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  • 11
    Electronic Resource
    Electronic Resource
    Springer
    Meteorology and atmospheric physics 70 (1999), S. 227-238 
    ISSN: 1436-5065
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Summary  Data assimilation in meteorology and oceanography for strongly nonlinear dynamical systems is challenging. The dynamical system studied here is the classical three-variable Lorenz model. In this context data assimilation with weak-constraint variational methods performs better than other methods like strong-constraint variational methods or Kalman filters. The difficulty in tracking the chaotic Lorenz orbit by assimilation of noisy observations results from the inherent instability in the system. In variational methods a cost function has to be minimized. It is known, that in the Lorenz case the structure of the cost function becomes more and more complex with increasing length of the assimilation time interval and with reduction of the observational data quality. This paper proposes a non-standard implementation of a genetic algorithm for searching the global minimum in case of a weak-constraint formulation. The good performance of this non-local search is shown, but the algorithm is computationally demanding due to a very large number of control parameters within the weak-constraint formulation and, thus, the algorithm is applicable for simple systems only.
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 344 (1992), S. 559-560 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The detection of opiates and their metabolites in human hair has obtained an increasing importance in forensic toxicology, but many compounds [e.g. the heroin marker 6-monoacetylmorphine (MAM)] are regularly destroyed by the use of invasive extraction and hydrolysis procedures. This paper describes a method for the analysis of such sensible structures by means of guanidine/mercaptoethanol treatment, followed by specific solid phase extraction. The detection limit is better than 1 μg/g hair.
    Type of Medium: Electronic Resource
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  • 13
    Publication Date: 2019-07-17
    Description: The West African monsoon rainfall is essential for regional food production, and decadal predictions are necessary for policy makers and farmers. However, predictions with global climate models reveal precipitation biases. This study addresses the hypotheses that global prediction biases can be reduced by dynamical downscaling with a multimodel ensemble of three regional climate models (RCMs), a RCM coupled to a global ocean model and a RCM applying more realistic soil initialization and boundary conditions, i.e., aerosols, sea surface temperatures (SSTs), vegetation, and land cover. Numerous RCM predictions have been performed with REMO, COSMO-CLM (CCLM), and Weather Research and Forecasting (WRF) in various versions and for different decades. Global predictions reveal typical positive and negative biases over the Guinea Coast and the Sahel, respectively, related to a southward shifted Intertropical Convergence Zone (ITCZ) and a positive tropical Atlantic SST bias. These rainfall biases are reduced by some regional predictions in the Sahel but aggravated by all RCMs over the Guinea Coast, resulting from the inherited SST bias, increased westerlies and evaporation over the tropical Atlantic and shifted African easterly waves. The coupled regional predictions simulate high-resolution atmosphere-ocean interactions strongly improving the SST bias, the ITCZ shift and the Guinea Coast and Central Sahel precipitation biases. Some added values in rainfall bias are found for more realistic SST and land cover boundary conditions over the Guinea Coast and improved vegetation in the Central Sahel. Thus, the ability of RCMs and improved boundary conditions to reduce rainfall biases for climate impact research depends on the considered West African region.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
    Format: application/pdf
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  • 14
    Publication Date: 2021-05-19
    Description: The Mediterranean is expected to be one of the most prominent and vulnerable climate change “hotspots” of the twenty-first century, and the physical mechanisms underlying this finding are still not clear. Furthermore, complex interactions and feedbacks involving ocean–atmosphere–land–biogeochemical processes play a prominent role in modulating the climate and environment of the Mediterranean region on a range of spatial and temporal scales. Therefore, it is critical to provide robust climate change information for use in vulnerability–impact–adaptation assessment studies considering the Mediterranean as a fully coupled environmental system. The Mediterranean Coordinated Regional Downscaling Experiment (Med-CORDEX) initiative aims at coordinating the Mediterranean climate modeling community toward the development of fully coupled regional climate simulations, improving all relevant components of the system from atmosphere and ocean dynamics to land surface, hydrology, and biogeochemical processes. The primary goals of Med-CORDEX are to improve understanding of past climate variability and trends and to provide more accurate and reliable future projections, assessing in a quantitative and robust way the added value of using high-resolution and coupled regional climate models. The coordination activities and the scientific outcomes of Med-CORDEX can produce an important framework to foster the development of regional Earth system models in several key regions worldwide.
