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  • 1
    Keywords: Heat shock proteins. ; Nervous system -- Degeneration. ; Neuroprotective agents. ; Nerve tissue proteins. ; Electronic books.
    Description / Table of Contents: This book reviews current progress on heat shock proteins in the brain and their implications for neurodegenerative diseases, neuroprotection, aging and control of life span. It features contributions from laboratories from major universities around the world.
    Type of Medium: Online Resource
    Pages: 1 online resource (373 pages)
    Edition: 1st ed.
    ISBN: 9781402082313
    Series Statement: Heat Shock Proteins Series ; v.3
    DDC: 612.8042
    Language: English
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  • 2
    Online Resource
    Online Resource
    San Diego :Elsevier Science & Technology,
    Keywords: Molecular neurobiology. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (434 pages)
    Edition: 1st ed.
    ISBN: 9781483282299
    Language: English
    Note: Front Cover -- Molecular Approaches to Neurobiology -- Copyright Page -- Table of Contents -- LIST OF CONTRIBUTORS -- PREFACE -- CHAPTER 1. CURRENT GENETIC APPROACHES TO THE MAMMALIAN NERVOUS SYSTEM -- I. INTRODUCTION -- II. INHERITED VARIATIONS IN GENES AND GENE PRODUCTS -- III. GENERATING GENETIC VARIANTS -- IV. ASSESSING THE ROLE OF HEREDITY IN BEHAVIOR AND DISEASE -- V. CONCLUSION -- REFERENCES -- CHAPTER 2. CHROMOSOMAL COMPONENTS IN BRAIN CELLS -- I. INTRODUCTION -- II. ORGANIZATION OF CHROMATIN -- III. BRAIN HISTONES -- IV. NONHISTONE CHROMOSOMAL PROTEINS (NHCP) OF THE BRAIN -- V. DNA POLYMERASE -- VI. RNA POLYMERASE -- VII. CONCLUDING REMARKS -- ACKNOWLEDGMENT -- REFERENCES -- CHAPTER 3. THE SEQUENCE COMPLEXITY OF BRAIN RIBONUCLEIC ACIDS -- I. INTRODUCTION -- II. RNA-DNA HYBRIDIZATION ANALYSIS -- III. COMPLEXITY OF GENE TRANSCRIPTION IN THE BRAIN -- IV. RNA SEQUENCE COMPLEXITY AT THE LEVEL OF TRANSLATION -- V. REGIONAL AND CELLULAR DISTRIBUTION OF GENE TRANSCRIPTS -- VI. GENE ACTIVITY DURING DEVELOPMENT AND AGING -- VII. CONCLUDING REMARKS -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 4. MOLECULAR CHARACTERIZATION OF SYNAPSES OF THE CENTRAL NERVOUS SYSTEM -- I. INTRODUCTION -- II. ISOLATION AND CHARACTERIZATION OF SYNAPTIC JUNCTIONAL COMPLEXES AND POSTSYNAPTIC DENSITIES -- III. PROTEIN COMPOSITION OF ISOLATED SYNAPTIC JUNCTIONS AND POSTSYNAPTIC DENSITIES -- IV. FUNCTIONAL PROPERTIES OF SYNAPTIC JUNCTIONS AND POSTSYNAPTIC DENSITIES -- V. DEVELOPMENT OF THE SYNAPSE -- VI. CONCLUSIONS -- REFERENCES -- CHAPTER 5. AXONAL TRANSPORT OF MACROMOLECULES -- I. INTRODUCTION -- II. SLOW AXONAL TRANSPORT -- III. RAPID AXONAL TRANSPORT -- IV. CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 6. MECHANISTIC STUDIES ON THE CELLULAR EFFECTS OF NERVE GROWTH FACTOR -- I. NGF AND ITS TARGET CELLS. , II. ROLE OF TRANSCRIPTION IN NGF MECHANISM OF ACTION ON NEURITE OUTGROWTH -- III. PRIMING MODEL OF NEURITE OUTGROWTH -- IV. TRANSCRIPTIONAL REGULATION OF NGF RESPONSES OTHER THAN NEURITE OUTGROWTH -- V. NGF RECEPTORS AND TRANSCRIPTION -- VI. NONTRANSCRIPTIONAL, ANABOLIC, AND