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  • 1
    ISSN: 1530-0358
    Keywords: Interferon-gamma ; Radioimmunotherapy ; Antitumor-associated glycoprotein-72 mono-clonal antibody ; Antigen augmentation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: This study was designed to determine whether the ability of interferon-γ to upregulate the expression of a human tumor antigen improved the therapeutic efficacy of a radionuclide-conjugated monoclonal antibody. METHODS: Tumor xenografts of the moderately differentiated human colon tumor cell line HT-29 were grown in athymic mice. Constitutive levels of the human tumor antigen, tumor-associated glycoprotein-72, were measured before and after treatment with interferon-γ. Antitumor effects of an131I-labeled antitumor-associated glycoprotein-72 monoclonal antibody, CC49, were determined by measuring changes in tumor volumes in the respective groups of athymic mice. RESULTS: Interferon-γ induced a time-dependent and dose-dependent increase in tumor-associated glycoprotein-72 expression in the HT-29 tumors. Immunohistochemical staining revealed a more homogeneous tumor-associated glycoprotein-72-positive tumor cell population in tumors isolated from mice treated for eight days with interferon-γ, which accounted for the enhanced tumor localization of131I-CC49 in mice. That experimental model was used to examine the antitumor effects of combining interferon-γ with131I-CC49. Administration of 300 μCi of131I-CC49 to mice bearing HT-29 tumors induced a transient suppression of tumor growth. Conversely, a long-term, sustained HT-29 tumor growth suppression was achieved in mice given 300μCi of131I-CC49 and interferon-γ. In fact, the cytokine/radioimmunoconjugate combination eradicated any evidence of tumor in approximately 30 percent of the mice. CONCLUSION: The ability of interferon-γ to enhance tumor-associated glycoprotein-72 expression substantially augmented the antitumor effects of the radioimmunoconjugate. Those observations provide additional argument for use of a radioimmunoconjugate in combination with a cytokine to improve tumor diagnosis and therapy.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Intensivmedizin und Notfallmedizin 37 (2000), S. 69-77 
    ISSN: 1435-1420
    Keywords: Key words Ventricular assist devices – mechanical circulatory support – low-cardiac output syndrome – bridging to transplant ; Schlüsselwörter Pulsatile Ventrikel-Assist-Systeme (VAD) – Mechanische Kreislaufunterstützung – Low cardiac output-Syndrom –Überbrückung zur Transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die terminale Herzinsuffizienz kann nach Ausschöpfung medikamentöser Therapie oft nur mit mechanischer Kreislaufunterstützung beherrscht werden. Besonders die Therapieergebnisse des rechtzeitigen elektiven Einsatzes von pulsatilen kardialen Assist-Systemen als Überbrückung zur Herztransplantation unterstreichen den Erfolg der Behandlungsmethode. Durch die Aufrechterhaltung bzw. die Wiederherstellung einer ausreichenden Zirkulation mittels mechanischer Kreislaufunterstützung kommt es bei vielen Patienten auch zur Erhaltung oder Wiederherstellung einer ausreichenden Organfunktion. Bei Patienten der NYHA-Klasse IV mit Kontraindikation gegen eine Herztransplantation bietet sich die Implantation eines Langzeitsystems als allerdings bisher noch zeitlich limitierte Alternative zur Transplantation. Eine postkardiotomiebedingte Kreislaufunterstützung bietet bei ansonsten infauster Prognose vielen Patienten die einzige Möglichkeit des Überlebens. Wenn Hauptkomplikationen wie Thrombembolie, Blutung und Infektion nicht auftreten, lohnen gute Ergebnisse den hohen personellen und technischen Aufwand. Das postoperative intensivmedizinische und pflegerische Management erfordert eine spezielle Ausbildung der Mitarbeiter einer Intensivstation.
    Notes: Summary Despite medical therapy, chronic heart failure can often only be treated using a mechanical assist system. The results, when using such devices electively, underline that it is an effective therapy. In many patients, “dependent” organs, such as liver or kidneys etc., can regain their usual function soon after adequate circulatory function is reestablished by the mechanical assist system. In patients with NYHA class IV heart failure and contraindications for heart transplantation, implantation of a long-lasting system is an alternative approach, even though available systems do not yet last forever. Post-cardiosurgical implantation of an assist device is the only option in some patients. The good results are rewarding the high technical and personal efforts if no major-complications, such as thromboembolism, bleedings or infections, occur. Postoperative treatment of these patients requires special training of all those involved.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 37 (1898), S. 387-388 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 33 (1894), S. 582-582 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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