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  • 1
    Online Resource
    Online Resource
    Handbook of Clinical Electrophysiology of Vision (2019)
    Cham : Springer International Publishing | Cham : Imprint: Springer
    Details Availability
    Keywords: Human physiology ; Ophthalmology ; Eye Diseases physiopathology ; Eye Diseases diagnosis ; Vision, Ocular physiology ; Electroretinography methods ; Electrooculography methods ; Electrophysiological Phenomena
    Description / Table of Contents: This book provides an analytical and thorough review of clinical electrophysiology of vision, and the progress made in the field in the past decade. Handbook of Clinical Electrophysiology of Vision is designed to aid the readers in understanding the types of electrophysiologic tests that should be used in specific diseases, how to explain the results of these exams, and how to perform the tests of clinical electrophysiology of vision. Concise in format, the Handbook of Clinical Electrophysiology of Vision is divided into two sections that discuss a wide range of relevant topics, such as technology of electroretinography, electrooculography, visual evoked potential, characteristics of electroretinography in retinal diseases, and the characteristics of optic nerve diseases. Part one begins with a discussion on the basic theory of electrophysiology of vision, illustrating physiologic sources of electrophysiological responses, the techniques of the recording, and analysis of electrophysiologic signals. Part two then dives into the clinical application of electrophysiology of vision, and subsequently summarizes the characteristics of the electrophysiological signals in a number of disorders of retina and optic nerve. Written by experts in the field, Handbook of Clinical Electrophysiology of Vision is an invaluable resource for ophthalmologists, optometrists, electrophysiologists, residents, fellows, researchers, technicians and students in ophthalmology, optometry and vision science.
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource(IX, 219 p. 109 illus., 83 illus. in color.)
    Edition: 1st ed. 2019.
    ISBN: 9783030304171
    Series Statement: Springer eBook Collection
    URL: https://doi.org/10.1007/978-3-030-30417-1
    DOI: 10.1007/978-3-030-30417-1
    Language: English
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  • 2
    Online Resource
    Online Resource
    Handbook of Clinical Electrophysiology of Vision. (2019)
    Cham :Springer International Publishing AG,
    Details
    Keywords: Vision. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (218 pages)
    Edition: 1st ed.
    ISBN: 9783030304171
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=6001944
    Language: English
    Note: Intro -- Preface -- Contents -- Contributors -- Part I: Basic Theory of Electrophysiology of Vision -- Chapter 1: Electroretinography -- Components of ERG -- Types of ERG -- Full-Field ERG -- Dark-Adapted Rod-Driven Scotopic and Mixed Flash ERGs -- Light-Adapted Cone-Driven ERG -- Pattern ERG -- Multifocal ERG -- Focal Flash ERG -- Electrodes, Stimulation, and Recording Methods -- ERG Electrodes -- Stimulation -- Recording Method -- Dilation, Dark Adaptation, and Topical Anesthesia -- Testing Infants -- Advanced Analysis of ERG Data -- Intensity-Response Function of ERG B-Wave -- Oscillatory Potentials (OPs) Analysis -- References -- Chapter 2: Visually Evoked Potentials -- Origins of VEP Components -- Electrode Placement -- Amplifier and Analysis -- Types of VEP -- Steady-State and Transient VEP -- Flash and Pattern VEP -- Multifocal VEP -- Clinical Protocol -- References -- Chapter 3: Electrooculography -- Origin of EOG -- Placement of Recording Electrodes, Parameters of Amplifier, and Stimulation -- Recording Procedure -- References -- Part II: Clinical Application of Electrophysiology of Vision -- Chapter 4: Congenital Non-Degenerative Retinal Diseases -- Night-Blinding Disorders (Fig. 4.1) -- Congenital Stationary Night Blindness -- Oguchi Disease -- Fundus Albipunctatus -- Photophobia Disorders -- Achromatopsia (ACHM) and Blue Cone Monochromatism (BCM) -- Phenotypes Associated with Mutations in the Paired Box 6 Gene -- References -- Chapter 5: Macular Dystrophies -- Stargardt's Disease/Fundus Flavimaculatus -- X-Linked Retinoschisis -- Vitelliform Macular Dystrophy (Best's Disease) -- Pattern Dystrophies/Macular Pattern Dystrophy (MPD) -- Doyne's Honeycomb Macular Dystrophy (Malattia Leventinese) -- Occult Macular Dystrophy -- North Carolina Macular Dystrophy (NCMD) -- References. , Chapter 6: Degenerative Night-Blinding Disorders and Cone and Cone-Rod Dystrophies -- Retinitis Pigmentosa -- Leber's Congenital Amaurosis/EORP/SECORD -- Enhanced S-Cone Syndrome -- Choroideremia -- Gyrate Atrophy of Choroid and Retina -- Late-Onset Retinal Degeneration (L-ORD) -- Bietti's Crystalline Dystrophy -- Cone Dystrophies -- Cone-Rod Dystrophies -- References -- Chapter 7: Syndromic Disorders -- Hearing Loss Syndromes -- Usher Syndrome -- Refsum Disease -- Wolfram Syndrome (DIDMOAD) -- Mitochondrial Diseases -- Kearns-Sayre Syndrome -- Neuropathy-Ataxia-Retinitis Pigmentosa Syndrome -- Maternally Inherited Diabetes and Deafness Syndrome -- Obesity Syndromes -- Bardet-Biedl Syndrome -- Alström Syndrome -- Cohen Syndrome -- Other Syndromes -- Cockayne Syndrome -- Alagille Syndrome (Arteriohepatic Dysplasia) -- Senior-Loken Syndrome -- Joubert Syndrome -- Metabolic Disorders -- Abetalipoproteinemia (Bassen-Kornzweig Syndrome) -- Neuronal Ceroid Lipofuscinoses (Batten's Disease) -- Mucopolysaccharidosis -- References -- Chapter 8: Characteristics of Visual Electrophysiology in Inflammatory Disorders -- Acute Zonal Occult Outer Retinopathy (AZOOR) -- Multiple Evanescent White Dot Syndrome -- Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE) -- Birdshot Chorioretinopathy -- Autoimmune Retinopathy and Neuroretinopathy -- References -- Chapter 9: Characteristics of Visual Electrophysiology in Retinal Toxicities -- Vigabatrin -- Hydroxychloroquine (Plaquenil) and Chloroquine -- Antipsychotics -- Cis-Platinum -- Deferoxamine -- Digoxin -- Ethambutol -- Indomethacin -- Isotretinoin -- Ocular Siderosis -- Phosphodiesterase (PDE) Type 5 Inhibitors (Erectile Dysfunction Medication) -- Quinine -- References -- Chapter 10: Characteristics of Visual Electrophysiology in the Diseases of Optic Nerve or Visual Pathway -- Multiple Sclerosis. , Ischemic Optic Neuropathy -- Optic Neuritis -- Optic Nerve Hypoplasia -- Traumatic Optic Neuropathy -- Neurofibromatosis -- Optic Nerve Toxicities -- Ethambutol -- Neonatal Hyperbilirubinemia -- Radiotherapy -- Leber's Hereditary Optic Neuropathy -- Amblyopia -- References -- Chapter 11: Characteristics of Visual Electrophysiology in Albinism -- References -- Index.
