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  • 1
    Electronic Resource
    Electronic Resource
    Negative symptoms in schizophrenia: considerations for clinical trials (1994)
    Springer
    Psychopharmacology 115 (1994), S. 221-228 
    Details
    ISSN: 1432-2072
    Keywords: Schizophrenia ; negative symptoms ; clinical trials ; psychiatric status rating scales ; neuroleptics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract There is little agreement about the methodology of clinical trials of antipsychotic drugs in patients with negative symptoms. A literature review revealed wide variation in experimental design, rating scales and study duration. This reflects differing views as to the definition and response to treatment of negative symptoms. Some degree of standardization would improve comparability of studies and aid the development of new compounds. Patients included in such studies should have displayed negative symptoms for at least 6 months. Depressive symptoms, positive schizophrenic symptoms and extrapyramidal signs may all influence or be confused with negative symptoms and may respond to treatment; they should be at a low level at baseline and should be measured during the study period. Studies should last at least 8 weeks. Several scales are available for measuring negative symptoms and are reviewed; a global impression score should be used additionally.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244775
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Bacampicillin in the treatment of pelvic inflammatory disease: A study of two dosage regimens (1980)
    Springer
    Infection 8 (1980), S. 290-292 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Beurteilung einer zweimal täglichen Dosierung von Bacampicillin wurde bei Patienten mit entzündlichen Erkrankungen der Organe des kleinen Beckens eine klinische multizentrische Studie durchgeführt. Insgesamt 75 Patienten wurden zufallsgemäß mit entweder 800 mg Bacampicillin zweimal täglich oder 400 mg dreimal täglich über vierzehn Tage behandelt. Die Studie wurde nach klinischen Symptomen und bakteriologischen Befunden bei insgesamt 70 Patienten beurteilt. Es konnte kein signifikanter Unterschied zwischen den beiden Dosierungen festgestellt werden. Gute Resultate wurden bei 93% der Patienten erreicht, 7% wurden gebessert. Zu gastrointestinalen Beschwerden kam es selten (bei drei von 75 Patienten). In sechs Fällen trat ein Exanthem auf.
    Notes: Summary In order to evaluate a twice daily dosage regimen of bacampicillin a multicenter clinical trial was performed in patients suffering from pelvic inflammatory disease (PID). A total of 75 patients were allocated at random to treatment with 800 mg bacampicillin twice daily or 400 mg three times daily for fourteen days (PID). The study was performed double-blind. The therapeutic effect was assessed in 70 patients. The therapeutic response was judged on the basis of clinical symptoms and bacteriology. There was no significant difference in the overall efficacy of the two dosages in the patient groups studied. Good response was obtained in 93% of the patients, and 7% were improved. Gastrointestinal side-effects were infrequent (three cases out of 75). Exanthema occurred in six patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01640921
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    EMLA cream as a topical anaesthetic for ulcer debridement and simultaneous split-skin grafting (1994)
    Springer
    European journal of plastic surgery 17 (1994), S. 277-282 
    Details
    ISSN: 1435-0130
    Keywords: EMLA cream ; Local anaesthetics ; Ulcer debridement ; Split-skin grafting
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The object of the study was to investigate the effect of EMLA cream when used as an anaesthetic for the debridement of ulcers and wounds. The cream was applied to a fresh, standardized wound caused by a dermatome, to an ulcer which was to be revised and for simultaneous split-skin grafting to both donor site and recipient area to be debrided. The effect on wound healing, the plasma concentrations of lidocaine and prilocaine and the analgesic effect following the application of EMLA to the ulcer and to both ulcer and donor site were studied. The study showed that EMLA cream when topically applied has a sufficient analgesic effect for revision of an open ulcer and can be used concomitantly for both revision of the ulcer and cutting of the split-skin graft. The application of EMLA cream to the fresh wound, or to the recipient area prior to cleaning, did not cause any clinical signs of a delayed healing at the applied areas compared to the control sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00181091
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    Paper (German National Licenses)
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