RAPID EFFECTS OF NGF -- VII. GENETIC APPROACHES TO NGF MOLECULAR MECHANISM -- VIII. NGF AND CELL PROLIFERATION -- IX. CONCLUDING REMARKS -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 7. CELL INTERACTIONS IN EMBRYONIC NEURAL RETINA: ROLE IN HORMONAL INDUCTION OF GLUTAMINE SYNTHETASE -- I. INTRODUCTION -- II. NEURAL RETINA OF CHICK EMBRYO -- III. GLUTAMINE SYNTHETASE (GS) IN AVIAN NEURAL RETINA -- IV. INDUCTION OF GS -- V. CELL INTERACTIONS AND GS INDUCTION -- VI. CORTISOL RECEPTORS -- VII. COMMENT -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 8. SEXUAL DIFFERENTIATION OF THE BRAIN: GONADAL HORMONE ACTION AND CURRENT CONCEPTS OF NEURONAL DIFFERENTIATION -- I. INTRODUCTION -- II. GENERAL PLAN OF SEXUAL DIFFERENTIATION FOR MAMMALS -- III. SEXUAL DIFFERENTIATION IN RATS -- IV. MORPHOLOGICAL SEX DIFFERENCES IN THE BRAIN -- V. SEXUAL DIFFERENTIATION IN RELATION TO CURRENT CONCEPTS OF NEURONAL DEVELOPMENT AND DIFFERENTIATION -- VI. CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 9. ANALYSIS OF PROTEIN SYNTHESIS IN THE MAMMALIAN BRAIN USING LSD AND HYPERTHERMIA AS EXPERIMENTAL PROBES -- I. INTRODUCTION -- II. PERTURBATION OF PROTEIN SYNTHESIS IN THE BRAIN -- III. EFFECT OF LSD ON THE TRANSLATIONAL APPARATUS OF THE BRAIN -- IV. EFFECT OF HYPERTHERMIA ON THE TRANSLATIONAL APPARATUS OF THE BRAIN -- V. EFFECTS OF LSD AND HYPERTHERMIA ON BRAIN PROTEIN SYNTHESIS IN VIVO -- VI. EFFECT OF LSD AND HYPERTHERMIA ON SUBSEQUENT CELL-FREE PROTEIN SYNTHESIS IN THE BRAIN -- VII. CONCLUDING REMARKS -- ACKNOWLEDGMENTS -- REFERENCES. , CHAPTER 10. NEUROPEPTIDES AS PUTATIVE NEUROTRANSMITTERS: ENDORPHINS, SUBSTANCE P, CHOLECYSTOKININ, AND VASOACTIVE INTESTINAL POLYPEPTIDE -- I. INTRODUCTION -- II. ENDOGENOUS OPIOID PEPTIDES -- III. SUBSTANCE P -- IV. CHOLECYSTOKININ AND VASOACTIVE INTESTINAL POLYPEPTIDE -- V. CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 11. MOLECULAR CORRELATES BETWEEN PITUITARY HORMONES AND BEHAVIOR -- I. INTRODUCTION -- II. BEHAVIORAL EFFECTS OF PITUITARY PEPTIDE HORMONES -- III. MOLECULAR CORRELATES OF PITUITARY PEPTIDE HORMONES -- IV. CONCLUDING REMARKS -- ACKNOWLEDGMENT -- REFERENCES -- CHAPTER 12. MACROMOLECULES AND BEHAVIOR -- I. INTRODUCTION -- II. GENERAL APPROACHES TO THE RELATIONSHIPS BETWEEN MOLECULES AND BEHAVIOR -- III. DEOXYGLUCOSE PROCEDURE -- IV. LEARNING AND MEMORY STUDIES -- V. NEUROPEPTIDES AS TOOLS FOR STUDYING THE BIOCHEMISTRY OF BEHAVIOR -- VI. RECEPTORS -- VII. CONCLUDING REMARKS -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 13. ISOLATION AND CULTURE OF SPECIFIC BRAIN CELLS AND THEIR EXPERIMENTAL USE -- I. INTRODUCTION -- II. GENERAL APPROACHES TO THE ISOLATION OF BRAIN CELLS -- III. MICROSCALE ISOLATION METHODS -- IV. MACROSCALE ISOLATION METHODS -- V. BIOCHEMICAL PROPERTIES OF NEURONAL AND GLIAL CELLS ISOLATED FROM "NORMAL" BRAIN TISSUE -- VI. BIOCHEMICAL PROPERTIES OF NEURAL CELLS ISOLATED FROM PATHOLOGICALLY ALTERED BRAIN TISSUE -- VII. CULTURING OF ISOLATED NEURONS AND GLIA FROM BRAINS OF YOUNG ADULT ANIMALS-A PRELIMINARY SURVEY -- VIII. SUMMARY AND OUTLOOK -- REFERENCES -- INDEX -- CELL BIOLOGY: A Series of Monographs.