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  • 3
    Electronic Resource
    Electronic Resource
    Identification of the gene that, when mutated, causes the human obesity syndrome BBS4 (2001)
    [s.l.] : Nature Publishing Group
    Nature genetics 28 (2001), S. 188-191 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Bardet–Biedl syndrome (BBS, MIM 209900) is a heterogeneous autosomal recessive disorder characterized by obesity, pigmentary retinopathy, polydactyly, renal malformations, mental retardation, and hypogenitalism. The disorder is also associated with diabetes mellitus, hypertension, and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/88925
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  • 4
    Electronic Resource
    Electronic Resource
    Clinical heterogeneity of dominant optic atrophy: the contribution of visual function investigations to diagnosis (1994)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 232 (1994), S. 717-727 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract • Background: The variability of the visual function impairment in dominant optic atrophy (DOA) makes it difficult to diagnose the disease within genealogies. Physiologic investigations were conducted on a family with DOA to evaluate methods of detecting clinical and subclinical signs in obligate heterozygotes, in order to identify affected subjects within the genealogy and to formulate the individual and reproductive risks • Methods: Investigations included tests for color vision, contrast sensitivity function (CSF), kinetic and static computerized perimetry, transient pattern reversal visual evoked potentials (VEPs) and steady-state flash VEPs • Results: Eight subjects from the pedigree were diagnosed as having DOA. Two of them were unaware of their affection, and six showed wide clinical variability. CSF paralleled the central visual impairment, but was also slightly impaired in the two unaware subjects. Static computerized perimetry disclosed mild sensitivity defects in the central visual fields in these two patients. VEPs showed heteregeneous results as well, ranging from normal findings to severely altered tracings • Conclusions: This investigation suggests that combined clinical and functional evaluation is necessary to diagnose DOA. Particularly, the combined use of computerized perimetry, CSF, and VEPs allowed the identification of cases at a subclinical stage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00184274
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  • 5
    Electronic Resource
    Electronic Resource
    Low-noise electroretinogram recording techniques in retinitis pigmentosa (1994)
    Springer
    Documenta ophthalmologica 88 (1994), S. 27-37 
    Details
    ISSN: 1573-2622
    Keywords: Electroretinogram ; Electrophysiology ; Retinitis pigmentosa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The achievement of a sharp retinal signal depends on many factors, particularly the stability of the electrodes on the corneal surface, the maximal reduction of electrical and electromagnetic disturbances and the avoidance of the noise caused by events that are synchronous with the stimulation. The availability of a low-noise recording system becomes critical in the detection of the electroretinogram in patients with retinitis pigmentosa. We studied an electroretinographic recording technique specifically designed to enhance the signal-to-noise ratio in patients with retinitis pigmentosa. The main features of the method are a membrane suction pump connected to the corneal electrodes to improve contact lens stability on the corneal surface, and a differential derivation system to record the signal. One corneal electrode is used as the recording electrode, while the other, acting as the reference electrode, is covered during full-field ganzfeld stimulation. In addition, computerized averaging and signal postrecording analyses were performed on 100 iterations. The methods described here resulted in a sharp reduction in the number of undetectable electroretinograms in our case material (28.8%). This investigation demonstrates that some of the undetectable signals reported in the literature may be due to noisy recording methods rather than to actually extinguished retinal responses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01203699
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  • 6
    Electronic Resource
    Electronic Resource
    Correlation between Goldmann perimetry and maximal electroretinogram response in retinitis pigmentosa (1995)
    Springer
    Documenta ophthalmologica 90 (1995), S. 129-142 
    Details
    ISSN: 1573-2622
    Keywords: Electroretinogram ; Kinetic perimetry ; Psychophysics ; Retinitis pigmentosa ; Visual field
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the relationship between Goldmann perimetry and maximal electroretinographic responses in patients with retinitis pigmentosa, analyses were performed on 220 affected subjects and separately on two subgroups with autosomal dominant (n = 35) and autosomal recessive (n = 29) inheritance. Electroretinograms were recorded averaging 100 iterations elicited with a 20-lux/s, 0.5-Hz white flash ganzfeld stimulation. The peripheral isopters of the visual fields were delimited with I4e, IIIe and V4e targets, measured on conventional perimetry charts with a light pen and expressed in square centimeters. Unlike most previously published reports, this investigation showed a definite correlation (p = 0.0001) between maximal electroretinographic response amplitude and visual field areas. This correlation was more evident for I4e and IIIe isopters (r = 0.89 and 0.87, respectively) than for V4e isopter (r = 0.69). This phenomenon appears to be related to distortion occurring on standard isometric charts and to spatial summation effects in the peripheral field. Such correlations held for both the autosomal dominant and autosomal recessive subgroups. It appears that, if enough accuracy is provided, maximal electroretinographic responses and Goldmann visual fields are both good measures of the remaining functioning retina in nonsyndromic retinitis pigmentosa, irrespective of inheritance models and dystrophic patterns.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01203333
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