Note: Intro -- RECENT ADVANCES IN PROTEOMICS RESEARCH -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- Chapter 1 Protein Level Analysis from Specific Cell Types in Heterogeneous Tissue -- Abstract -- Introduction -- Laser Capture Microdissection and the Proteome -- Immuno-LCM -- Immuno-PCR -- Biobarcoding and Nanoparticles -- Aptamers -- Mass Spectrometry -- Discussion -- Acknowledgments -- References -- Chapter 2 Neuroproteomics and Its Applicationin Drug Addiction Study -- Abstract -- 1. Introduction -- 2. Proteome Dynamics and Complexity in Substance Abuse Research -- 3. Proteomic Techniques -- 4. Bioinformatics -- 5. Challenges and Limitations of Neuroproteomics Approaches -- 6. Protein arrays -- 7. Recent Applications of Neuroproteomics in Research on Nicotine and Other Substances of Abuse -- 8. Proteomics Provides Insights into Mechanisms Underlying Drug Addiction -- Summary and Conclusion -- Acknowledgments -- References -- Chapter 3 Current Proteomics Methods for Analysing the Human Microbiome -- Abstract -- Introduction -- Proteomics in Bacterial Research -- Proteomic Tools -- Protein Identification -- The Limits of Proteomics -- Future Directions -- References -- Chapter 4 Analysis of Pleural Fluid: The Path Travelled with Proteomic Guidance -- Abstract -- 1. Introduction -- 2. Why Proteomics? - Limitations of Microscopic Analysis of Pleural Fluid -- 3. Pre-Analytic and Intra-Analytical Variables of the Pleural Fluid Proteome -- 4. The Pleural Fluid Proteome is a Great Place to Search for Cancer Biomarkers - Why? -- 5. Early Efforts - Challenges and Promising Discoveries -- 6. Cancer Specific Discovery Proteomic Efforts -A Gold Mine of Information -- 7. Secretome Analysis with Pleural Effusion Proteome Study - A Promising Path -- 8. Recent Studies with Mudpit and Other Methods- Many New Biomarker Candidates. , Conclusion -- References -- Chapter 5 Application of Quantitative Proteomics to Disease Diagnosis and Prognosis Using Stable Isotope Dimethyl Labeling Coupled with Shotgun Proteomics Strategy and Multiple Reaction Monitoring -- Abstract -- 1. Introduction -- 2. Proteomic Methodologies and Platforms -- 3. Proteomics Study on Three Exemplar Clinical Cases -- Conclusion -- Acknowledgments -- References -- Chapter 6 Mitochondria Protein Profilingin Striated Muscle: Insights into Pathophysiological Conditions -- Abstract -- 1. Introduction -- 2. Mitochondrial Proteome Characterization in Striated Muscle -- 3. Mitochondrial Proteome Plasticity in Pathophysiological Conditions -- 4. Future Perspectives -- Acknowledgments -- References -- Chapter 7 Structural Mass Spectrometry of Halophilic Proteasomal Nanomachines Using Chemical Cross-Linking -- Abstract -- Introduction -- Structural Mass Spectrometry -- General Principle and Strategies of CXMS -- Characteristics of Cross-Linkers -- Bioinformatics in Cross-Link Identification -- CXMS and Comparative Modeling -- Investigation of Multiprotein Complexes by Methods of Structural Proteomics -- Software to Incorporate CXMS Distance Constraints for Validation of Theoretical Models -- Case Study: The Multiprotein 20S Proteasome Core Particles of Haloarchaea -- Specificity of Halophilic Haloarchaeal CP Nanomachines and Strategy of Its Investigation -- Use of Cross-Linking Distance Constraints to Optimize Models of Halophilic Multisubunit Complexes on a Routine Basis -- Conclusion -- Acknowledgments -- References -- Chapter 8 Introduction to Protein Arrays and their Application to Nicotine Research in Macrophages -- Abstract -- Introduction -- Designs of Protein Arrays -- Array Data Processing and Analysis -- Application of Protein Arrays to Nicotine Research -- Conclusion and Prospective -- References. , Chapter 9 Quantitative Proteomic Approaches for Environmental Toxicology -- Abstract -- Introduction -- 1. Overview of Proteomic Techniques -- Conclusion and Prospective -- References -- Chapter 10 Toxin Proteomics for the Identification and Differentiation of Botulinum Neurotoxins -- Abstract -- Abbreviations -- Introduction -- Botulinum Neurotoxin Serotype Identification by Mass Spectrometry -- Neurotoxin-Associated Proteins Identification with Mass Spectrometry -- Serotype Detection of Bont in Complex Matrices -- Mass Spectrometry-Based Differentiation of Bont at the Subtype/Toxin Variant Level -- Conclusion and Future Directions -- References -- Chapter 11 Challenges of Mining Low to Medium Abundant Proteins for Proteomics -- Abstract -- 1. Introduction -- Removal of Contaminants -- Common Highly Abundant Proteins in Plant/Animal Tissues -- Removal of Highly Abundant Proteins in Plant/Animal Tissues -- Conclusion -- Acknowledgments -- References -- Index.