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  • 3
    Online Resource
    Online Resource
    Dordrecht :Springer Netherlands,
    Keywords: Ion bombardment. ; Electronic books.
    Description / Table of Contents: Proceedings of the NATO Advanced Research Workshop, held in Lake Baikal, Russia, 24-28 June 2002.
    Type of Medium: Online Resource
    Pages: 1 online resource (229 pages)
    Edition: 1st ed.
    ISBN: 9789401002776
    Series Statement: NATO Science Series II: Mathematics, Physics and Chemistry Series ; v.88
    DDC: 530.4/16
    Language: English
    Note: Emerging Applications of Vacuum-Arc-Produced Plasma, Ion and Electron Beams -- Editor's page -- Copyright -- TABLE OF CONTENTS -- PREFACE -- COHESIVE ENERGY RULE FOR VACUUM ARCS -- PHYSICAL BASIS OF PLASMA PARAMETERS CONTROL IN A VACUUM ARC -- SOURCES OF MULTIPLY CHARGED METAL IONS: VACUUM DISCHARGE OR LASER PRODUCED PLASMA? -- STATUS OF MEVVA EXPERIMENTS IN ITEP* -- UNDERLYING PHYSICS OF E-MEVVA OPERATION: Explaining Past Results, Guiding Future Improvements -- TECHNICAL DESIGN OF THE MEVVA ION SOURCE AT GSI AND RESULTS OF A LONG URANIUM BEAM TIME PERIOD -- SIMULATION OF THE EXTRACTION FROM A MEVVA ION SOURCE -- PRODUCING OF GAS AND METAL ION BEAMS WITH VACUUM ARC ION SOURCES -- HIGH CURRENT ELECTRON SOURCES AND ACCELERATORS WITH PLASMA EMITTERS -- EMISSION METHODS OF EXPERIMENTAL INVESTIGATIONS OF ION VELOCITIES IN VACUUM ARC PLASMAS -- GASEOUS PLASMA PRODUCTION USING ELECTRON EMITTER BASED ON ARC DISCHARGE -- VACUUM ARC ION SOURCES: CHARGE STATE ENHANCEMENT AND ARC VOLTAGE -- LINEAR VACUUM ARC EVAPORATORS FOR DEPOSITION OF FUNCTIONAL MULTI-PURPOSE COATINGS -- ARC GENERATORS OF LOW-TEMPERATURE PLASMA AND THEIR APPLICATIONS -- ELECTRON BEAM DEPOSITION OF HIGH TEMPERATURE SUPERCONDUCTING THIN FILMS -- DEPOSITION OF NANOSCALE MULTILAYERED STRUCTURES USING FILTERED CATHODIC VACUUM ARC PLASMA BEAMS -- IMPLANTATION OF STEEL FROM MEVVA ION SOURCE WITH BRONZE CATHODE -- RESISTANCE TO HIGH TEMPERATURE OXIDATION IN Si-IMPLANTED TiN COATINGS ON STEEL -- VACUUM ARC DEPOSITED DLC BASED COATINGS -- APPLICATIONS OF VACUUM ARC PLASMAS TO NEUROSCIENCE -- CONCERNING REGULARITIES OF PARTICLE'S DRIVING IN POTENTIAL FIELDS (ON EXAMPLE OF ELECTRON'S MOVEMENT IN ELECTRICAL FIELD WITH DISTRIBUTED POTENTIAL ). -- HIGH CURRENT PLASMA LENS (STATUS AND NEW DEVELOPMENTS) -- INDEX.
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  • 4
    Online Resource
    Online Resource
    Newark :John Wiley & Sons, Incorporated,
    Keywords: Ion sources. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (399 pages)
    Edition: 2nd ed.