    Description: Published
    Keywords: MED-CORDEX ; Climate changes
    Repository Name: AquaDocs
    Type: Journal Contribution , Refereed
    Format: pp.1187-1208
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  • 15
    Publication Date: 2017-09-02
    Description: The development of improved breast cancer screening methods is hindered by a lack of cancer-specific imaging agents and effective small-animal models to test them. The purpose of this study was to evaluate 64 Cu-DOTA-alendronate as a mammary microcalcification-targeting PET imaging agent, using an ideal rat model. Our long-term goal is to develop 64 Cu-DOTA-alendronate for the detection and noninvasive differentiation of malignant versus benign breast tumors with PET. Methods: DOTA-alendronate was synthesized, radiolabeled with 64 Cu, and administered to normal or tumor-bearing aged, female, retired breeder Sprague–Dawley rats for PET imaging. Mammary tissues were subsequently labeled and imaged with light, confocal, and electron microscopy to verify microcalcification targeting specificity of DOTA-alendronate and elucidate the histologic and ultrastructural characteristics of the microcalcifications in different mammary tumor types. Tumor uptake, biodistribution, and dosimetry studies were performed to evaluate the efficacy and safety of 64 Cu-DOTA-alendronate. Results: 64 Cu-DOTA-alendronate was radiolabeled with a 98% yield. PET imaging using aged, female, retired breeder rats showed specific binding of 64 Cu-DOTA-alendronate in mammary glands and mammary tumors. The highest uptake of 64 Cu-DOTA-alendronate was in malignant tumors and the lowest uptake in benign tumors and normal mammary tissue. Confocal analysis with carboxyfluorescein-alendronate confirmed the microcalcification binding specificity of alendronate derivatives. Biodistribution studies revealed tissue alendronate concentrations peaking within the first hour, then decreasing over the next 48 h. Our dosimetric analysis demonstrated a 64 Cu effective dose within the acceptable range for clinical PET imaging agents and the potential for translation into human patients. Conclusion: 64 Cu-DOTA-alendronate is a promising PET imaging agent for the sensitive and specific detection of mammary tumors as well as the differentiation of malignant versus benign tumors based on absolute labeling uptake.
    Print ISSN: 0022-3123
    Topics: Medicine
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  • 16
    Publication Date: 2020-02-12
    Description: A wide variety of processes controls the time of occurrence, duration, extent, and severity of river floods. Classifying flood events by their causative processes may assist in enhancing the accuracy of local and regional flood frequency estimates and support the detection and interpretation of any changes in flood occurrence and magnitudes. This paper provides a critical review of existing causative classifications of instrumental and preinstrumental series of flood events, discusses their validity and applications, and identifies opportunities for moving toward more comprehensive approaches. So far no unified definition of causative mechanisms of flood events exists. Existing frameworks for classification of instrumental and preinstrumental series of flood events adopt different perspectives: hydroclimatic (large‐scale circulation patterns and atmospheric state at the time of the event), hydrological (catchment scale precipitation patterns and antecedent catchment state), and hydrograph‐based (indirectly considering generating mechanisms through their effects on hydrograph characteristics). All of these approaches intend to capture the flood generating mechanisms and are useful for characterizing the flood processes at various spatial and temporal scales. However, uncertainty analyses with respect to indicators, classification methods, and data to assess the robustness of the classification are rarely performed which limits the transferability across different geographic regions. It is argued that more rigorous testing is needed. There are opportunities for extending classification methods to include indicators of space–time dynamics of rainfall, antecedent wetness, and routing effects, which will make the classification schemes even more useful for understanding and estimating floods.
    Language: English
    Type: info:eu-repo/semantics/article
    Format: application/pdf
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  • 17
    Publication Date: 2023-01-18
    Description: The dataset comprises a range of variables describing characteristics of flood events and river catchments for 480 gauging stations in Germany and Austria. The event characteristics are asscoiated with annual maximum flood events in the period from 1951 to 2010. They include variables on event precipitation, antecedent catchment state, event catchment response, event timing, and event types. The catchment characteristics include variables on catchment area, catchment wetness, tail heaviness of rainfall, nonlinearity of catchment response, and synchronicity of precipitation and catchment state. The variables were compiled as potential predictors of heavy tail behaviour of flood peak distributions. They are based on gauge observations of discharge, E-OBS meteorological data (Haylock et al. 2008), mHM hydrological model simulations (Samaniego et al., 2010), 4DAS climate reanalysis data (Primo et al., 2019), and the 25x25 m resolution EU-DEM v1.1. A short description of the data processing is included in the file inventory and more details can be found in Macdonald et al. (2022).
