In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 2 ( 2021-2-4), p. e0245844-
Kurzfassung:
Mean kurtosis (MK), one of the parameters derived from diffusion kurtosis imaging (DKI), has shown increased sensitivity to tissue microstructure damage in several neurological disorders. Methods Thirty-seven patients with relapsing-remitting MS and eleven healthy controls (HC) received brain imaging on a 3T MR scanner, including a fast DKI sequence. MK and mean diffusivity (MD) were measured in the white matter of HC, normal-appearing white matter (NAWM) of MS patients, contrast-enhancing lesions (CE-L), FLAIR lesions (FLAIR-L) and black holes (BH). Results Overall 1529 lesions were analyzed, including 30 CE-L, 832 FLAIR-L and 667 BH. Highest MK values were obtained in the white matter of HC (0.814 ± 0.129), followed by NAWM (0.724 ± 0.137), CE-L (0.619 ± 0.096), FLAIR-L (0.565 ± 0.123) and BH (0.549 ± 0.12). Lowest MD values were obtained in the white matter of HC (0.747 ± 0.068 10 −3 mm 2 /sec), followed by NAWM (0.808 ± 0.163 10 −3 mm 2 /sec), CE-L (0.853 ± 0.211 10 −3 mm 2 /sec), BH (0.957 ± 0.304 10 −3 mm 2 /sec) and FLAIR-L (0.976 ± 0.35 10 −3 mm 2 /sec). While MK differed significantly between CE-L and non-enhancing lesions, MD did not. Conclusion MK adds predictive value to differentiate between MS lesions and might provide further information about diffuse white matter injury and lesion microstructure.
Materialart:
Online-Ressource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0245844
DOI:
10.1371/journal.pone.0245844.g001
DOI:
10.1371/journal.pone.0245844.g002
DOI:
10.1371/journal.pone.0245844.g003
DOI:
10.1371/journal.pone.0245844.g004
DOI:
10.1371/journal.pone.0245844.t001
DOI:
10.1371/journal.pone.0245844.t002
DOI:
10.1371/journal.pone.0245844.t003
DOI:
10.1371/journal.pone.0245844.t004
DOI:
10.1371/journal.pone.0245844.s001
DOI:
10.1371/journal.pone.0245844.s002
DOI:
10.1371/journal.pone.0245844.s003
DOI:
10.1371/journal.pone.0245844.r001
DOI:
10.1371/journal.pone.0245844.r002
DOI:
10.1371/journal.pone.0245844.r003
DOI:
10.1371/journal.pone.0245844.r004
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2021
ZDB Id:
2267670-3
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