    ISBN: 9783527604548
    DDC: 541.372
    Language: English
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  • 5
    Publication Date: 2024-02-17
    Keywords: 74JC20121115; 74JC20121115-track; Algorithm; CT; DATE/TIME; Depth, bathymetric, interpolated/gridded; DEPTH, water; Distance; extracted from GLOBALVIEW-CO2; extracted from the 2-Minute Gridded Global Relief Data (ETOPO2); extracted from the NCEP/NCAR 40-Year Reanalysis Project; extracted from the World Ocean Atlas 2005; Fugacity of carbon dioxide (water) at equilibrator temperature (wet air); Fugacity of carbon dioxide (water) at sea surface temperature (wet air); James Clark Ross; LATITUDE; LONGITUDE; Partial pressure of carbon dioxide (water) at sea surface temperature (wet air); Pressure, atmospheric; Pressure, atmospheric, interpolated; Pressure at equilibration; Quality flag; Recomputed after SOCAT (Pfeil et al., 2013); Salinity; Salinity, interpolated; SOCAT; Surface Ocean CO2 Atlas Project; Temperature, water; Temperature at equilibration; Underway cruise track measurements; xCO2 (air), interpolated
    Type: Dataset
    Format: text/tab-separated-values, 5040 data points
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  • 6
    Publication Date: 2024-02-17
    Keywords: 74JC20130318; 74JC20130318-track; Algorithm; CT; DATE/TIME; Depth, bathymetric, interpolated/gridded; DEPTH, water; Distance; extracted from GLOBALVIEW-CO2; extracted from the 2-Minute Gridded Global Relief Data (ETOPO2); extracted from the NCEP/NCAR 40-Year Reanalysis Project; extracted from the World Ocean Atlas 2005; Fugacity of carbon dioxide (water) at equilibrator temperature (wet air); Fugacity of carbon dioxide (water) at sea surface temperature (wet air); James Clark Ross; LATITUDE; LONGITUDE; Partial pressure of carbon dioxide (water) at sea surface temperature (wet air); Pressure, atmospheric; Pressure, atmospheric, interpolated; Pressure at equilibration; Quality flag; Recomputed after SOCAT (Pfeil et al., 2013); Salinity; Salinity, interpolated; SOCAT; Surface Ocean CO2 Atlas Project; Temperature, water; Temperature at equilibration; Underway cruise track measurements; xCO2 (air), interpolated
    Type: Dataset
    Format: text/tab-separated-values, 14864 data points
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  • 7
    Publication Date: 2024-02-17
    Keywords: 74JC20130109; 74JC20130109-track; Algorithm; CT; DATE/TIME; Depth, bathymetric, interpolated/gridded; DEPTH, water; Distance; extracted from GLOBALVIEW-CO2; extracted from the 2-Minute Gridded Global Relief Data (ETOPO2); extracted from the NCEP/NCAR 40-Year Reanalysis Project; extracted from the World Ocean Atlas 2005; Fugacity of carbon dioxide (water) at equilibrator temperature (wet air); Fugacity of carbon dioxide (water) at sea surface temperature (wet air); James Clark Ross; LATITUDE; LONGITUDE; Partial pressure of carbon dioxide (water) at sea surface temperature (wet air); Pressure, atmospheric; Pressure, atmospheric, interpolated; Pressure at equilibration; Quality flag; Recomputed after SOCAT (Pfeil et al., 2013); Salinity; Salinity, interpolated; SOCAT; Surface Ocean CO2 Atlas Project; Temperature, water; Temperature at equilibration; Underway cruise track measurements; xCO2 (air), interpolated
    Type: Dataset
    Format: text/tab-separated-values, 400 data points
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  • 8
    Publication Date: 2024-02-17
    Keywords: 74JC20130715; 74JC20130715-track; Algorithm; CT; DATE/TIME; Depth, bathymetric, interpolated/gridded; DEPTH, water; Distance; extracted from GLOBALVIEW-CO2; extracted from the 2-Minute Gridded Global Relief Data (ETOPO2); extracted from the NCEP/NCAR 40-Year Reanalysis Project; extracted from the World Ocean Atlas 2005; Fugacity of carbon dioxide (water) at equilibrator temperature (wet air); Fugacity of carbon dioxide (water) at sea surface temperature (wet air); James Clark Ross; LATITUDE; LONGITUDE; Partial pressure of carbon dioxide (water) at sea surface temperature (wet air); Pressure, atmospheric; Pressure, atmospheric, interpolated; Pressure at equilibration; Quality flag; Recomputed after SOCAT (Pfeil et al., 2013); Salinity; Salinity, interpolated; SOCAT; Surface Ocean CO2 Atlas Project; Temperature, water; Temperature at equilibration; Underway cruise track measurements; xCO2 (air), interpolated
    Type: Dataset
    Format: text/tab-separated-values, 26128 data points
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  • 9
    Publication Date: 2024-02-17
