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  • 1
    ISSN: 1436-2813
    Schlagwort(e): Key Words: malignant gastrinoma ; multimodality treatment ; liver transplantation ; review
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    ISSN: 1436-2813
    Schlagwort(e): liver transplantation ; Cyclosporin A
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Liver transplantation has gained increasing interest. While liver grafting for tumor is successful over prolonged periods only in its early course, liver grafting for end-stage cirrhosis may lead to a long survival. Liver grafting in children is the most successful indication; in adults the results depend largely on timing and indication. Actual developments are mainly seen in the following points: a. Improvement in immunosuppression by use of Cyclosporin A. The resorption and metabolism of the drug, in relation to liver function, have to be carefully observed. b. The tendency to perform liver grafting electively instead of in emergency. c. Improvement in operative management, particularly the use of veno-venous bypass. d. The best possible anaesthesiological and intensive care management for the patients. It can be expected, that these developments will enable continuous improvement of results, particularly in an elective situation. One hundred and forty liver grafts have been done in our institution and the results are discussed herein. Progress in liver transplantation is marked by steadily growing numbers of liver grafts performed, and of centers performing grafts, as well as by improved success rates and the recommendation of the U.S. National Institutes of Health, based on discussions at a liver transplantation consent meeting, held in June 1983. This interest is also reflected in discussions among the medical and non-medical community. The first section of this paper will deal with the present state and results of liver grafting particularly, at our own institution and some actual developments in this field will be discussed.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    ISSN: 1432-2277
    Schlagwort(e): Preservation, liver endothelial cells ; Liver endothelial cells, preservation ; Endothelial cells, liver, preservation ; Preservation solutions
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Previously, we demonstrated an energy-dependent injury to cultured liver endothelial cells during cold incubation in University of Wisconsin (UW) solution. Here, the effects of Histidine-Tryptophan-Ketoglutarate (HTK) and Euro-Collins (EC) solutions on these cells were studied. In HTK solution, 83%±4% of the cells had lost viability after 9 h of incubation at 4°C. The addition of cyanide (1 mM) to simulate hypoxic conditions protected the cells to the extent that only 9%±1% of the cells lost viability over the same period; the addition of glucose (10 mM) led to increased cell injury. ATP levels were highest in the incubations with the most rapid loss of viability. In Krebs-Henseleit buffer and EC solution, in contrast, cell injury increased upon addition of cyanide; the addition of glucose to Krebs-Henseleit buffer decreased injury. We conclude that the injury to cultured liver endothelial cells during cold incubation in HTK solution is energy-dependent, as it is in UW solution, whereas cells behave differently in EC solution and Krebs-Henseleit buffer.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    CardioVascular & interventional radiology 19 (1996), S. 242-247 
    ISSN: 1432-086X
    Schlagwort(e): Key words: Liver transplantation—Biliary complications—Bile ducts—Interventional procedures
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Purpose: Biliary complications contribute significantly to morbidity and mortality in the liver transplant recipient. Surgery has been the mainstay of therapy, but interventional radiological techniques have made significant progress. Methods: Diagnostic percutaneous transhepatic cholangiography (PTC) was performed in 12 patients; percutaneous transhepatic drainage (PTD) was performed in 10 patients. Additional interventional procedures included laser lithotripsy, biopsy, dilatation, and stent implantation. Results: In 6 patients PTC revealed anastomotic, and in 6 patients nonanastomotic biliary strictures. Four patients had intrahepatic stones. Biliary strictures were treated by implantation of Palmaz stents in 5 of 6 patients with anastomotic strictures, and in 3 of 6 patients with nonanastomotic strictures. The intrahepatic stones were fragmented with dye laser lithotripsy under cholangioscopic control in 3 of 4 patients. One spontaneous stent migration after 24 months and one stent occlusion were observed; the remaining stents are still patent. Patients with anastomotic strictures had a more favorable outcome: 5 of 6 of these patients are still alive and symptom-free after an average of 27.4 months, but only 3 of 6 patients with nonanastomotic strictures are alive after an average of 9.8 months. Conclusion: The different outcomes in patients with anastomotic versus nonanastomotic strictures may be explained by the different causes of these types of stricture.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    ISSN: 1432-2323
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé Pour traiter le cancer de la partie supérieure de l'arbre biliaire la stratégie actuelle des auteurs est de procéder à l'exérèse radicale de la tumeur ou de pratiquer une transplantation lorsque la tumeur ne peut Être réséquée dès lors qu'il n'y a pas d'extension extra-hépatique du processus tumoral. L'exérèse de la tumeur est effectuée par résection isolée du hile biliaire ou résection associée de la lésion et d'un segment du foie; cette dernière méthode qui s'applique aux cancers plus étendus est recommandée car plus radicale. Leur conception repose sur leur expérience concernant 108 cas opérés de février 1975 à octobre 1986. Chez 10 malades aucune intervention radicale ou palliative ne put Être pratiquée en raison du stade avancé de la tumeur. Chez 30 patients: différentes opérations de drainage furent pratiquées. En revanche, 52 sujets subirent une exérèse: 25 une résection biliaire, 27 une résection du hile associée à une hépatectomie partielle; 28 de ces résections étant considérées comme opération palliative, 24 comme palliative. Seize malades qui présentaient une lésion inacessible à l'exérèse ont été traités par une transplantation hépatique mais 7 d'entre eux accusèrent ultérieurement une extension extra-hépatique du processus tumoral. Les temps de survie furent de 1 mois après laparotomie, 5 mois après intervention de drainage, 15 mois après résection, 23 mois après opération dite curative, 7 mois après opération dite palliative, 21 mois après transplantation chez 7 malades. En raison des résultats favorables chez les derniers malades, la transplantation hépatique constitue pour les auteurs l'ultime chance de traitement radical des patients qui relèveraient autrement d'une opération palliative de drainage du fait de l'importance de la tumeur.
