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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of low temperature physics 41 (1980), S. 639-651 
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: The magnetic ordering temperatures of the primitive tetragonal rare earth (RE) rhodium boride compounds exhibit a peak at DyRh4B4, rather than GdRh4B4 as predicted from ordering via the indirect RKKY exchange interaction. This deviation is analyzed in terms of the depression of the superconducting transition temperature of LuRh4B4 by dilute amounts of RE impurity ions and the magnetic heat capacities of the RERh4B4 compounds for RE = Gd, Tb, Dy, and Ho. The strength of anisotropic crystalline electric field forces, as inferred from magnetic entropy considerations, may be the origin of the anomalous magnetic ordering temperatures. In addition, the depression of the superconducting transition temperatures of ErRh4B4 and TmRh4B4 from that of LuRh4B4 is shown to arise primarily from elastic exchange scattering of the conduction electrons by the magnetic RE ions.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of low temperature physics 35 (1979), S. 651-669 
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Detailed heat capacity measurements of the ternary compounds ErRh4B4 and LuRh4B4 have been performed between 0.5 and 36 K and in magnetic fields up to 4 kG, yielding new information on crystal field effects in these materials and on the influence of externally applied magnetic fields on the coupled superconducting-ferromagnetic reentrant transition in ErRh4B4. Static magnetic susceptibility data on LuRh4B4 are presented which allow qualitative conclusions to be drawn regarding the magnitude of exchange enhancement and orbital paramagnetic effects in the RERh4B4 compounds. The electrical resistivity of ErRh4B4 has also been determined between 4 K and room temperature.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: The ac electrical resistance, heat capacity, static magnetic susceptibility, thermal conductivity, and linear thermal expansion coefficient have been measured for the superconducting ternary compound TmRh4B4. The results indicate that the Tm3+ magnetic moments order at about 0.4 K, while bulk superconductivity, which occurs at 9.8 K, persists to temperatures below 60 mK, which was the low-temperature limit of the apparatus. Various possibilities for the type of magnetic order are examined.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1569-8041
    Keywords: chemotherapy ; necrotising fasciitis ; recurrent inflammation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present the case history of a patient with breast carcinoma who developed repeated inflammation at the site of previous necrotising fasciitis following each cycle of intravenous CMF chemotherapy. This complication has not previously been reported.
    Type of Medium: Electronic Resource
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  • 5
    Publication Date: 2017-05-17
    Description: Volcanic ash layers preserved within the geologic record represent precise time markers that correlate disparate depositional environments and enable the investigation of synchronous and/or asynchronous behaviors in Earth system and archaeological sciences. However, it is generally assumed that only exceptionally powerful events, such as supereruptions (≥450 km3 of ejecta as dense-rock equivalent; recurrence interval of ∼105 yr), distribute ash broadly enough to have an impact on human society, or allow us to address geologic, climatic, and cultural questions on an intercontinental scale. Here we use geochemical, age, and morphological evidence to show that the Alaskan White River Ash (eastern lobe; A.D. 833–850) correlates to the “AD860B” ash (A.D. 846–848) found in Greenland and northern Europe. These occurrences represent the distribution of an ash over 7000 km, linking marine, terrestrial, and ice-core records. Our results indicate that tephra from more moderate-size eruptions, with recurrence intervals of ∼100 yr, can have substantially greater distributions than previously thought, with direct implications for volcanic dispersal studies, correlation of widely distributed proxy records, and volcanic hazard assessment.
