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Expression patterns of the p53 tumor suppressor gene and the mdm2 proto-oncogene in human meningiomas

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Abstract

Meningiomas represent a common class of tumors of the central nervous system. However, the molecular events underlying theirformation are poorly understood. Because altered expression ofthe p53 tumor suppressor gene and the mdm2 proto-oncogene havebeen demonstrated in a wide variety of tumors, we carried out studies to assess the possible involvement of these two genes in meningiomatumorigenesis. We used Western blot analysis to examine the levelof expression of the mdm2 and p53 proteins in a seriesof sixteen primary meningiomas and four meningioma cell lines. The data obtained from these studies suggest that elevated expression of the p53 or mdm2 protein products does not representa common event in the development of human meningiomas.

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Authors and Affiliations

  1. Department of Genetics, University of Pennsylvania School of Medicine, Room 713b, Basic Research Building, 422 Curie Blvd., Philadelphia, PA, 19104-6069, USA

    Mark J. Pykett, John Landers & Donna L. George

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  1. Mark J. Pykett
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  2. John Landers
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  3. Donna L. George
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Pykett, M.J., Landers, J. & George, D.L. Expression patterns of the p53 tumor suppressor gene and the mdm2 proto-oncogene in human meningiomas. J Neurooncol 32, 39–44 (1997). https://doi.org/10.1023/A:1005779406636

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