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  • 1
    Electronic Resource
    Electronic Resource
    The codon 72 polymorphic variants of p53 have markedly different apoptotic potential (2003)
    [s.l.] : Nature Publishing Group
    Nature genetics 33 (2003), S. 357-365 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The gene TP53, encoding p53, has a common sequence polymorphism that results in either proline or arginine at amino-acid position 72. This polymorphism occurs in the proline-rich domain of p53, which is necessary for the protein to fully induce apoptosis. We found that in cell lines containing ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1093
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  • 2
    Electronic Resource
    Electronic Resource
    Regional mapping of human genes for hexosaminidase B and diphtheria toxin sensitivity on chromosome 5 using mouse × human hybrid cells (1977)
    Springer
    Somatic cell and molecular genetics 3 (1977), S. 629-638 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Mouse 3T3 (TK−) cells were fused to human leukocytes containing a balanced translocation [ins(3;5) (q27;q13q15)] in which part of the long arm of a chromosome 5 has been inserted into the long arm of a chromosome 3. Two independent, primary hybrid clones (XVI-10C; XVI-18A) retained the deleted chromosome 5 [del(5) (q13q15)] translocation product and were informative for regional mapping on chromosome 5 of genes involved in expression of hexosaminidase B (HEX B ) and diphtheria toxin sensitivity (DTS). Both XVI-10C and XVI-18A clones were sensitive to diphtheria toxin. Toxin-resistant derivatives of these clones (XVI-10C DTR; XVI-18A DTR) were analyzed for chromosome content and expression of Hex B activity, as were XVI-10C and XVI-18A cells which had not been exposed to diphtheria toxin. The results of this study provide evidence for localization ofDTS to region 5q15→5qter on the long arm of chromosome 5, and localization ofHEX B to region 5pter→5q13.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01539070
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  • 3
    Electronic Resource
    Electronic Resource
    Assignment of the human gene for muscle-type phosphofructokinase (PFKM) to chromosome 1 (region cen→q32) using somatic cell hybrids and monoclonal anti-M antibody (1982)
    Springer
    Somatic cell and molecular genetics 8 (1982), S. 95-104 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Human phosphofructokinase (PFK; EC 2.7.1.11) is under the control of three structural loci which encode muscle-type (M), liver-type (L), and platelet-type (P) subunits; human diploid fibroblasts and leukocytes express all three loci. In order to assign human PFKMlocus to a specific chromosome we have analyzed human × Chinese hamster somatic cell hybrids for the expression of human M subunits, using an anti-human M subunit-specific mouse monoclonal antibody. In 18 of 19 hybrids studied, the expression of the PFKMlocus segregated concordantly with the presence of chromosome 1 (discordancy rate 0.05) as indicated by chromosome and isozyme marker analysis. The discordancy rates for all the other chromosomes were 0.32 or greater, indicating that the PFKMlocus is on chromosome 1. For the regional mapping of PFKM,eight hybrids were studied that contained one of five distinct regions of chromosome 1. These results further localize the human PFKMlocus to region cen→q32 of chromosome 1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01538653
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  • 4
    Electronic Resource
    Electronic Resource
    Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line (1987)
    Springer
    Somatic cell and molecular genetics 13 (1987), S. 235-244 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We are exploring the origin and function of amplified DNA sequences associated with double minutes (DMs) in a spontaneously transformed derivative of mouse 3T3 cells. Toward that goal, we have constructed a cDNA library using RNA from these cells and have isolated cDNA clones representing sequences that are amplified and overexpressed in these 3T3-DM cells. From results of Northern- and Southern-blot analyses, we conclude that these cDNAs represent two distinct genes, which we have designated mdm-1and mdm-2.Using DNAs from a panel of Chinese hamster-mouse somatic cell hybrids together with in situ hybridization protocols for gene mapping studies, we have found that these DM-associated, amplified DNA sequences originate from mouse chromosome 10, region C1–C3. Sequences homologous to mdm-1and mdm-2are present in the genomes of several species examined, including that of man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01535205
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  • 5
    Electronic Resource