Note: Intro -- Preface -- Contents -- List of Contributors -- Part 1: General Properties of T-Type Ca2+ Channels -- 1: Physiology and Pathology of Voltage-Gated T-Type Calcium Channels -- 1.1 Structural Features of T-Type Channels -- 1.2 T-Type Channels Are Optimized for Regulating Cellular Excitability -- 1.3 Pharmacology of T-Type Channels -- 1.4 Roles in Secretion and Contraction -- 1.5 Cell Division and Cancer -- 1.6 Hypertension and Cardiac Hypertrophy -- 1.7 Sleep Disturbances, Epilepsy, and Autism Spectrum Disorders -- 1.8 Neuropathic Pain -- Conclusions -- References -- 2: Regulation of T-Type Ca2+ Channels by Intercellular and Intracellular Signals -- 2.1 Introduction -- 2.2 Intercellular Signals -- 2.2.1 Glucose -- 2.2.2 Cytokines -- 2.2.3 Hormones -- 2.2.3.1 Testosterone -- 2.2.3.2 Estrogen -- 2.2.3.3 Aldosterone/Angiotensin II -- 2.2.3.4 IGF-I -- 2.2.4 Anandamide -- 2.2.5 Nitric Oxide/Nitrous Oxide -- 2.2.6 Zinc -- 2.3 Intracellular Signals -- 2.3.1 Heterotrimeric G-Protein -- 2.3.2 Rho-Associated Kinase -- 2.3.3 Protein Kinase C -- 2.3.4 ATP -- 2.3.5 cAMP and Protein Kinase A -- 2.3.6 Ca2+ and Ca2+/Calmodulin-Dependent Kinase II -- 2.3.7 Tyrosine Kinase -- 2.3.8 Transcription Factors -- Conclusions -- References -- 3: Pharmacological Profiles of T-Type Calcium Channel Antagonists -- 3.1 Introduction -- 3.2 Existing T-Type Calcium Channel Blockers -- 3.2.1 Mibefradil -- 3.2.2 Dihydropyridine Derivatives -- 3.2.3 Antiepilepsy Agents -- 3.3 T-Type Calcium Channel Blockers Under Clinical Development -- 3.3.1 Mibefradil (Redevelopment) -- 3.3.2 Z-944 -- 3.4 T-Type Calcium Channel Blockers Under Preclinical Research -- 3.4.1 A-1048400 -- 3.4.2 TTA-A2, TTA-P2 -- 3.4.3 KST-5468 -- 3.4.4 KYS05090 -- 3.4.4.1 2-(1-Alkylpiperidin-4-yl)-N-[(1R)-1-(4-Fluorophenyl)-2-Methylpropyl] Acetamide Derivatives -- 3.4.5 R(-)-Efonidipine. , 3.4.5.1 N-[[1-[2-(Tert-Butylcarbamoylamino)Ethyl]-4-(Hydroxymethyl)-4-Piperidyl]Methyl]-3,5-Dichloro-Benzamide -- 3.4.6 Mibefradil Derivatives -- Conclusions -- References -- Part 2: Role of T-Type Ca2+ Channels in Disease -- 4: Role of T-Type Calcium Channels in Neuroendocrine Differentiation -- 4.1 Introduction -- 4.2 Features of NE Cells and NE Differentiation -- 4.3 Activation of NE Differentiation -- 4.3.1 Cell Models -- 4.3.2 Signalling Pathways -- 4.4 Alterations in Calcium Homeostasis -- 4.5 Expression of Voltage-Dependent Calcium Channels -- 4.5.1 Neuroblastoma Cell Lines -- 4.5.2 Retinoblastoma Cells -- 4.5.3 Embryonic Stem Cells -- 4.5.4 NE Cell Lines -- 4.6 Role of T-Type Calcium Channels in NE Differentiation -- 4.6.1 Role in the Expression of Molecular NE Markers -- 4.6.2 Role in Neuritic Extension -- 4.6.3 Role in Hormone or Neurohormone Secretion -- 4.7 How Do T-Type Calcium Channels Mediate NE Differentiation? Putative Signalling Mechanisms -- 4.8 Other Calcium Channels -- 4.9 NE Differentiation in Cancer Progression: Perspectives on the General Involvement of T-Type Calcium Channels -- Concluding Remarks -- References -- 5: Regulation of Cardiac Hypertrophy by T-Type Ca2+ Channel -- 5.1 Physiological Roles of Myocardial Ca2+ Channels -- 5.2 T-Type Ca2+ Channel Involvement in Myocardial Hypertrophy and