    Kurzfassung: Resumen Nuestra estrategia actual en el tratamiento del adenocarcinoma de la porción proximal del canal biliar es la resección radical del tumor y, para los pacientes con tumores no resecables, la posibilidad de trasplante hepático si se ha demostrado que no hay crecimiento tumoral extrahepático. La resección tumoral es realizada mediante la resección del hilio solamente o combinada con hepatectomía parcial. Este Último procedimiento, que hace posible el tratamiento radical de los estados tumorales más avanzados y que eventualmente logra un mayor grado de radicalidad, es el recomendado. El concepto se fundamenta en la experiencia con 108 pacientes con carcinoma del canal biliar proximal operados entre febrero de 1975 y octubre de 1986. En 10 pacientes no fue posible realizar procedimiento alguno de tipo terapéutico o paliativo durante la laparotomía debido al avanzado estado del tumor. Diversos procedimientos de drenaje fueron ejecutados en 30 pacientes. Cincuenta y dos pacientes fueron sometidos a resección, 25 con resección del hilio solamente, 27 con resección combinada con resección parcial del hígado; 28 de las resecciones fueron clasificadas como curativas y 24 como paliativas; 16 pacientes con tumores no resecables reciberion trasplante hepático, y en 7 de ellos había crecimiento tumoral extrahepático en el momento del trasplante hepático. Las supervivencias medias fueron: laparotomía, 1 mes; procedimientos de drenaje, 5 meses; resección total, 15 meses; resección curativa, 23 meses; resección paliativa, 7 meses; trasplante hepático, 16 meses. Siete pacientes se hallan vivos a los 21 meses posttrasplante. Con base en los resultados favorables en el grupo más reciente de nuestros pacientes, el trasplante de hígado como la Última posibilidad de remoción del tumor en pacientes que no podrían ser tratados sino mediante procedimientos paliativos de drenaje, puede estar justificado.
    Notizen: Abstract In the treatment of adenocarcinoma of the proximal bile duct, our current strategy is to resect the tumor radically and to offer patients with unresectable tumors the chance of hepatic transplantation, if extrahepatic tumor growth is exluded. Tumor resection is performed by resection of the hilum alone or combined with partial hepatectomy. The latter procedure enables radical treatment of more advanced tumor stages and, eventually, a higher degree of radically is achieved, and is recommended. This concept is based on our experience with 108 patients with proximal bile duct carcinoma operated on between February, 1975 and October, 1986. In 10 patients, no therapeutic or palliative surgical procedure could be performed during laparotomy because of advanced tumor stage. In 30 patients, various drainage procedures were performed. Fifty-two patients underwent resection: 25 underwent resection of the hilum only, and 27 underwent resection of the hilum combined with partial liver resection. Twenty-eight of these resections were classified as curative and 24 as palliative. Sixteen patients with unresectable tumors had hepatic transplantation. In 7 of these patients, extrahepatic tumor growth was already present at the time of liver transplantation. Median survival times were: laparotomy only, 1 month; drainage procedures, 5 months; total resection, 15 months; curative resection, 23 months; palliative resection, 7 months; liver grafting, 16 months. Seven patients are alive up to 21 months posttransplantation. On the basis of favorable results in our more recent group of patients, liver grafting as the ultimate chance for tumor removal in patients otherwise treatable only by palliative drainage procedures may be justified.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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