    Keywords: 74JC20131009; 74JC20131009-track; Algorithm; CT; DATE/TIME; Depth, bathymetric, interpolated/gridded; DEPTH, water; Distance; extracted from GLOBALVIEW-CO2; extracted from the 2-Minute Gridded Global Relief Data (ETOPO2); extracted from the NCEP/NCAR 40-Year Reanalysis Project; extracted from the World Ocean Atlas 2005; Fugacity of carbon dioxide (water) at sea surface temperature (wet air); James Clark Ross; LATITUDE; LONGITUDE; Pressure, atmospheric; Pressure, atmospheric, interpolated; Pressure at equilibration; Quality flag; Recomputed after SOCAT (Pfeil et al., 2013); Salinity; Salinity, interpolated; SOCAT; Surface Ocean CO2 Atlas Project; Temperature, water; Temperature at equilibration; Underway cruise track measurements; xCO2 (air), interpolated
    Type: Dataset
    Format: text/tab-separated-values, 47801 data points
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  • 10
    Publication Date: 2024-03-15
    Description: The assimilation and regeneration of dissolved inorganic nitrogen, and the concentration of N2O, was investigated at stations located in the NW European shelf sea during June/July 2011. These observational measurements within the photic zone demonstrated the simultaneous regeneration and assimilation of NH4+, NO2- and NO3-. NH4+ was assimilated at 1.82-49.12 nmol N/L/h and regenerated at 3.46-14.60 nmol N/L/h; NO2- was assimilated at 0-2.08 nmol N/L/h and regenerated at 0.01-1.85 nmol N/L/h; NO3-was assimilated at 0.67-18.75 nmol N/L/h and regenerated at 0.05-28.97 nmol N/L/h. Observations implied that these processes were closely coupled at the regional scale and that nitrogen recycling played an important role in sustaining phytoplankton growth during the summer. The [N2O], measured in water column profiles, was 10.13 ± 1.11 nmol/L and did not strongly diverge from atmospheric equilibrium indicating that sampled marine regions were neither a strong source nor sink of N2O to the atmosphere. Multivariate analysis of data describing water column biogeochemistry and its links to N-cycling activity failed to explain the observed variance in rates of N-regeneration and N-assimilation, possibly due to the limited number of process rate observations. In the surface waters of five further stations, ocean acidification (OA) bioassay experiments were conducted to investigate the response of NH4+ oxidising and regenerating organisms to simulated OA conditions, including the implications for [N2O]. Multivariate analysis was undertaken which considered the complete bioassay data set of measured variables describing changes in N-regeneration rate, [N2O] and the biogeochemical composition of seawater. While anticipating biogeochemical differences between locations, we aimed to test the hypothesis that the underlying mechanism through which pelagic N-regeneration responded to simulated OA conditions was independent of location. Our objective was to develop a mechanistic understanding of how NH4+ regeneration, NH4+ oxidation and N2O production responded to OA. Results indicated that N-regeneration process responses to OA treatments were location specific; no mechanistic understanding of how N-regeneration processes respond to OA in the surface ocean of the NW European shelf sea could be developed.
    Keywords: Alkalinity, total; Ammonia, oxidation rate; Ammonia, oxidation rate, standard deviation; Ammonium; Ammonium, standard deviation; Ammonium regeneration rate; Ammonium regeneration rate, standard deviation; Aragonite saturation state; Bacteria; Bicarbonate ion; Biomass/Abundance/Elemental composition; Bottles or small containers/Aquaria (〈20 L); Calcite saturation state; Calculated using CO2SYS; Calculated using seacarb after Nisumaa et al. (2010); Carbon, inorganic, dissolved; Carbonate ion; Carbonate system computation flag; Carbon dioxide; Coast and continental shelf; Coulometric titration; D366_E1; D366_E2; D366_E3; D366_E4; D366_E5; Dimethyl sulfide; Dimethylsulfoniopropionate; Entire community; Event label; EXP; Experiment; Flag; Fugacity of carbon dioxide (water) at sea surface temperature (wet air); Identification; Laboratory experiment; Nanoflagellates, heterotrophic; Nitrate; Nitrous oxide, dissolved; North Atlantic; OA-ICC; Ocean Acidification International Coordination Centre; Open ocean; Other metabolic rates; Partial pressure of carbon dioxide (water) at sea surface temperature (wet air); Pelagos; pH; Phosphate; Potentiometric titration; Salinity; Silicate; Temperate; Temperature, water; Time in hours; Treatment; UKOA; United Kingdom Ocean Acidification research programme
    Type: Dataset
    Format: text/tab-separated-values, 12526 data points
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