Heart Failure -- 5.2.1 Initiation of Hypertrophy by Angiotensin II and Norepinephrine -- 5.3 Potential Role of T-Type Ca2+ Channels in Development of Pathological Hypertrophy -- Conclusions -- References -- 6: Role of T-Type Ca2+ Channels in the Development of Arrhythmias and Ischemia-Reperfusion Injury -- 6.1 Ionic Currents Involved in Diastolic Depolarization -- 6.2 Role of L-Type Ca2+ Channel in Action Potential Upstroke and Diastolic Depolarization -- 6.3 Role of T-Type Ca2+ Channel in Diastolic Depolarization. , 6.4 T-Type Ca2+ Channels in AV Nodal, Purkinje, and Bundle of His Cells -- 6.5 Role of L-Type and T-Type Ca2+ Channels in Atrial Remodeling -- 6.6 Role of L-Type and T-Type Ca2+ Channels in Ischemic Injury -- Conclusions -- References -- 7: Link Between Absence Seizures and T-Type Calcium Channels -- 7.1 Introduction -- 7.2 Low-Threshold Calcium Current from T-Type Calcium Channels Gene Is Involved in the Formation of Absence Seizures -- 7.2.1 Calcium-Dependent Burst Firing, Driven by T-Type Calcium Currents, Is Necessary for the Genesis of Spike-Wave Discharge ... -- 7.2.2 Absence Seizure Animal Model GAERS Has Alternative Alpha1 H Transcripts and Selectively Increases T-Current in RT Neurons -- 7.2.3 The Absence Seizures Associated with Mutations of Cacna1a, and Cacna1a´s Ancillary Calcium Channel Subunits in Mice Are ... -- 7.2.4 Mice with Genetically Modified T-Type Calcium Channels Show Aberrant t-Current Implicated in the Genesis of Absence Seiz... -- 7.2.4.1 Cav3.1 Genetically Modified Mice -- 7.2.4.2 Knockout of Cav3.2 -- 7.2.4.3 Knockout of Cav3.3 -- 7.2.5 Antiseizure Drugs and T-Type Calcium Channel -- 7.3 Genetics of Absence Seizure -- 7.3.1 CACNA1H Is a Susceptibility Gene of Idiopathic Epilepsy -- 7.3.1.1 Variants of CACNA1H Gene Detected in Patients with CAE -- 7.3.1.2 Variants Detected in Other Types of Idiopathic Epilepsy -- 7.3.1.3 Variations in CACNA1G and CACNA1I in Patients with CAE -- 7.4 Alternative Transcripts of Cacna1h Gene May Be Major Factors Implicated in the Formation of Complex Absence Seizures -- Conclusions and Future Directions -- References -- 8: Regulation of T-Type Ca2+ Channels in Cancer Cell Cycle -- 8.1 Calcium and Cell Proliferation -- 8.2 T-Type Calcium Channels in Cell Proliferation -- 8.3 T-Type Calcium Channels in Cancer Cell Proliferation -- 8.4 Targeting T-Type Calcium Channels in Oncology -- References. , 9: T-Type Calcium Channels and Management of Pain -- 9.1 Introduction -- 9.2 T-Type Calcium Channel in Nociception -- 9.3 T-Type Calcium Channels in Pain Models -- 9.4 Dual Use of T-Type Calcium Channels in Diseases -- Conclusions -- References -- 10: Role of T-Type Ca2+ Channels in Basal Insulin Release -- 10.1 Introduction -- 10.2 T-Type Ca2+ Channels Are Upregulated by Chronic High Glucose -- 10.3 T-Type Ca2+ Currents Enhance Excitability of Pancreatic beta-Cells -- 10.4 T-Type Ca2+ Currents Modify Basal [Ca2+]i of Pancreatic beta-Cells -- 10.5 T-Type Ca2+ Channels Sustain a Small Current Near the Resting Potential of beta-Cells -- 10.6 Changes in Basal [Ca2+]i Regulate Trafficking of L-Type Ca2+ Channels On/Off Cytoplasmic Membrane -- 10.7 Biophysical Kinetics of L- and T-Type Ca2+ Channels Are Altered by Changes in Basal [Ca2+]i -- 10.8 Changes in Basal [Ca2+]i Regulate Basal Insulin Release -- 10.9 The T-Type Ca2+ Channel Upregulation Hypothesis of Insulin Resistance -- References -- Index.