    Electronic Resource
    Direct regional assignment of the gene for vitamin D binding protein (Gc-globulin) to human chromosome 4q11-q13 and identification of an associated DNA polymorphism (1986)
    Springer
    Human genetics 〈Berlin〉 73 (1986), S. 225-229 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Using a characterized human vitamin D binding protein (DBP) cDNA probe and a panel of rodent X human somatic cell hybrids, we established the chromosomal location of the structural gene for DBP on human chromosome 4. In situ hybridization of 3H-labeled DBP cDNA to human metaphase chromosomes confirmed this assignment and allowed regional localization to bands 4q11–4q13. A restriction fragment length polymorphism associated with the DBP gene that should prove useful in future linkage studies was identified with the enzyme BamHI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401232
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  • 6
    Electronic Resource
    Electronic Resource
    The genes for growth hormone and chorionic somatomammotropin are on the long arm of human chromosome 17 in region q21→qter (1981)
    Springer
    Human genetics 〈Berlin〉 57 (1981), S. 138-141 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We used a cloned cDNA probe for human growth hormone and Southern blotting techniques to analyze DNA from a series of rodentxhuman somatic cell hybrids for the presence of growth hormone-related sequences. Our results provide evidence for the assignment of the genes for growth hormone and chorionic somatomammotropin as well as a growth hormone-like gene to human chromosome 17. Analysis of mousexhuman hybrid cells containing only part of the long arm of chromosome 17 enabled us to localize these genes to region 17q21→17qter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00282009
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  • 7
    Electronic Resource
    Electronic Resource
    Slow excision repair in an mfd mutant of Escherichia coli B/r (1974)
    Springer
    Molecular genetics and genomics 133 (1974), S. 283-291 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A mutant of Escherichia coli B/r designated mfd is very deficient in the ability to exhibit “mutation frequency decline”, the characteristic loss of potential suppressor mutations which occurs when protein synthesis is briefly inhibited after irradiation with ultraviolet light (UV). This mutant is known to excise pyrimidine dimers at an abnormally slow rate, although it is as UV-resistant as its mfd + B/r parent strain. We have found that the mfd mutant performs the initial incision step of excision repair normally, but repairs the resulting single-strand breaks much more slowly than the mfd + strain. We conclude that the mfd mutant performs the excision step of pyrimidine dimer excision inefficiently, but our data do not rule out the possibility that one or more subsequent steps of repair may also be slow. In spite of the slow dimer excision in the mfd mutant, single-strand DNA breaks do not accumulate during post-irradiation incubation, implying that incision and excision are well coordinated. The prolonged post-irradiation lag in cell division and DNA synthesis which accompany slow excision in the mfd strain indicates that resumption of these processes at optimal rates is linked to the timing of excision repair. The normal UV-resistance of the mfd mutant also suggests such coordination and shows that the rate of excision repair is independent of its ultimate efficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00332704
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  • 8
    Electronic Resource
    Electronic Resource
    Expression patterns of the p53 tumor suppressor gene and the mdm2 proto-oncogene in human meningiomas (1997)
    Springer
    Journal of neuro-oncology 32 (1997), S. 39-44 
    Details
    ISSN: 1573-7373
    Keywords: meningiomas ; p53 ; mdm2 ; protein overexpression ; NF2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Meningiomas represent a common class of tumors of the central nervous system. However, the molecular events underlying theirformation are poorly understood. Because altered expression ofthe p53 tumor suppressor gene and the mdm2 proto-oncogene havebeen demonstrated in a wide variety of tumors, we carried out studies to assess the possible involvement of these two genes in meningiomatumorigenesis. We used Western blot analysis to examine the levelof expression of the mdm2 and p53 proteins in a seriesof sixteen primary meningiomas and four meningioma cell lines. The data obtained from these studies suggest that elevated expression of the p53 or mdm2 protein products does not representa common event in the development of human meningiomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005779406636
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