    Type: Article , PeerReviewed
    Format: text
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  • 6
    Publication Date: 2012-12-01
    Description: Cervical cancer develops through progression from normal cervical epithelium through squamous intraepithelial lesions (SIL) to invasive cancer. Cervical cancer is associated with oncogenic human papillomavirus (HPV). The HPV E6 oncoprotein binds to the tumor suppressor gene product p53, promoting its degradation; the Arg allele of p53 Arg72Pro polymorphism binds more ardently with HPV E6 than the Pro variant. Here we evaluate the role of p53 Arg72Pro polymorphism and HPV status on the initiation, progression, and development of cervical cancer. A systematic review and meta-analysis were conducted. Events of interest were the initiation of neoplasia (SIL vs. normal), progression to invasive cancer (cervical cancer vs. SIL), and risk of invasive cancer (cervical cancer vs. normal) by HPV status. OR were extracted from individual studies and pooled using generic inverse variance and random effects modeling. Forty-nine studies were included. In individuals showing HPV positivity, there was a significantly higher odds of progression from SIL to cervical cancer with the p53 Arg allele [OR 1.37; 95% confidence intervals (CI), 1.15–1.62; P 〈 0.001]. This association was not seen in HPV-negative individuals. p53 Arg72Pro was not associated with the risk of cervical cancer or initiation of SIL in either HPV-positive or HPV-negative patient subsets. The Arg variant of p53 Arg72Pro is associated with progression of SIL to cervical cancer only in the presence of HPV positivity. There were no associations of this variant with overall risk or initiation of cancer in either HPV-positive or HPV-negative patients. Clin Cancer Res; 18(23); 6407–15. ©2012 AACR .
    Print ISSN: 1078-0432
    Electronic ISSN: 1557-3265
    Topics: Medicine
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  • 7
    Publication Date: 2012-09-01
    Description: Angiogenesis is an important host process that interacts with cancer cells to promote growth, invasion, and metastasis. Numerous therapeutic agents targeting the VEGF pathway have been developed. Host variability in VEGF pathway can influence angiogenesis-dependent signaling, altering sensitivity to antiangiogenic drugs and prognosis. A systematic review and meta-analysis was conducted (May 1990–July 2011). Eligible studies involved cancer patients and compared polymorphisms in the VEGF pathway [VEGF and molecules directly interacting with VEGF: KDR, FLT1, FGF, FGF2, FGFR, NRP1, endostatin (encoded by COL18A1 )], and reported one of the following outcomes: overall survival, progression-free survival, time to recurrence, disease-free survival, response rate, or drug toxicity. We identified 48 cancer studies assessing prognosis and 12 cancer studies exploring pharmacogenetics of anti-VEGF therapy across various VEGF pathway polymorphisms. There was marked inter- and intradisease site heterogeneity in the effect of polymorphisms on both outcome and response to therapy. Meta-analyses of 5 VEGF polymorphisms (+936 C 〉 T , –460 T 〉 C , +405 G 〉 C , –1154 G 〉 A , and –2578 C 〉 A ) identified a significant prognostic relationship: VEGF +405 G 〉 C variants showed a highly statistically significant improvement in overall survival [HR, 0.74; 95% confidence interval, 0.60–0.91; P = 0.004]. Variants (heterozygotes and/or homozygotes) of VEGF +405 G 〉 C were significantly associated with improved survival in a meta-analysis of multiple cancer sites. Clin Cancer Res; 18(17); 4526–37. ©2012 AACR .
    Print ISSN: 1078-0432
    Electronic ISSN: 1557-3265
    Topics: Medicine
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  • 8
    Publication Date: 2013-08-14
    Description: Mineralization of rare-earth elements (REEs) has been discovered in the Karrat Isfjord region of West Greenland (~72°N) at Niaqornakavsak on the island of Qeqertarssuaq along the southwestern margin of the Kangigdleq-Íngia Fjord gneiss dome complex. Mineralization occurs within a distinct ~30-m-thick horizon in an amphibolite host rock, which defines the upper boundary of the Paleoproterozoic Qeqertarssuaq Formation. REE mineralization extends across the entire Niaqornakavsak Peninsula (1.5 km) with a continuation of the unit 7 km east at Umiamako Nuna. Concentrations of whole-rock Y + REE oxide across 1-m sections in the mineralized horizon reach a maximum of 2.6 wt %, with an average of 1.0 wt %. The REE-enriched horizon is divided into two major units: (1) the upper unit (Calcium Carbonate Amphibolite) is characterized by abundant calcite, ankerite, and fluorite (〉50% modal), with lesser amounts of grunerite, cummingtonite, magnetite, biotite, apatite, sphalerite, thorium silicate, fergusonite, bastnasite, allanite, and monazite; and (2) the lower unit (Biotite Layered Carbonate) contains modal biotite (〉50%), with lesser amounts of calcite, ilmenite, magnetite, allanite, fergusonite, and monazite. Monazite formed within the mineralized horizon; the Calcium Carbonate Amphibolite unit yields a 207 Pb/ 206 Pb model age of 1859 ± 15 Ma. The combined attributes of the deposit (REE patterns, whole-rock chemistry, and mineralogy) suggest that the REE mineralization was produced by metasomatic alteration of the host amphibolites by a ferrocarbonatite-derived fluid. Monazite 207 Pb/ 206 Pb age results indicate that mineralization occurred during Paleoproterozoic continental convergence (1.95–1.80 Ma) between the North Atlantic and Rae cratons and emplacement of the Prøven Igneous Complex and potentially related carbonatite intrusions.