Note: Intro -- NEW DEVELOPMENTS IN SEROTONIN RESEARCH -- NEW DEVELOPMENTS IN SEROTONIN RESEARCH -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- Chapter 1: Significant Contribution of Variants in Serotonin Transporter and Receptor Genes to Drug Addiction Through Gene-by-Gene Interaction -- Abstract -- Genetic Epidemiology of Nicotine Dependence and Alcoholism -- Serotonin Transporter and Receptor Genes in Humans -- Contribution of Variants in Serotonin Transporter and Receptor Genes to Nicotine Addiction -- Contribution of Variants Serotonin Transporter and Receptor Genes to Alcoholism -- Contribution of Variants in Serotonin Transporter and Receptor Genes to Addictions Through -- Gene-Gene Interaction -- Comparison of Main Verse Interactive Effect of Variants in Serotonin Transporter and Receptors on ND -- Comparison of Main versus Interactive Effect of Variants in Serotonin Transporter and Receptors on AD -- Conclusion -- References -- Chapter 2: The Serotonergic Network and Sudden Infant Death Syndrome -- Abstract -- Introduction -- Serotonin Transporter -- Monoamine Oxidase A -- Serotonergic Receptors -- Tryptophan Hydroxylase -- Human Fifth Ewing Variant -- PHOX2B -- Conclusion -- References -- Chapter 3: Influence of Environmental and Social Stress Factors on Distribution of Serotonin in the Brain and Development of Killer and Self-Killer Organisms -- Abstract -- Introduction -- Conclusion -- References -- Chapter 4: Recent Discoveries on Serotonin Developmental Functions: What We Learned from Xenopus -- Abstract -- 1. Introduction: An Overview -- of Serotonin Diverse Functions -- 2. Xenopus, a Non-Mammalian -- Tetrapod Model System -- 3. Serotonin Developmental Functions: -- What We Learned from Xenopus -- Establishment of Left/Right Asymmetry -- Developmental Role of 5-HT2B Receptor. , 5-HT2B Receptor in Eye Morphogenesis -- Shaping the First Branchial Arch: Requirement of Serotonin Signaling in Craniofacial Morphogenesis and Jaw Joint Formation -- Conclusion -- References -- Chapter 5: Effect of Serotonin on Exotrophy Processes in Fish -- Abstract -- Introduction -- 1. Localization of Serotonin -- 2. The Functions of Serotonin -- 3. Regulation of Feeding Behavior -- 4. Regulation of Digestive Processes -- Conclusion -- Acknowledgments -- References -- Chapter 6: Engagement of Serotonin-Modulating Anticonsolidation Protein in Memory Formation and Suppression of Drug Addiction and Epileptic Seizures -- Abstract -- Introduction -- 1. Participation of SMAP in Memory Formation -- 2. Engagement of Smap in Drug Addiction -- 3. Role of Smap in the Action and Suppression of Epileptic Seizures -- Conclusion -- References -- Chapter 7: Participation of Serotonin-Modulating Anticonsolidation Protein in Regulation of Mutagenesis and Adaptation -- Abstract -- Introduction -- 1. SMAP Possessing with Antimutagenic Activity -- 2. Role for SMAP in Processes of Adapatation and Disadaptation -- Discussion -- Conclusion -- References -- Index.

