observed in 11 (40.7%), 7 (25.9%), and 18 (67%) patients with acute NANB hepatitis, respectively. Twenty-four (24.2%) and 40 (40.4%) patients with chronic HCV infection also had detectable IgM and IgA, respectively. IgM anti-HCc inconsistently detected acute infection, and HCV ribonucleic acid (RNA) could be detected preceding the rise in anti-HCc antibodies in five consecutive patients with acute hepatitis. IgM anti-HCc also could not distinguish acute from chronic infection and did not correlate with histologic progression. However, the form of IgA present (polymeric vs monomeric) did discriminate acute from chronic infection and the IgA anti-HCc titer correlated with histologic evidence of liver disease in patients with chronic HCV infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02088141
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Clinical evaluation of three anti-HCV ELISAs in patients with various liver diseases (1992)
    Springer
    Digestive diseases and sciences 37 (1992), S. 1268-1274 
    Details
    ISSN: 1573-2568
    Keywords: ELISA systems ; HCV antibody ; HCV-RNA ; liver disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We measured antibodies to hepatitis C virus (HCV) in 380 patients with various liver diseases by three enzyme-linked immunosorbent assays (ELISAs): HCV antibody ELISA test (C100), KCL-163 (KCL) corresponding to the nonstructural protein of HCV, and JCC based on the translation product of the presumptive HCV core gene. Of 233 cases of non-A, non-B (NANB) liver disease, 63.9% were anti-C100 positive, 69.1% were anti-KCL positive, and 79.8% were anti-JCC positive. Detection of serum HCV-RNA in 213 cases of chronic NANB liver disease revealed that the concordance was 80.3% for C100, 86.4% for KCL, 94.8% for JCC, and 95.3% for all three ELISAs. Overall, 85.4% of chronic NANB cases were considered to have type C disease with HCV infection. The most reliable assays for diagnosing chronic NANB liver disease as type C appeared to be the KCL and JCC ELISAs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296571
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