    Language: English
    Type: info:eu-repo/semantics/workingPaper
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  • 18
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    In:  XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)
    Publication Date: 2023-07-07
    Description: Recent studies have focused on the relationship between global warming and extreme precipitation events. The risk of flooding is increasing due to global warming, since warmer air temperatures accommodates more moisture content according to Clausius-Clapeyron relation. One of the major flood sources is known as Vb cyclones, i.e. cyclones travelling through the Mediterranean then moving northwards on the eastern flank of the Alps towards central Europe. In this study, the convection process during major Vb events is investigated. Two detection methods for convection are used. The first is Lagrangian convection tracking method (Purr et al. 2021) and the second is mid-tropospheric vertical velocity and vorticity method (Poujol et al. 2019) on convective-permitting simulations (3km resolution) driven by ERA5 reanalysis data for selected Vb cases. The results show that at least one third of the total amount of rainfall is produced by convection. Both methods show similar patterns and comparable amplitudes of convective precipitation. The second method is tuned to detect convective precipitation on a lower resolution parameterised-convection simulations. A comparable fraction due to convection during a Vb event is identified and the method is applied on more events to allow statistical significance. Convection is investigated in a warmer climate scenario, and it is found that convective fraction increases as high as two thirds of precipitation during Vb-events accounting for the global warming signal. This concludes that while the mean precipitation rate decreases due to global warming, extreme localised convection increases indicating more risk of flooding events in central Europe.
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
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  • 19
    Publication Date: 2023-04-11
    Description: In some catchments, the distribution of annual maximum streamflow shows heavy tail behavior, meaning the occurrence probability of extreme events is higher than if the upper tail decayed exponentially. Neglecting heavy tail behavior can lead to an underestimation of the likelihood of extreme floods and the associated risk. Partly contradictory results regarding the controls of heavy tail behavior exist in the literature and the knowledge is still very dispersed and limited. To better understand the drivers, we analyze the upper tail behavior and its controls for 480 catchments in Germany and Austria over a period of more than 50 years. The catchments span from quickly reacting mountain catchments to large lowland catchments, allowing for general conclusions. We compile a wide range of event and catchment characteristics and investigate their association with an indicator of the tail heaviness of flood distributions, namely the shape parameter of the GEV distribution. Following univariate analyses of these characteristics, along with an evaluation of different aggregations of event characteristics, multiple linear regression models as well as random forests are constructed. A novel slope indicator, which represents the relation between the return period of flood peaks and event characteristics, captures the controls of heavy tails best. Variables describing the catchment response are found to dominate the heavy tail behavior, followed by event precipitation, flood seasonality and catchment size. The pre-event moisture state in a catchment has no relevant impact on the tail heaviness even though it does influence flood magnitudes.
    Language: English
    Type: info:eu-repo/semantics/article
    Format: application/pdf
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  • 20
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    In:  XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)
    Publication Date: 2023-05-19
    Description: Given the climate change and more frequent extreme climate events, frozen soils face a potential future extensive degradation. Climate models allow us to understand the possible future course of frozen soil and its effects towards local and global climate. Snow and soil hydrothermal dynamics are the most important parts of the frozen soil land surface process. There have been substantial efforts made to improve snow simulation. Some climate models are already able to realistically reproduce the variability of the snow and its physical parameters. Soil water has a direct impact on soil hydrothermal parameters, topography, and local water circulation under the repeatedly freeze-thaw process. Frequent occurrence of phase change in soil make frozen soil unique in land process simulating. LS3MIP provides us the opportunity to compare the snow and soil moisture condition between a set of climate models’ land components under identical forcing. We collected more than 200 stations in Siberia and Alaska recording snow depth, 2 m air temperature, soil temperature and soil moisture. Together with ERA5-Land reanalysis data, evaluations are done for LS3MIP models. Based on the present results, significant differences are found between the models, especially in terms of soil water content. We will make further analysis to identify the sources of these disagreements.
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
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