Note: Intro -- Preface -- Contents -- 1 Introduction -- 1.1 Study on the Formation of Lithological Reservoirs -- 1.2 The Core Technology of Lithological Reservoir Exploration -- 1.3 Reservoir Prediction Technology Based on the Geological Concept and Quantitative Model -- References -- 2 Geophysical Exploration Methods for Lithological Reservoirs -- 2.1 Method Thinking -- 2.2 High-Resolution Sequence Stratigraphy -- 2.2.1 Sedimentary Background Analysis -- 2.2.2 Contrast of Sequence Division -- 2.2.3 Sequence Interface Tracking Closure -- 2.2.4 Identification of Seismic Sequence Interface -- 2.2.5 Identification of Drilling/Logging Sequence Interface -- 2.3 Sequence Constrained Reservoir Prediction Techniques -- 2.3.1 Reservoir Characteristic Curve Reconstruction -- 2.3.2 Seismic Attributes Analysis -- 2.3.3 Interpretation of Inversion Data -- 2.4 Cognition and Conclusion -- References -- 3 Lithological Reservoir Exploration Technology -- 3.1 Research of Sequence Stratigraphy -- 3.1.1 Sequence Level and Its Geological Significance -- 3.1.2 Procedures for the Study of Sequence Stratigraphy -- 3.2 Seismic Attribute Analysis Technology -- 3.2.1 Seismic Attribute Classification -- 3.2.2 Seismic Attribute Analysis -- 3.3 Coherent Volume Technique -- 3.3.1 Coherent Volume Concept -- 3.3.2 Fundamental Principles of Coherence Computation -- 3.3.3 Technical Processes and Procedures -- 3.4 3D Visualization and Virtual Reality Technology -- 3.4.1 Concepts and Principles of 3D Visualization -- 3.4.2 Basic Visualization Methods -- 3.4.3 Visualization of Full 3D Interpretation Technology -- 3.4.4 Virtual Reality Technology -- 3.5 Seismic Inversion Technique -- 3.5.1 Concepts and Classification of Seismic Inversion -- 3.5.2 Basic Principles and Application Conditions of Seismic Inversion -- 3.5.3 Comparison of Different Seismic Inversion Methods. , 3.5.4 Reconstruction Method of Reservoir Characteristics -- 3.5.5 Seismic Inversion and Sequence Stratigraphy -- References -- 4 Realization and Application of Geophysical Technologies for Lithological Reservoirs -- 4.1 Realization of Geophysical Technologies for Lithological Reservoirs -- 4.1.1 High-Resolution Sequence Stratigraphy and Prediction and Evaluation of Lithological Traps -- 4.1.2 Seismic Imaging and Identification of Concealed Geological Bodies -- 4.1.3 Prediction Technology of Reservoir Pore Growing Zone -- 4.1.4 Main Understanding -- 4.2 Application of Geophysical Technologies for Lithological Reservoirs in Yingtai Area -- 4.2.1 Analysis of Geological Background in the Study Area -- 4.2.2 Establishment of Stratigraphic Sequence Framework -- 4.2.3 Division of Stratigraphic Sequence -- 4.2.4 Study on Sedimentary System -- 4.2.5 Reservoir Inversion -- 4.2.6 Oil and Gas Distribution and Prediction of Favorable Facies Zones -- 4.3 Cognition and Conclusion -- References -- Index.

