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  • 1
    In: Marine geology, Amsterdam [u.a.] : Elsevier Science, 1964, 272(2010), Seite 6-25, 1872-6151
    In: volume:272
    In: year:2010
    In: pages:6-25
    Description / Table of Contents: This paper is an introduction to and an overview of papers presented in the Special Issue of Marine Geology "Methane seeps at the Hikurangi Margin, New Zealand". In 2006 and 2007, three research cruises to the Hikurangi Margin at the east coast of New Zealand's North Island were dedicated to studying methane seepage and gas hydrates in an area where early reports suggested they were widespread. Two cruises were carried out on RV TANGAROA and one on RV SONNE using the complete spectrum of state-of-the-art equipment for geophysics (seismic, sidescan, controlled source electromagnetics, ocean bottom seismometers and hydrophones, singlebeam and multibeam), seafloor observations (towed camera systems, ROV), sediment and biological sampling (TV-guided multi-corer, gravity-corer, grab, epibenthic sled), deployment of in-situ observatories (landers) as well as water column sampling and oceanographic studies (CTD, moorings). The scientific disciplines involved ranged from geology, geophysics, petrography, geochemistry, to oceanography, biology and microbiology. These cruises confirmed that a significant part of the Hikurangi Margin has been active with locally intense methane seepage at present and in the past, with the widespread occurrence of dead seep faunas and knoll-forming carbonate precipitations offshore and on the adjacent land. A close link to seismically detected fluid systems and the outcropping of the base of the gas hydrate stability zone can be found at some places. Pore fluid and free gas release were found to be linked to tides. Currents as well as density layers modulate the methane distribution in the water column. The paper introduces the six working areas on the Hikurangi Margin, and compiles all seep locations based on newly processed multibeam and multibeam backscatter data, water column hydroacoustic and visual data that are combined with results presented elsewhere in this Special Issue. In total, 32 new seep sites were detected that commonly show chemoherm-type carbonates or carbonate cemented sediment with fissures and cracks in which calyptogenid clams and bathymodiolid mussels together with sibloglinid tube worms live. White bacterial mats of the genus Beggiatoa and dark gray beds of heterotrophic ampharetid polychaetes typically occur at active sites. Bubble release has frequently been observed visually as well as hydroacoustically (flares) and geochemical analyses show that biogenic methane is released. All seep sites, bubbling or not, were inside the gas hydrate stability zone. Gas hydrate itself was recovered at three sites from the seafloor surface or 2.5 m core depth as fist-sized chunks or centimeter thick veins. The strong carbonate cementation that in some cases forms 50 m high knolls as well as some very large areas being paved with clam shells indicates very strong and long lasting seep activity in the past. This activity seems to be less at present but nevertheless makes the Hikurangi Margin an ideal place for methane-related seep studies in the SW-Pacific.
    Type of Medium: Online Resource
    Pages: Ill., graph. Darst
    ISSN: 1872-6151
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Comparative Biochemistry and Physiology -- Part B: Biochemistry and 56 (1977), S. 311-319 
    ISSN: 0305-0491
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    International Journal of Biochemistry 15 (1983), S. 167-177 
    ISSN: 0020-711X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 2 (1984), S. 349-355 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Homogeneous enzyme membrane immunoassays (EMIAs) have been developed for thyroxine (T4) and human immuno-globulin G (IgG). Liposomes tagged with T4 and containing alkaline phosphatase were used as a model system for optimization of (a) liposome membrane attack in the presence of T4 antiserum and ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism 795 (1984), S. 293-296 
    ISSN: 0005-2760
    Keywords: Anabolic steroid ; Apolipoprotein B ; Apolipoprotein D ; Lecithin-cholesterol acyltransferase ; Lp(a) particle ; Stanozoloi
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The frequency of α+-thalassaemia, but not other unlinked DNA polymorphisms, exhibits an altitude- and latitude-dependent correlation with malaria endemicity throughout Melanesia, supporting the hypothesis that protection against this parasitic disease is the major factor ...
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The a+-thalassaemias are usually caused by the deletion of one of the linked pair of a-globin genes on chromosome 16 (ref. 5). The normal genotype is represented by aa/aa. Heterozygotes (á€"a/aa) are clinically normal, whereas homozygotes (á€"a/- a) have a mild ...
