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  • 1
    Digitale Medien
    Digitale Medien
    Susceptibility to Atrial Fibrillation: (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 9 (1998), S. 0 
    Details
    ISSN: 1540-8167
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Propensity for Extrastimulus to Induce AF. Introduction: The development of susceptibility to atrial fibrillation (AF) is a common consequence of many forms of cardiovascular disease, especially heart failure. In this study we used a sheep model of pacing-induced stable early heart failure to describe, quantify, and relate the level of susceptibility to AF to changes in structural and electrophysiologic parameters. Methods and Results: Epicardial electrodes were implanted on the atria and right ventricles of nine sheep. The AF thresbold, atrial vulnerability period, atrial effective refractory period (ERP), and interatrial conduction time were examined during control and over a 6-week period of ventricular pacing at 190 beats/min. Left atrial (LA) area and left ventricular (LV) fractional shortening were monitored using echocardiography. There were significant increases in LA susceptibility to AF (P 〈 0.0003), LA area (P 〈 0.0002), and LA FRP400 (P 〈 0.0002). Rate of increase in LA area was related positively to AF susceptibility (P = 0.02) and inversely to LA ERP400 (P = 0.002). LV fractional shortening decreased to approximately 50% of control value (P 〈 0.00001). No changes were observed in right atrial electrophysiology. Conclusion: In this study, susceptibility (the ability of an extrastimulus to induce AF) was rigorously measured within a predetermined format. Significant relationships were found to exist between susceptibility, certain of the observed changes in atrial electrophysiology and structure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1540-8167.1998.tb00930.x
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  • 2
    Digitale Medien
    Digitale Medien
    Authors' reply (1991)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 98 (1991), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1991.tb10332.x
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  • 3
    Digitale Medien
    Digitale Medien
    Autoimmune ovarian failure with elevated serum levels of luteinizing hormone and enlarged ovaries Case report (1990)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 97 (1990), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1990.tb01816.x
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  • 4
    Digitale Medien
    Digitale Medien
    Vasopressin V1A Receptor Antagonism Does Not Reverse Adrenocorticotrophin-Induced Hypertension In The Rat (2000)
    Melbourne, Australia : Blackwell Science Pty
    Clinical and experimental pharmacology and physiology 27 (2000), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. The role of arginine vasopressin (AVP) was examined in adrenocorticotrophin (ACTH)-induced hypertension in Sprague-Dawley rats using the non-peptide AVP V1a receptor antagonist OPC 21268.2. In an acute study, six rats were pretreated with ACTH for 11 days and direct arterial blood pressure (4 h), plasma osmolality and electrolyte concentrations were measured after OPC 21268 gavage. In a chronic study, 40 rats were randomly divided into four groups: (i) sham injection + sham gavage; (ii) ACTH + sham gavage; (iii) sham injection + OPC 21268; or (iv) ACTH + OPC-21268 for 16 days. Systolic blood pressure (SBP), water intake, urine volume (UV), urine osmolality and electrolytes, food intake, bodyweight and plasma osmolality and electrolyte concentrations were measured.3. In the acute study, direct mean arterial blood pressure did not change with OPC 21268 (122±2 and 120±3 mmHg at 0 and 240 min, respectively).4. In the chronic study, OPC 21268 did not affect ACTH-induced rises in blood pressure (from 125±2 (control) to 145±5 mmHg (group 4) compared with 122±3 (control) to 149±5 mmHg (group2)). Water intake and UV increased (from 29±2 to 83±6 mL/day; and from 5±1 to 36±5 mL/day, respectively) and the change in bodyweight decreased from 0±2 to –107±7 g.5. These results suggest that AVP (at the V1a receptor) does not play a significant role in the maintenance of ACTH-induced hypertension.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1440-1681.2000.03350.x
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  • 5
    Digitale Medien
    Digitale Medien
