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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 55 (1990), S. 1757-1761 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Biochemistry 30 (1991), S. 3432-3436 
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Biochemistry 30 (1991), S. 9414-9420 
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 485 (1986), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of low temperature physics 19 (1975), S. 75-82 
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We have shown experimentally that the electrical contact resistance between a thin copper wire and a bulk superconductor contains a small contribution that varies with temperature below T c . The observed temperature dependence is always close to that of the energy gap in the superconductor.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 32 (1986), S. 281-291 
    ISSN: 0730-2312
    Keywords: protease nexin ; cellular binding sites ; extracellular matrix ; elastase ; thrombin ; urokinase ; fibroblasts ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: This review summarizes the mechanisms by which several serine proteases, particularly urokinase, thrombin, and elastase, interact with cultured fibroblasts. Many of these studies were prompted by findings that interactions of these proteases with cells and the extracellular matrix are important in a number of physiologic and pathologic processes. Two main pathways have been identified for specific interactions of these proteases with fibroblasts. One involves surface binding sites for the free protease that appear to bind only one particular protease. An unusual feature collectively shared by the binding sites for urokinase, thrombin, and elastase is that the bound protease is not detectably internalized by the fibroblasts. The other pathway by which serine proteases interact with fibroblasts involves proteins named protease nexins (PNs). Three PNs have been identified. They are secreted by fibroblasts and inhibit certain serine proteases by forming a covalent complex with the protease catalytic site serine. The complexes then bind back to the fibroblasts via the PN portion of the complex and are internalized and degraded. Recent studies showing that the fibroblast surface and extracellular matrix accelerate the inactivation of thrombin by PN-1 support the hypothesis that the PNs control protease activity at and near the cell surface. The PNs differ from plasma protease inhibitors in their molecular properties, absence in plasma, site of synthesis, and site of clearance of the inhibitor:protease complexes.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 134 (1988), S. 179-188 
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Protease nexin-1 (PN-1) is a protease inhibitor that is secreted by fibroblasts and several other cultured cells. PN-1 forms complexes with certain serine proteases in the extracellular environment including thrombin, urokinase, and plasmin. The complexes then bind to the cells and are rapidly internalized and degraded. This report demonstrates that PN-1 is present on the surface of fibroblasts, bound to the extracellular matrix. Immunofluorescent studies showed that PN-1 colocalized with fibronectin on both intact cells and in preparations of extracellular matrix made from these cells. In contrast, PN-1 did not colocalize with the epidermal growth factor receptor, a plasma membrane marker. An enzyme-lined immunosorbent assay was developed which showed that the extracellular matrix contained at least 60-80% of the cellular immunoreactive PN-1. Extraction of the matrix with 2 M NaCl removed PN-1 in a form which reacted with 125l-thrombin to form complexes which were immunoprecipitated by anti-PN-1 lgG and were of identical size as complexes made from soluble PN-1 and 125l-thrombin. These data indicate that in addition to its role as a soluble protease inhibitor, PN-1 is also a component of the extracellular matrix and might control its proteolysis.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Publication Date: 2022-05-27
    Description: © The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Stevens, B., Bony, S., Farrell, D., Ament, F., Blyth, A., Fairall, C., Karstensen, J., Quinn, P. K., Speich, S., Acquistapace, C., Aemisegger, F., Albright, A. L., Bellenger, H., Bodenschatz, E., Caesar, K.-A., Chewitt-Lucas, R., de Boer, G., Delanoë, J., Denby, L., Ewald, F., Fildier, B., Forde, M., George, G., Gross, S., Hagen, M., Hausold, A., Heywood, K. J., Hirsch, L., Jacob, M., Jansen, F., Kinne, S., Klocke, D., Kölling, T., Konow, H., Lothon, M., Mohr, W., Naumann, A. K., Nuijens, L., Olivier, L., Pincus, R., Pöhlker, M., Reverdin, G., Roberts, G., Schnitt, S., Schulz, H., Siebesma, A. P., Stephan, C. C., Sullivan, P., Touzé-Peiffer, L., Vial, J., Vogel, R., Zuidema, P., Alexander, N., Alves, L., Arixi, S., Asmath, H., Bagheri, G., Baier, K., Bailey, A., Baranowski, D., Baron, A., Barrau, S., Barrett, P. A., Batier, F., Behrendt, A., Bendinger, A., Beucher, F., Bigorre, S., Blades, E., Blossey, P., Bock, O., Böing, S., Bosser, P., Bourras, D., Bouruet-Aubertot, P., Bower, K., Branellec, P., Branger, H., Brennek, M., Brewer, A., Brilouet , P.