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Low-noise electroretinogram recording techniques in retinitis pigmentosa

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Abstract

The achievement of a sharp retinal signal depends on many factors, particularly the stability of the electrodes on the corneal surface, the maximal reduction of electrical and electromagnetic disturbances and the avoidance of the noise caused by events that are synchronous with the stimulation. The availability of a low-noise recording system becomes critical in the detection of the electroretinogram in patients with retinitis pigmentosa. We studied an electroretinographic recording technique specifically designed to enhance the signal-to-noise ratio in patients with retinitis pigmentosa. The main features of the method are a membrane suction pump connected to the corneal electrodes to improve contact lens stability on the corneal surface, and a differential derivation system to record the signal. One corneal electrode is used as the recording electrode, while the other, acting as the reference electrode, is covered during full-field ganzfeld stimulation. In addition, computerized averaging and signal postrecording analyses were performed on 100 iterations. The methods described here resulted in a sharp reduction in the number of undetectable electroretinograms in our case material (28.8%). This investigation demonstrates that some of the undetectable signals reported in the literature may be due to noisy recording methods rather than to actually extinguished retinal responses.

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Abbreviations

RP:

retinitis pigmentosa

S/N:

signal-to-noise

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Authors and Affiliations

  1. Institute of Ophthalmology, Department of Ocular Electrophysiology, Center for Hereditary Degenerative Retinal Disorders, University of Rome ‘La Sapienza’, Viale del Policlinico 1, 00161, Rome, Italy

    Eduardo Rispoli, Alessandro Iannaccone & Enzo M. Vingolo

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  1. Eduardo Rispoli
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  2. Alessandro Iannaccone
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  3. Enzo M. Vingolo
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Rispoli, E., Iannaccone, A. & Vingolo, E.M. Low-noise electroretinogram recording techniques in retinitis pigmentosa. Doc Ophthalmol 88, 27–37 (1994). https://doi.org/10.1007/BF01203699

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