    VALIDATION OF AN ECHOCARDIOGRAPHIC ASSESSMENT OF CARDIAC FUNCTION FOLLOWING MODERATE SIZE MYOCARDIAL INFARCTION IN THE RAT (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 23 (1996), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. The present study determined whether two dimensional guided M-mode echocardiography could assess left ventricular (LV) geometry and function following a moderate size myocardial infarction in the rat.2. Myocardial infarction (MI) was induced by left coronary artery ligation and rats were studied 4 weeks later. Infarct rats showed increased LV internal diastolic diameter (7.33 ± 0.8 vs 5.91 ± 0.6 mm; P 〉 0.001), LV systolic diameter (3.73 ± 1.2 vs 1.87 ± 0.6 mm; P 〉 0.001) and thickening of the noninfarcted posterior wall compared with sham operated rats (1.81 ± 0.2 vs 1.47 ± 0.3; P 〉 0.001; n= 10/group; mean ± s.d.). Systolic function was impaired in infarct rats who showed reduced fractional shortening (50 ± 12 vs 68 ± 9%; P 〉 0.001) and fractional area change (41 ± 14 vs 78 ± 5%; P 〉 0.001). Infarct size measured echocardiographically was comparable to that measured by quantitative histological examination (29 ± 10 vs 28 ± 5%; NS).3. The present study indicates that postinfarction remodelling leading to LV cavity dilation, hypertrophy of surviving myocardium and impaired systolic function is apparent 4 weeks following moderate size MI in the rat.4. Transthoracic echocardiography is a noninvasive technique that may be used to assess serially the efficacy of therapeutic interventions designed to prevent remodelling in moderate size MI in the rat.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1996.tb02782.x
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  • 6
    Digitale Medien
    Digitale Medien
    HUMAN INTERNAL MAMMARY ARTERY RESPONSES TO NON-PEPTIDE VASOPRESSIN ANTAGONISTS (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 21 (1994), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. OPC-21268 and OPC-31260 are newly developed orally active non-peptide vasopressin (AVP) V1 and V2 receptor antagonists, respectively. The effects of the two compounds on human vessels have not been studied.2. The effects of the two compounds on AVP-induced contraction of human internal mammary arteries (IMA) were investigated. Their effects were compared with the peptide V1 and V2 antagonists d(CH2)sSar7AVP (SAVP) and d(CH2)5D-Ileu211eu4AVP (Ileu2 Ileu4AVP), respectively.3. The V1 antagonist OPC-21268 failed to antagonize AVP-induced contraction at low concentrations and potentiated the contraction at higher concentration (3 × 10−-7 mol/L, P〈0.05). It also caused a mild direct contractile effect on IMA. In contrast, the peptide V1 antagonist SAVP potently inhibited the AVP-induced contraction, indicating that functionally constrictor V1 receptors exist in IMA. Both the nonpeptide and peptide V2 antagonists OPC-31260 (3X10−-6 mol/L) and Ileu2Ileu4AVP significantly antagonized the AVP-induced contraction (P〈0.01).4. The AVP-induced contraction was reversed by high concentrations of OPC-31260 (10−-6 mol/L-3×10−-5 mol/L) but not by OPC-21268 (up to 3X 10−-5 mol/L).5. These studies indicate that, in human IMA, OPC-21268 is a partial VI receptor agonist with no V1 receptor antagonist activity, while OPC-31260 is a V1 receptor antagonist. The results also indicate that Ileu2 Ileu4AVP may be a Vl receptor antagonist in humans.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1994.tb02478.x
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  • 7
    Digitale Medien
    Digitale Medien
    Pustular vasculitis of the hands (1999)
    Melbourne, Australia : Blackwell Science Pty
    Australasian journal of dermatology 40 (1999), S. 0 
    Details
    ISSN: 1440-0960
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: A case of pustular vasculitis of the hands with evidence of systemic involvement is described. A 64-year-old woman presented with a 2-day history of large, tense bullae arranged symmetrically over the dorsum of the three radial digits and extending on to the radial aspect of the dorsum of each hand. The bullae caused some discomfort and prevented normal use of her hands. There was no response to antibiotic therapy initiated prior to referral to hospital. Initial investigations revealed a raised white cell count with a neutrophilia, a raised erythrocyte sedimentation rate and a raised C-reactive protein. Abnormalities of liver function were detected. Aspirates from the bullae and blood cultures were sterile. The histology of debrided tissue demonstrated a florid neutrophilic dermal infiltrate with many blood vessels associated with prominent fibrin. A diagnosis of pustular vasculitis of the hands was made. The bullae were surgically debrided and treatment with oral corticosteroids was started. Two days after commencement of oral prednisolone, a crusted pustule appeared on her upper cutaneous lip. There was rapid resolution of both the vasculitis of the hands and the pustule on her upper lip following an increase in the dose of oral prednisolone. The patient was discharged on the seventeenth day following admission.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1440-0960.1999.00362.x
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