Note: Intro -- Foreword -- Series Preface -- Contents -- Editors' Introduction to the Volume -- Neurodevelopmental Genomic Strategies in the Study of the Psychosis Spectrum -- Introduction -- The Course of Psychosis -- Brain Behavior Endophenotypes in the Study of Psychosis -- Neurocognition -- Neuroimaging -- Community-Based Psychosis Spectrum Approach -- The Philadelphia Neurodevelopmental Cohort -- Psychosis Spectrum Features -- Neurocognition and Psychosis Spectrum -- Neuroimaging Measures in Psychosis Spectrum -- Genetically Informative: 22q11.2 Deletion Syndrome -- Psychosis Spectrum Features in 22q11.2 Deletion Syndrome -- Neurocognition in 22q11.2 Deletion Syndrome -- Neuroimaging in 22q11DS -- Further Links to Genomics -- Implications for the Study of Psychosis -- References -- Alterations in Prefrontal Cortical Circuitry and Cognitive Dysfunction in Schizophrenia -- Schizophrenia as a Disorder of Cognition -- DLPFC as a Locus of Pathology in Schizophrenia -- Potential Mechanisms Underlying Dendritic Spine Deficits in Schizophrenia -- Components of DLPFC Neural Circuitry that Generate Gamma Oscillations Are Altered in Schizophrenia -- Explanatory Models of DLPFC Layer 3 Circuitry Alterations and Gamma Oscillation Impairments in Schizophrenia -- References -- Visual Perception Disturbances in Schizophrenia: A Unified Model -- Introduction -- Altered Subjective Visual Experience in Schizophrenia -- Laboratory Psychophysical Studies of Visual Processing2 in Schizophrenia -- Contextual Modulation: An Integrated Model of Visual Impairment in Schizophrenia -- What Does the World Look Like for People with Schizophrenia? -- Conclusions and Future Directions -- References -- Avolition, Negative Symptoms, and a Clinical Science Journey and Transition to the Future -- Introduction -- The Negative Symptom Construct. , Primary vs. Secondary Negative Symptoms and "Deficit Schizophrenia" -- Special Issues Relating to Negative Symptom Therapeutics -- Negative Symptom Assessment -- Negative Symptoms Are a Multidimensional Construct -- Dimensional vs. Categorical Structure of Negative Symptoms -- Summary and Conclusions -- References -- An Affective Neuroscience Model of Impaired Approach Motivation in Schizophrenia -- Overview -- Overview: A New Model of Impaired Approach Motivation in Schizophrenia -- Part I: Emotion Generation and Emotion Regulation -- Emotion Generation -- Insight from the Evaluative Space Model -- Insight from the Modal Model of Emotional Experience -- Emotion Regulation -- Emotional Memory -- Schema/Hedonic Beliefs -- Part II: Reward Processing and Dysfunctional Corticostriatal Interactions -- Reinforcement Learning -- Reward Anticipation -- Value Representation -- Effort-Cost Computation -- Uncertainty-Driven Exploration -- Reward Processing Summary -- Overall Model Summary and Conclusions -- References -- Multimodal Brain and Behavior Indices of Psychosis Risk -- Introduction -- A Brief Overview of the Origins of Neuropsychology -- The Clinical-Pathological Correlation Method -- Neuropsychological Testing -- Neuroimaging Effects on Neuropsychology -- The Development of Computerized Neurocognitive Testing -- Findings from the PNC -- Summary and Future Directions -- References -- Changing the Diagnostic Concept of Schizophrenia: The NIMH Research Domain Criteria Initiative -- Historical Perspective on the Diagnostic Concept of Schizophrenia -- RDoC: Rationale and Principles -- Dimensional Conceptualizations of Schizophrenia -- Across-Disorders Dimensions -- Integration Across Multiple Units of Analysis -- Neurodevelopment -- Summary and Future Directions -- References -- Index.

Note: Includes bibliographical references

Note: Description based on publisher supplied metadata and other sources

Note: Description based on publisher supplied metadata and other sources