-E., Brügmann, B., Buehler, S. A., Burke, E., Burton, R., Calmer, R., Canonici, J.-C., Carton, X., Cato Jr., G., Charles, J. A., Chazette, P., Chen, Y., Chilinski, M. T., Choularton, T., Chuang, P., Clarke, S., Coe, H., Cornet, C., Coutris, P., Couvreux, F., Crewell, S., Cronin, T., Cui, Z., Cuypers, Y., Daley, A., Damerell, G. M., Dauhut, T., Deneke, H., Desbios, J.-P., Dörner, S., Donner, S., Douet, V., Drushka, K., Dütsch, M., Ehrlich, A., Emanuel, K., Emmanouilidis, A., Etienne, J.-C., Etienne-Leblanc, S., Faure, G., Feingold, G., Ferrero, L., Fix, A., Flamant, C., Flatau, P. J., Foltz, G. R., Forster, L., Furtuna, I., Gadian, A., Galewsky, J., Gallagher, M., Gallimore, P., Gaston, C., Gentemann, C., Geyskens, N., Giez, A., Gollop, J., Gouirand, I., Gourbeyre, C., de Graaf, D., de Groot, G. E., Grosz, R., Güttler, J., Gutleben, M., Hall, K., Harris, G., Helfer, K. C., Henze, D., Herbert, C., Holanda, B., Ibanez-Landeta, A., Intrieri, J., Iyer, S., Julien, F., Kalesse, H., Kazil, J., Kellman, A., Kidane, A. T., Kirchner, U., Klingebiel, M., Körner, M., Kremper, L. A., Kretzschmar, J., Krüger, O., Kumala, W., Kurz, A., L'Hégaret, P., Labaste, M., Lachlan-Cope, T., Laing, A., Landschützer, P., Lang, T., Lange, D., Lange, I., Laplace, C., Lavik, G., Laxenaire, R., Le Bihan, C., Leandro, M., Lefevre, N., Lena, M., Lenschow, D., Li, Q., Lloyd, G., Los, S., Losi, N., Lovell, O., Luneau, C., Makuch, P., Malinowski, S., Manta, G., Marinou, E., Marsden, N., Masson, S., Maury, N., Mayer, B., Mayers-Als, M., Mazel, C., McGeary, W., McWilliams, J. C., Mech, M., Mehlmann, M., Meroni, A. N., Mieslinger, T., Minikin, A., Minnett, P., Möller, G., Morfa Avalos, Y., Muller, C., Musat, I., Napoli, A., Neuberger, A., Noisel, C., Noone, D., Nordsiek, F., Nowak, J. L., Oswald, L., Parker, D. J., Peck, C., Person, R., Philippi, M., Plueddemann, A., Pöhlker, C., Pörtge, V., Pöschl, U., Pologne, L., Posyniak, M., Prange, M., Quiñones Meléndez, E., Radtke, J., Ramage, K., Reimann, J., Renault, L., Reus, K., Reyes, A., Ribbe, J., Ringel, M., Ritschel, M., Rocha, C. B., Rochetin, N., Röttenbacher, J., Rollo, C., Royer, H., Sadoulet, P., Saffin, L., Sandiford, S., Sandu, I., Schäfer, M., Schemann, V., Schirmacher, I., Schlenczek, O., Schmidt, J., Schröder, M., Schwarzenboeck, A., Sealy, A., Senff, C. J., Serikov, I., Shohan, S., Siddle, E., Smirnov, A., Späth, F., Spooner, B., Stolla, M. K., Szkółka, W., de Szoeke, S. P., Tarot, S., Tetoni, E., Thompson, E., Thomson, J., Tomassini, L., Totems, J., Ubele, A. A., Villiger, L., von Arx, J., Wagner, T., Walther, A., Webber, B., Wendisch, M., Whitehall, S., Wiltshire, A., Wing, A. A., Wirth, M., Wiskandt, J., Wolf, K., Worbes, L., Wright, E., Wulfmeyer, V., Young, S., Zhang, C., Zhang, D., Ziemen, F., Zinner, T., and Zöger, M.: EUREC4A. Earth System Science Data, 13(8), (2021): 4067–4119, https://doi.org/10.5194/essd-13-4067-2021.
    Description: The science guiding the EUREC4A campaign and its measurements is presented. EUREC4A comprised roughly 5 weeks of measurements in the downstream winter trades of the North Atlantic – eastward and southeastward of Barbados. Through its ability to characterize processes operating across a wide range of scales, EUREC4A marked a turning point in our ability to observationally study factors influencing clouds in the trades, how they will respond to warming, and their link to other components of the earth system, such as upper-ocean processes or the life cycle of particulate matter. This characterization was made possible by thousands (2500) of sondes distributed to measure circulations on meso- (200 km) and larger (500 km) scales, roughly 400 h of flight time by four heavily instrumented research aircraft; four global-class research vessels; an advanced ground-based cloud observatory; scores of autonomous observing platforms operating in the upper ocean (nearly 10 000 profiles), lower atmosphere (continuous profiling), and along the air–sea interface; a network of water stable isotopologue measurements; targeted tasking of satellite remote sensing; and modeling with a new generation of weather and climate models. In addition to providing an outline of the novel measurements and their composition into a unified and coordinated campaign, the six distinct scientific facets that EUREC4A explored – from North Brazil Current rings to turbulence-induced clustering of cloud droplets and its influence on warm-rain formation – are presented along with an overview of EUREC4A's outreach activities, environmental impact, and guidelines for scientific practice. Track data for all platforms are standardized and accessible at https://doi.org/10.25326/165 (Stevens, 2021), and a film documenting the campaign is provided as a video supplement.