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0428
    Keywords: Keywords Hepatocyte nuclear factor, Type II diabetes, transcription factors, gene expression, promoter.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Linkage and association studies in Caucasian patients with Type II (non-insulin-dependent) diabetes mellitus suggest that one or more diabetes susceptibility gene(s) reside within human chromosome 20q12–13.1. This region of chromosome 20 contains the maturity-onset diabetes of the young type 1 gene, HNF4 α. The purpose of this study was to assess the possible involvement of HNF4 α in Type II diabetes.¶Methods. Mutation analysis was done on the 12 exons and promoter regions of the HNF4 α gene in 182 Caucasian diabetic nephropathic patients and 100 Caucasian control subjects. The functional consequences of a novel promoter mutation were examined using a reporter system in the HepG2 liver cell line and electrophoretic mobility shift assays.¶Results. We identified two novel mutations in the HNF4α, an R323H missense mutation in exon 8, and a 7 bp deletion (Δ7) in the proximal promoter region resulting in deletion of a single putative Sp1 binding site. Using a reporter assay system, the Δ7 sequence was found to exhibit a 51.2 % (standard error ± 4.2 %) reduction in promoter activity relative to the normal sequence. In electrophoretic mobility shift assays using specific and non-specific competitors, the Δ7 sequence had a 45.5 % (range 40.4–46.6) reduction in binding compared with the normal sequence. The Δ7 allele occurs in a family with multiple cases of Type II diabetes in a pattern consistent with coinheritance of the Δ7 allele and diabetes.¶Conclusion/interpretation. Analysis of the HNF4 α gene revealed two possible mutations in 182 diabetic patients which suggests that the HNF4 α gene does not make a large contribution to diabetes susceptibility in the general population of Caucasian diabetic nephropathic patients. Functional analysis of the Δ7 promoter deletion suggests, however, that promoter mutations in otherwise normal genes could contribute to diabetes susceptibility. [Diabetologia (2000) 43: 364–372]
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of atmospheric chemistry 29 (1998), S. 85-107 
    ISSN: 1573-0662
    Keywords: Henry's law ; solubility ; aerosol ; fluoroacetic acid ; chloroacetic acid ; bromoacetic acid ; difluoroacetic acid ; dichloroacetic acid ; dibromoacetic acid ; trifluoroacetic acid ; trichloroacetic acid ; tribromoacetic acid ; chloro-difluoroacetic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences
    Notes: Abstract Henry's law constants K′H (mol kg-1 atm-1) have been measured between 278.15 K and 308.15 K for the following organic acids: CH2FCOOH (ln(K′H[298.15 K]) = 11.3 ± 0.2), CH2ClCOOH (11.59 ± 0.14), CH2BrCOOH (11.94 ± 0.21), CHF2COOH (10.32 ± 0.10), CHCl2COOH (11.69 ± 0.11), CHBr2COOH (12.33 ± 0.29), CBr3COOH (12.61 ± 0.21), and CClF2COOH (10.11 ± 0.12). The variation of K′H with temperature was determined for all acids except CH2FCOOH and CBr3COOH, with Δr H° for the dissolution reaction ranging from −85.2 ± 2.6 to −57.1 ± 2.5 kJ mol-1, meaning that their solubility is generally more sensitive to temperature than is the case for the simple carboxylic acids. The Henry's law constants show consistent trends with halogen substitution and, together with their high solubility compared to the parent (acetic) acid (ln(K′H[298.15 K]) = 8.61), present a severe test of current predictive models based upon molecular structure. The solubility of haloacetic acids and strong dissociation at normal pH mean that they will partition almost entirely into cloud and fog in the atmosphere (0.05–1.0 g H2O m-3), but can reside in both phases for the liquid water contents typical of aerosols (10-5-10-4 g H2O m-3).
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-7284
    Keywords: Australia ; Hepatitis B virus ; Hepatitis C virus ; Human immunodeficiency virus ; Injecting drug users
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To describe the epidemiology of infection with hepatitis C virus (HCV), hepatitis B virus (HBV) and human immunodeficiency virus (HIV) among injecting drug users (IDUs) in Australia, in relation to the potential for further spread of HIV in IDUs, a cross-sectional analysis was performed on data from a sample of injecting drug users, correlating markers of exposure to blood-borne viruses with sex, age, sexual orientation, primary current drug injected and duration of injecting in rural and metropolitan Victoria, Australia. The subjects were currently active IDUs from a wide spectrum of age, sex, sexual orientation, geographical location and social background, contacted and recruited through their social networks and from community agencies and prisons by trained peer workers who interviewed and collected blood from them in the field. Sera were tested for antibody to HIV, HCV and hepatitis B core antigen (HBcAg), for hepatitis B surface antigen (HBsAg), and for HCV RNA using reverse transcription and polymerase chain reaction (RT-PCR). At entry to the study, 4.5% (14/311) had antibody to HIV, 47% (146/308) to HBcAg and 68% (206/303) to HCV. Prevalence of HBsAg was 1.8% overall (5/282), and 50% (84/168) were positive for HCV RNA. By multivariate analysis, HIV seropositivity was strongly associated with a history of homosexual contact in males and with exposure to HBV but not to HCV. Those who reported their current primary injected drug to be amphetamines were at greater and continuing risk of HIV infection than were current heroin injectors, while the reverse applied for HCV. The different patterns of exposure to different blood-borne viruses in this particular population of IDUs probably reflects different interactions among different social networks. HCV exposure provides a good surrogate marker for risk behaviour among these IDUs, but HBV exposure provides a better marker for risk of HIV infection. More detailed surveillance strategies for HIV infection, and more targeted HIV prevention programs are necessary to detect and to prevent further spread of HIV in these populations.
    Type of Medium: Electronic Resource
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