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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 121 (1995), S. 287-288 
    ISSN: 1432-2072
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2072
    Keywords: Dopamine ; D1 receptor ; Antipsychotic ; Schizophrenia ; Schizoaffective disorder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Six psychotic patients were included in a four-week study of the effects of the D1 selective antagonist SCH 39166 given as monotherapy. Four had a diagnosis of schizophrenia, and two suffered from a schizoaffective disorder. All presented with an acute psychotic exacerbation at the beginning of the trial. SCH 39166 was progressively increased from 50 mg/day to 600 mg/day. In the four schizophrenic patients, the BPRS worsened, and three out of the four failed to complete the study because of this. Three schizophrenic patients were aggressive or violent after abrupt discontinuation of treatment. In the two patients with schizoaffective disorder the BPRS improved during the trial, but they had an acute relapse immediately after treatment discontinuation. Extrapyramidal symptoms improved in three of the six patients, and worsened in one.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2072
    Keywords: Schizophrenia ; negative symptoms ; clinical trials ; psychiatric status rating scales ; neuroleptics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract There is little agreement about the methodology of clinical trials of antipsychotic drugs in patients with negative symptoms. A literature review revealed wide variation in experimental design, rating scales and study duration. This reflects differing views as to the definition and response to treatment of negative symptoms. Some degree of standardization would improve comparability of studies and aid the development of new compounds. Patients included in such studies should have displayed negative symptoms for at least 6 months. Depressive symptoms, positive schizophrenic symptoms and extrapyramidal signs may all influence or be confused with negative symptoms and may respond to treatment; they should be at a low level at baseline and should be measured during the study period. Studies should last at least 8 weeks. Several scales are available for measuring negative symptoms and are reviewed; a global impression score should be used additionally.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 82 (1983), S. 95-101 
    ISSN: 1432-2072
    Keywords: Antipsychotic drugs ; Neuroleptic side effects ; Akathisia ; Foot tremor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a previous clinical investigation, jerky foot movements were observed in patients with akathisia. Tremographic techniques were empolyed in the present study to characterise this motor activity. Six psychiatric patients with signs and symptoms of akathisia, six control patients matched for antipsychotic drug dose, and five drug-free normal subjects, were selected and assessed for evidence of drug-induced movement disorders. The two patient groups proved to be closely matched on clinical and demographic variables. An accelerometer was used to record finger and toe tremor in all subjects according to a standard procedure. Analysis of the amplitude, frequency and wave-form data collected revealed that the akathisia patients were characterised by the presence of large amplitude, low frequency (less than 4 Hz), rhythmic foot movements. Changes in the severity of akathisia at follow-up were reflected in changes in the amplitude and frequency of this dyskinesia. Possible clinical and pathophysiological implications of the findings are presented.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1433-9285
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Depot fluphenazine decanoate and oral pimozide drug treatments were compared in 36 schizophrenic outpatients over one year in a double-blind, placebo-controlled trial, utilising a “double dummy” design. Analysis of Social Behaviour Assessment Schedule (SBAS) data from the pretrial and end-of-study assessments revealed no significant advantage for either of the drug treatments. However, social performance had improved in both groups over the trial period and this was associated with some relief of related “distress” in the patients' relatives and friends. The most prevalent disturbed behaviours in the sample reflected the negative symptoms of schizophrenia and showed no change over the year. These disturbed behaviours were much in evidence and were associated with a relatively high level of distress in the patients' relatives and friends. These findings suggest that the maintenance therapy of schizophrenic patients, with either depot fluphenazine or oral pimozide, by controlling psychotic symptoms and providing a period of illness stability, may allow a natural process of gradual recovery of social functioning to take place.
    Type of Medium: Electronic Resource
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  • 6
    Publication Date: 2015-10-03
    Description: Objectives To increase the frequency and quality of screening for the metabolic syndrome in people prescribed continuing antipsychotic medication. Design An audit-based, quality improvement programme (QIP) with customised feedback to participating mental health services after each audit, including benchmarked data on their relative and absolute performance against an evidence-based practice standard and the provision of bespoke change interventions. Setting Adult, assertive outreach, community psychiatric services in the UK. Participants 6 audits were conducted between 2006 and 2012. 21 mental health Trusts participated in the baseline audit in 2006, submitting data on screening for 1966 patients, while 32 Trusts participated in the 2012 audit, submitting data on 1591 patients. Results Over the 6 years of the programme, there was a statistically significant increase in the proportion of patients for whom measures for all 4 aspects of the metabolic syndrome had been documented in the clinical records in the previous year, from just over 1 in 10 patients in 2006 to just over 1 in 3 by 2012. The proportion of patients with no evidence of any screening fell from almost 1/2 to 1 in 7 patients over the same period. Conclusions The findings suggest that audit-based QIPs can help improve clinical practice in relation to physical healthcare screening. Nevertheless, they also reveal that only a minority of community psychiatric patients prescribed antipsychotic medication is screened for the metabolic syndrome in accordance with best practice recommendations, and therefore potentially remediable causes of poor physical health remain undetected and untreated.
    Keywords: Open access, Evidence based practice, Mental health, Pharmacology and therapeutics
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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