    Print ISSN: 0361-0128
    Topics: Geosciences
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  • 9
    Publication Date: 2014-09-20
    Description: Volcanic ash layers preserved within the geologic record represent precise time markers that correlate disparate depositional environments and enable the investigation of synchronous and/or asynchronous behaviors in Earth system and archaeological sciences. However, it is generally assumed that only exceptionally powerful events, such as supereruptions (≥450 km 3 of ejecta as dense-rock equivalent; recurrence interval of ~10 5 yr), distribute ash broadly enough to have an impact on human society, or allow us to address geologic, climatic, and cultural questions on an intercontinental scale. Here we use geochemical, age, and morphological evidence to show that the Alaskan White River Ash (eastern lobe; A.D. 833–850) correlates to the "AD860B" ash (A.D. 846–848) found in Greenland and northern Europe. These occurrences represent the distribution of an ash over 7000 km, linking marine, terrestrial, and ice-core records. Our results indicate that tephra from more moderate-size eruptions, with recurrence intervals of ~100 yr, can have substantially greater distributions than previously thought, with direct implications for volcanic dispersal studies, correlation of widely distributed proxy records, and volcanic hazard assessment.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
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  • 10
    Publication Date: 2015-08-29
    Description: Polymorphisms in the vascular endothelial growth factor (VEGF)/angiogenesis pathway have been implicated previously in cancer risk, prognosis and response to therapy including in esophageal adenocarcinoma. Prior esophageal adenocarcinoma studies focused on using candidate polymorphisms, limiting the discovery of novel polymorphisms. Here, we applied the tagSNP (single nucleotide polymorphism) approach to identify new VEGF pathway polymorphisms associated with esophageal adenocarcinoma prognosis and validated them in an independent cohort of esophageal adenocarcinoma patients. In 231 esophageal adenocarcinoma patients of all stages/treatment plans, 58 genetic polymorphisms (18 KDR , 7 VEGFA and 33 FLT1 ) selected through tagging and assessment of predicted function were genotyped. Cox-proportional hazard models adjusted for important socio-demographic and clinico-pathological factors were applied to assess the association of genetic polymorphisms with overall survival (OS) and progression-free survival (PFS). Significantly associated polymorphisms were then validated in an independent cohort of 137 esophageal adenocarcinoma patients. Among the 231 discovery cohort patients, 86% were male, median diagnosis age was 64 years, 34% were metastatic at diagnosis and median OS and PFS were 20 and 12 months, respectively. KDR rs17709898 was found significantly associated with PFS (adjusted hazard ratio, aHR = 0.69, 95% confidence interval (CI): 0.53–0.90; P = 5.9E-3). FLT1 rs3794405 and rs678714 were significantly associated with OS (aHR = 1.44, 95% CI: 1.04–1.99; P = 0.03 and aHR = 1.50, 95% CI: 1.01–2.24; P = 0.045, respectively). No VEGFA polymorphisms were found significantly associated with either outcome. Upon validation, FLT1 rs3794405 remained strongly associated with OS (aHR = 1.59, 95% CI: 1.04–2.44; P = 0.03). FLT1 rs3794405 is significantly associated with OS in esophageal adenocarcinoma, whereby each variant allele confers a 45–60% increased risk of mortality. Validation and evaluation of this association in other cancer sites are warranted.
    Print ISSN: 0143-3334
    Electronic ISSN: 1460-2180
    Topics: Medicine
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