    Description: This research has been supported by the people and government of Barbados; the Max Planck Society and its supporting members; the German Research Foundation (DFG) and the German Federal Ministry of Education and Research (grant nos. GPF18-1_69 and GPF18-2_50); the European Research Council (ERC) advanced grant EUREC4A (grant agreement no. 694768) under the European Union’s Horizon 2020 research and innovation program (H2020), with additional support from CNES (the French National Centre for Space Studies) through the EECLAT proposal, Météo-France, the CONSTRAIN H2020 project (grant agreement no. 820829), and the French AERIS Research Infrastructure; the Natural Environment Research Council (NE/S015868/1, NE/S015752/1, and NE/S015779/1); ERC under the European Union’s H2020 program (COMPASS, advanced grant agreement no. 74110); the French national program LEFE INSU, by IFREMER, the French research fleet, CNES, the French research infrastructures AERIS and ODATIS, IPSL, the Chaire Chanel program of the Geosciences Department at ENS, and the European Union's Horizon 2020 research and innovation program under grant agreement no. 817578 TRIATLAS; NOAA’s Climate Variability and Prediction Program within the Climate Program Office (grant nos. GC19-305 and GC19-301); NOAA cooperative agreement NA15OAR4320063; NOAA's Climate Program Office and base funds to NOAA/AOML's Physical Oceanography Division; Swiss National Science Foundation grant no. 188731; the UAS Program Office, Climate Program Office, and Physical Sciences Laboratory and by the US National Science Foundation (NSF) through grant AGS-1938108; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy – EXC 2037 “CLICCS – Climate, Climatic Change, and Society” – project no. 390683824; and Poland’s National Science Centre grant no. UMO-2018/30/M/ST10/00674 and Foundation for Polish Science grant no. POIR.04.04.00-00-3FD6/17-02.
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 9
    Publication Date: 2022-05-26
    Description: © The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Surveys in Geophysics 38 (2017): 1529–1568, doi:10.1007/s10712-017-9428-0.
    Description: Trade-wind cumuli constitute the cloud type with the highest frequency of occurrence on Earth, and it has been shown that their sensitivity to changing environmental conditions will critically influence the magnitude and pace of future global warming. Research over the last decade has pointed out the importance of the interplay between clouds, convection and circulation in controling this sensitivity. Numerical models represent this interplay in diverse ways, which translates into different responses of trade-cumuli to climate perturbations. Climate models predict that the area covered by shallow cumuli at cloud base is very sensitive to changes in environmental conditions, while process models suggest the opposite. To understand and resolve this contradiction, we propose to organize a field campaign aimed at quantifying the physical properties of trade-cumuli (e.g., cloud fraction and water content) as a function of the large-scale environment. Beyond a better understanding of clouds-circulation coupling processes, the campaign will provide a reference data set that may be used as a benchmark for advancing the modelling and the satellite remote sensing of clouds and circulation. It will also be an opportunity for complementary investigations such as evaluating model convective parameterizations or studying the role of ocean mesoscale eddies in air–sea interactions and convective organization.
    Description: The EUREC4A project is supported by the European Research Council (ERC), under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No. 694768), by the Max Planck Society and by DFG (Deutsche Forschungsgemeinschaft, German Research Foundation) Priority Program SPP 1294.
    Keywords: Trade-wind cumulus ; Shallow convection ; Cloud feedback ; Atmospheric circulation ; Field campaign
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 10
    Publication Date: 2020-02-06
    Description: Trade-wind cumuli constitute the cloud type with the highest frequency of occurrence on Earth, and it has been shown that their sensitivity to changing environmental conditions will critically influence the magnitude and pace of future global warming. Research over the last decade has pointed out the importance of the interplay between clouds, convection and circulation in controling this sensitivity. Numerical models represent this interplay in diverse ways, which translates into different responses of trade-cumuli to climate perturbations. Climate models predict that the area covered by shallow cumuli at cloud base is very sensitive to changes in environmental conditions, while process models suggest the opposite. To understand and resolve this contradiction, we propose to organize a field campaign aimed at quantifying the physical properties of trade-cumuli (e.g., cloud fraction and water content) as a function of the large-scale environment. Beyond a better understanding of clouds-circulation coupling processes, the campaign will provide a reference data set that may be used as a benchmark for advancing the modelling and the satellite remote sensing of clouds and circulation. It will also be an opportunity for complementary investigations such as evaluating model convective parameterizations or studying the role of ocean mesoscale eddies in air–sea interactions and convective organization
    Type: Article , PeerReviewed
    Format: text
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